Argonaut Technologies QUEST 205 User manual

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ARGONAUT
TECHNOLOGIES
Part Number 102965
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

..
.......
Quest 205 . User Manual Revision
B 12/03/98
1 Introduction ................................................................................................................................. 1-7
Quest205 Product Description
................................................................................................. 1-8
. . ...............................................................................................................
Quest205 Specifications.. 1-9
..................................................................................
Quest205 Limited Warranty Agreement 1-10
WarrantyTerm
.......................................................................................................................... 1-10
Who Is Protected?
..................................................................................................................... 1-10
......................................................................................................................
What Is Covered? 1-10
..............................................................................................................
What Is Not Covered? 1-10
........................................................................................................
Preparation and Installation 1-12
How to Get Warranty Service
..................................................................................................... 1-12
..............................................................................................................
InterferenceInformation 1-12
.................................................................................................................
Immunity Information 1-13
.............................................................................................................................................
Safety -1-13
......................................................................................................................
Laboratory Safety 1-14
MaterialSafetyData Sheets(MSDS)
.......................................................................................... 1-14
.....................................................................................................................
Contact Information 1-15
.................................................................................................................
2 Quest 205 Installation 2-1
....................................................................................................................
InstallationProcedure 2-1
..............................................................................................................................................
Parts 2.1
...................................................................................................................
User-Supplied Items 2-1
...................................................................................................................
InstallationGlossary 2.2
Settingup the Quest 205 Synthesizer
...................................................................................... 2-2
Connecting the Interface Harnessto the Controller Unit
..................................................... 2-3
Connecting the BottleCap Assembly
...................................................................................... 2-3
........................................................................
Connecting the Reactor Unit Manifold Tubes 2-4
..........................................................................................................
Installingthe Waste Tank 2-6
Settingthe Manifold ControlValves
....................................................................................... 2-6
....................................................................................
Connecting Gasto the Controller Unit 2-7
Connecting a SingleGas Source
........................................................................................... 2-7
Connecting Two GasSources
................................................................................................ 2-7
.........................................................................................
Connecting Power to the Quest205 2-8
Installingthe SolventBottle
...................................................................................................... 2-8
...................................................................................................................
3 Quest 205 Overview 3-1
.....................................................................................................................................
Reactor Unit 3-1
............................................................................
ReactionVessel Bank and ReactionVessels
3-2
....................................................................................................................
ReactionVessels 3-2
..............................................................................................................
ReactionVessel Bank 3-2
Argonaut Technologies
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Quest 205 . User Manual Revision
B 72/03/98
Heatingand Cooling .................................................................................................................. 3-2
..................................................................................................
Heatingand CoolingBlocks 3-2
..........................................................................................................................
Reaction Mixing 3-3
. .
...................................................................................................................................
Agitation 3-3
...............................................................................................................................
Magnet Bar 3-3
Fluidic System
............................................................................................................................. 3-3
ManifoldControl Valves
....................................................................................................... 3-4
....................................................................................................
Metered Gas Needle Valve 3-5
Utility Ports
.......................................................................................................................... 3-5
Upper Manifold
...................................................................................................................... 3-6
Luer Ports
................................................................................................................................. 3-6
Lower Manifold Drain Valves
.............................................................................................. 3-7
.............................................................................................................................. Waste Tank 3-7
SampleCollection
................................................................................................................... 3-7
ControllerUnit
................................................................................................................................ 3.8
LCD Screen and Keypad
............................................................................................................ 3-8
LCD Screen
.............................................................................................................................. 3-8
Keypad
..................................................................................................................................... 3.9
Mode Button
............................................................................................................................ 3-9
Forward and Back Buttons
.................................................................................................. 3-10
Parameter SettingButtons
.................................................................................................. 3-10
START/STOPButton
.......................................................................................................... 3.10
Agitator Control Buttons
..................................................................................................... 3.11
Agitation Needle Valve
........................................................................................................ 3-11
ControllerUnit Gas and Power Connections
....................................................................... 3-12
SystemGas
........................................................................................................................... 3-12
ElectricalOutlet
..................................................................................................................... 3-12
Power Switch
........................................................................................................................ 3-12
InterfaceHarness
......................................................................................................................... -3-12
SolventBottle Assembly
............................................................................................................. -3-13
............................................................................................................
4 Operatingthe Quest205 4-1
...................................................................................... Preparingthe Quest205 for a Synthesis 4-1
Remove Used Reaction Vessels
................................................................................................ 4-1
...............................................................................................
InstallingNew ReactionVessels 4-4
ShuttingOffIndividualReaction Vessels
............................................................................... 4-6
Waste Tank
.................................................................................................................................. 4-7
.......................................................................................................................... Startinga Reaction 4-7
......................................................
Settingthe Reaction Temperature, Time, and Aptation 4-8
Argonaut Technologies
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...
Quest 205 . User Manual Revision
B 12/03/98
..........................................................................................
Settingthe Agitation Parameters 4.8
................................................................................................................
TemperatureControl 4-10
..................................................................................
Enteringthe TemperatureSet-Point 4-12
Chillingthe ReactionVessels
.............................................................................................. 4-13
Upper Manifold MembraneSwitch
....................................................................................... 4-14
ParallelSolvent Addition and Vessel Draining
.................................................................... 4-14
....................................................................................................
ParallelSolventAddition 4-14
Drainingthe ReactionVessels
............................................................................................ -4-16
Changinga SolventBottle
................................................................................................... 4-17
Adding Solventor Reagents Throughthe Luer Ports
......................................................... 4-18
................................................................................................
Adding Solventor Reagents 4-18
Adding Liquid Solventor Reagents to an Air-SensitiveChemistry
............................. 4-19
ReactionVessel Bank-to-Bank Transfer
................................................................................. 4-20
Providing a GasSweep Over the Reaction Vessels
............................................................. 4-21
Collection of Liquid Reaction Products
.................................................................................... -4-22
DrainingSynthesisProductsto CollectionFlasks
............................................................... 4-22
5 Maintenance
............................................................................................................................. 5-1
Post SynthesisCleaning
................................................................................................................ 5-1
...................................................................................................................
Manifold Maintenance 5.3
........................................................................................................................................
6 Glossary 6-1
...............................................................................................
7 ControllerUnit Display Screens 7-1
Sign-OnScreen
................................................................................................................................ 7-1
Firmware Version Screen
............................................................................................................... 7-2
AgitationControlScreen
............................................................................................................... 7-3
.
Set Temperature Screen ................................................................................................................. 7-5
........................................................................................................
Monitor Temperature Screen 7-6
..................................................................................................................
Other Functions Screen 7-7
.................................................................................................................
Contrast ControlScreen 7.9
Self Test Screen
.............................................................................................................................. 7-10
Restore DefaultsScreen
................................................................................................................ 7-11
...........................................................................................................
Start/Stop HeatersScreen 7-12
8 Reactor Unit PlumbingSchematic
............................................................................................ 8-1
9 Accessories
................................................................................................................................... 9-1
Quest 205 Magnet Stirrer (P/N 900200)
.................................................................................. 9-1
.................................................................... Quest 205 Magnet Extraction Bar (P/N 102288) 9-1
.........................................................................................
Quest205 Flask Rack (P/N 900199) 9-1
...................
Quest 205 RestrictorTubing (P/N 900201) and InsertionTool (P/N 900202) 9-1
.............................................................................
Quest 205 WeighingFunnel (P/N 900196) 9-2
Argonaut Technologies
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Quest 205 . User Manual Revision
B 12/03/98
Quest 205 Addition Funnel (P/N 900197) ............................................................................... 9-2
Quest 205
RV Tapered Caps (P/N 900203) ........................................................................ 9-3
............................................................................................. Quest 205 RV Rack (P/N 900204) 9-3
............................................................ Quest 205 Hex Ball Driver 3/32" Tool (P/N 900205) 9-3
Quest 205
Hex Ball Driver 7/ 64" Tool (P/ N 900206) ........................................................... 9-3
...........................................................................
Quest 205 Bubbler Accessory (P/N 900125) 9-4
............................................................................. Quest 205 TransferCannula (P/N 900207) 94
.................................................................
Quest 205 Multi-FlaskAdapter Kit (P/N 900209) 9-5
.............................................................
Quest 205 SPE Cartridge Adapter Kit (P/N 900210) 9-5
Quest 205 SeptumLuer Plugs (P/N 900145)
.......................................................................... 9-6
10 User Tutorial
.............................................................................................................................. 10-1
Overview
........................................................................................................................................ 1 0-1
Instrument and SolutionPreparation
........................................................................................ 10-2
....................................................
RV Removal, Instrument Cleaning, and RV Installation 10-5
Reductive Amination
................................................................................................................... 10-6
Fillingthe Dead Volume Between the
RV frit and the Lower Manifold Drain Valve .... 10-6
Addition of Reagentsof RVs
................................................................................................... 10-7
Addition of NaBH4 Solutionto eachRV
............................................................................... 10-9
Product Work Up and Collection
............................................................................................ .10-11
In-Line Purification: Bank to Bank TransferCannulation (optional)
............................. 10-11
Off-Line Purification: 60 mL or 75 mL SPE cartridge (optional)
.................................... 10-12
............................................................................................................ Cleaning and Maintenance 10-13
Systemswithout the Automated SolventWash Option
.................................................. .I 0-14
Systemswith Automated SolventWash
............................................................................. 10-14
Product Analysis
......................................................................................................................... 10-16
SpectroscopicData
.................................................................................................................. 10-17
Argonaut Technologies
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Quest 205 - User Manual
Quest 205 User Manual.
Part Number 102965
Rev
B 12/03/98
Argonaut Technologies
887 Industrial Rd., Suite G
San Carlos, CA 94070
All rights reserved. Printed in the Unitec
d States.
Revision B 12/03/98
Argonaut Technologiesreservesthe right to make changes in any products herein to improve
reliability, fimction,or design. Argonaut Technologiesdoes not assume any liability arising out of the
applicationor use of any product or circuitdescribed herein; neither does it convey any license.
-
Quest is a trademark of Argonaut Technologies. Other product names in this document are registered
trademarksor trademarks of their respective holders.
Argonaut Technologies
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Quest 205 - User Manual
Revision 6 72/03/98
1 Introduction
This manual will assist with operating and maintaining the Quest 205 Synthesizer
and is organized into the following sections.
Section
1, Introduction: Contains general information on the Quest 205
Synthesizer, brief description of the instrument, warranties, and safety
information.
Section 2, Quest 205 Installation: Provides instructions on installing the Quest
205 Synthesizer.
Section
3, Quest 205 Overview:Defines the Quest 205 hardware parts and
provides
an overview of how these parts work together.
Section 4, Operatingthe Quest 205: Provides step-by-step instructions for
performing solid phase or solution phase reactions.
Section 5, Maintenance:Provides step-by-step instructions on maintenance
procedures for optimum instrumentperformance.
Section
6, Glossary: Definesterms specific to the Quest 205 Synthesizer.
Section
7, Controller Unit Display Screens:Provides a list of the possible display
screens and how to changeparameters on the appropriate screens.
Section
8, Reactor Unit Plumbing Schematic
Section
9, Accessories:Describes accessories available for the Quest 205
Synthesizer. Includes installation and use instructions.
Section 10,User Tutorial: Provides
an introductionto the instrument by guiding
the user through a parallel solution phase reaction, work-up and purification.
Argonaut Technologies
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Quest 205 - User Manual Revision
B 12/03/98
Quest 205 Product Description
WARNING: The Quest 205 Synthesizer is designed for use in chemical syntheses,
including potentially hazardous chemical reactions and should be operated in a fume hood.
Potential hazards of chemical synthesis include but are not limited to burns, explosions,
and exposure to carcinogens and toxic chemicals. Always wear eye protection and suitable
gloves.
The Quest 205 Synthesizerruns in parallel up to 10liquid or solid phase organic
chemistry reactions. The unique design of the Quest 205 incorporates
heating/cooling,agitation,and the inert environmentneeded to
run these
reactions. The mechanical featuresof the Quest 205 also provide for simple
operation of the instrument.
The Quest 205 consistsof four main parts: the Reactor Unit, the Controller Unit,
the Solvent Bottle Assembly, and the Reactor InterfaceHarness.
The
Reactor Unit containsthe manual solvent and gas control valves and
components for heating, cooling, agitation,as well as holds the Teflon Reaction
Vessels. Solventsmay be added to the Reaction Vessels (RVs) in parallel using
the manual rotary valves. Reagents are added via luer ports located at the top of
each Reaction Vessel.
The
Controller Unit contains the controlsto set the reaction temperature, heating
duration, and agitationconditions. The ControllerUnit also contains connections
for system power and gas, and interfaceconnectionsfor the Reactor Unit. A
serial computerport is included on the ControllerUnit to download firmware
upgrades.
The
Solvent Bottle Assembly consists of the solvent bottle, plastic bottle safety
carrier, and a Bottle Cap Assembly. The Bottle Cap Assembly can either
pressurize or vent the solvent bottle. The Solvent Bottle Assembly connects to
the Quest Reactor Unit and providesthe solvent for parallel deliveryto the
Reaction Vessels for resin washing and system cleaning.
The
Interface Harness linksthe Control Unit to the Reactor Unit. Solvent, drain
gas, metered gas, agitationpressure, and temperature control information are
supplied and/or communicatedthrough the harness. The solvent, drain gas, and
metered gas movements are directed via the Reactor Unit's manual control
valves. The agitation and heating parameters are set using the Controller Unit
components.
Argonaut Technologies
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com