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Curr Pediatr Res 2017; 21 (1): 148-157
ISSN 0971-9032
www.currentpediatrics.com
Curr Pediatr Res 2017 Volume 21 Issue 1
148
Introduction
According to the International Association for the Study of
Pain (IASP) Pain is “an un-pleasant sensory and emotional
experience associated with actual and potential tissue
damage”. Pain has also been dened as “existing whenever
they say it does rather than whatever the experiencing
person says” [1-4]. It is one of the most dreading and
devastating symptom commonly propagated in peoples
with advanced chronic conditions including cancer patents.
Pediatric patients are the most under treated and present to
hospital for pain compared to adults; because of the wrong
belief that they neither suffer pain nor they remember
painful experiences [5]. The quality of life experienced
by the patient can greatly reduce, regardless of their basic
diagnosis. Thus, if pain will be poorly managed, it can
reect the inuence on family and careers causing different
which may leads to increased rates of hospital admission
[5,6]. Uncontrolled pain has also direct impact on health
outcomes and more than a few effects on all areas of life.
The emotional, cognitive, and behavioral components of
pediatric patient are also important to assess pain and to
simplify the management practices [7,8].
A long-term negative effect of untreated pain on pain
sensitivity, immune functioning, neurophysiology,
attitudes, and health care behavior are supported with
numerous evidences. Health care professionals’ who care
for children are mainly responsible for abolishing or
assuaging pain and suffering when possible [5,7,9]. The
practice of pediatric pain treatment protocol has made
great progress in the last decade with the development
and validation of pain valuation tools specic to pediatric
patients. Almost all the major children hospitals now
have dedicated pain services to provide evaluation and
immediate treatment of pain in any child [10,11].
In pediatric age, it is more difcult to assess and treat pain
effectively relatively to adults. The lack of ability to notice
pain, immaturity of remembering painful experiences
and other reasons are the reection of persistence of
myths related to the infant’s ability to perceive pain [12].
However, the treatment of pain in childhood is like the adult
management practice which includes pharmacological and
non-pharmacological interventions. On the other hand,
it critically depends on an in-depth understand of the
developmental and environmental factors that inuence
nociceptive processing, pain perception and the response
to treatment during maturation from infancy to adolescence
[13,14].
The practice of assessing pain and its management in
pediatric patients can show a discrepancy based on the
different countries and their respective health institutions.
So, this review focused on the contemporary practice
and new advances in pediatric pain assessment and its
management.
Classication of Pain
Many classication systems are used to describe the
different types of pain. The most common classication
schemes refer to pain as acute or chronic; malignant or
nonmalignant; and nociceptive or neuropathic [15]. Most
studies are agreed with the following classication of pain
(Table 1).
Assessment and treatment of pain in pediatric patients.
Halefom Kahsay
Department of Pharmacy, Collage of Health Science, Adigrat University, Adigrat, Ethiopia.
Pediatric patients experience pain which is more difcult to assess and treat relatively to
adults. Evidence demonstrates that controlling pain in the pediatrics age period is benecial,
improving physiologic, behavioral, and hormonal outcomes. Multiple validated scoring
systems exist to assess pain in pediatrics; however, there is no standardized or universal
approach for pain management. Healthcare facilities should establish pediatrics pain control
program. This review summaries a collection of pain assessment tools and management
practices in different facilities. This systematic approach should decrease pediatric pain and
poor outcomes as well as improve provider and parent satisfaction.
Abstract
Keywords: Pain, Pain assessment, Pain management, Pediatric patients.
Accepted January 30, 2017

Assessment and treatment of pain in pediatric patients.
Curr Pediatr Res 2017 Volume 21 Issue 1
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Assessment of Pain in Pediatrics
Pain is often referred to as the “fth vital sign” and it should
be assessed and recorded as often as other vital signs.
The appropriate intervention of pain is planned based
on the accurate valuation of pain. Organized and routine
pain assessment by using the standardized and validated
measures is accepted as a corner stone for effective pain
management in patients, unrelatedly to the age or other
conditions [21]. A study in Brazil suggests that consistent
accomplishment of assessments of pain using ordinary
scales, such as Face, Legs, Activity, Cry and Consolability
score and other bodily parameters are mandatory to
optimize pain management in pediatric intensive care
units [22]. As pain is a subjective experience, individual
self-reporting is the favorite method for assessing
pain. However, when valid self-report is not available
as in children who cannot communicate due to age or
developmental status, the observational and behavioral
assessment tools are acceptable substitutions [5,7,22].
The use of the pain management algorism on Stollery
children’s hospital shows signicant improvement for
assessment of pain in pediatrics. The pre and post analysis
indicated in a staff (n=17) given that a feedback of 41.2%
felt that the algorism improved their ability to assess and
manage pain in children equally, 35% felt that it increased
their capacity to communicate a child’s pain with other
health care team members, 52.9% felt that the algorism
should be further applied on other units across the hospital
[23]. Even though, the assessment of pain symptoms is
easy in adults, selection of appropriate pain assessment
tools should consider age, cognitive level and the presence
of eventual disability, type of pain and the situation in
which pain is occurring in children. Therefore, healthcare
professionals need to be aware of their limitations in
addition to trained in the use of pain assessment tools
[7,24,25].
The assessment in Canadian pediatric teaching hospitals
indicated out of 265 children, majority (63%) of them
found with a minimum of one documented pain assessment
tool, 30% of children had at least two assessment tools,
17% had 3-5 measurement tools and 16% had at least
six assessments in 24 h of admission. Most (63%) of
the children were nd a different document of 666 pain
assessment tools, with a median of three assessments per
one child [14]. Parent, patient, as well as staff satisfaction
is positively associated with accurate assessment of pain in
addition to well improvement of pain management. Brief
and well validated tools are available for the assessment
of pain in non-specialist settings. Nevertheless, each tool
cannot be broadly suggested for assessment of pain in all
Category Sub-classication Description
Pathophysiological
Nociceptive pain
This type of pain arises as the tissue injury activates specic pain receptors
named nociceptors, which are sensitive to noxious stimuli. These
receptors’ can respond to different stimulus and chemical substances
released from tissues in response to oxygen deprivation, tissue disruption
or inammation. It can be somatic or visceral pain based on the site of
the activated receptors.
Neuropathic pain This type of pain arises when the abnormal processing of sensory input
recognized by the peripheral or central nervous system.
Etiologically
Non-malignant
It includes the pain due to chronic musculoskeletal pains, neuropathic
pains, visceral pain (like distension of hollow viscera and colic pain) and
chronic pain in some specic anemia. Rehabilitation care is there main
treatment protocol.
Malignant
This is the pain in potentially life-limiting diseases such as multiple
sclerosis cancer, HIV/AIDS, end stage organ failure, amyotrophic lateral
sclerosis, advanced chronic obstructive pulmonary disease, Parkinsonism
and advanced congestive heart failure. These illnesses are indicating for
similar pain treatment that emphases more on symptom control than
function.
Based on duration
Acute
This is pain of recent onset and probable limited duration. It usually has
an identiable temporal and causal relationship to injury or disease. Most
acute pain resolves as the body heals after injury.
Chronic
It is the pain which lasts a long time mostly 6 months, which commonly
persisting beyond the time of curing of an injury and may be without any
clearly identiable cause.
Based on location
When Pain is often classied by body site (e.g. on head, on the back
or neck) or it can be the anatomic function of the affected tissue (e.g.
vascular, rheumatic, myofascial, skeletal, and neurological). It does not
provide a background to resolve pain, but it can be useful for differential
diagnoses.
Table 1. The general classication of pain in pediatrics [3,4,8,15-20]

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Curr Pediatr Res 2017 Volume 21 Issue 1
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after observing the infant for 1 min. Among two observers
a reliability of FLACC was established in a total of 30
children in the post anesthetics care unit (PACU) (r=0.94).
After analgesic administration, validity was established
by demonstrating a proper decrease in FLACC scores.
Correspondingly, a high degree of association was found
between PACU nurse’s global pain rating scale, FLACC
scores, and with the objective scores of pains scale. This
tool has been established in various settings and in diverse
patient populations and nds that as reliable and valuable.
It provides a simple background for computing pain
behaviors in children who may not be able to put into words
the incidence or severity of pain. Lastly, the constructed
validity is supported by analgesic administration as the
scores decreases signicantly. Another recent studies
have demonstrated that FLACC was the most chosen in
terms of sensible qualities by clinicians at their respective
institutions [27,29,32-35]. Although the tool can be
used by clinicians, it is more effective with parent input
to provide a description of ‘baseline’ behavior. This is
supported by the ndings of the Malvinas study, which
suggested that the addition of unique descriptors allowed
parents to augment the tool with individual behaviors
unique to their children. In addition, for infants who show
good comprehension and motor skills, this pain assessment
tool can be used as an alternative [36]. The FLACC scale
has 98% sensitivity and 88% specicity in assessing pain
levels [34]. Therefore, those different studies concluded
that FLACC scale is the most appropriate measurement
tool for pain assessment in infants (Table 3).
Cries Pain Rating Scale
0 1 2
Crying No high pitched inconsolable
Requires O2 for sat >95% No <30% >30%
Increased vital signs HR and BP <or=pre-op
HR and BP;
Increased <20% of
pre-op
HR and BP; Increased >20% of
pre-op
Expression None Grimace Grimace/grunt
Sleepless No Wakes at frequent
intervals Constantly awake
Table 2. Neonatal pain rating scale [27-29]
children and across all settings. Individual needs of the
children lead to assess and re-evaluate of pain consistently
as a mandatory in every situation. On top of that,
ethnicity, language, and cultural factors should be under
consideration as they may inuence pain assessments and
its expression [5,12,26].
Most formal and commonly used means of pediatric
assessment tools for pain are available and categorized
depending the pediatrics age.
Pain Assessment in Neonates
Neonates pain rating scale (NPR-S): Major guidelines
indicate that the assessment of pain in neonates (term
babies up to 4 weeks of age) had better be use the Crying,
Requires oxygen for saturation above 95%, Increasing
vital signs, Expression and Sleepless (CRIES) scale
(Table 2) [2,24,27-30].
Several other pain scales have been designed for the
objective assessment of neonatal pain, including the
COMFORT (“behavior”) score, pain assessment tool, scale
for use in newborns, distress scale for ventilated newborns
and infants. Although these assessments are validated as
research tools, the mainstay of appropriate management
includes the caregiver’s awareness, knowledge of clinical
situations where in pain occurs, and sensitivity to the
necessity of preventing and controlling pain [31].
Assessment of pain in infants: On a study in Australia
hospitals, Infants (1 month to approximately 4 years) were
scored using the face, leg, activity, cancelability and cry
(FLACC) measuring tool. Scoring should be done by staff
FLACC Behavioral Pain Assessment Tool
0 1 2
Face No particular expression
or smile
Occasional grimace/frown withdrawn or
disinterested
Frequent/constant quivering
chin, clenched jaw
Legs Normal position or
relaxed Uneasy, restless or tense Kicking or legs drawn up
Activity Lying quietly, normal
position, moves easily squirming, shifting back and forth, tense Arched, rigid or jerking
Cry No cry Moans or Whimpers, occasional complaint Crying steadily, screams or
sobs, frequent complaints
Cancelability Content or relaxed Reassured by occasional touching,
hugging or being talked to, distractible Difcult to console or comfort
Table 3. FLACC assessment tool [27,29,32-35]

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Assessment of pain in older children:
Self-report: The single most reliable indicator of
the existence and intensity of pain and any resultant
distress is the patient’s self -report. For older children,
the use of a self-reporting scale can be helpful to staff
and empowering to the patient [24]. A self-report of
pain from a patient with limited verbal and cognitive
skills may be a simple yes/no or other vocalizations
or gestures, such as hand grasp or eye blink. When
self-report is absent or limited, explain why self-
report cannot be used and further investigation and
observation are needed [4,28]. Myriad guidelines are
coming together in using different self-report methods
in assessing pain in older children such as the Visual
Analogue Scale (VAS) (Figure 1) which is described
by a horizontal line with “no pain” at the beginning to
“worst possible pain” at the termination and patients
draw a line to show their severity of pain. It has several
benets: it avoids imprecise descriptive terms, quick
and simple to score, and offers many determining
points. However, it can be difcult in post-operatively
or in children with neural and psychological disorder as
it needs a concentration and coordination [1,12,24,29].
Wong-Baker faces pain rating scale is the other self-
report tool mainly used to assess acute pain. Expressed
by six line-drawn faces range from no pain at one end to
worst pain at the other end and assigns by number with
word descriptors to each face to indicate the intensity
of pain [11,37].
However, many studies take a type of self-report, face
scale method for assessing pain in older children. Below
is the Faces scale, currently used by the children’s hospital
at West Mead:
These faces show how much something can hurt. From no
pain to very much pain pointing to the face by the patient
him/herself to show how much he/she hurt to simplify
pain assessment (Figure 2).
Generally, most institutions approved using the pain
assessment tools as their basic instrument for diagnosis
and management of the different type of pains encountered
in pediatrics.
Management of Pain in Pediatrics
The management of pain in pediatrics is still
misunderstood. Explicitly, neonates and infants are not
managed for pain effectively, due to the misperception
that they are not able to sense pain as adults [16,18].
American academy of pediatrics suggested that the
lack of pain assessment and fears of adverse effects of
analgesic medications including respiratory depression
and addiction are the main barriers to the treatment
of pain in children [9]. As the underlying disease is
expected to advance a continuous adjustment of pain
therapy is required. A study in Toronto hospitals shows
that out of the total 265 children, 58.9% received a
minimum of one documented intervention of pain
management. Out of 66 children with recognized pain
(mild, moderate or severe), 55 of them received an
intervention for their pain [14]. It extends beyond pain
relief, encompassing the patient’s quality of life and
ability to work productively and to enjoy recreation.
Pain management is a joint responsibility among
the members of the health care team. This includes
addressing pain status of each patient daily on inpatient
unit rounds or with each patient visit, consultation if
pain treatment is ineffective, and discharge planning for
continuing pain management needs [3,15,38].
Generally, on consideration of the above challenges
Managements of pain in pediatrics encompass the use of
pharmacological and non-pharmacological interventions
to control the patient’s identied pain.
Non-Pharmacological Interventions
Non-pharmacological measures should be favored as base
line for both adults and children intervention of pain. in
conjunction with pharmacological options to help lower
levels of anxiety, pain and distress, the psychological
comfort measures such as relaxation techniques and
distraction as well as physical interventions including
the use of massage repositioning or heat and/or cold
compresses are useful Strategies [3,4,15,19,24,39].
According to the guidelines for clinical practice of
the American pain society, pain education such as the
interventions and options for pain relief during the pre-
Figure 2. Face scale assessment tool [27]
Figure 1. Visual analogue scale [21,25]

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surgical visit for patients and their families is important to
develop their perception towards pain management [40].
A study by Lm Zhu et al. in Canadian pediatric teaching
hospitals indicated that out of the 55 (83.3%) children
who take pain management intervention, six of them
received a physical treatment and ve children received a
psychological intervention [14].
General the following interventions are considered as non-
pharmacological treatment of pain based on the recent and
numerous studies.
Sucrose
Concentrated sucrose solutions (2 ml of 24% solution)
may be used as a pain relief measure in preterm and term
newborns up to 1 month of age as its analgesic effect lasts
approximately 3 to 5 min. It promotes natural pain relief
by activating endogenous opioids in contact with the oral
mucosa. The effectiveness of sucrose solution enhanced
by allowing the infant to continue sucking on a pacier
or breastfeed [41]. A randomized controlled clinical
trial found that a single dose oral sucrose is effective
and safe for minimizing physiological response to a
painful stimulus and behavioral expressions in preterm
infants [37]. The proposed hypothesis initiated from the
endogenous opioid release can cause by taking oral 20-
30% glucose through unknown mechanism. Therefore,
Several studies recommended to considered oral sucrose
as one of the non-pharmacological interventions of pain
[30,31,37].
Distraction
Distraction involves engaging a child in a wide variety of
pleasant activities that help focus attention on something
other than pain and the anxiety. Examples of distraction
activities are listening to music, singing a song, blowing
bubbles, playing a game, watching television or a video,
and focusing on a picture while counting. Guided imagery
and breathing techniques may be forms of distraction for
school-age children and adolescents [42]. A randomized
control trial suggested that a virtual reality games were
found to be effective distraction for children with acute
burn injuries [43].
Breast Feeding
Breast milk is the best alternative to no intervention or
to the use of sucrose in patient suffering with a single
painful procedure. During venipunctures and heel stick
procedures, neonates who were breastfed showed a
substantial decrease in the variability of physiologic
response as compared to other non-pharmacological
interventions [30,39,44].
Skin-to-Skin Contact
Skin to skin contact demonstrated as effective non-
pharmacological intervention in reduction of pain
especially when used as adjunctive therapy to breastfeeding
or other sweet solutions. Canadian medical association
demonstrated that skin-to-skin contact principally
Kangaroo care plays its own role in reducing and caring
their children as the care giver and the baby have a direct
physical contact [4,30].
Pharmacological Management of Pain
The current pharmacologic treatment protocol of pain for
children is primarily extrapolated from adult intervention
without any evidence of value in children [32]. High-
quality pediatric experimental researches are needed
to demonstrate efcacy and safety of analgesics for
innumerable pain conditions in children to avoid continued
use of analgesics empirically [8]. The development of age-
appropriate pain assessment tools leads to improvement
in the management of pain in children in the last two
decades. Depending on the severity of pain, non-opioids
and opioids are the most common analgesic agents used
a “step-wise” approach in management of pain in both
children and adults [19,24,28]. It is important that pain be
reassessed soon after any pharmacological intervention to
guide further interventions and to ensure the achievement
of pain relief ensured by reassessment of pain regularly
after any pharmacological intervention. Multimodal
analgesia practice should be considered in patients with
pain by concomitant use of the opioids, NSAIDs and other
adjuvant therapies [14].
Generally, World Health Organization (WHO)
demonstrated three-step analgesic ladder for treatment of
pain (Figure 3) [45].
Non-Opioids Used for Management of Pain in Pediatrics
Acetaminophen: It is the most frequently used pain-
relieving agent in pediatric patients. It has lack of
signicant side effects and excellent safety prole with
benet to all levels of pain in children [39]. In common to
the guideline of different institutions (Table 4), initially a
loading dose of 30 mg/kg should be given, then 10-15 mg/
kg every four to six hours as maintenance with maximum
dose of 90 mg/kg/day for children. But, for term neonates
of less than ten days 60 mg/kg and 45 mg/kg for premature
infants. Neonates have a slower clearance rate so the drug
must be given less frequently. Acetaminophen is manly
used for mild to moderate pain independently and in
combination of opioids for patients with severe pain for
example acetaminophen with codeine) [24,37,45]. Rectal
preparations of this analgesics used for infants and toddlers
who are unable or unwilling to take orally. However,
several studies have conrmed that rectal absorption
comparatively inefcient and slow. Hepatotoxicity is
not associated with single rectal doses of 30 to 45 mg/kg
produced plasma concentrations that were generally in the
effective range [46].
In relative to oral doses rectal doses are slowly decline in
plasma concentrations. Based on a day pharmacokinetic
study, the dosing interval for rectal dose extended to at
least 6 h [29]. Acetaminophen toxicity can result when the

Assessment and treatment of pain in pediatric patients.
Curr Pediatr Res 2017 Volume 21 Issue 1
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toxic metabolite acetyl-p-benzoquinone-imine (NAPQI)
is produced in high quantities. This may lead infants
and children to hepatotoxicity. However, rodent study
compared weanling to adult rats and suggested that infants
produce high levels of sulfhydryl group of glutathione
(GSH) to bind NAPQI as a part of hepatic growth and this
may provide some protection against the hepatotoxicity
produced by overdose [7].
Non-Steroidal Anti-Inammatory Drugs (NSAIDs)
NSAIDs are commonly used analgesics with less
contraindication in relative to opioids. Mainly these are
used as analgesic regimen in mild and moderate pain
by preventing the conversion of arachidonic acid to
prostaglandins and thromboxane. Prostaglandins are
pro inammatory mediators that sensitize nociceptors to
increase afferent nociceptive signal to pain. Diclofenac,
ketoprofen and ibuprofen commonly used NSAIDs in
pediatric practice [7]. An observational study on the use
of non-steroidal anti-inammatory drugs (NSAIDs) was
done in a sample of 51 patients in Italy resulted that
ibuprofen was the most (68.6%) used NSAID followed
by ketoprofen 9.8% and acetylsalicylic acid 7.8% for pain
management of in pediatrics. The use of NSAIDs is now
well established in clinical pain management [47].
This show to decrease morphine consumption and improve
the quality of analgesia without increasing the incidence of
side effects. These drugs are now a standard peri-operative
analgesic agent in many pediatric institutions. Ibuprofen
mainly used is available in oral suspension, infant drops,
Figure 3. The WHO analgesic ladder [15,24,45]
Drug Oral peak time Usual Pediatric
dosage Usual Adult dosage Comments
Acetaminophen 0.5–2 h
10–15 mg/kg every
4 h orally
20-40 mg every 6 h
rectally
650–1000 mg every 4 h
Lacks the peripheral anti-
inammatory activity of other
NSAIDs
Choline magnesium
trisalicylate
(Trilisate)
2 h 25 mg/kg every
12 h
1000–1500 mg every
12 h
Does not increase bleeding time
like other NSAIDs; available as
oral liquid
Ibuprofen 0.5 h 6–10 mg/kg every
6–8 h
200–400 mg every
4–6 h
Fewer GI effects than other non-
selective NSAIDs
Naproxen 2–4 h 5 mg/kg every 12 h 250–500 mg every
6–8 h
Delayed-release tablets are not
recommended for initial treatment
of acute pain
Ketorolac 0.75–1 h 0.25–0.5 mg/kg IV
or IM, every 6 h
30 mg IV loading dose,
then 15–30 mg every
6 h
IV or IM use only in children less
than 50 kg; should not be used for
children with bleeding disorder or
at risk for bleeding complications
Celecoxib 3-6 h 1-2 mg/kg 100-200 mg every 12 h
sparing of COX-1 reduces the
risk of serious GI side effects and
renal toxicity Also, no effects on
platelet aggregation
Table 4. Dosage guidelines for the common non-opioids used in the management of pain in pediatrics [12,48]

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tablet and intravenous formulations. It is used to close
patent ductus arteriosus (PDA) and as pain reliever in
perioperative in neonates and children weighing greater
than 7 kg. It is available as different dosage form such
as oral suspensions, tablets, infant drops and intravenous
preparations with a dose of 30 mg/kg in 3-4 divided doses.
Besides, diclofenac is available like ibuprofen dosage
forms with the recommended dose to children at a dose
of 0.3–1 mg/kg with a maximum dose of 50 mg 3 times
daily. However, ketorolac is not approved for use in
children under 16 years of age. It only used for short term
interventions of acute post-operative pain at a dose of 10-
40 mg every 4-6 h for a maximum of 7 days [7,12,48].
Meta-analysis of studies comparing ibuprofen and
diclofenac reveal that both drugs work well and that
choosing between them is an issue of dose, safety and
cost. An oral ibuprofen dose of 30-40 mg/kg per day
appears to render equivalent analgesia to oral/rectal
diclofenac 2-3 mg/kg per day. No difference in safety
has been documented in these dose ranges [27]. Clinical
pharmacology understanding for non-opioid analgesics
is required for optimal administration. Because, for
patients with post-operative pain, the minimal effective
for analgesic dose and toxic dose is not known certainly.
These doses may be higher or lower than the usual dose
ranges recommended for the drug involved. On top of that,
NSAIDs and acetylsalicylic acid have a potential toxicity,
most commonly bleeding diathesis due to inhibition
of platelet aggregation, renal impairment and gastro
duodenopathy due to prostaglandin inhibition [12].
Opioids
Like adult population, management of acute pain in
pediatric is also targeted with opioids. The analgesic
effect comes through binding the mu-opioid receptor
which is widely distributed at sites of peripheral
inammation and throughout the CNS. The variation in
pharmacological response of opioids in pediatrics leads to
adjustment based on clinical response, age and presence
of side effects [7,27]. The indications for opioids include
postoperative pain, pain due to sickle cell disease, and
pain due to cancer [49]. A study in the Canadian teaching
hospitals conrms that opioids are mainly used in severe
pain and shows an improvement in all patients from
the their experience of severe pain received an opioid
treatment [14]. Most currently practiced guidelines in
recent advanced pediatric hospitals are commonly used
the following opioids in the management moderate to
severe pain in pediatrics (Tables 5-7).
Morphine: It is the most commonly used phenanthrene
derivative opioid in children with severe pain.
Pharmacokinetics disparity (Table 5) exists for this drug
between age groups. Because the plasma concentrations
of morphine in neonates and infants display a prolonged
half-lives (2-3fold) difference even with administration of
constant infusion [7,12,27].
Codeine: It is a prodrug which activated to morphine by
the enzyme cytochrome CYP2D6. However, the activity of
this enzyme is highly variable and shows inter-individual
variation which leads to a variation in analgesic effect of
codeine [7,10]. Caucasian population are considered as
‘Super Metabolizers’ whose approximately carry 10% of
this variant. Therefore, even low dose codeine put them at
risk of respiratory depression and excess sedation. Indeed,
codeine is now infrequently prescribed in Australia [7,27].
Tramadol: It is structurally related to morphine which
has a central analgesic effect by the formation of
O-desmethyl-tramadol with a mu-opioid receptor afnity
200 times greater due to biotransformation in the liver by
cytochrome P450(10). A dose of 50–100 mg every 4 h to a
maximum of 400 mg per day is recommended to children
between 12–18 years [7]. However, now a day’s tramadol
does not recommend for pediatrics under 12 years of age.
Fentanyl: Even though it is metabolized to inactive
metabolites, fentanyl has 100 times more effect of analgesic
than morphine. Commonly it used by the trans mucosal,
intravenous, inhalational or intra-nasal and transdermal
routes for procedural related pains in surgery due to
its rapid onset and offset [7]. Case series and outcome
studies of children not undergoing intubation suggest a
higher frequency of opioid-induced respiratory depression
among neonates than among infants over six months
of age or older children [27]. In addition to the use of
naloxone 10-20 mcg /kg for urgent situations, deep breath
encouragement, awakening of the patient and withholding
further doses may manage mild respiratory depression in
children. Non-respiratory side effects of opioids, including
nausea, ileus, itching, and urinary retention, are common
among infants and children and may cause considerable
distress. Many opioid side effects can be ameliorated by
drug therapy directed at the side effect (e.g. antiemetic’s to
treat nausea and vomiting, antihistamines to treat itching
and laxatives to treat constipation) [12,49].
Generally, WHO guideline recommends analgesic
treatment in two steps according to the child’s level of
pain severity [15,24,48].
Age Group
Volume of
Distribution
(l/kg)
Clearance
(ml/kg/min)
Half Life
(Hours)
Preterm neonate 1.8-5.2 2.7-9.6 7.4-10.6
Term neonate 2.9-3.4 2.3-20 6.7-13.9
1-8 Years 1.4-3.1 6.2-56.2 0.8-1.2
Adult 1.1-2.1 Dec 34 1.4-3
Table 5. Pharmacokinetics of morphine [27]
Age Appropriate Initial Dose
1-6 Month 50-150 µg/Kg every 4 h
6 Month-12 years 100-300 µg/Kg every 4 h
12-18 years 3-20 mg every 4 h
Table 6. Dose administration of morphine [7,12]

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Indication Based on Pain Intensity
• Stage 1 – Non-opioid +/- adjuvant agent for mild
pain
• Stage 2 – Opioid +/- non-opioid +/- adjuvant agent.
For moderate to severe pain or pain uncontrolled
after Step 1.
Common Analgesic Adjuvant
When a drug has a primary indication other than pain
but is analgesic in some conditions it can be describe
as adjuvant analgesic. Such adjuvants mainly used
for the treatment of non-malignant pain in combined
with primary analgesics to improve the outcome and to
maintain the balance between relief and side effect [12].
Moreover, adjuvants can provide independent analgesic
activity and treat concurrent symptoms that exacerbate
pain for specic types of pain. The most commonly used
adjuvants such as anti-depressants (amitriptyline), topical
and local anesthetics and anticonvulsants (e.g. gabapentin
and pregabaline) for neuropathic pain, steroids in edema
induced pains, bisphosphonates and radiation therapy for
metastases bone pain, neuroleptics for pain associated
with anxiety, restlessness or nausea) [7,27,52].
Conclusion
In summary, numerous clinical practice guidelines and
policy statements have been published in the last 10 years
about pediatric pain. These publications are valuable
resources for physical therapists and other health care
providers who serve infants, children, and adolescents
who have, or are at risk for, pain resulting from diverse
etiologies. Improved management is contingent on valid
and reliable measurement of pain. Fortunately, there
are many excellent pediatric pain measures. Selection
of appropriate measures requires an understanding of
pain, measurement, and child development. Because,
measurement of pain in infants, young children, and
children with disabilities who are unable to self-
report is particularly challenging and merits increased
attention. These assessment tools have a basic benet to
the health care providers who are involved in pediatric
health management to control the pain through non-
pharmacological and pharmacological interventions. On
top of that, pediatric institutions are well positioned to
support and implement policy initiatives to improve the
identication and management of pediatric pain and to
contribute new knowledge through research.
Recommendations
An appropriate pain assessment measurements and
techniques are needed to manage pain in pediatric
patients and should be applied in every pediatric health
care institution. Firstly, high possible standard of pain
care for all patients should be provided through a
multi modal (non-pharmacological, pharmacological
and adjuvants) approach. Secondly, pediatric centers
collaboration will be necessary to share the standard
treatment protocol. Finally, even though the incidence
of pain in children is like that of adults, clinicians should
have considered the distinctiveness of children. The
Cooperation of the caregivers and families are essential
for successful pain assessment and its intervention in
pediatric patients.
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Correspondence to:
Halefom Kahsay,
Department of Pharmacy,
Collage of Health Science,
Adigrat University,
Adigrat,
Ethiopia.
Tel: [phone]
E-mail: [email protected]