Thermo Scientific 1851 Operating instructions

Models:
1852, 1854, 1856 and 1857
Forma Laminar Airflow Workstation
Class 100
Operating and Maintenance Manual
Manual No: 7001850 Rev. 6

Model 1850 Series _________________________________________________________________________
i
Read This Instruction Manual.
Failure to read, understand and follow the instructions in
this manual may result in damage to the unit, injury to operat-
ing personnel, and poor equipment performance.
CAUTION! All internal adjustments and maintenance must
be performed by qualified service personnel.
The material in this manual is for information purposes only. The
contents and the product it describes are subject to change with-
out notice. Thermo Scientific makes no representations or war-
ranties with respect to this manual. In no event shall Thermo be
held liable for any damages, direct or incidental, arising out of or
related to the use of this manual.
MANUAL NO. 7001850
6 24102/HD-1508 9/6/07 Updated 1857 electrical schematic (225241 ballast to 500034) ccs
5 23871/SI-9779 4/3/07 Black outlet 460022 (low volume) replaced by white 460024, schematics ccs
4 21732/HD-1464 8/15/05 Updated parts list ccs
-- 21077/HD-1376 9/20/02 Removed certifiers list, added reference to website ccs
3 19029/HD-1295 6/19/00 Noted FLA rating with exclusion ccs
2 18826/HD-1286 2/25/00 Added mercury disposal warning ccs
-- 18582/HD-1269 11/4/99 Added airflow test sheet to Certification Test Procedures ccs
1 17913/HD-1237 12/7/98 Add info on levelers to prevent vibration-B. Morrison ccp
0 -- 9/87 Original manual
REV ECN DATE DESCRIPTION
WARNING! Lamps, thermometers and ther-
moregulators contain mercury. Do not put in
trash. Recycle or dispose as hazardous waste.

Model 1850 Series _________________________________________________________________________
ii
Alerts the user to important operating and/or maintenance instructions. May be used alone or with other safety sym-
bols. Read the accompanying text carefully.
Potential electrical hazards. Only qualified persons should perform the instructions and procedures associated with
this symbol.
Hazard. Do not touch. Instructions associated with this symbol should only be carried out when using special hand-
ing equipment or when wearing special, protective clothing.
Potential biological hazards. Proper protective equipment and procedures must be used when following instructions
associated with this symbol. Reference O.S.H.A. Regulation 1910-1030.
Potentially hazardous energy. Equipment being maintained or serviced must be turned off and locked off to prevent
possible injury. Reference O.S.H.A. Regulation 1910-147.
Hot surface(s) present which may cause burns to unprotected skin or to materials which may be damaged by elevated
temperatures
Warning. Skin damage and/or eye injury can result from the light produced by ultra violet light sources installed in
this equipment. Never work in this unit with the ultra violet light operating.
* Always use the proper protective equipment (clothing, gloves, goggles etc.).
* Always dissipate extreme cold or heat, or wear protective clothing.
* Always follow good hygiene practices.
* Each individual is responsible for his/her own safety.

Model 1850 Series _________________________________________________________________________
iii
Do You Need Information or Assistance on
Thermo Scientific Products?
If you do, please contact us 8:00 a.m. to 6:00 p.m. (Eastern Time) at:
1-740-373-4763 Direct
1-888-213-1790 Toll Free, U.S. and Canada
1-740-373-4189 FAX
http://www.thermo.com Internet Worldwide Web Home Page
Service E-Mail Address
Thermo Scientific
Controlled Environment Equipment
401 Millcreek Road, Box 649
Marietta, OH 45750
Our staff can provide information on pricing and give you quotations. We can
take your order and provide delivery information on major equipment items or make
arrangements to have your local sales representative contact you. Our products are listed on the
Internet and we can be contacted through our Internet home page.
Our staff can supply technical information about proper setup, operation or
troubleshooting of your equipment. We can fill your needs for spare or replacement parts or
provide you with on-site service. We can also provide you with a quotation on our Extended
Warranty for your Thermo Scientific products.
Whatever Thermo Scientific products you need or use, we will be happy to discuss your
applications. If you are experiencing technical problems, working together, we will help you
locate the problem and, chances are, correct it yourself...over the telephone without a service
call.
When more extensive service is necessary, we will assist you with direct factory trained
technicians or a qualified service organization for on-the-spot repair. If your service need is
covered by the warranty, we will arrange for the unit to be repaired at our expense and to your
satisfaction.
Regardless of your needs, our professional telephone technicians are available to assist you
Monday through Friday from 8:00 a.m. to 6:00 p.m. Eastern Time. Please contact us by
telephone or fax. If you wish to write, our mailing address is:
International customers, please contact your local Thermo Scientific distributor.
Sales Support
Service Support
[email protected]

Model 1850 Series _________________________________________________________________________
iv
Table of Contents
Section 1 - Receiving . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 - 1
1.1 Preliminary Inspection . . . . . . . . . . . . . . . . . . . . . . .2 - 1
1.2 Visible Loss or Damage . . . . . . . . . . . . . . . . . . . . . .2 - 1
1.3 Responsibility for Shipping Damage . . . . . . . . . . . .2 - 1
Section 2 - Introduction . . . . . . . . . . . . . . . . . . . . . . . . .2 - 1
2.1 Description . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 - 1
Section 3 - Installation and Start-Up . . . . . . . . . . . . . .3 - 1
3.1 Removal of Shipping Blocks . . . . . . . . . . . . . . . . . .3 - 1
3.2 Installing the Feet . . . . . . . . . . . . . . . . . . . . . . . . . . .3 - 1
3.3 Location and Leveling . . . . . . . . . . . . . . . . . . . . . . . .3 - 1
3.4 Optional Stand . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 - 1
3.5 Power Connection . . . . . . . . . . . . . . . . . . . . . . . . . . .3 - 1
3.6 General Recommendations . . . . . . . . . . . . . . . . . . . .3 - 1
3.8 Start-Up Procedure . . . . . . . . . . . . . . . . . . . . . . . . . .3 - 1
3.9 Cabinet Shutdown . . . . . . . . . . . . . . . . . . . . . . . . . . .4 - 1
Section 4 - Operation . . . . . . . . . . . . . . . . . . . . . . . . . . .4 - 1
4.1 Controls and Indicating Devices . . . . . . . . . . . . . . . .4 - 1
Section 5 - Testing Procedures . . . . . . . . . . . . . . . . . . . .5 - 1
5.1 HEPA Filter Leak Test (DOP Test) . . . . . . . . . . . . . .5 - 1
5.2 Air Velocity Profile Test . . . . . . . . . . . . . . . . . . . . . .5 - 1
Section 6 - Routine Maintenance . . . . . . . . . . . . . . . . . .6 - 1
6.1 Checking the Static Pressure Gauge “Zero” . . . . . . .6 - 1
6.2 Replacing the Pre-Filters . . . . . . . . . . . . . . . . . . . . . .6 - 1
6.3 Replacing the Fluorescent Lamp . . . . . . . . . . . . . . . .6 - 1
Section 7 - Service . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 - 1
7.1 Replacing the Supply HEPA Filter . . . . . . . . . . . . . .7 - 1
7.2 Replacing the Blower and/or Motor . . . . . . . . . . . . .7 - 1
7.3 Replacing the Blower Speed Control . . . . . . . . . . . .7 - 1
Section 8 - Troubleshooting . . . . . . . . . . . . . . . . . . . . . .8 - 1
8.1 Troubleshooting Guide . . . . . . . . . . . . . . . . . . . . . . .8 - 1
Section 9- Specifications . . . . . . . . . . . . . . . . . . . . . . . . . .9-1
Section 10 - Parts List . . . . . . . . . . . . . . . . . . . . . . . . . . .10-1
Section 11 - Electrical Schematics . . . . . . . . . . . . . . . . . .11-1
Section 12 - Warranty Information . . . . . . . . . . . . . . . .12-1

Model 1850 Series __________________________________________________________________Receiving / Introduction
2 - 1
Section 1 - Receiving
1.1 Preliminary Inspection
This item was thoroughly inspected and carefully packed
prior to shipment and all necessary precautions were taken to
ensure safe arrival of the merchandise at its destination.
Immediately upon receipt, before the unit is moved from the
receiving area, carefully examine the shipment for loss or dam-
age. Unpack the shipment and inspect both interior and exterior
for any in-transit damage.
1.2 Visible Loss or Damage
If any loss or damage is discovered, note any discrepancies
on the delivery receipt. Failure to adequately describe such evi-
dence of loss or damage may result in the carrier refusing to
honor a damage claim. Immediately call the delivering carrier
and request that their representative perform an inspection. Do
not discard any of the packing material or move the shipment
from the receiving area.
1.3 Responsibility for Shipping Damage
For products shipped F.O.B. Marietta, Ohio, the responsi-
bility of Thermo Fisher Scientific ends when the merchandise is
loaded onto the carrier’s vehicle.
On F.O.B. Destination shipments, Thermo and the carrier’s
responsibility ends when your Receiving Department personnel
sign a free and clear delivery receipt.
Whenever possible, Thermo will assist in settling claims
for loss or in-transit damage.
Section 2 - Introduction
2.1 Description
The horizontal laminar flow clean cabinet provides a par-
ticulate-free work environment for the performance of sterile
and/or dust sensitive procedures. The unit is recommended for
use in sterile apparatus assembly, media preparation sterility
testing, sterile filling and related industrial and biomedical pro-
cedure.
The cabinet provides product protection only. The opera-
tor/technician is exposed to any particulate, aerosol or gas
released from the work procedures. Therefore, procedures
involving viable agents, work involving drugs, or chemicals
that produce a toxic, allergic or carcinogenic response in
humans should not be performed within this unit.
Consult an institutional bio-safety officer or an industrial
hygienist before beginning any procedure that might endanger
the operator or contaminate the environment.

Section 3 - Installation and Start-Up
3.1 Removal of Shipping Blocks
Before putting the unit into operation, remove the card-
board shipping block from the front and back of the blower.
Remove the prefilter and the prefilter grille to gain access for
block removal.
3.2 Installing the Feet
The packing list includes eight white rubber “stick-on”
feet. Install these feet before placing the unit in its final loca-
tion.
3.3 Location and Leveling
Locate the cabinet on a level surface in an area of mini-
mum temperature change. The cabinet should be placed away
from personnel traffic, air-conditioning or heating ductwork,
and/or laboratory windows and doors. Proper cabinet location is
essential as drafts can disrupt critical airflow characteristics and
allow room contaminants to enter or escape the cabinet work
area.
Place the cabinet on an existing table or counter. The depth
of the table or table must be at least 36 inches to accommodate
the unit.
The cabinet weighs approximately 475 lbs.
Allow a 4” minimum clearance between the top of the cab-
inet and the laboratory ceiling to ensure an adequate air supply
to the blower.
Place a bubble-type level on the work surface and ensure
the cabinet is level.
3.4 Optional Stand
If the optional stand is to be used, adjust the leg levelers to
obtain the correct height (30”-36”) for the work surface. Make
sure all four levelers are in full contact with the floor.
3.5 Power Connection
Connect the power cord to a grounded dedicated power
source. Refer to the electrical data plate mounted on the unit,
or the electrical schematic, for exact electrical specifications.
3.6 General Recommendations
• Keep the activity in the room to a minimum when the cabi-
net is in use.
• Keep all laboratory doors closed to prevent drafts that will
disturb critical airflow characteristics.
• Segregate clean and dirty materials.
• Do not place anything on the intake grille, or block the pre-
filter grille.
• The operator should work at a normal pace, avoiding rapid
arm movements.
• Practice good aseptic technique to ensure safe use of the
cabinet.
• To increase the life of the HEPA filters, check the pre-fil-
ters regularly and replace them as necessary (Section 6.2).
3.7 Cabinet Wipe-down
Before operating the cabinet, allow the unit to run for
about 30 minutes. Then turn the blowers off and wipe the entire
interior surface with a laboratory detergent/disinfectant to
remove any remaining surface dirt.
3.8 Start-Up Procedure
1. Turn the cabinet lights on.
2. Check the intake grille to ensure that it is not blocked.
3. Turn on the blower on and allow the unit to warm up for
15 minutes before use.
4. Wash your hands and lower arms with germicidal deter-
gent.
5. Disinfect the entire work area.
6. Place everything needed at least 6 inches inside the
cabinet.
Model 1850 Series __________________________________________________________________Installation and Start-Up
3 - 1