cetoni neMESYS User manual

NEMESYS LOW PRESSURE
Hardware Manual and Reference
ORIGINAL INSTRUCTI ONS 1 .01–MAY 2020

2neMESYS Low Pressure Hardware Manual
CETONI GmbH
Wiesenring 6
07554 Korbussen
Germany
T+49 (0) 36602 338-0
F+49 (0) 36602 338-11
E[email protected]
www.cetoni.de

neMESYS Low Pressure Hardware Manual 3
The information and data contained in this document are subject to change without notice. CETONI
GmbH is constantly striving to develop all its products. This means that there may be changes in form,
equipment and technology. Claims can therefore not be made on the basis of information, illustration or
descriptions in these instructions. The description for the product specification in this manual does not
constitute an integral part of the contract.
If you control the products with a software from CETONI GmbH, you agree to the applicable license
agreement, which can be read in the corresponding software manual. This and all other current product
manuals can be found at https://www.cetoni.com/service/manuals.
CETONI GmbH grants its customers the right to reproduce this manual for the purpose of providing
technical information to potential users of CETONI products. Extracts of these documents may only be
reproduced or transmitted with a precise reference to the authorship of CETONI GmbH, irrespective of
the manner in which they are reproduced or transmitted, either electronically or mechanically. Any
duplication or use of excerpts for other purposes requires the written permission of CETONI GmbH.
We are always open to comments, corrections and requests. Please send them to [email protected].
The general terms and conditions of CETONI GmbH shall apply. Alternative agreements must be in
written form.
Copyright © CETONI GmbH –Automation and Microsystems. All rights reserved.

4neMESYS Low Pressure Hardware Manual
1Overviews and Directories
1.1 Table of Contents
1Overviews and Directories 4
1.1 Table of Contents 4
1.2 Revision History 6
2Introduction 7
2.1 Foreword 7
2.2 Symbols and Key Words Used 7
2.3 Norms and Guide Lines 8
2.4 Application Purpose 8
2.4.1 General Description of the Advice 8
2.4.2 Intended Use 8
2.4.3 Reasonably Foreseeable Faulty Application 8
2.4.4 Safety Advice 9
2.4.5 Measures for Safe Operation 10
2.4.6 Safety Devices on the System 10
2.4.7 Condition of the Devices 10
2.5 Warranty and Liability 11
3Scope of Delivery 12
4Technical Data 13
4.1 Product Image 13
4.2 Environment 13
4.3 Mechanical Data 13
4.4 Electrical Data 14
4.5 Interfaces 14
4.6 Dosing Performance 14

neMESYS Low Pressure Hardware Manual 5
4.7 Valve 15
4.7.1 Technical Data 15
5Hardware Operation 16
5.1 Mounting a Syringe 16
5.2 Fluidics / Valve 19
5.2.1 Valve Installation and Removal 21
6Accessory Port 22
7RS232 Connection 24
7.1 Pin Assignment of Module Interfaces 24
7.2 OEM RS232 Cable Set 24
7.2.1 RS232 Wiring 24
7.2.2 Communication Settings 25
7.2.3 Pin Assignment of the RS232 Cable 25
8Transport and Storage 26
9Maintenance and Care 27
10 Disposal 28

6neMESYS Low Pressure Hardware Manual
1.2 Revision History
REV
DATE
CHANGE
VALID FOR
1.00
16.01.2020
Separation of the neMESYS manual into
individual device manuals
NEM-B101-01 D, E
NEM-B101-02 C, D, E
NEM-B101-03 A
1.01
07.05.2020
New layout of revision history
Added section Scope of Delivery
IMPORTANT. In its current revision, this manual applies only to the product types
listed in the last line. Should you require a manual from a previous revision, please do not
hesitate to contact us. Please let us know your device type and email address and we will
send you the appropriate manual as a pdf file.
The type of your product can be found on the label behind "Type:", according to the marked number in
the following example:

neMESYS Low Pressure Hardware Manual 7
2Introduction
2.1 Foreword
Thank you for choosing a product from CETONI. With this user manual we would like to support you as
much as possible in using your neMESYS pump. If you have any questions or suggestions, please do not
hesitate to contact us directly.
The neMESYS syringe pump may only be put into operation after having read this manual thoroughly.
We wish you every success in working with the device.
2.2 Symbols and Key Words Used
The following symbols are used in this manual and are designed to aid your navigation through this
document:
HINT. Describes practical tips and useful information to facilitate the handling of the
software.
IMPORTANT. Signifies important hints and other useful information that may not
result in potentially dangerous or harmful situations.
ATTENTION. Identifies a potentially harmful situation. Failure to avert this situation
may result in damage to the product or anything in its proximity.
CAUTION. Indicates a potentially dangerous situation. Failure to avert this situation
may result in light or minor injuries or property damage.

8neMESYS Low Pressure Hardware Manual
2.3 Norms and Guide Lines
CETONI GmbH declares under its sole responsibility, that the device complies with the
health and safety requirements of the relevant European directives.
2.4 Application Purpose
2.4.1 General Description of the Advice
The neMESYS devices are syringe pumps. They allow emptying and filling syringes by the relative linear
movement of a syringe- and a piston holder.
2.4.2 Intended Use
The neMESYS syringe pump serves for precise and pulsation-free dosing of fluids in the range of
nanolitres per second up to millilitres per second. Pressures of up to several hundred bar can be reached
depending on the device.
Application usually takes place in laboratory-like rooms.
2.4.3 Reasonably Foreseeable Faulty Application
A use for applications distinct from the intended purpose can lead to dangerous situations and is to be
omitted.
CAUTION. The unit must not be used as a medical device or for medical purposes.

neMESYS Low Pressure Hardware Manual 9
2.4.4 Safety Advice
The safety of the user and a failure-free operation of the devices are assured only if original parts are
used. Only original accessories may be used. Warranty claims will not be accepted for damage due to
the use of alien accessories or expendables.
The devices have been developed and constructed in such a way as to largely rule out hazards due to its
intended use. Nevertheless, you must observe the following security measures in order to exclude any
remaining hazards:
•CETONI GmbH points out the responsibilities of the operator for the operation of the devices.
The laws and regulations of the place of installation must be observed while operating the
devices! To ensure a safe work routine, operators and users must assume responsibility for
adhering to regulations.
•The devices must not be used as a medical device or for medical purposes.
•Before operating the unit, the user must at all times ensure the operational reliability and the
adequate and orderly condition of the unit.
•The user must be familiar with the operation of the devices and the software.
•The devices and pipes must be checked for damage before operation. Damaged pipes and plug
devices must be replaced immediately.
•Cables must be laid in a way that avoids any risk of stumbling.
•Any moving parts must not be touched whilst the devices are in operation. There is a risk of
crushing!
•It is not allowed to use the devices in an explosive atmosphere or with potentially explosive
substances.
•The device is designed and approved to work in fluidic systems, which fall within the scope of
Article 4 Paragraph 3 of the Pressure Equipment Directive 2014/68/EU. This means that the
system may not exceed a maximum volume of 1 liter. With the use of fluids from Group 1
according to Article 13 of the Pressure Equipment Directive 2014/68/EU, the maximum
allowable system pressure is 200 bar. For fluids from Group 2 it is 1000 bar. If different,
product-specific values for the maximum pressure are given in the section "Technical Data",
these values must be complied with. Regarding the maximum operating temperature, the
specification from the section "Technical Data" must be observed.
CETONI GmbH is not liable for consequences that may arise if the user expands the system by
peripheral devices, such that one of the values or both values are exceeded.

10 neMESYS Low Pressure Hardware Manual
It is the user's responsibility to become familiar with the mentioned Pressure Equipment
Directive and to comply with the prevailing requirements.
•Wear protective glasses if you are working with corrosive, hot or otherwise dangerous
substances during assembly work on the device.
•Transportation, storage or operation of the devices below 0°C with water in the fluid passages
may cause damage to the modules.
2.4.5 Measures for Safe Operation
2.4.5.1 ELECTROMAGNETIC EMISSIONS
The Qmix system is intended for use in any type of facility, connected directly to the public power
supply network that supplies buildings used for domestic purposes.
2.4.5.2 ELECTROSTATIC DISCHARGE
Floors should be made of wood, concrete, or ceramic tiles. If the flooring is made of a synthetic material;
the relative humidity must be at least 30%.
2.4.5.3 ELECTRIC DISTURBANCES
The quality of the supply voltage should be to the standard of a typical business or hospital
environment.
2.4.5.4 MAGNETIC DISTURBANCES
Do not place power connector cables, even of other appliances, in close proximity of the devices and
their cables. Mobile communication devices may not be used in closer proximity of the devices or their
cables than the recommended safety distance!
2.4.6 Safety Devices on the System
The system can be switched off at any time in an emergency using the mains switch on the Base
Module (toggle switch on the side of the housing); this will cause no damage to the unit.
2.4.7 Condition of the Devices
Irrespective of the faultless manufacture of the devices, damage can occur whilst the unit is in
operation. With this in mind, always carry out a visual check of the components mentioned before use.
Pay particular attention to crushed cables, damaged tubing, and deformed plugs. If you should notice
any damage, please do not use the devices and inform CETONI GmbH without delay. CETONI will put

neMESYS Low Pressure Hardware Manual 11
your devices back to an operational condition at the earliest. Do not attempt to repair the devices
yourself.
2.5 Warranty and Liability
The devices left our company in perfect condition. Only the manufacturer is permitted to open the
devices. All guarantee and liability entitlements, particularly damage entitlements due to personal
injuries, are void if the devices are opened by an unauthorized person.
The duration of the warranty is 1 year from the day of delivery. It is not extended or renewed due to
work carried out under warranty.
CETONI GmbH considers itself responsible for the devices with regard to safety, reliability and function
only if assembly, new settings, changes, extensions and repairs are carried out by CETONI GmbH or an
authorized centre, and if the devices have been used in accordance with the instruction manual.
The device conforms to the basic safety regulation standards. Industrial property rights are reserved on
the circuits, methods, names, software programs, and units.

12 neMESYS Low Pressure Hardware Manual
3Scope of Delivery
The following items are supplied with your neMESYS syringe pump:
NEMESYS LOW PRESSURE SYRINGE PUMP
INCLUDING:
•3/2-way solenoid valve
•30 mm syringe holder
Other accessories such as syringes, tubing material, pressure sensors etc. have to be purchased
separately.

neMESYS Low Pressure Hardware Manual 13
4Technical Data
4.1 Product Image
4.2 Environment
OPERATING TEMPERATURE
0°C to 45°C
STORAGE TEMPERATURE
-20°C to 75°C
OPERATION AIR HUMIDIT Y
20% to 90%, non-condensing
STORAGE AIR HUMIDITY
20% to 90%, non-condensing
4.3 Mechanical Data
DIMENSIONS (L X W X H)
310 x 47 x 56 mm
WEIGHT
≈1300 g

14 neMESYS Low Pressure Hardware Manual
4.4 Electrical Data
SUPPLY VOLTAGE
24 VDC
CURRENT DRAW
0,3 A
POWER CONSUMPT ION
7 W
4.5 Interfaces
CAN
1 Mbit/s
RS-232
section 7
ACCESSOR Y PORT
section 6
4.6 Dosing Performance
The following table provides an overview of minimum and maximum dosing speeds of the various gear
configurations as well as the resulting flow rates, using the example of a 1 ml syringe with a 60 mm
stroke. Dosing precision slowly decreases below the speeds and flow rates referred to as pulsation-free.
Gear
w/o
14:1
29:1
Min. speed [µm/min]
1
0,071
0,034
Min. pulsation–free speed [µm/min]
878,9
62,5
30,141
Max. speed [mm/s]
89
6,33
3,05
1 ml syringe with 60mm stroke
Min. flow [nl/min]
16,667
1,185
0,572
Min. pulsation-free flow [µl/min]
14,648
1,042
0,502
Max. flow [ml/min]
89
6,33
3,05

neMESYS Low Pressure Hardware Manual 15
4.7 Valve
4.7.1 Technical Data
HOUSING MATERIAL
PEEK
SEALING MATERIAL
FFKM (perfluoroelastomer)
MEDIA TEMPERATUR E
0 to +50°C
MAX. VISCOSITY
21 mm²/s
INTERNAL VOLUME
approx. 45 µl
MAX. PRESSURE
3 bar
NOMINAL SIZE
0,6 mm
FLUIDIC CONNEC TIONS
¼“ – 28 UNF

16 neMESYS Low Pressure Hardware Manual
5Hardware Operation
Connect the syringe pump to your base module / system as described in the CETONI System manual.
If the module has not been configured, you will be required to perform a reference move during the
configuration process. During the reference move the piston holder will move to its front position and
be synchronized with the software display. To avoid damage the reference move may only be performed
without a syringe.
After deactivating the base module the piston holder can be moved by applying some force (e.g.
through residual pressure in the system). Therefore, it is sensible to repeat the reference run from time
to time.
ATTENTION. The reference move must be performed without syringe. Otherwise the
device or the syringe may be damaged.
CAUTION. Do not touch any moving parts on the device during operation! There is a
danger of crushing.
5.1 Mounting a Syringe
The syringe holder of Low Pressure Syringe Pump allows the use of syringes with outside diameters
ranging from 6 to 30 mm and a piston stroke of up to 65 mm.
IMPORTANT. Please use high-quality glass syringes with outside diameters ranging
from 6 to 30 mm to ensure precise flow rates.
Before mounting a syringe to the Low Pressure Syringe Pump, it must be configured and selected in the
operating software. The respective process is described in the software manual. You need the volume
(scale volume), the nominal stroke (scale length) and the total stroke (piston stroke), which may be
different.

neMESYS Low Pressure Hardware Manual 17
Use the following process to mount a syringe to the Low Pressure Syringe Pump:
Loosen the knurled screw of the syringe receptacle. Now you can push the bracket off the pins and lift it
up.
Disassembly syringe holder
Loosen the knurled screw of the piston holder and remove the adapter plate. Lift up the clamping piece.
Scale Length
Piston Stroke
Scale Volume

18 neMESYS Low Pressure Hardware Manual
Disassembly piston holder
In order to make use of the entire syringe volume, move the piston holder to the front position through
the software. Place an empty syringe on the remaining base of the syringe holder in such way that the
piston touches the piston holder.
The syringe position can be varied somewhat by moving the piston holder. For this purpose loosen the
screw with a 4 mm Allen wrench.
ATTENTION. To avoid damage, please make sure that the remaining syringe stroke is
always the same as or larger than that of the module.
Replace the bracket of the syringe holder, insert into the pins and lock the syringe by using the large
knurled screw.
Screw

neMESYS Low Pressure Hardware Manual 19
Replace the clamping piece and insert the adapter plate suitable for the piston diameter in such way
that the “piston plate” is located between piston holder and adapter plate.
The piston is locked in place by slightly tightening the knurled screw on the back. Make sure that
syringe and syringe piston are in alignment.
IMPORTANT. The syringes, particularly the seals, are wear parts. Check them on a
regular basis and replace them, if necessary.
5.2 Fluidics / Valve
The Low Pressure Syringe Pump can be fitted with an optional valve. The valve allows you to switch the
syringe connection between your application (outlet) and a reservoir (intake), allowing an automatic
refilling of the syringe. Through the software, you can set the valve in such way that it automatically
switches to the intake during filling.
The three connections are fitted with a ¼“-28 UNF thread and therefore allow the use of common HPLC
fittings.

20 neMESYS Low Pressure Hardware Manual
A rocker inside the valve (green) connects the syringe port (1) alternatively with the outlet (2) or the
intake (3). In the following image the syringe is connected with the outlet (blue), while the intake is
closed (red).
A FFKM membrane connected to the rocker (shaded in green) seals the fluidic system. This membrane
limits the operating pressure of the valve to 3 bar.
ATTENTION. To avoid damaging the valve, please observe the maximum operating
pressure of 3 bar.
ATTENTION. Before using the valve, please check the chemical resistance of the PEEK
housing material and the FFKM sealing material (perfluoroelastomer) against the dosing
liquid.
Intake
(normally
closed)
Outlet
(normally
open)
Syringe
connection