cetoni NEMESYS XL User manual

Original Instruction 1.04 - May 2015
Hardware Manual
NEMESYS XL

2NEMESYS XL Manual
The information and data contained in this documentation may be amended
without notice. The reproduction, distribution, and utilization of this document
as well as the communication of its contents to others without explicit
authorization are prohibited. Offenders will be held liable for the payment of
damages.
All rights reserved in the event of the grant of a patent, utility model or design.
The General Terms and Conditions of cetoni GmbH apply. Deviating agreements
must be in written form.
Copyright © cetoni GmbH –automation and microsystems. All rights reserved.
cetoni® and NEMESYS® are registered trademarks of the cetoni GmbH.
WINDOWS is a registered trade mark of the Microsoft Corporation.
The Windows logo is a registered trade mark ™ of the Microsoft Corporation.

NEMESYS XL Manual 3
Software License
The software and the documents provided are protected by copyright.
Installation declares your acceptance of the conditions of the licensing contract.
License Agreement
cetoni GmbH grants the purchaser the non-exclusive and non-transferable
license right to use the software on a standalone computer or a networked
computer system (LAN). It is expressly forbidden to copy or duplicate the
software in part or in whole in any way. The same applies to mixing and
combining the software with other software. The purchaser may create one
back-up copy of the software for archival purposes. cetoni GmbH reserves the
right to alter, develop and improve the software or develop new software to
replace it. cetoni is not obliged to inform the purchaser of any alterations, new
developments or improvements to the software or make these available to him.
No legally binding assurance of certain features is given. cetoni is not liable for
damages unless the damages are as a result of willful intent or gross negligence
on the part of cetoni GmbH or its employees. Any liability for indirect, collateral,
or consequential damages is excluded.

4NEMESYS XL Manual
cetoni GmbH
Wiesenring 6
07554 Korbussen
GERMANY
Tel.: [phone]
Fax: [phone]
E-mail: [email protected]
Internet: www.cetoni.de

NEMESYS XL Manual 5
1. Document Information
1.1. Content
1. Document Information ................................................................... 5
1.1. Content ................................................................................................. 5
2. Introduction ................................................................................... 8
2.1. Preamble............................................................................................... 8
2.2. Symbols & Keywords ............................................................................ 8
2.3. Norms & Guidelines............................................................................ 10
2.4. Application.......................................................................................... 10
2.4.1. General Device Description ................................................................ 10
2.4.2. Intended Use ...................................................................................... 10
2.4.3. Reasonably Foreseeable Misuse ........................................................ 11
2.4.4. Safety Measures ................................................................................. 11
2.4.5. Measures for Safe Operation ............................................................. 14
2.4.6. Device Safety Features ....................................................................... 14
2.4.7. Device Condition................................................................................. 15
2.5. Warranty & Liability............................................................................ 15
3. The NEMESYS XL Module............................................................... 16
3.1. List of Supplies.................................................................................... 16
3.2. Technical Data .................................................................................... 17
3.3. Transport & Storage ........................................................................... 18
3.4. Maintenance....................................................................................... 18
3.5. Disposal............................................................................................... 19
4. Initial Operation ........................................................................... 20
4.1. Software Installation .......................................................................... 20
4.2. Device Set Up...................................................................................... 20
4.3. Connecting Device .............................................................................. 21
4.3.1. Stand-Alone Use ................................................................................. 21

6NEMESYS XL Manual
4.3.2. Use with Existing NEMESYS or with QMIX Modules............................. 22
4.3.3. Connecting Additional Modules......................................................... 23
4.3.4. Connection via RS232......................................................................... 24
5. Set Up & Operation ...................................................................... 26
5.1. Syringes .............................................................................................. 26
5.1.1. Syringe Configuration......................................................................... 26
5.1.2. Mounting of Syringes ......................................................................... 27
5.1.3. Disassembly & Maintenance of Syringes ........................................... 30
5.2. Fluidic Connection .............................................................................. 32
5.2.1. Initial SwagelokSetup ..................................................................... 33
5.2.2. Disassembly ........................................................................................ 33
5.2.3. Reassembly......................................................................................... 34
5.3. Signal Interface................................................................................... 34
5.4. Overload Clutch.................................................................................. 36
5.4.1. Overload Procedure ........................................................................... 36
5.5. Valve Interface.................................................................................... 37

NEMESYS XL Manual 7
Revision History
Rev
Date
Changes
1.0.0
03.08.2012
Creation of the NEMESYS XL module hardware manual
1.0.1
14.01.2012
Changes considering the new 12-pole sensor interface
1.0.2
21.02.2013
Added colors to the 12-pole sensor interface table
1.0.3
06.02.2014
Changes considering the 12-pole sensor interface
1.0.4
06.05.2015
Notes inserted to Pressure Equipment Directive
2014/68/EU

8NEMESYS XL Manual
2. Introduction
2.1. Preamble
Thank you for purchasing a cetoni product. With this manual we would like to
support you as far as possible in your interaction with the NEMESYS XL module.
Please do not hesitate to contact us in case of any questions or suggestions.
The NEMESYS XL module must only be put into operation after a thorough and
complete reading of the present manual.
We wish you every success when working with the NEMESYS XL module.
2.2. Symbols & Keywords
The following symbols and information boxes are used throughout to aid your
navigation:
TIPP
Describes practical tips and useful information to facilitate the handling
of the software.
IMPORTANT
Describes important information and other especially useful notes, in
which no dangerous or damaging situations can arise.
CAUTION
Identifies a potentially harmful situation. Failure to avert this situation
may result in damage to the product or anything in its proximity.

NEMESYS XL Manual 9
ATTENTION
Indicates a potentially dangerous situation. Failure to avert this
situation may result in light or minor injuries or damages.

10 NEMESYS XL Manual
2.3. Norms & Guidelines
This device has been tested and approved for compliance according
Class 1 Group B for industrial instruments. cetoni GmbH declares its
exclusive responsibility that this product is consistent with the relevant
provisions stated at the end of this document.
Operation is to conform to the following requirements:
1. The device must not cause harmful interfering radiation.
2. The device must be able to handle interfering radiation, including radiation
that may cause unintended operation.
The device complies with critical values according to EN55011 Class 1 Group B.
The device has passed the tests according to DIN EN 61000-4-4 (Burst) and DIN
EN 61000-4-5 (Surge).
2.4. Application
2.4.1. General Device Description
cetoni's NEMESYS devices are syringe pumps. They allow the filling and emptying
of syringes based on a relative linear movement between a syringe body fixture
and a syringe piston fixture.
2.4.2. Intended Use
The NEMESYS XL ultra-high pressure module is for the precise and pulsation-
limited dosage of fluid streams with an operating pressure of up to 890 bar and
flow rates of nanoliters to mililiters per second.
Its default operating environment is a laboratory-like room.

NEMESYS XL Manual 11
2.4.3. Reasonably Foreseeable Misuse
The use of the device beyond its intended use may lead to dangerous or harmful
situations and must be avoided.
ATTENTION
The device must not be used as a medical product nor in medical
applications.
2.4.4. Safety Measures
To ensure the safety of the user and a failure-free operation of the device, only
original parts as well as original accessories must be used. No damages can be
claimed when third-party components or accessories are used.
The device has been developed and designed to avoid harmful situations during
intended use. However, the following safety measures have to be observed to
exclude potentially remaining risks:
cetoni GmbH advices of the operator's responsibility during use. Relevant
laws and regulations at the location of use must be observed. In the
interest of safety, operators and users are responsible to adhere to all
relevant regulations.
The device must not be used as a medical product nor in medical
applications.
The device is designed and approved to work in fluidic systems, which fall
within the scope of Article 4 Paragraph 3 of the Pressure Equipment
Directive 2014/68/EU.
This means that the system may not exceed a maximum volume of 1 liter.
With the use of fluids from Group 1 according to Article 13 of the
Pressure Equipment Directive 2014/68/EU, the maximum allowable
system pressure is 200 bar. For fluids from Group 2 it is 1000 bar. If
different, product-specific values for the maximum pressure are given in
the section "Technical Data", these values must be complied with.

12 NEMESYS XL Manual
Regarding the maximum operating temperature, the specification from
the section "Technical Data" must be observed.
Cetoni GmbH is not liable for consequences that may arise if the user
expands the system by peripheral devices, such that one of the values or
both values are exceeded.
It is the user's responsibility to become familiar with the mentioned
Pressure Equipment Directive and to comply with the prevailing
requirements.
The operator has to ensure functional safety and proper condition of the
device before use.
The operator must be familiar with how to operate the device and the
software.
The device, accessories, and cables must be checked for damages before
use. Damaged cables and interfaces must be replaced immediately.
Cables are to be laid out such as to prevent the danger of tripping.
The device must only be operated with the safety cover firmly attached.
Any safety installations must not be tampered with nor rendered in-
operational.
Touching any of the devices moving parts during operation must be
avoided due to the danger of contusions.
It is forbidden to use the device in an explosive atmosphere or with
potentially explosive materials.
Safety goggles must be worn when operating or handling the device, in
particular with corrosive, hot, or otherwise dangerous substances.
Potential leakages at the device or connected parts and accessories may
cause medium to exit under high pressures. This may cause potentially
harmful situations. Tight fittings of all interconnected parts and the use of
safety goggles must be ensured at all times.
Please note that continuous use of the device may cause wear of the
syringes. This may increase the likelihood of leakages. Leaking syringes
must be replaces immediately.

NEMESYS XL Manual 13
Assembly tasks, such as replacing of the syringe, may only be carried out
when the device is not operating and completely de-pressurized. The
device must not be shut down or stored with pressurized syringes. Before
switching off the software that operates the device, the syringe must be
de-pressurized.
Operate the device on safety benches equipped with an emergency-stop
button.
The user has to ensure that the application setup includes measures and
devices, such as safety valves, that relieve the system pressure in case of
errors or malfunctions.
Only stainless steel syringes specified for the device are to be used to
avoid dangers due to bursting syringes.
Transport, storage, and operation of the device at a temperature below
0°C/32°F with water within the fluidic system may cause damage to the
device.

14 NEMESYS XL Manual
2.4.5. Measures for Safe Operation
2.4.5.1 Electromagnetic Emissions
The NEMESYS XL module may be used in any type of facility, including living
quarters, as well as those that are connected to the public utilities network that
also supplies buildings used for living purposes.
2.4.5.2 Electrostatic Discharge
Flooring materials should be wood, concrete or ceramic tiles. If the flooring is
made of a synthetic material, the relative humidity must be at least 30%.
2.4.5.3 Electric Disturbances
The quality of the supplied voltage should conform to the standard of a typical
business or hospital environment.
2.4.5.4 Magnetic Disturbances
Do not place power connector cables, including those of other appliances, in
close proximity of the device and its cables. Portable and mobile communication
devices may not be used in closer proximity of the unit or its cables than the
recommended safety distance for said devices.
2.4.6. Device Safety Features
In case of an emergency, the device may be switched off at any time using the
mains switch (rocker switch) on the back of the housing or by pulling the power
supply connector from the device. This will cause no damage to the device itself.
Additionally, the device features a safety cover that shields all moving parts and
reduces the risk of injury. Removing the cover will stop and switch off the device.
Using the pressure sensor interface, the device may be programmed to
automatically stop if a preset maximum pressure is exceeded.
The device has a built-in overload clutch that will disconnect the driving unit and
switch off the device.

NEMESYS XL Manual 15
2.4.7. Device Condition
Despite a faultless manufacture of the unit, damage may occur at any time whilst
the unit is in operation. With this in mind, the user must always carry out a visual
check of the device and any attached or co-operated components prior to use.
Particular attention must be paid to crushed power cables and deformed plugs
as well as damaged feed lines (tubing, capillaries, etc.). If any damage to the
device is noticed, the device is not to be used and cetoni GmbH should be
informed without delay. cetoni will ensure that operational conditions are
reestablished within a reasonable time. Do not attempt to repair the unit
yourself.
2.5. Warranty & Liability
This device left our company in perfect condition. Only the manufacturer is
permitted to open the device. All guarantee and liability entitlements, in
particular damage entitlements due to personal injuries, are void if the unit is
opened by personnel not authorized by cetoni.
The duration of the warranty is 1 year from the date of delivery. It is not
extended or renewed due to work carried out under warranty.
cetoni GmbH considers itself responsible for the unit with regard to safety,
reliability, and function only if assembly, new settings, changes, extensions, and
repairs are carried out by cetoni GmbH or an authorized center or agent, and if
the unit has been used in accordance with this instruction manual.
The NEMESYS XL module conforms to the basic safety regulation standards.
Industrial property rights are reserved on the circuits, methods, names, software
programs, and devices.

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3. The NEMESYS XL Module
3.1. List of Supplies
The following components are delivered by default:
NEMESYS XL module
Power supply
Mains cable (US or EU model as
applicable)
USB-to-CAN adaptor & CAN
Interconnect cable
Terminator plug

NEMESYS XL Manual 17
Syringe(s) (as per order)
Manual & software CD
3.2. Technical Data
Operating Environment
Operating Temperature........................................................0°C –45°C
Storage Temperature ....................................................... -20°C –75°C
Operating Humidity ........................................... 20% –90%, not cond.
Storage Humidity............................................... 20% –90%, not cond.
Sound Power Level ............................................................... ≤70 dB(A)
Mechanical Data
Weight ..........................................................................................21 kg
Size (L x W x H)......................................................600 x 194 x 146 mm
Electrical Data
Supply Voltage (Power Supply) ...................................... 90 –264 V AC
Frequency .............................................................................47 –63 Hz
Interfaces
CAN .................................................................................max. 1 Mbit/s
RS-232...................................................................... max. 115200 bit/s
Configuration
Syringes................................................... 10 ml, 25 ml, 100 ml, 250 ml
Tubing/Pipe Connector....................................................... 1/16“, 1/8“
Pressure Sensor ...................................................................... (various)

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Medium-touching Parts
Syringes & Syringe Holder ............................................. Stainless Steel
Sealing Gasket ...........................................................EPDM, NBR, FKM
Drawing
CAUTION
Check material compatibility of medium-touching parts vs. intended
chemicals prior to use.
3.3. Transport & Storage
Always use the original packaging for transport and shipping.
For storage, pay attention to the details given in chapter 3.1.
3.4. Maintenance
The device is maintenance-free under intended use. In case of problems or
failure that cannot be solved by the operator or that require opening the device,
please contact cetoni GmbH to arrange help. The device may be opened only by
cetoni GmbH or its authorized service personnel; failure to comply will void all
warranty and claims.
Potential disruptions of operation in connection with operating software are
detailed in the relevant software manual.

NEMESYS XL Manual 19
For cleaning of the device housing, use a damp but not wet cloth so as to prevent
any liquid to drip into the device. Detergent or alcohol may be used to remove
heavier stains.
3.5. Disposal
Old and unused devices must be returned to cetoni GmbH who will ensure
proper disposal or recycling of the device in accordance to relevant regulations,
such as the Electric and Electronic Devices law.
The device must be decontaminated prior to returning the device as necessary
and the completed Contamination Declaration form provided by cetoni.

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4. Initial Operation
To ensure a trouble-free initial operation of your NEMESYS XL module, work
through the sections below.
IMPORTANT
Carefully read both this manual as well as the related software manual
before setting up and operating your NEMESYS XL module.
4.1. Software Installation
Supplied software and drivers must be installed prior to connecting this or any
other cetoni device to a computer. Please refer to the accompanying software
manual, which may be found on the supplied CD, for a detailed description.
IMPORTANT
Please follow the instructions and install software and device drivers
before connecting the device to your PC.
4.2. Device Set Up
Place the NEMESYS XL module on an even, horizontal, and stable surface, such as
a table, base cabinet, or instrument trolley.