COBIO S80 User manual

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S80 Fully Automated Urine Sediment Analyzer
User Manual
COBIO Smart Healthcare Technology Co., Ltd.
Applicant/Manufacturer：COBIO Smart Healthcare Technology Co., Ltd.
Resident: No.122-34-8 Chunxiao Pudong, Shanghai China
Manufacturing address：No.122-34-8 Chunxiao Pudong, Shanghai China
Zip code：201203
Tel：[phone]
Issued Date: 2015.12.23 Ver.: 1.0

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FOREWORD
This manual is used for the installation, commissioning, operation, use and maintenance of
the S80 Fully Automated Urine Sediment Analyzer. If the version updated, it will not be
notified.
This equipment complies with the emission and immunity requirements described in GB /
T 18268.1-2010 and GB / T 18268.26-2010.
This equipment has been designed and tested to CISPR 11 Class A equipment which is
defined in GB 4824. In a domestic environment it may cause radio interference, in which case,
you may need to take measures to mitigate the interference.
An advisory that the electromagnetic environment should be evaluated prior to operation of
the device.
Do not use this device in close proximity to sources of strong electromagnetic radiation (e.g.
unshielded intentional RF sources), or these may interfere with the proper operation.
If the equipment is not used according to the manufacturer's method, it may damage the
protection provided by the equipment.

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Contents
1.1 Overview.........................................................................................................错误!未定义书签。
1.2 Scope of Application.......................................................................................错误!未定义书签。
1.3 Contraindication .............................................................................................错误!未定义书签。
1.4 Main Structure Composition ..........................................................................错误!未定义书签。
2 Instrument Installation ..............................................................................................错误!未定义书签。
2.1 Accessories List...............................................................................................错误!未定义书签。
2.2 Packaging....................................................................................................................................... 6
2.3 Installation......................................................................................................错误!未定义书签。
2.4 Cleaning System Installation...........................................................................错误!未定义书签。
2.5 Dealing for Nonuse for S80.............................................................................错误!未定义书签。
2.6 Pasting Bar Code on Test Tube........................................................................错误!未定义书签。
2.7 Boot Sequence................................................................................................错误!未定义书签。
3 Menu System.............................................................................................................错误!未定义书签。
3.1 Working ..........................................................................................................错误!未定义书签。
3.1.1 Operation Test .....................................................................................错误!未定义书签。
3.1.2 Alarm ...................................................................................................错误!未定义书签。
3.1.3 User .....................................................................................................错误!未定义书签。
3.2 Filing ...............................................................................................................错误!未定义书签。
3.2.1 Sample/Elements Overview ................................................................错误!未定义书签。
3.2.2 Sample Information Modifying............................................................错误!未定义书签。
3.2.3 Sample Selection .................................................................................错误!未定义书签。
3.2.4 Elements Information Modifying.........................................................错误!未定义书签。
3.2.5 Sample backup.....................................................................................错误!未定义书签。
3.2.6 Image Thumbnail.................................................................................错误!未定义书签。
3.2.7 Image Editing.......................................................................................错误!未定义书签。
3.3 Setting.............................................................................................................错误!未定义书签。
3.3.1 Routine ................................................................................................错误!未定义书签。
3.3.2 Maintenance........................................................................................错误!未定义书签。
3.4 Others.............................................................................................................错误!未定义书签。
4 Operation...................................................................................................................错误!未定义书签。
5 Quality Control ..........................................................................................................错误!未定义书签。
5.1 Quality Control ...............................................................................................错误!未定义书签。
5.2 Quality Control Serum Management..............................................................错误!未定义书签。
5.3 View History Data...........................................................................................错误!未定义书签。
6 Maintenance Methods for Product .........................................................................错误!未定义书签。
7 Errors and Handling...................................................................................................错误!未定义书签。
8 Performance Anlaysis ................................................................................................错误!未定义书签。
9 Support......................................................................................................................错误!未定义书签。
9.1 Maintenance Statement.................................................................................错误!未定义书签。
9.2 Order Information ..........................................................................................错误!未定义书签。
10 Product Performance, Specification and Storage Condition ...................................错误!未定义书签。

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11 Sybol Description.....................................................................................................错误!未定义书签。
12 Replace Fuse of Power Socket .................................................................................错误!未定义书签。
13 Transport Condition and Method............................................................................错误!未定义书签。
14 Product Feature.......................................................................................................错误!未定义书签。
15 Caution, Warning and Note .....................................................................................错误!未定义书签。
16 Product Information ................................................................................................错误!未定义书签。

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Introduction
Thank you for choosing S80 Fully Automated Urine Sediment Analyzer, manufactured by
COBIO Smart Healthcare Technology Co., Ltd in China. We hope that you will be satisfied with the
device.
1.1 Overview
S80 is easy and efficient to operation. The operator injects distilled water into the instrument's
cleaning liquid bucket, put the counting chamber bar into the counting chamber rotating disc, and put
the test tube containing the sample into the test tube rack, and then put the test tube rack on the
feeding platform. Then the rest of work can be left to S80. S80 can automatically push the test tube
to the sampling position, and then the injection needle is inserted into the test tube. After several
suction and spitting movements, the sample is fully mixed. S80 only needs 2 ml of urine sample to
get accurate test results. However, only 0.2ml was injected into the one-time counting chamber
through the injection needle. After completing injection, the injection needle will be moved into a
special cleaning barrel at the back of the instrument. The internal and external walls of the injection
needle will be thoroughly cleaned with distilled water to avoid cross interference between urine
samples.
Counting chambers containing urine samples were fed into the built-in centrifuge, centrifuging
for 10 seconds at a rate of 2,000 revolutions per minute. The visible elements distributed in the
sample are deposited to the bottom of the counting chamber, which is the side of the microscope.
After centrifugation, a built-in camera, through a built-in microscope, collects images at different
points in the count image collection area. All collected images are processed through a high-quality
image processing software to detect visible elements in urine.
The results and images can be stored in the hard drive of the S80's computer host, with a
standard storage capacity of 25,000 records.
1.2 Scope of Application
S80 can automatically checks for visible elements in urine: Red blood corpuscle (RBC), White
blood corpuscle (WBC), and cylinderuria (PAT/HYA).
1.3 Contraindication
None
1.4 Main Structure Composition
S80 is mainly composed of hydraulic system, optical system, mechanical system, circuit control
system, analysis and processing software, input and output equipment.

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2Instrument Installation
2.1 Accessories List
Power cord 2pcs
RS232 1pc
USB cable 1pc
1394 wire（1394 special for camera）or network cable（special for webcam）1pc
VGA cable 1pc
Fuse（T6.3AL250V）2pcs
Fuse（T3.15AL250V）3pcs
Liquid waste barrel 1pc
Cleaning fluid barrel 1pc
Feeding disk 1pc
Catheterφ6 1pc
Catheterφ8 2pcs
Rotating disk 1pc
Former rail 1pc
Rear rail 1pc
Feeding module 1pc
Counting chamber bar (contain 50 visible elements counting chamber) 12pcs
Test tube + Test tube cap 100pcs
Test tube rack 10pcs
Product Manual 1pc
Computer host 1pc
2.2 Packaging
Preparations
Caution
⚫Inspect parts are intact comparing to the accessories list before the instrument installed. If the
package is incomplete or damaged, please contact your distributor immediately, otherwise,
continue to read the following operation.
⚫Don't place the instrument in direct sunlight, because of the strong sunlight may interfere with
the instrument of optical sensors.
S80 is packed with foam model and wooden case in transportation. Before installation, clean
the table of the instrument to be placed, and need a solid and stable table of 100 x 200 cm that can
support the equipment of 100 kg. Refer to the packing list above for the detailed number of parts
Biohazard risk
This instrument is likely to be infectious and pathogenic during use. Please
discard it as biological waste according to local regulations.

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involved. Please pay attention to the shipping mark on the box when opening the package. Cut off
the tape to keep the wooden box intact. It is suggested to keep wooden box, foam box, self-tapping
screw and fastening screw for internal fixation of instrument for future transportation.
Instrument placement space: the minimum installation distance needed to be set aside from
walls or other devices is shown below.
Figure 2-1
Caution:
⚫Because the backside of Instrument need to connect the pipe, wire, etc., also need to put
cleaning fluid barrel and liquid waste barrel, so it should be convenient for people to come in and
out when the instrument put.
Input and Output introductions
1. Introduction for interface panel, as shown below:
1——1394 camera exclusive interface, connect the computer host
2——USB control interface for the liquid waste, connect the liquid waste barrel
3——Function reserved interface, forbidden
4——VGA interface on the display screen of the instrument host, connected to the computer
host5——RS232 control interface for the lower computer, connected to the computer host
6——USB control interface for cleaning fluid, connected to the cleaning fluid barrel
7——USB control interface for the touch screen, connected to the computer host
8——Power switch of the instrument host
9——The power interface of the instrument host, connected with the power supply of external
network
16——Connection bridge reserved interface, use when connected with dry chemical machine
17——Network camera professional interface, connected to computer host

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Figure 2-2
After the wire is inserted, it is shown in the following figure:
Figure 2-3
2. Piping joint description, as shown in the figure below:
10——Quick connection of cleaning fluid pipe, connected to the cleaning liquid barrel
11——Quick connection of liquid waste, connected to the liquid waste barrel
12——Quick connection of liquid waste, connected to the liquid waste barrel
1
2
3
4
5
6
7
8
16
9

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Figure 2-4 Figure 2-5
3. Instructions of the emergency stop button and the waste materials box, as shown below:
13——Stop button: Press the emergency stop button to stop all mechanical actions of the
instrument host in case of the instrument failure such as collision.
14——Waste materials box, is the collection device for waste counting chamber. Please clean
up the waste counting chamber when it is full or not used for a long time.
15——Handle of waste materials box: Hold the handle and gently pull outward to remove the
waste materials box.
16——Barcode scanning port: When scanning the bar code on the sample tube, LED light is
emitted. Don’t look directly into the light, which can cause damage to the eyes.
16 Scanning port
Figure 2-6
2.3 Installation
1. At least two persons are required to hold the bottom and place it smoothly on the
workbench.
2. Remove protective objects for safety during transportation and remove the M5x60 inner
hexagon cylinder head screw used for instrument fixation during transportation. It is
recommended that they be kept for use the next time the instrument is moved.
3. Take out the counting chamber former rail from the waste materials box and install it on the
position of injection sample where right side of the centrifuge.
4. Take out the counting chamber rear rail from the waste materials box and install it on the
position closed to microscope where left side of the centrifuge.
5. Install the counting chamber disk on the axle closed to the counting chamber former rail.
6. Put the counting chamber bar into the counting chamber rotating disk, and then cover the
feed disk and lock the butterfly bolt.

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7. Connect the feedstock module with the communication conductor of the main machine.
8. Aim the positioning pin hole and the buckle of the feedstock module at the pin and the
buckle of the host, and then push in, and the sound of "click" is heard, that is installed in
place.
9. Connect the computer with the main machine.
10. Connect power to the main machine and computer host respectively. Earth protection must
be proved when power is connected.
11. Please restart the instrument after each installation or upgrade procedure.
Precaution
⚫It is very important that tearing down the plastic ribbon which fixed sampling module
and fixing screw before starting up. When the power is turned on, the instrument is
initialized, including the motion check of each elements. If the ribbon and fixing screw
are not removed, the instrument may be damaged.
⚫ac voltage range 100-240 - v, the scope of this instrument can automatically adjust
the power supply voltage. Do not exceed this power supply range.
⚫Non-professional personnel shall not open the instrument rear panel.
2.4 Cleaning System Installation
1. Connect the two thick catheters to the inside of the liquid waste barrel through the jack on
the liquid waste barrel lid. Leave the two thick catheters 10cm long in the liquid waste barrel
and the other end connected to the equipment main machine.
2. Connect the liquid waste barrel sensor to the No. 2 liquid waste USB control interface of the device
main machine by USB cable, see figure 2-2.
3. Pour distilled water into the cleaning fluid barrel.
4. Insert the thin catheter into the cleaning fluid barrel through the lock buckle on the cover of
the cleaning fluid barrel. One end of the thin catheter is inserted into the bottom of the barrel
and the other end is connected to the device main machine. The No.10 cleaning fluid
catheter is jointed to the quick connector, inserted tightly, see figure 2-4 is.
5. Connect the cleaning fluid barrel sensor to the No.6 cleaning fluid USB control interface of
the device main machine by USB cable, see figure 2-2.
6. Put the two barrels closed the device main machine.
Note:
Put the liquid waste barrel under the water level of the instrument. According to the
principle of gravity, the remaining liquid in the instrument can be introduced downward into
the container without suction. Put it on the ground, the suction pump suck up the liquid
waste depending on the principle of siphon, so the catheter of liquid waste bottle should not
be too long. So pay special attention to the fact that the tube continues down.

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2.5 Dealing for Nonuse for S80
When S80 is not in use, there is no special processing arrangement. Just follow the following
steps to store it:
Warning
⚫Because urine is a fluid from people, there may be contagious and the biological risk.
Trained people are treated according to local regulations.
⚫Handle carefully with the counting chamber and the urine containers which were
used.
⚫When operating S80, pay attention to wear rubber gloves and other protective clothing.
1. Clean the instrument with disinfectant, close the S80 and PC host, and then disconnect the
line.
2. Discard the used counting chambers in the waste materials box.
3. Empty all the liquid in both barrels and clean them, pack them after drying, and keep the lids
open.
4. Fix the sampling module by set screws.
5. Clean S80 carefully and remove all removable elements. Package after drying in the same
state as before. If you want the instrument to return to normal operation, please refer to
steps in section 2.3 for instrument installation.

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2.6 Pasting Bar Code on Test Tube
The S80's built-in bar code scanner automatically identifies the barcode attached to the test tube
of the urine sample being tested. S80 can identify the type of bar code: one dimensional code
including code39\Codabar\code128\UPC\EAN, etc. two dimensional code including QR Code\Data
Martix, etc.
The barcode should be pasted in the middle of the test tube, as shown below, between two red
horizontal lines.
Note: if the pasting position of the barcode is beyond the red horizontal line, it may cause the
S80 built-in bar code scanner to be unable to identify properly. In addition, the bar-coded side must
be placed on the open side of the test tube rack, otherwise the S80 built-in bar code scanner will not
be recognized.
Figure 2-6
2.7 Boot Sequence
1. Turn on the power switch behind the S80.
2. Turn on the power switch of S80 matching computer.
3. Double-click the S80 software icon to start the program and wait for instrument initialization.
4.After the S80 initialization window is closed, sample detection can be conducted.
3Menu System
3.1 Working
During normal inspection, the working page is shown in the following figure:

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Figure 3-1
Top bar icon:
Figure 3-2
3.1.1 Operation Test
After the red indicator light on the feeding platform is off, put the tube rack on the feeding
platform and click the "run" menu on the top. There are different ways of testing according to different
situations.
Automatic: Use for batch automatic inspection for a large number of samples.
The equipment will continue to work, continuously complete automatic sampling and
sampling inspection, and automatically output results (can be viewed on the archive
page), without manual intervention.
Manual: you can specify the sample size for a test and the number of tests
passed.
Quality control: quality control for checking the availability of instrument.
Prepare the quality control product, the low-value quality control product is first, the
high-value quality control product is second, then start the quality control inspection. Status shows
success indicates availability and failure indicates unavailability.
You can set the start number before starting the instrument, as shown in the figure below.
Note: you can indicate different meanings by setting different starting Numbers, such as the
number starting from 5000, the number of hospitalized patients, and the number starting from 8000,
the patients who have participated in the physical examination.
Figure 3-3

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Figure 3-4
In the automatic detection process, the run menu has the option of "emergency".
Emergency: In the process of automatic inspection, if you encounter an emergency sample,
you can use the "emergency" function to insert the emergency sample into the test sequence. Before
the emergency starts, the test tube rack currently under examination should be completed. The
emergency sample, the test tube rack was used as the unit.
Upon completion of the emergency, the instrument will return to the automatic examination
mode and continue to examine the remaining samples.
3.1.2 Alarm
System failure states (both software and hardware) are indicated in different colors. [see top bar
icon: Figure 3-2, failure status]
Green indicates system normal, yellow indicates warning, red indicates error.
Click the status light to see the details when red and yellow appear.
3.1.3 User
Indicate the current user, namely the instrument operator, [see top bar icon: Figure 3-2-User],
click to view user information, change password and switch users.(User’s other related operations
can be seen in the top bar icon: Figure 3-2 Settings -> Maintenance sub-page)
Figure 3-5
After the sample is tested, it will be archived automatically. You can go to the archive page to
view it.

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3.2 Filing
3.2.1 Sample/Elements Overview
Figure 3-6
The archive page is divided into two parts: the left (dark background) is the tested sample, and
the right (light background) is the selected sample information: composition table and image.
The conclusions of the sample are various: Negative( ), Positive( ), Mass( ), Blank( ).
Note: Negative means that all the element/cells in the sample are negative.
Positivity refers to the presence at least one positivity among the many element/cells in the
sample.
Mass means that the sample has too many element/cells to be properly analyzed by the system
and needs to be manually reviewed.
Blank means that the image of the sample is blank, which is usually due to the lack of liquid
extraction by the instrument.
If the sample belongs to the quality control sample, there are only two conclusions: Pass( ),
Failure( )
Pass means the elements/cell content determined by the instrument conforming to the content
range of quality control requirements, that is, in control.
Failure refers to the loss of control when the elements/cell content determined by the instrument
exceeds or falls below the quality control requirements.
Note:

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⚫It can hide or show some column of the sample list and composition list, see the top bar
icon: Figure 3-2 Settings - > Routine/show subpages.
The operation at the bottom of the sample list (except modification) can be applied to multiple
samples at one time by checking the circular selection box to the left of the list item: --》
The [confirm and transmit] at the bottom of the elements list transmits the information to LIS. A
tick mark in the sample list LIS indicates that the sample information has been transmitted to
LIS.(note: transmission is related to LIS system of a specific hospital, which needs to be realized
separately.)
From the thumbnail list on the right, you can see the original image and its information. See
Figure 3-9.
3.2.2 Sample Information Modifying
Compared with the manual microscopic examination, a few samples with differences can be
modified manually.
Click the "modify" button below the sample list to modify the information of the selected sample,
as shown below.
Figure 3-7
Press the [restore] button to restore to the initial test conclusion.(see section 3.2.1 for the
meaning of the conclusion)
After modification, there will be a modification mark (pencil) next to the conclusion, indicating
that some sample conclusions have been manually modified .
3.2.3 Sample Selection
A selection button at the top of the sample list can be used to screen samples that meet certain
criteria.
Negative, positive, mass, blank only filter the samples in the current sample list. Favorites and
lookups can change the list.
Lookup: Click this button to specify the selection criteria.

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Figure 3-8
The date can be specified either as a day or as a time period.
Multiple conditions, the "and" relationship: if a number (or bar code) is specified, indicates the
date of the screening, and the number (or bar code) is a sample of a value.
3.2.4 Elements Information Modifying
In the elements statistics results section, select a elements and click the [edit] button at the top
right of the list to modify the content or qualitative results of the elements. When modified, the list
item background is highlighted. Press the [restore] button to restore the elements results
automatically recognized by the device.
3.2.5 Sample backup
The [save as] button at the bottom of the elements list can be used to store a copy of the sample.
The copy is saved in the form of a web page. For relevant Settings for storing copies, see the top bar
icon: Figure 3-2 Settings -> routine subpage.
3.2.6 Image Thumbnail
On the far right is the list of thumbnail images of the sample. Double-click the mouse or long
press a thumbnail to see the high clear image and its elements distribution. Some images can be left
out of the composition statistics (see image editing section), and the thumbnail will appear gray-white
if not in the statistics. The left side of the graph is involved in the statistics, and the right side is not
involved in the statistics)

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Figure 3-9
3.2.7 Image Editing
Default display and Settings, as shown in the following figure:
Figure 3-10
Top:
Grid display switch and elements display switch used to control grid and elements display or
hiding.
Note: The "visible" column of the contents list in the lower right corner allows certain element to
be displayed or hidden.
Image participation statistical switch: if the image's composition distribution and content are in
line with the actual situation and can reflect the disease condition, check. Otherwise, if the image has
large blank or dark areas and the composition distribution and content are not objective, do not
check.
Right side:
The upper part is the basic information of the sample (including this image), the lower part is the
content information of this image, and the middle part is the operation related to composition editing.
Browse images: At this point, the image can be viewed front and back through the navigation
buttons on both sides of the image. If the "touch" switch on the top of the window is checked, you can
use your fingers to drag the image to switch the image. You can use two fingers to zoom the image.

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After zooming, you can use one finger to move the image. At last, click the "fit window" button at the
top to make the image fit the window size. If the "touch control" switch is not checked, you can use
the mouse wheel to zoom the image. After zooming, you can press the left button to drag the image,
and click the "fit window" button or the left button to click the image to make the image adapt to the
size of the window.
Delete elements: At this point, you can remove an element by clicking it with your finger or
mouse. (The finger or mouse depends on the top switch)
Add elements: at this point, select the added elements type in the drop-down list (the
drop-down list is immediately below the [add elements] button) and click on the image to add to the
image.
Undo all changes: restore the original elements statistics.
Note: If more elements are added or deleted, mouse operation is recommended. Mouse is
more accurate and faster than finger.
After finishing operation, click the top right corner to close and return to the archive
page.
3.3 Setting
3.3.1 Routine
Figure 3-11
The output part, Automatic Sending and Automatic Printing means that every time a sample is
tested, the sample is sent to LIS or printed out. Selectively send or print based on setting according
to the conclusion type. The sample conclusion type is shown in section 3.2.1. Inclusion of only
positive elements means that only those elements/cells that are positive in the sample are sent or
printed.
Startup screen keyboard of the display section: Whether to display the system soft keyboard
when you need to input text.

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Note: the options in the setting page cannot be changed during detection.
3.3.2 Maintenance
Figure 3-12
User list is that records all users using the system.
Automatic clearing, used to clear historical data on computer disks to make room.(Note: This
will only clear the default archive, not a copy of the sample stored.)
The name of the laboratory will appear on the copy or printed report to indicate the source.
3.4 Others
Figure 3-13
1. The dark background is today, and the blue background is the date you choose
2. Click the title at the top of the calendar control to switch to the year/month selection panel.
Click the title again to switch to the year/decade (ten years) selection panel
3. Click on the bottom of [today] and it will jump to today
Spinner Control：
Press and hold the mouse button or long press the + and - on both sides to rapidly increase and
decrease the value.
4Operation
1. Open the door of S80 equipment under the shutdown state.