GRUNDIUM OCUS User manual

USER GUIDE

Ocus® User Guide version 5.0
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Hermiankatu 6-8G, 33720 Tampere, Finland
©2019 Grundium. All rights reserved.
CONTENT
1Sales package contents .............................................................................................................................................................. 3
2To use the Ocus® scanner, you also need .................................................................................................................................. 3
3Introduction to the Ocus® Portable Whole Slide Image Scanner............................................................................................... 3
4Technical specifications.............................................................................................................................................................. 4
5Before you start ......................................................................................................................................................................... 4
6Scanner parts ............................................................................................................................................................................. 6
6.1 Scanner connectors ........................................................................................................................................................... 7
6.2 Power button lights........................................................................................................................................................... 7
7First use...................................................................................................................................................................................... 8
7.1 First use with a network cable connection........................................................................................................................ 8
7.2 First use with a WLAN connection..................................................................................................................................... 9
7.3 Network settings ............................................................................................................................................................. 10
8Log in to the scanner................................................................................................................................................................ 11
8.1 Log in to the scanner with Internet connection .............................................................................................................. 11
8.2 Log in to the scanner with direct WLAN connection....................................................................................................... 11
9Start scanning........................................................................................................................................................................... 12
10 View the images....................................................................................................................................................................... 17
11 Export an image ....................................................................................................................................................................... 17
12 Change scanners ...................................................................................................................................................................... 18
13 Switch off the scanner.............................................................................................................................................................. 19
14 Keep the software up to date .................................................................................................................................................. 19
15 Clean the scanner..................................................................................................................................................................... 19
16 SCANNER SETTINGS.................................................................................................................................................................. 20
17 Create a new team................................................................................................................................................................... 21
17.1 Create a new team when Ocus® is taken into use at first time....................................................................................... 21
17.2 Create a new team when Ocus® has already been taken into use ................................................................................. 22
18 Add new team members.......................................................................................................................................................... 23
19 Taking scanner to another location ......................................................................................................................................... 24
20 Product and safety information ............................................................................................................................................... 24
21 Disposal .................................................................................................................................................................................... 25
22 Troubleshooting ....................................................................................................................................................................... 25
22.1 The scanner is unresponsive ........................................................................................................................................... 25
22.2 Device cannot be found................................................................................................................................................... 25
22.3 Forgot your password...................................................................................................................................................... 25

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22.4 Power button light is steady red ..................................................................................................................................... 25
22.5 Connecting to Internet via Proxy..................................................................................................................................... 25
22.6 First use is interrupted after the WLAN setup is completed ........................................................................................... 25
22.7 Scanner always connects to an unwanted WLAN and does not go into WLAN access point mode ............................... 26
22.8 Scanner WLAN access point password is forgotten ........................................................................................................ 26
22.9 Download does not start automatically when exporting to WebDL ............................................................................... 26
23 Certifications ............................................................................................................................................................................ 26
24 Customer care and support...................................................................................................................................................... 27
25 Company information .............................................................................................................................................................. 27

Ocus® User Guide version 5.0
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Hermiankatu 6-8G, 33720 Tampere, Finland
©2019 Grundium. All rights reserved.
GRUNDIUM OCUS® USER GUIDE
Note: This user guide is for Ocus with software version 2.0 onwards. In case you need user guide for older software
versions, please contact your distributor or [e-mail].
1SALES PACKAGE CONTENTS
oOcus® scanner (MGU-00001)
oProtective cover
oPower supply and mains cable
oQuick guide
oCarrying case
2TO USE THE OCUS® SCANNER, YOU ALSO NEED
oComputer or tablet
oInternet connection
oGrounded mains outlet (recommended to use UPS device in critical operations)
oBrowser (recommended Chrome, Firefox, Safari) –Internet Explorer not supported
It is recommended to use the latest available browser version. The functionality of Ocus® has been verified with
these versions:
oGoogle Chrome (73.0)
oMozilla Firefox (67.0) and
oApple Safari (12.0 & 12.0 Mobile)
3INTRODUCTION TO THE OCUS® PORTABLE WHOLE SLIDE IMAGE SCANNER
Grundium Ocus® is a professional imaging instrument for digitizing microscope slides. The device is used in in vitro
diagnostics, which aims to gather information about the physiological or pathological state of the patient based on
the specimens derived from the human body. The device produces image data, which medical professionals can use
as input information when making patient diagnosis or therapeutic measures.
Grundium Ocus® is CE marked according to EU 2017/746 regulation for in vitro diagnostic (IVD) medical devices.
Ocus® technology has been granted U.S. Patent No. 10,341,551.
Important Notice: In the USA, Grundium Ocus is for research use only (RUO) and not for use in diagnostic
procedures.
Important Notice: The functionality of the scanner must be verified every time before critical operation. The
scanner intended usage flow, including the connectivity, scanning and exporting, must be verified. It must be
verified that the user’s slide preparation process produces slides suitable for scanning with Ocus®. Image quality
must be verified with known sample. Also, there must be a back-up solution for critical operations.

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4TECHNICAL SPECIFICATIONS
Slide capacity
1
Objective / resolution
20x : 0.48um /pix 1x
overview: 10um /pix
Slide format
75mm x 25mm
Scan speed, 15x15mm
~2 min
Connectivity
1GigE, 802.11ac WLAN
Image formats
TIFF, SVS
W x D x H (cm)
18 x 18 x 19
Weight (kg)
3.5 kg
Image sensor
6M pixel
Illumination
Koehler LED
Focusing
Manual coarse, automatic scan, fine-tune in live mode
Stage
Motorized, automatic
Scan area selection
Freely selectable
Storage
500GB internal and USB memory support
Computer
Embedded Nvidia visual computer
User interface
Major web browsers. Touch screen support.
Image viewer
Included + major 3rd party viewers supported.
5BEFORE YOU START
Check the carrying case for damages. If you notice any damage on the case or the scanner, contact primarily your
distributor or [e-mail].
Remove the transportation support pin from the bottom of the scanner by turning the pin counter-clockwise.
Remember to handle the scanner carefully to avoid dropping or damaging it and avoid leaving fingerprints on the
glass surfaces or lenses while removing the pin.

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Image 1 Remove the transportation support pin by turning it counterclockwise.
Place the scanner on a flat surface and make sure there is at least 10 centimetres (4 inches) free space around it.
Tip: To ensure safe transportation, screw the transportation support pin back in before moving the scanner to
another location. Do not overtighten the pin, turning it until it stops is enough.

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6SCANNER PARTS
Image 2 Scanner parts
1. Focus knob
2. Power button
3. Objective
4. Cover plate
5. X-Y-stage
6. Lever
7. Slide holder
8. Slide support glass
9. Overview camera

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6.1 SCANNER CONNECTORS
Image 3 Scanner connectors
1. USB connector
2. Power supply connector. Use only the power supply delivered with the scanner.
Important notice: In case there are any damages in the mains cable or the power supply, do not use the
device.
3. Network cable connector
6.2 POWER BUTTON LIGHTS
Light
Explanation
Green breathing
Scanner is switched off. Power cable is connected.
Green steady
Scanner is connected to the Internet.
Green blinking
Scanner is in live view mode, scanning or exporting.
Yellow steady
Scanner is connected to the Internet, but remote use is disabled.
Red steady
Scanner is in error state (see Troubleshooting).
Red blinking
Scanner is powering up or shutting down.
Blue steady
Scanner’s WLAN access point is on.
Purple steady
Scanner’s first start-up is ongoing.
Purple blinking
Scanner’s software update is in progress.

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7FIRST USE
When you use the scanner for the first time, you need to connect it to your computer or tablet and set up an
Internet connection for the scanner. You can use either a network cable or a WLAN for the connection.
Note: When starting up the scanner for the first time, you must have an Internet connection. After that, it is possible
to use the scanner even without an Internet connection, but the feature set will be limited (See Table 1). The
scanner must be connected to Internet at least once in every 2 months.
Image 4 Label example with a serial number, SSID and a password
Note: For the first-time use, the scanner requires that the network has a DHCP server providing IP address. If the use
of static IP is required, this can be done after the first time use by entering device settings.
Note: If the network you use has a firewall, make sure that the scanner is allowed to use the outgoing connection to
the Internet (TCP ports 80 & 443 for use within same network and TCP port 471 for use from remote network). If the
firewall uses a MAC filter, you can find the MAC address of the scanner on the label at the bottom of the scanner.
Also, traffic between devices in the network must be allowed.
7.1 FIRST USE WITH A NETWORK CABLE CONNECTION
1. Attach the power cable to the scanner and plug the cable in a wall outlet. The power button shows a
breathing green light.
2. Connect one end of the network cable to the scanner and the other end to the Ethernet connector for
your network.

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3. Press the power button. The power button flashes red. Once the scanner is switched on and connected to
the Internet, the power button shows a steady green light. In case the light turns purple, the scanner could
not connect to the Internet. If this happens, you can do the initial setup using WLAN (see chapter 7.2).
4. Open the browser in your computer or tablet and type the following in the browser’s address field:
http://mgu-00001-XXXXXX.device.grundium.net
Note: Make sure that the browser is using http instead of https at this phase.
5. Replace the X’s with the scanner’s serial number (six digits) found on the label at the bottom of the
scanner or on the sticker attached to quick start guide (Image 4).
6. Follow the instructions on your computer or tablet to register a new user account or to use an existing
one. The account enables you to use the scanner.
You can also create a new team. A team enables you to share the scanner with other team members. If you
want to join an existing team, ask someone from the team to add you. See instruction for Create a new
team.
7.2 FIRST USE WITH A WLAN CONNECTION
To use a WLAN connection, you need:
• The name of the WLAN (SSID) provided by the scanner and your password. These are found on the label at
the bottom of the scanner or on the sticker attached to quick start guide.
• The name and password of the WLAN to which the scanner connects for an Internet access. Contact your
system administrator for assistance, if needed.
Tip: You can use your smart phone hotspot feature to create WLAN Internet connection
1. Attach the power cable to the scanner and plug the cable in a wall outlet. The power button shows a
breathing green light.
2. Press the power button. The power button flashes red. Once the scanner is switched on and acts as a
WLAN access point, the power button shows a steady purple light.
3. Open the WLAN settings in your computer or tablet and search for available networks.
4. Connect to “Ocus_XX” WLAN (XX is replaced by the two last digits of the scanner’s serial number). The
password for the scanner WLAN can be found on the label at the bottom of the scanner or on the sticker
attached to quick start guide (Image 4). If the computer asks for a PIN code instead of a password, switch to
using a passphrase.
5. Open the browser in your computer or tablet and type the following in the browser’s address field:
http://www.grundium.net
Note: Make sure that the browser is using http instead of https at this phase.
6. Follow the instructions on your computer or tablet to connect the scanner to a WLAN that has access to
the Internet.

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7. Follow the instructions on your computer or tablet to register a new user account or to use an existing
one. The account enables you to use the scanner.
You can also create a new team. A team enables you to share the scanner with other team members. If you
want to join an existing team, ask someone from the team to add you. See instruction for Create a new team.
7.3 NETWORK SETTINGS
The scanner can be used either with wired or wireless Internet connection (either directly or via proxy) or with
direct WLAN connection between the scanner and the PC or tablet. Table 1 summarizes the features, which
are available for each connection method.
Feature
Internet
Connection
(Green Light)
Internet
Connection via
Proxy (Yellow
Light)
Direct
WLAN
Connection
(Blue Light)
First time use
X
-
-
Remote Use (use from different premises / network)
X
-
-
Live view
X
X
X
Scan Images
X
X
X
View Images
X
X
X
Delete Images
X
X
X
Export Image to USB
X
X
X
Export Image to Cloud services
X
X
-
Change User Settings (e.g. password)
X
X
-
Change Team Settings (e.g. team members)
X
X
-
Change Device Settings
X
X
X
Table 1 Feature availability vs. connection method (X = available, - = not available)
Your organization may not allow direct internet traffic from your network but is enabling internet browser use
through a proxy server instead. Connection to Internet via proxy can be configured in scanner Settings view.
Please consult your IT administrator for assistance and see Troubleshooting for more information.

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8LOG IN TO THE SCANNER
8.1 LOG IN TO THE SCANNER WITH INTERNET CONNECTION
This connection method works when the power button light is green or yellow.
1. Open the browser in your computer or tablet and type https://www.grundium.net
2. Type your e-mail address and password and press Login.
3. Select your team and the scanner you want to use, and press Connect to device.
8.2 LOG IN TO THE SCANNER WITH DIRECT WLAN CONNECTION
To enable the WLAN direct mode, the scanner must be powered on without access to network. In this case,
the scanner will activate its WLAN access point after 30 seconds. Power button light is blue when WLAN access
point is active.
1. Open the WLAN settings from your computer or tablet and connect to WLAN access point provided by the
scanner (WLAN name/SSID and password can be found from the sticker on the bottom of the device or
quick guide, see Image 4).
Image 5 Log in to the scanner by giving your e-mail address and password.
Image 6 Select your team and scanner from the list.

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2. Open the browser in your computer or tablet and type http://www.grundium.net
3. Type your e-mail address and password and press Login (Image 5).
9START SCANNING
Important notice: Both in local and remote use, remember to keep at least 10 centimetres (4 inches) free space
around the scanner. Make sure that nobody touches the scanner when the stage is moving.
1. On your computer or tablet, press Eject slide tray.
Image 7 For inserting a slide into scanner click Eject slide tray.
2. Push the lever underneath the cover plate left to open the slide holder (Image 8).

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Image 8 Open the slide holder and place the slide in the scanner.
3. Place the slide on the scanner so that the sticker end is on the right.
4. Push the lever right to secure the slide.
5. Press New scan to take an overview image.
Image 9 Start taking an overview image by selecting New Scan.
6. To zoom the specimen, use your mouse scroll, or press +, - or 5x/10x/20x quick buttons next to zoom bar
on display. To pan the image, use your fingertip or mouse left button to move it.

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Image 10 Zooming options
Tip: The image is saved automatically to the scanner’s hard drive. If you want to give the image a specific name,
write the name in the File name field.
7. For best results, scanner’s mechanical focus needs to be adjusted for each sample, especially if slide
thickness has even slightly changed. To do this, press Start and pick a target area using the crosshair
cursor or zoom in to 100%. Use the focus knob on the scanner to adjust the focus. Quick tip dialog will
assist you with knob directions. Focus is properly adjusted, when Focus in range is shown on screen.
Image 11 Information in Navigator -box when Focus not in range.
Image 12 Information in Navigator -box when Focus in range.

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Image 13 Quick tip dialog when not in focus.
Image 14 Live view when focus in range.
Tip: You can use the scanner in live view for quick viewing of details on a slide. Image can be panned by dragging the
image with mouse or fingertip. Full screen live view can be activated by pressing Start . You can also take a
snapshot image of the live view by pressing Save live view image.
Tip: Scanners electronic fine focus can be adjusted with the slider on the right side of the live view image. If you use
a mouse with roller wheel, the roller will move the focus when mouse cursor is on top of the slider. The electronic
focus is much more precise than the mechanical focus but is limited in range. Pressing AF next to the slider activates
the automatic focusing mode, where the electronic focus will be continuously kept in optimal position.

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Image 15 Auto focus slider in the foot of the live view window.
8. Zoom out, press Add and select one or more areas you want to scan. To adjust the areas further, drag
the borders of the areas. Estimated scan time is shown on screen.
Image 16 Navigator window
If Focus not in range is shown on screen, you need to adjust the mechanical focus using live view (Image 10
and Image 12).
Tip: To quickly remove extra areas from the selected scanning area, press Trim all.
9. Press Scan to start the scanning. The remaining scan time is shown on screen and once the scan is
completed, the scanned areas are marked to the overview image and you can zoom into them.

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10 VIEW THE IMAGES
To view your saved images, press Scan archive.
Image 17 Images are saved in the scan archive.
To move back to the microscope view, press Microscope.
11 EXPORT AN IMAGE
You can export the scanned images in three ways:
1. Export from Scan Archive slide selection view. This will automatically export all scanned areas on the slides
selected
OR
2. Export from Scan Archive single slide view –you can select the scanned areas you want to export
OR
3. Export from Microscope view by using Scan&Export button. This automatically exports all scanned areas on
the slide after the scanning is completed.
Common to all these three export methods is that the export parameters, meaning destination and format, need to
be first configured by using Export recipe (Image 16). You can configure the recipe either from Microscope or Scan
Archive view.
The progress of ongoing scans can be followed from Exports list (Image 18).

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Image 18 Ongoing and completed exports.
Note: Some export destinations are enabled by plugins and are not available before they are enabled from plugin
settings.
Note: Time of the exported USB files is always in UTC time zone. Some file systems are naturally always in UTC and
hence various operating systems will display the time stamps properly in local times. Some file systems are not and
hence it is possible to see time stamps with offset to local time.
12 CHANGE SCANNERS
If you have several scanners available and want to switch between them, press the scanner name at the top of the
display and select another scanner.
Image 19 If you want to change a scanner, select another device from menu.

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13 SWITCH OFF THE SCANNER
There are two ways to switch off the scanner:
1. In the microscope view, press Change slide > Shutdown.
Note: If you are preparing the scanner for transportation, remove the slide from the scanner before pressing
Shutdown.
OR
2. Press the power button.
During the shutdown, the power key blinks red. When the scanner is switched off, the power key shows a breathing
green light.
Important Notice: To prevent scanner damage, always switch off the scanner with above mentioned steps. Never
pull off the power cord without shutting down the scanner first. Sudden power loss can corrupt scanner’s internal
data storage and can potentially lead to data loss or scanner becoming unusable.
14 KEEP THE SOFTWARE UP TO DATE
From time to time, Grundium provides software updates. When a new update is available, you will get a notification
and instructions on how to update the software. Scanner intended usage flow must be verified after each software
update. This involves testing at least that the connectivity, scanning and exporting function properly.
15 CLEAN THE SCANNER
1. Switch off the scanner.
2. Remove the power cable and the network cable from the scanner.
3. Turn the focus knob until the camera lens is in the uppermost position.
4. Slide the topmost plate to the front and carefully remove the cover plate by pushing for example the
tip of a pen to the small hole under the right edge of the cover plate.
Note: when removing the cover plate, be careful not to damage any optics in the scanner.