H&O Equipments CryoPen User manual

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User Manual

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TABLE OF CONTENTS
User manual .................................................................................................................................................................................................................................................... 3-14
Notice explicative ....................................................................................................................................................................................................................................15-26
Gebrauchsanweisung .........................................................................................................................................................................................................................27-38
Gebruikershandleiding ......................................................................................................................................................................................................................39-50
Instrucciones de uso .............................................................................................................................................................................................................................51-62

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The serial number is engraved in the cavity for all
the devices except for the CryoPen M where the serial
number is engraved on the top of the frontend thread.
Please mention your instrument’s serial number
on all communication with H&O Equipments.
Cartridge
Backend
Gas release opening
Frontend
Trigger
Applicator
Applicator cap
Filter/opener
Cavity
Trocar
User manual
SN
CryoPen M Other device

4
This user manual is applicable for the following products and accessories.
INSTRUMENTS - Expected lifetime : minimum 10 years in normal use.
CryoPen M with blue/red and white/red dot micro-applicators .................................................................................................... S-HO-CMPE-XX-302
CryoPen O with blue/red, white/red and green/red dot micro-applicators...........................................................................................S-HO-COPE-01
CryoPen X+ with support, blue/red, white/red, green/red and yellow/red.....................................................................................
dot micro-applicators, with blue/red and white/red dot 60mm long micro-applicators ............................................................S-HO-CXPEP-01
CryoPen XP with support, blue, grey, green and yellow ring applicators ............................................................................................. S-HO-CEPE-00
The instrument, the applicators, the tweezer and the user manual come in a hard case for easy transportation.
CARTRIDGES
- Expiring date printed on the cartridges packaging.
8g N2O cartridges: 1 carton of 12 boxes each containing 24 cartridges
for use with CryoPen M, CryoPen O, CryoPen X+ and CryoPen XP .............................................................. S-HO-NOCX-12-S24
16g N2O cartridges: 1 carton of 12 boxes each containing 6 cartridges
for use with CryoPen O, CryoPen X+ and CryoPen XP ................................................................................. S-HO-NOCX-12-S06
APPLICATORS
Blue/red dot applicator for 1-3mm applications ........................................................................................ S-HO-CCXO-MA-004
White/red dot applicator for 2-6mm applications...................................................................................... S-HO-CCXO-MA-005
Green/red dot applicator for 4-8mm applications...................................................................................... S-HO-CCXO-MA-006
Yellow/red dot applicator for 7-20mm applications ................................................................................... S-HO-CCXO-MA-007
Blue/red dot long applicator 60mm for 1-3 mm applications ..................................................................... S-HO-CCXO-MA-008
White/red dot long applicator 60mm for 2-6 mm applications................................................................... S-HO-CCXO-MA-009
Green/red dot long applicator 120mm for 4-8mm applications ................................................................ S-HO-CCXO-MA-026
REF

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APPLICATORS - for use with CryoPen XP
Blue ring applicator for 1-3mm applications................................................................................................................................................. S-HO-CCXP-MA-001
Grey ring applicator for 2-4mm applications ................................................................................................................................................ S-HO-CCXP-MA-002
Green ring applicator for 3-5mm applications............................................................................................................................................. S-HO-CCXP-MA-003
Yellow ring applicator for 5-8mm applications............................................................................................................................................ S-HO-CCXP-MA-004
REF
The above list of products is correct at the time of printing. Some articles may no longer be available when reading
this document. Some articles may not be available in certain countries.
CryoPen® is the registered trademark of H&O Equipments nv/sa for Europe, the Middle East, Africa and Asia Pacific.
CryoPen® is manufactured by H&O Equipments nv/sa.
FDA certificate is available and can be obtained upon simple request.
EC Declaration of Conformity and EC certificate are available and can be obtained upon simple request.
Device classification
CryoPen is a non-invasive, non-sterile, reusable medical device.
Intended Use
CryoPen is dedicated for the cryogenic treatment of the following benign skin lesions : Acrochordon, actinic keratosis and
cheilitis, capillary haemangioma, cutaneous leishmaniasis, discoid lupus erythematosus, filiform, flat, vulgar, plantar and
anogenital warts, rosacea, lichen sclerosus, granuloma annulare, molluscum contagiosum, seborrheic keratosis, viral lesions by
dispensing an extremely precise flow of nitrous oxide applied directly on the lesion.

6
USED SYMBOLS:
All mentioned products are manufactured in the European Community by,
H&O Equipments nv/sa
Rue des Journaliers 1, 7822 Ghislenghien, Belgium
Catalogue number
Serial number
Batch number
Use-by date
Notified body nr 1639 SGS BELGIUM
Medical Device
Unique Device Identification
REF
SN
LOT
This manual’s version: Manual_CryoPen_20210728. The most recent version of this user manual and other language versions
can be downloaded from our website: www.ho-equipments.com
Attention! Reference is made to the liability waiver at the back of this manual.
Telephone: [phone]
Fax: [phone]
E-mail: [email protected]
Website: www.ho-equipments.com
50°C
/122°F
Manufacturer
Caution, consult accompanying documents
Consult the user’s guide
Do not expose the cartridges to temperatures above 50°C/122°F
Keep away from sunlight

7
IMPORTANT NOTICE:
• When used correctly, the device does not come into contact with the lesion nor the skin.
• When used normally, there is no need to perform any maintenance, cleaning or disinfection.
• Never clean the thread of frontend and backend. The existing coating should be protected.
• Should the applicator touch the patient in case of misuse, the applicator can be cleaned (autoclaved: 134 °C/273 °F - 4min
or 121 °C/250 °F – 20 min) and disinfected (use a non-corrosive disinfecting solution, follow the disinfecting solution
manufacturer’s recommendations with regards to the concentration and time of application).
• Always gently manipulate all components of CryoPen instruments. Never use more than gentle hand force. Never use pliers
or other tools to manipulate the instrument.
• Please ensure to only use the cartridges and filter/openers supplied from H&O Equipments nv/sa. Any other cartridges and
filter/openers would damage the instrument.
• Incorrect placement of the filter/opener device into the loading cavity will cause irreversible damage to the instrument.
• Residual foreign matters in the loading cavity while placing a new filter/opener can cause instrument failure.
• When loaded, the instrument is under high pressure. Any change to the construction of the instrument may cause a potential risk.
• Never put your hand on the gas release opening at the end of the backend while removing the cartridge!
• All external parts can be wiped with a cloth soaked in any noncorrosive disinfecting solution. Never immerse the entire
instrument in a disinfecting solution.
• The applicators must be kept away from dust and the cartridges must be kept away from high temperatures (max
50°C/122°F). Leave the applicator cap on when not in use.
• The CryoPen should be handled with care. When storing the instrument with a loaded cartridge in its case, position the CryoPen
in such a way that the trigger cannot be pressed when closing the lid of the case. This would cause undesired gas flow.
• CryoPen instruments are intended for professional use only.
• The N2O cartridges contain both a liquid and a gaseous phase in balance. The proportion of each phase depends on the room
temperature which affects the output flow. The best performances are achieved when the cartridge temperature is between
19°C and 22°C (66°F and 72°F). Lower and higher temperatures will give different values of pressure and density of the
cryogen. Over 25°C/77°F, the quantity of liquefied N2O in the CryoPen jet will decrease.
• Empty cartridges should be discarded as metal scrap.

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Contraindications:
• Unstable diabetes
• Skin conditions, e.g. skin tumors, esanthema, open
wounds, solar hyperkeratosis
• Unexplained, suspicious liver spots and moles
• Cancer tissues and malignant tumors
The contraindications related to temporary
conditions:
• Infections accompanied by fever
• Acute chemotherapy or radiotherapy from four weeks
before beginning the therapy to four weeks after
finishing the therapy
• Pregnancy or breastfeeding
• Cold intolerance
• Vascular insufficiency
Reduce possible side-effects:
Although cryotherapy is a relatively low-risk procedure, some
side effects may occur as a result of the treatment.
They include:
• Permanent changes in pigmentation. Both
hypopigmentation (lightening of the skin) and
hyperpigmentation (darkening of the skin) may occur after
cryotherapy. Both generally last a few months, but can be
longer lasting. Avoid freezing the basal cell layer where
melanocytes (pigment producing cells) are located.
• Sensory impairment. Though rare, damage to nerves is
possible, particularly in areas where they lie closer to the
surface of the skin, such as the fingers, the wrist, and the
area behind the ear. Reports suggest this will disappear
within several months.
• Spattering of the cryogen during spraying, when the
end nozzle freezes. The innovation of CryoPen is the
direct application of nitrous oxide under high pressure
(49-53 bar for a cartridge temperature of 66-72°F/19-
22°C). This high pressure jet may cause minor shards
of frozen humidity in the air blown away in a circle of
approximately 30cm of diameter. They will thaw the
moment they would eventually touch healthy skin.
• Hair loss. Hair follicles are easily damaged by cryosurgery
and permanent hair loss is not uncommon.

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Further side-effects
• Edemas
• Bleeding
• Pain and syncope
• Insufflation of subcutaneous tissue
• Retraction caused by freezing next to orifices
• Cartilage defect during treatment of the nose or the ear
• Infection
• Conjunctival ectopy due to treatments of the eyelid
• Milia
• Depressed or atrophic scars
Interact with your patients.
Inform patients that there will be a pain sensation similar to
a ballpoint being pushed onto the skin. Generally, little or no
discomfort is experienced during the first few seconds when
you manage to avoid treatment of healthy tissue. The ice will
reach the caudal extent of the lesion after a given amount of
time related to the depth of the lesion. From that moment
the patient will experience a pain sensation. This may be the
moment to stop treatment. You may eventually add a few
seconds more depending on the patient’s comfort level and
upon the clinical evaluation of the operation. There might be
a little residual stinging for a few minutes after treatment.
Occasionally, a blister might form and persist for a few hours.
Using the instrument:
Step 1 Load a new cartridge
The cartridges are packed in peel-pack blisters with an
assembled filter/opener included. The filters are used for
protection of the applicator, the opener for puncturing the
cartridge.
CryoPen M can be used with 8g N2O cartridges only.
CryoPen X+, CryoPen O, CryoPen XP can be used with 16g
N2O cartridges and with the 8g N2O cartridges, thanks to
the converter 16/8g. Ensure that the cavity is empty of any
remaining parts. Open the peel-pack. Take out the filter/
opener with the tweezers. Hold the CryoPen’s tip end pointed
downward. Place the filter/opener in the instrument and make
sure that it is seated flat at the bottom of the loading cavity.
The trocar of the opener should be pointed upward! Take the
cartridge and put it into the cavity with the narrow side down,
on top of the filter/opener.
NOYES
Installation of the assembled filter opener

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Step 2 Puncture the unused cartridge
Gently screw the CryoPen’s backend onto the frontend.
Go to the point where you feel that the contact between
the assembled filter/opener and the cartridge is established.
Now, position your hands so that the last turn will be in an
uninterrupted movement. Now, rotate quickly until you feel
that the end of the rotation is achieved.
You may eventually hear a short hissing sound.
The shorter the hiss, the better!
Step 3 Use your CryoPen
Remove the applicator cap. Gently squeeze the trigger
to start the flow of N2O. Release the trigger to close off the
flow of cryogenic liquid. 1 or 2 seconds after releasing the
trigger, the remaining gas in the applicator is discarded.
A cartridge can be used for several treatments and patients.
Let’s see how to load
your device?
- let’s see
our youtube channel -
Converter 16/8g:
Adapter to convert the backend
for a 8g cartridge
Discharge the used cartridge & empty the cavity
Before loading a new cartridge, first release any unused
gas from the current cartridge by unscrewing the applicator
followed by pressing the trigger. Then unscrew the backend.
Discard the used cartridge and filter/opener. Regarding
CryoPen X+, CryoPen O, CryoPen XP be careful not to throw
the converter 16/8g. Ensure that the used filter/opener does
not remain inside the cavity. You should have the cavity empty
of any remaining parts.
Empty loading cavity
Blistered cartridge and
assembled filter/opener *

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Applicators with various flow rates are available depending of the lesion size. Ask your distributor or check
on www.ho-equipments.com. The table below gives the estimated application with a continuous flow time depending
on the applicator and the cartridge size. The measurements were performed between 19°C/66°F and 21°C/70°F.
Select your applicators:
8g 16g Lesion size Power
Blue/red 135-155s 230-270s 1-3mm
White/red 80-100s 145-180s 2-6mm
Green/red 65-80s 110-130s 4-8mm
Yellow/red 55-65s 7-20mm
Blue/red 60mm 135-155s 230-270s 1-3mm
White/red 60mm 80-100s 145-180s 2-6mm
Green/red 120mm 110-130s 4-8mm
Only for CryoPen XP
Blue ring 200-215s 410-425s 1-3mm
Grey ring 155-170s 315-330s 2-4mm
Green ring 100-115s 175-190s 3-5mm
Yellow ring 50-60s 100-115s 5-8mm

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Position the CryoPen for treatment
The instrument must be held vertically with the tip directed downward.
An angle of less than 45° must be avoided.
Effective application
Before starting treatment take into account age, location, size and number of lesions, skin
type, degree of tanning and season.
The applicator tip (from where the liquefied N2O flows) should be held 0,5 to 3 mm from
the lesion. Further than 5 mm from the applicator tip the liquefied N2O will have expanded
into gas phase which is not effective for achieving therapeutic results.
By approaching the lesion with the gas flowing you will observe the focal point of the jet
on the tissue. The closer you approach the lesion, the more freezing power you apply
to the tissue. It is recommended to keep a greater distance for the smaller and more
delicate procedures.
The amount of liquid N2O that you wish to apply can be controlled by moving
the applicator quickly towards and away from the tissue. Circular and crossing movements
have the same effect.
Position the CryoPen correctly
Treatments Videos
Distance to lesion
OK!
OK!
OK!
OK!
- let’s see
our youtube channel -

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Condensation of humidity in the air may in some cases create an ice field on top of the lesion. This ‘igloo of ice’ will hinder the
effective working of the liquid phase of the cryogen (at -89°C/-128°F) and should be removed.
The learning curve for utilizing the CryoPen is short. CryoPen provides the possibility to have full control in the application of
freezing power. Start practicing on the regular lesions and treat the more delicate ones after having acquired some experience.
Duration/Depth of the treatment
Hold the tip of the applicator as close as possible to the lesion. In all literature, the rapid drop of temperature (thermal shock)
is described as a critical criterion. However, always relate to the part of the body where the operation is applied. In some parts,
skin is thinner which requires more caution.
A typical freeze on viral infections may last from 5 to 10 seconds for a small flat wart, and up to 45 seconds for a full thickness
plantar wart. For general purposes most lesions take about 2 to 30 seconds.
The duration of the treatment will depend on the surface and the thickness of the tissue being treated. Thickness must be
estimated based on clinical experience. After the first freezing cycle the tissue should be allowed to thaw for about 30 seconds
followed by a second freeze. Note that the tissue will freeze faster than during the first freezing cycle. This ‘freeze-thaw-freeze’
technique offers the best opportunity for success.
You will find this procedure in most literature on cryotherapy. A follow-up visit is recommended after 2 to 4 weeks to confirm
that all pathological tissue has disappeared and check if a follow-up treatment is necessary.

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Liability waiver
Improper use, including excess freezing levels beyond those, which are recommended or for an excessive duration,
may result in bodily injury to clients/patients or to operator. H&O Equipments nv/sa and their affiliates, respective
directors, officers, shareholders, employees, agents and contractors are not liable or responsible, regardless of
whether such liability or responsibility is based on breach of contract, tort, strict liability, breach of warranties,
failure of essential purpose, fundamental breach or otherwise, for any death or injury, whether physical or mental,
or for any incidental, consequential, indirect, special or punitive damages, arising out of the CryoPen, its design,
specifications, possession and use, and treatment procedures, and whether or not any such death, injury, loss,
damage(s) result from the negligence, default or error in judgment by H&O Equipments nv/sa, their affiliates,
respective directors, officers, shareholders, employees, agents and contractors, and even if advised of the possibility
of such damages. You agree to indemnify H&O Equipments nv/sa, their affiliates, respective directors, officers,
shareholders, employees, agents and contractors, from and against any and all liability, damages, losses, costs,
judgments, fines, penalties and expenses (including legal expenses) of any kind or nature, including, without
limitation, incidental, consequential, indirect, special or punitive damages, arising out of claims, demands, actions,
causes of action, proceeding or suits, whether in law or in equity, due to any death, injury, loss, damage or damages
as hereinbefore referred to.
For more information
visit our website: www.ho-equipments.com

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Le numéro de série est gravé dans la cavité pour tous
les instruments à l’exception du CryoPen M où il se situe
au-dessus du filetage de l’extrémité antérieure.
Veuillez mentionner le numéro de série de votre instrument
dans toutes vos communications avec H&O Equipments.
Cartouche
Extrémité postérieure
Ouverture d’expulsion du gaz
Extrémité antérieure
Déclencheur
Applicateur
Capuchon de l’applicateur
Filtre/perforateur
Cavité
Trocart
Notice explicative
SN
CryoPen M Autre instrument

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Ce manuel d’utilisation s’applique aux produits et accessoires suivants.
INSTRUMENTS - Durée de vie prévue : minimum 10 ans dans des conditions normales d’utilisation.
CryoPen M avec micro-applicateurs à point bleu/rouge et blanc/rouge .................................................................................. S-HO-CMPE-XX-302
CryoPen O avec micro-applicateurs à point bleu/rouge, blanc/rouge et vert/rouge ....................................................................... S-HO-COPE-01
CryoPen X+ avec support, micro-applicateurs à point bleu/rouge, blanc/rouge, vert/rouge et jaune/rouge,
et micro-applicateurs longs de 60 mm à point bleu/rouge et blanc/rouge.........................................................................................S-HO-CXPEP-01
CryoPen XP avec support et applicateurs à anneau bleu, gris, vert et jaune....................................................................................... S-HO-CEPE-00
L’instrument, les applicateurs, la pincette et le manuel d’utilisation sont fournis dans un étui rigide pour un transport facile.
CARTOUCHES
- Date d’expiration imprimée sur l’emballage des cartouches.
Cartouches de N2O de 8g: 1 carton de 12 boîtes contenant chacune 24 cartouches
pour CryoPen M, CryoPen O, CryoPen X+ et CryoPen XP ............................................................................ S-HO-NOCX-12-S24
Cartouches de N2O de 16g : 1 carton de 12 boîtes contenant chacune 6 cartouches
pour CryoPen O, CryoPen X+ et CryoPen XP............................................................................................... S-HO-NOCX-12-S06
APPLICATEURS
Applicateur à point bleu/rouge pour applications sur lésions de 1 à 3 mm................................................. S-HO-CCXO-MA-004
Applicateur à point blanc/rouge pour applications sur lésions de 2 à 6 mm ............................................... S-HO-CCXO-MA-005
Applicateur à point vert/rouge pour applications sur lésions de 4 à 8 mm ................................................. S-HO-CCXO-MA-006
Applicateur à point jaune/rouge pour applications sur lésions de 7 à 20 mm ............................................ S-HO-CCXO-MA-007
Applicateur long à point bleu/rouge de 60 mm pour applications sur lésions de 1 à 3 mm ........................ S-HO-CCXO-MA-008
Applicateur long à point blanc/rouge de 60 mm pour applications sur lésions de 2 à 6 mm ...................... S-HO-CCXO-MA-009
Applicateur long à point vert/rouge de 120 mm pour les applications sur lésions de 4 à 8 mm ................. S-HO-CCXO-MA-026
REF

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APPLICATEURS - à utiliser avec CryoPen XP
Applicateur à anneau bleu pour applications sur lésions de 1 à 3 mm ....................................................................................... S-HO-CCXP-MA-001
Applicateur à anneau gris pour applications sur lésions de 2 à 4 mm ......................................................................................... S-HO-CCXP-MA-002
Applicateur à anneau vert pour applications sur lésions de 3 à 5 mm ........................................................................................ S-HO-CCXP-MA-003
Applicateur à anneau jaune pour applications sur lésions de 5 à 8 mm .................................................................................... S-HO-CCXP-MA-004
REF
La liste de produits ci-dessus est correcte au moment de l’impression. Il se peut que certains articles ne soient plus disponibles
lorsque vous lirez ce document. Certains articles peuvent ne pas être disponibles dans certains pays.
CryoPen® est une marque déposée de H&O Equipments nv/sa pour l’Europe, le Moyen-Orient, l’Afrique et l’Asie-Pacifique.
CryoPen® est fabriqué par H&O Equipments nv/sa.
Le certificat de la FDA est disponible et peut être obtenu sur simple demande.
La déclaration de conformité CE et le certificat CE sont disponibles et peuvent être obtenus sur simple demande.
Classification du dispositif
CryoPen est un dispositif médical non invasif, non stérile et réutilisable.
Utilisation
CryoPen est prévu pour le traitement cryogénique des lésions cutanées bénignes suivantes : acrochordon, kératose et chéilite
actiniques, hémangiome capillaire, leishmaniose cutanée, lupus érythémateux discoïde, verrues plantaires et ano-génitales
filiformes, plates, vulgaires, rosacée, lichen scléro-atrophique, granulome annulaire, molluscum contagiosum, kératose
séborrhéique et lésions virales, en appliquant un flux extrêmement précis de protoxyde d’azote directement sur la lésion.

1818
SYMBOLES UTILISÉS:
Tous les produits mentionnés sont fabriqués dans la Communauté européenne par :
H&O Equipments nv/sa
Rue des Journaliers 1, 7822 Ghislenghien, Belgium
Référence article
Numéro de série
Numéro de lot
REF
SN
LOT
Date de péremption
Organisme notifié no 1639 SGS BELGIQUE
Version du présent manuel: Manual_CryoPen_20210728. La version la plus récente de ce manuel utilisateur et les versions
dans les autres langues peuvent être téléchargées à partir de notre site Web : www.ho-equipments.com
Attention! Il est fait référence à la décharge de responsabilité à la fin de ce manuel.
Téléphone: [phone]
Fax: [phone]
E-mail: [email protected]
Website: www.ho-equipments.com
50°C
/122°F
Fabricant
Attention, consultez la documentation connexe
Consulter la notice explicative
Ne pas exposer les cartouches à des températures supérieures à 50°C
Conserver à l’abri de la lumière
Dispositif médical
Identifiant Unique des Dispositifs

1919
REMARQUES IMPORTANTES:
• Utilisé correctement, l’instrument n’entre pas en contact avec la lésion ou la peau.
• Lorsqu’il est utilisé normalement, il n’est pas nécessaire d’effectuer d’entretien, de nettoyage ou de désinfection.
• Ne jamais nettoyer les filetages de l’extrémité antérieure et de l’extrémité postérieure. Le revêtement existant doit être protégé.
• Si l’applicateur touche le patient en cas de mauvaise utilisation, il peut être nettoyé (passé à l’autoclave à 134 °C pendant 4 min. ou à
121 °C pendant 20 min.) et désinfecté (utiliser une solution désinfectante non corrosive, suivre les recommandations du fabricant de la
solution désinfectante en matière de concentration et de temps d’application).
• Toujours manipuler délicatement tous les composants des instruments CryoPen. Ne jamais appliquer une force supérieure
à celle de la main. Ne jamais utiliser de pinces ou d’autres outils pour manipuler l’instrument.
• Veiller à n’utiliser que les cartouches et les filtres/perforateurs fournis par H&O Equipments nv/sa. Toute autre cartouche et tout autre
filtre/perforateur endommagerait l’instrument.
• Un positionnement incorrect du dispositif filtre/perforateur dans la cavité de chargement provoquera des dommages irréversibles à l’instrument.
• Les corps étrangers résiduels présents dans la cavité de chargement lors de l’insertion d’un nouveau filtre/perforateur
peuvent occasionner une défaillance de l’instrument.
• L’instrument chargé est sous haute pression. Toute modification apportée à la structure de l’instrument peut entraîner un risque potentiel.
• Ne jamais obstruer l’ouverture d’expulsion de gaz avec la main, à l’extrémité de la partie postérieure,
lors du retrait de la cartouche !
• Toutes les parties externes peuvent être essuyées à l’aide d’un chiffon imbibé de solution désinfectante non corrosive. Ne jamais
immerger totalement l’instrument dans une solution désinfectante.
• Les applicateurs doivent être tenus à l’abri de la poussière et les cartouches doivent être tenues à l’abri de la chaleur (max 50°C/122°F).
Laisser le capuchon de l’applicateur lorsque celui-ci n’est pas utilisé.
• L’instrument CryoPen doit être manipulé avec précaution. Lorsque l’instrument CryoPen est rangé dans son étui avec une cartouche
chargée, il doit être positionné de telle sorte que le déclencheur ne puisse pas être actionné lors de la fermeture du couvercle de l’étui, afin
d’éviter un flux de gaz indésirable.
• Les instruments CryoPen sont réservés exclusivement à un usage professionnel.
• Les cartouches de N2O contiennent à la fois une phase liquide et une phase gazeuse en équilibre. La proportion de chacune de ces phases
dépend de la température ambiante et influence le débit à la sortie. Les meilleures performances sont atteintes lorsque la température de la
cartouche se trouve entre 19 °C et 22 °C. Des températures inférieures ou supérieures donneront des valeurs différentes de pression et de
densité de la substance cryogénique. Au-dessus de 25 °C, la quantité de N2O liquéfié du jet du CryoPen va diminuer.
• Les cartouches vides doivent être jetées avec les déchets métalliques.

20
Contre-indications:
• Diabète instable
• Maladies de la peau, p.ex. tumeurs cutanées,
exanthème, plaies ouvertes, hyperkératose solaire
• Taches de vieillesse et grains de beauté inexpliqués
et suspects
• Tissus cancéreux et tumeurs malignes
Contre-indications relatives à des maladies
ponctuelles:
• Infections accompagnées de fièvre
• Chimiothérapie ou radiothérapie aiguë, à partir de
quatre semaines avant le début de la thérapie et jusqu’à
quatre semaines après la fin de celle-ci
• Grossesse ou allaitement
• Intolérance au froid
• Insuffisance vasculaire
Réduire les effets secondaires possibles:
Bien que la cryothérapie présente relativement peu de risques,
elle peut entraîner quelques effets secondaires.
Ceux-ci comprennent:
• Modifications permanentes de la pigmentation. Une
hypopigmentation (coloration plus claire de la peau)
et une hyperpigmentation (coloration plus foncée de
la peau) peuvent apparaître après la cryothérapie. En
général, ces phénomènes ne subsistent que quelques
mois. Cependant, des durées supérieures sont possibles.
Évitez de congeler la couche de cellules basales où sont
situés les mélanocytes (cellules produisant le pigment).
• Déficience sensorielle. Même si elles sont rares, des lésions
nerveuses peuvent survenir, surtout dans des endroits où les
nerfs passent près de la surface de la peau, tels que les doigts,
le poignet et la zone derrière l’oreille. Selon des rapports, ces
lésions disparaissent en quelques mois.
• Dispersion de la substance cryogénique lors de sa pulvérisation,
lorsque l’extrémité de l’embout gèle. L’innovation de CryoPen
réside dans l’application directe de protoxyde d’azote
sous pression élevée (49-53 bars pour une température
de cartouche de 19 à 22 °C). Ce jet à haute pression peut
provoquer la formation de petits fragments d’humidité
congelée dans l’air, qui seront dispersés dans le périmètre d’un
cercle d’environ 30 cm de diamètre. Ils décongèleront dès qu’ils
entreront en contact avec de la peau saine.
• Perte de poils. Les follicules pileux sont facilement
endommagés par la cryochirurgie et une perte de poils
permanente n’est pas rare.