illumina DRAGEN v3 User manual

Illumina DRAGEN Server v3
Site Prep and Installation Guide
Introduction 1
Delivery and Setup 1
Facility Requirements 2
Electrical Requirements 2
Environmental Considerations 3
Network Considerations 4
Security and Safety 5
Set Up the DRAGEN Server 6
Configure BMC 10
Configure the Server Network 11
Set Server Time 12
Configure External Storage 13
Activate DRAGEN Software License 14
Install the DRAGEN Software 16
Access the Server Remotely 16
Shut Down the Server 17
Advanced Exchange 17
Server Specifications 20
Document # 1000000097923 v02
September 2020
ILLUMINA PROPRIETARY
For Research Use Only. Not for use in diagnostic procedures.

Revision History 21
Technical Assistance 22
Document # 1000000097923 v02
For Research Use Only. Not for use in diagnostic procedures.
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

This document and its contents are proprietary to Illumina, Inc. and its affiliates ("Illumina"), and are intended solely for
the contractual use of its customer in connection with the use of the product(s) described herein and for no other
purpose. This document and its contents shall not be used or distributed for any other purpose and/or otherwise
communicated, disclosed, or reproduced in any way whatsoever without the prior written consent of Illumina. Illumina
does not convey any license under its patent, trademark, copyright, or common-law rights nor similar rights of any third
parties by this document.
The instructions in this document must be strictly and explicitly followed by qualified and properly trained personnel in
order to ensure the proper and safe use of the product(s) described herein. All of the contents of this document must be
fully read and understood prior to using such product(s).
FAILURE TO COMPLETELY READ AND EXPLICITLY FOLLOW ALL OF THE INSTRUCTIONS CONTAINED HEREIN MAY
RESULT IN DAMAGE TO THE PRODUCT(S), INJURY TO PERSONS, INCLUDING TO USERS OR OTHERS, AND DAMAGE
TO OTHER PROPERTY, AND WILL VOID ANY WARRANTY APPLICABLE TO THE PRODUCT(S).
ILLUMINA DOES NOT ASSUME ANY LIABILITY ARISING OUT OF THE IMPROPER USE OF THE PRODUCT(S)
DESCRIBED HEREIN (INCLUDING PARTS THEREOF OR SOFTWARE).
© 2020 Illumina, Inc. All rights reserved.
All trademarks are the property of Illumina, Inc. or their respective owners. For specific trademark information, see
www.illumina.com/company/legal.html.
Document # 1000000097923 v02
For Research Use Only. Not for use in diagnostic procedures.
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

Introduction
This guide provides instructions for setting up the Illumina® DRAGEN™ Server, including preparing your site
for installation and operation. You can use the following specifications and guidelines included to prepare your
facility:
uSpace requirements
uElectrical requirements
uEnvironmental considerations
uComputing requirements
uNetwork considerations
Safety Considerations
See the DRAGEN Bio-IT Platform Safety and Compliance Guide (document # 1000000096716) for important
information about safety considerations.
Additional Resources
The DRAGEN Bio-IT Platform support pages on the Illumina website provide additional system resources.
These resources include software, training, compatible products, and the following documentation. Always
check support pages for the latest versions.
Resource Description
DRAGEN Bio-IT Platform Safety and
Compliance Guide (document #
1000000096716)
Provides information about operational safety considerations, compliance
statements, and labeling.
llumina DRAGENBio-ITPlatform User Guide
(document # 1000000070494)
Provides an overview of the platform and associated procedures. Instructions
for use, maintenance, and troubleshooting procedures are included.
Delivery and Setup
The DRAGEN Server v3 is unpacked and installed by the customer. The space must be ready before
delivery.
Box Dimensions
Use the following dimensions to determine transport, setup, and storage plans.
Measurement Dimension
Height 41.0 cm (16.0 in)
Width 85.1 cm (33.5 in)
Depth 62.2 cm (24.5 in)
Weight 33.1 kg (73 lb)
Shipping Box Components
The DRAGEN Server v3 and components are shipped in one box. The following components are included:
uPower cord, country-specific
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

uDRAGEN License USBkey
uRack mount rails
uRack mount screws
Facility Requirements
Use the specifications and requirements provided in this section to set up your lab space.
Equipment Dimensions
Measurement Dimension
Height 8.8 cm (3.5 in)
Width 47.8 cm (19 in)
Depth 49.32 cm (19.4 in)
Weight 16.10 kg (35 lbs)
Placement Requirements
Position the DRAGEN Server v3 to allow proper ventilation, access to one power outlet, and access for
servicing.
uAllow a rack height of at least 2U.
uMake sure that there is one standard pocket outlet within 10 ft (3 m) of the server.
uPosition the instrument so personnel can quickly disconnect the power cords from the outlets.
Electrical Requirements
Power Specifications
Power Specification
Power Supply Rating 1574 Watts at 100%. Maximum power draw under load
800 W
Input Voltage 100–240 V AC at 50/60 Hz, autoranging
Receptacles
Your facility must be wired with the following receptacles:
uFor 100–110 Volts AC—Two 10 amp grounded, dedicated lines with proper voltage and electrical
ground.
uFor 220–240 Volts AC—Two 6 amp grounded lines with proper voltage and electrical ground.
uNorth America and Japan—NEMA 5-15.
uIf the voltage fluctuates more than 10%, power line regulators are required.
Protective Earth
The has a connection to protective earth through the enclosure. The safety ground on the
power cord returns protective earth to a safe reference. The protective earth connection on
the power cord must be in good working condition when using this device.
Document # 1000000097923 v02
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

Power Cords
The DRAGEN Server v3 has international standard IEC 60320 C13 receptacles and is shipped with one
region/country-specific power cords.
Hazardous voltages are removed from the DRAGEN Server v3 only when the power cords are disconnected
from the AC power source.
To obtain equivalent receptacles or power cords that comply with local standards, consult a third-party
supplier such as Interpower Corporation (www.interpower.com).
CAUTION
Never use an extension cord to connect the DRAGEN Server v3 to a power supply.
Fuses
The DRAGEN Server v3 contains no user-replaceable fuses.
Environmental Considerations
The following table specifies temperature, humidity, and other environmental considerations for safely housing
the instrument.
Element Specification
Temperature Maintain a server room temperature of 0°C to 40°C. This temperature is the operating
temperature of the DRAGEN Server v3. Do not allow the ambient temperature to vary by
more than ±2°C.
Humidity Maintain a noncondensing relative humidity between 10–95%.
Altitude Locate the DRAGEN Server v3 at an altitude below 2,000 meters (6,500 ft).
Air Quality Operate the server in a data center environment with air filtration per ISO 14644-1 Class 8
with a 95% upper confidence limit.
Ventilation Consult your facilities department for ventilation requirements sufficient for the level of heat
output expected from the DRAGEN Server v3.
Location Operate the server in an indoor environment only. The server is not suitable for use in
locations where children are likely to be present.
Heat Output
Measured Power Thermal Output
1100 Watts 4100 BTU/hr
Noise Output
A measurement of ≤ 70 dB is within the level of a normal conversation at a distance of approximately 1 meter
(3.3 feet).
Acoustical Performance Noise Output (dB)
Idle at 25°C Ambient 36
Max. Loading at 35°C Ambient <75
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

Uninterruptible Power Supply
Illumina recommends using a user-supplied uninterruptible power supply (UPS).
Illumina is not responsible for data loss caused by interrupted power, regardless of whether the DRAGEN
Server v3 is connected to a UPS. Standard generator-backed power is often not uninterruptible, so a brief
power outage occurs before power resumes. This power outage interrupts analysis and data transfer.
The following table shows three example recommended UPS models for the DRAGEN Server v3.
Specification Japan
APC Model
# SMX1500RMJ2U
North America
APC Model
# SMX1500RM2UNC
International
APC Model
# SMX1500RMI2UNC
Maximum
Output
Capacity
1200 W 1500 VA 1200 W 1440 VA 1200 W 1500 VA
Input Voltage
(Nominal)
100 VAC 120 VAC 230 VAC
Input
Frequency
50/60 Hz 50/60 Hz 50/60 Hz
Input
Connection
NEMA 5–15P NEMA 5–15P IEC-320 C14
Schuko CEE7/EU1-16P
British BS1363A
Built-In UPS
Output
Receptacles
Six NEMA 5–-15 R (battery backup) Eight NEMA 5–15R (battery
backup)
Eight IEC 320 C13 (battery
backup)
Dimensions 8.9 cm × 43.2 cm × 46.8 cm 8.9 cm × 43.1 cm × 49.0 cm
(3.5 in × 17.0 in × 19.3 in)
8.9 cm × 43.2 cm × 49.0 cm
Weight 27.8 kg 24.8 kg (54.6 lb) 24.8 kg
Typical Run
Time (at 500
Watt Average
Draw)
19.5 minutes 22.9 minutes 22.9 minutes
Table 1 Region-Specific UPS Recommendations
Network Considerations
Before running tests, make sure that your network contains the required components and meets the network
connection recommendations.
DRAGEN Server v3 setup requires the following network components:
uDefault gateway address
uDNS Server IP address
uIP addresses (2)
uSubnet mask for the IP addresses
The following operations require an external internet connection using TCP on ports 80 and 443:
uUpdating the software
uRemote assistance from Illumina Technical Support
uAccess to license server
Document # 1000000097923 v02
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

Network Connections
Use the following recommendations to install and configure a network connection:
uRecommended bandwidth for a connection is as follows.
u10 Gb per second connection to storage.
uSwitches and other network equipment must have a minimum of 10 Gb per second.
uCalculate the total capacity of the workload on each network switch. The number of connected
instruments and ancillary equipment, such as a printer, can impact capacity.
uFor 10 Gb connections, SFP+ and RJ45 connections are supported. If using SFP+ ports, twinax cables
or SFP+ transceivers are required. Validated transceivers include Intel and Finisar.
uAsk your IT professional to review network maintenance activities for potential compatibility risks with the
system.
Third-Party Software
DRAGEN Server v3 does not support software beyond what is provided at installation. Do not install any
software that was not provided with the DRAGEN Bio-IT Platform. Third-party software is untested and can
interfere with performance and security.
User Behavior
The DRAGEN Server v3 is designed to analyze sequencing data. Do not consider it a general-purpose
computer. For quality and security reasons, do not use the computer for web browsing, checking email,
reviewing documents, or other unnecessary activity. These activities can result in degraded performance or
loss of data.
Security and Safety
The DRAGEN Server v3 is designed to resist attacks. Supplement this design with the following security
recommendations:
uA secure internal LAN to prevent the distribution of data to all web browsers.
uLimited access to the DRAGEN Server v3 to prevent the removal of the RAID controller, disk drives, and
access to data. Booting in single-user mode allows access to the whole system.
Antivirus Software
Illumina does not recommend running any virus scanners on the DRAGEN Server v3. Virus scanners often
impact the performance of High-Performance Computing (HPC) systems.
Restricted Ports and Authentication
Outbound Connections lus.edicogenome.com port 80
Inbound Connections SSH: TCP port 22
Stack Overflow Protection
Modern processors disable coded execution in data sections of the program to address stack overflow
attacks. By default, this feature is enabled.
Document # 1000000097923 v02
For Research Use Only. Not for use in diagnostic procedures.
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

Set Up the DRAGEN Server
This section provides information on installing the DRAGEN Server v3. Before beginning, make sure that you
have all the components and your facility meets the necessary requirements. For more information, see
Shipping Box Components on page 1 and Facility Requirements on page 2.
The following components are not included with the DRAGEN Server v3 and required to set up the sever:
uMonitor with a HDMI input
uHDMI cable
uKeyboard with a USB input
uMouse with a USB input
uTwo USB cables
Install the Server Racks
Use the following instructions to mount the DRAGEN Server v3 to your server rack.
1 Pull the mounting bracket rail out from the rail assembly until you reach the safety lock.
2 Press the safety lock trigger down, and then remove the mounting bracket rail from the rail assembly.
3 Release the sliding lock on both ends of the rail assembly.
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Illumina DRAGEN Server v3 Site Prep and Installation Guide

4 Extend the slide rail out from the rail assembly.
5 Insert the rail assembly end that was not extended into the server rack brackets.
An audible click indicates that the rail assembly is in place.
6 Push the rail assembly forward to secure.
7 Insert the other end of the rail assembly into the server rack brackets.
An audible click indicates that the rail assembly is in place.
8 Push the sliding locks forward to secure.
Document # 1000000097923 v02
For Research Use Only. Not for use in diagnostic procedures.
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Illumina DRAGEN Server v3 Site Prep and Installation Guide