National Instruments USB device 622x User manual

USER GUIDE
NI USB-622x/625x/628xOEM
M Series USB-6221/6225/6229/6251/6255/6259/6281/6289 OEM Devices
This document provides dimensions, pinouts, and information
about the connectors, switch, LEDs, and chassis ground of the National
Instruments USB-6221 OEM, USB-6225 OEM, USB-6229 OEM,
USB-6251 OEM, USB-6255 OEM, USB-6259 OEM, USB-6281 OEM,
and USB-6289 OEM devices. It also explains how to modify the USB
device name in Microsoft Windows.
Caution There are no product safety, electromagnetic compatibility (EMC), or
CE marking compliance claims made for the USB-622x/625x/628xOEM devices.
Conformity to any and all compliance requirements rests with the end product supplier.
Caution (USB-628xDevices) Exercise caution when placing USB-628xOEM devices inside
an enclosure. Auxiliary cooling may be necessary to keep the device under the maximum
ambient temperature rating of 45 °C, as specified in the NI 628x Specifications.
Figure 1 shows the USB-6221/6251/6281 OEM and
USB-6225/6229/6255/6259/6289 OEM devices.
Figure 1. USB-622x/625x/628xOEM Devices
USB-6221/6251/6281 USB-6225/6229/6255/6259/6289

NI USB-622x/625x/628x OEM User Guide 2 ni.com
Refer to the NI 622x Specifications document for USB-6221/6225/6229
specifications, the NI 625x Specifications document for
USB-6251/6255/6259 specifications, and the NI 628x Specifications
document for USB-6281/6289 specifications. Refer to the M Series User
Manual for more information about USB-622x/625x/628xdevices.
You can find all documentation at ni.com/manuals.
Dimensions
Figure 2 shows the dimensions of the USB-6221/6251/6281 OEM device.

©National Instruments Corporation 3 NI USB-622x/625x/628x OEM User Guide
Figure 2. USB-6221/6251/6281 OEM Dimensions in Inches (Millimeters)
0.436 (11.07)
0.392 (9.96)
0.362 (9.19)
0.162 (4.11)
0.062 (1.57)
0.000 (0.00)
0.396 (10.06)
0.304 (7.72)
0.256 (6.50)
0.116 (2.95)
0.000 (0.00)
6.950 (176.53)
4x 6.718 (170.63)
6.270 (159.26)
6.140 (155.96)
5.930 (150.62)
0.000 (0.00)
0.200 (5.08)
2.072 (52.63) 3.296 (83.72)
6.200 (157.48)
6.400 (162.56)
0.000 (0.00) 6.400 (162.56)
0.393 (9.98) 0.200 (5.08)
0.918 (23.32) 3.734 (94.84) 3.730 (94.74) 3.180 (80.77) 3.220 (81.79) 3.198 (81.22) 6.013 (152.74) 5.900 (149.86) 5.210 (132.33) 0.390 (9.91)
1.057 (26.85) 1.750 (44.45) 2.300 (58.42) 2.606 (66.19) 3.080 (78.23)
0.200 (5.08)
5.290 (134.37)
6.140 (155.96)
0.304 (7.72)
0.515 (13.08)
2X Ø 0.140 Cutout
in Panel for LEDs
Ø 0.330 Cutout in Panel
for Power Connector
7X Ø 0.125 (3.18)
4X Ø 0.110 (2.79)
0.609 (15.47)
0.442 (11.23)

NI USB-622x/625x/628x OEM User Guide 4 ni.com
Figure 3 shows the dimensions of the USB-6225/6229/6255/6259/6289
OEM device.
Figure 3. USB-6225/6229/6255/6259/6289 OEM Dimensions in Inches (Millimeters)
0.436 (11.07)
0.392 (9.96)
0.362 (9.19)
0.162 (4.11)
0.062 (1.57)
0.000 (0.00)
0.396 (10.06)
0.304 (7.72)
0.256 (6.50)
0.116 (2.95)
0.000 (0.00)
6.950 (176.53)
4x 6.718 (170.63)
6.270 (159.26)
6.140 (155.96)
5.930 (150.62)
5.839 (148.31)
5.499 (139.67)
0.000 (0.00)
0.200 (5.08)
2.072 (52.63) 3.296 (83.72)
6.200 (157.48)
6.400 (162.56)
0.000 (0.00) 6.400 (162.56)
0.393 (9.98) 0.200 (5.08)
0.918 (23.32) 3.734 (94.84) 3.730 (94.74) 3.180 (80.77) 3.220 (81.79) 3.198 (81.22) 6.013 (152.74) 5.900 (149.86) 5.210 (132.33) 0.390 (9.91)
1.057 (26.85) 1.750 (44.45) 2.300 (58.42) 2.606 (66.19) 3.080 (78.23)
0.200 (5.08)
5.290 (134.37)
6.140 (155.96)
0.304 (7.72)
2X Ø 0.140 Cutout
in Panel for LEDs
Ø 0.330 Cutout in Panel
for Power Connector
7X Ø 0.125 (3.18)
4X Ø 0.110 (2.79)
0.515 (13.08)
0.609 (15.47)
0.442 (11.23)

©National Instruments Corporation 5 NI USB-622x/625x/628x OEM User Guide
I/O Connector Pinouts
Figures 4 through 9 show the connector pinouts for the USB-6221 OEM,
USB-6225 OEM, USB-6229 OEM, USB-6251 OEM, USB-6255 OEM,
USB-6259 OEM, USB-6281 OEM, and USB-6289 OEM devices.
Refer to the M Series User Manual at ni.com/manuals for more
information about USB-622x/625x/628xsignals and how to connect them.

NI USB-622x/625x/628x OEM User Guide 6 ni.com
Figure 4. USB-6221 OEM Connector Pinout
AO 0
AO 1
AI GND
AI GND
AI GND
AI 8
AI 1
AI GND
AI 10
AI 3
AI GND
AI 12
AI 5
AI GND
AI 14
AI 7
AI GND
AO GND
AO GND
NC
AI 0
AI GND
AI 9
AI 2
AO GND
AI SENSE
AI GND
AI 11
AI 4
AI GND
AI 13
AI 6
AI GND
AI 15
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
P0.0
P0.1
P0.2
P0.3
P0.4
P0.5
P0.6
P0.7
PFI 0
PFI 1
PFI 2
PFI 3
PFI 4
PFI 5
PFI 6
PFI 7
PFI 8
PFI 9
PFI 10
PFI 11
PFI 12
PFI 13
PFI 14
PFI 15
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
+5 V
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
Bank 0
Bank 0
Bank 0
50-Pin Digital Connector
34-Pin Analog Connector
NC = No Connect
Bank 0

©National Instruments Corporation 7 NI USB-622x/625x/628x OEM User Guide
Figure 5. USB-6225 OEM Connector Pinout
AO 0
AO 1
AI GND
AI GND
AI GND
AI 8
AI 1
AI GND
AI 10
AI 3
AI GND
AI 12
AI 5
AI GND
AI 14
AI 7
AI GND
AO GND
AO GND
NC
AI 0
AI GND
AI 9
AI 2
AO GND
AI SENSE
AI GND
AI 11
AI 4
AI GND
AI 13
AI 6
AI GND
AI 15
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
AI GND
AI 24
AI 17
AI GND
AI 26
AI 19
AI GND
AI 28
AI 21
AI 30
AI GND
AI 31
AI 32
AI 33
AI 42
AI GND
AI 43
AI SENSE 2
AI GND
AI 25
AI GND
AI 27
AI 20
AI GND
AI 16
AI 18
AI 29
AI 22
AI 23
AI 40
AI GND
AI 41
AI 34
AI 35
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
P0.0
P0.1
P0.2
P0.3
P0.4
P0.5
P0.6
P0.7
PFI 0
PFI 1
PFI 2
PFI 3
PFI 4
PFI 5
PFI 6
PFI 7
PFI 8
PFI 9
PFI 10
PFI 11
PFI 12
PFI 13
PFI 14
PFI 15
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
+5 V
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
AI 36
AI GND
AI 37
AI 38
AI 47
AI GND
AI 56
AI 49
AI 50
AI 59
AI GND
AI 60
AI 53
AI 54
AI 63
AI GND
AI 72
AI 65
AI 66
AI 75
AI GND
AI 76
AI 69
AI 70
AI 79
AI 44
AI GND
AI 46
AI 48
AI 57
AI GND
AI 58
AI 45
AI 39
AI 51
AI 52
AI 61
AI GND
AI 62
AI 55
AI 64
AI 73
AI GND
AI 74
AI 67
AI 68
AI 77
AI GND
AI 78
AI 71
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
Bank 0
Bank 0
50-Pin Analog/Digital
Connectors
34-Pin Analog Connectors
Bank 1
Bank 1
Bank 1
Bank 0
Bank 1
Bank 0
NC = No Connect

NI USB-622x/625x/628x OEM User Guide 8 ni.com
Figure 6. USB-6229 OEM Connector Pinout
AO 0
AO 1
AI GND
AI GND
AI GND
AI 8
AI 1
AI GND
AI 10
AI 3
AI GND
AI 12
AI 5
AI GND
AI 14
AI 7
AI GND
AO GND
AO GND
NC
AI 0
AI GND
AI 9
AI 2
AO GND
AI SENSE
AI GND
AI 11
AI 4
AI GND
AI 13
AI 6
AI GND
AI 15
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
AO 2
AO 3
AI GND
AI GND
AI GND
AI 24
AI 17
AI GND
AI 26
AI 19
AI GND
AI 28
AI 21
AI GND
AI 30
AI 23
AI GND
AO GND
AO GND
NC
AI 16
AI GND
AI 25
AI 18
AO GND
AI SENSE 2
AI GND
AI 27
AI 20
AI GND
AI 29
AI 22
AI GND
AI 31
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
P0.0
P0.1
P0.2
P0.3
P0.4
P0.5
P0.6
P0.7
PFI 0
PFI 1
PFI 2
PFI 3
PFI 4
PFI 5
PFI 6
PFI 7
PFI 8
PFI 9
PFI 10
PFI 11
PFI 12
PFI 13
PFI 14
PFI 15
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
+5 V
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
P0.8
P0.9
P0.10
P0.11
P0.12
P0.13
P0.14
P0.15
P0.16
P0.17
P0.18
P0.19
P0.20
P0.21
P0.22
P0.23
P0.24
P0.25
P0.26
P0.27
P0.28
P0.29
P0.30
P0.31
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
+5 V
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
Bank 0
Bank 0
50-Pin Digital Connectors
34-Pin Analog Connectors
Bank 1
Bank 1
NC = No Connect NC = No Connect
Bank 1
Bank 0
Bank 1
Bank 0

©National Instruments Corporation 9 NI USB-622x/625x/628x OEM User Guide
Figure 7. USB-6251/6281 OEM Connector Pinout
AO 0
AO 1
AI GND
AI GND
AI GND
AI 8
AI 1
AI GND
AI 10
AI 3
AI GND
AI 12
AI 5
AI GND
AI 14
AI 7
AI GND
AO GND
AO GND
APFI 0
AI 0
AI GND
AI 9
AI 2
AO GND
AI SENSE
AI GND
AI 11
AI 4
AI GND
AI 13
AI 6
AI GND
AI 15
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
P0.0
P0.1
P0.2
P0.3
P0.4
P0.5
P0.6
P0.7
PFI 0
PFI 1
PFI 2
PFI 3
PFI 4
PFI 5
PFI 6
PFI 7
PFI 8
PFI 9
PFI 10
PFI 11
PFI 12
PFI 13
PFI 14
PFI 15
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
+5 V
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
Bank 0
Bank 0
50-Pin Digital Connector
34-Pin Analog Connector
Bank 0
Bank 0

NI USB-622x/625x/628x OEM User Guide 10 ni.com
Figure 8. USB-6255 OEM Connector Pinout
AO 0
AO 1
AI GND
AI GND
AI GND
AI 8
AI 1
AI GND
AI 10
AI 3
AI GND
AI 12
AI 5
AI GND
AI 14
AI 7
AI GND
AO GND
AO GND
APFI 0
AI 0
AI GND
AI 9
AI 2
AO GND
AI SENSE
AI GND
AI 11
AI 4
AI GND
AI 13
AI 6
AI GND
AI 15
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
AI GND
AI 24
AI 17
AI GND
AI 26
AI 19
AI GND
AI 28
AI 21
AI 30
AI GND
AI 31
AI 32
AI 33
AI 42
AI GND
AI 43
AI SENSE 2
AI GND
AI 25
AI GND
AI 27
AI 20
AI GND
AI 16
AI 18
AI 29
AI 22
AI 23
AI 40
AI GND
AI 41
AI 34
AI 35
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
P0.0
P0.1
P0.2
P0.3
P0.4
P0.5
P0.6
P0.7
PFI 0
PFI 1
PFI 2
PFI 3
PFI 4
PFI 5
PFI 6
PFI 7
PFI 8
PFI 9
PFI 10
PFI 11
PFI 12
PFI 13
PFI 14
PFI 15
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
+5 V
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
AI 36
AI GND
AI 37
AI 38
AI 47
AI GND
AI 56
AI 49
AI 50
AI 59
AI GND
AI 60
AI 53
AI 54
AI 63
AI GND
AI 72
AI 65
AI 66
AI 75
AI GND
AI 76
AI 69
AI 70
AI 79
AI 44
AI GND
AI 46
AI 48
AI 57
AI GND
AI 58
AI 45
AI 39
AI 51
AI 52
AI 61
AI GND
AI 62
AI 55
AI 64
AI 73
AI GND
AI 74
AI 67
AI 68
AI 77
AI GND
AI 78
AI 71
2
4
6
8
10
12
14
16
18
20
22
24
26
28
30
32
34
36
38
40
42
44
46
48
50
1
3
5
7
9
11
13
15
17
19
21
23
25
27
29
31
33
35
37
39
41
43
45
47
49
Bank 0
Bank 0
50-Pin Analog/Digital
Connectors
34-Pin Analog Connectors
Bank 1
Bank 1
Bank 1
Bank 0
Bank 1
Bank 0