Thermo Scientific Vanquish VH-P10-A-02 User manual

Vanquish
Pumps
VH-P10-A-02
Operating Manual
4820.4411-EN Revision 1.0 •October 2017
thermoscientific

Copyright © 2017 Thermo Fisher Scientific Inc. All rights reserved.
Original Operating Manual
The hardware descriptions in this manual revision refer to pumps VH-P10-A-02. For the manual
release history, see page 229.
Trademarks
MP35N is a trademark of SPS Technologies. PharMed is a trademark of Saint-Gobain
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All other trademarks are property of Thermo Fisher Scientific and its subsidiaries.
Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to
use in the product operation. The document is copyright protected; any reproduction of the
whole or any part of this document is strictly prohibited, except with the written authorization
of Thermo Fisher Scientific Inc.
This manual is provided "as is." The contents of this manual are subject to being changed,
without notice, in future revisions.
Thermo Fisher Scientific Inc. makes no representations that this document is complete,
accurate, or error-free. Thermo Fisher Scientific Inc. assumes no responsibility and will not be
liable for any errors, omissions, damage, or loss that might result from any use of this document,
even if the information in the document is followed properly.
This document is not part of any sales contract between Thermo Fisher Scientific Inc. and a
purchaser. This document shall in no way govern or modify any Terms and Conditions of Sale.
The Terms and Conditions of Sale shall govern all conflicting information between the two
documents.
Printed manual version only
Printed in Germany on 100% chlorine-free bleached, high-white paper that is produced in an
environmentally friendly process, leading to a paper profile of zero CO2emissions.
Manufacturer's address
Dionex Softron GmbH, Part of Thermo Fisher Scientific
Dornierstrasse 4, D-82110 Germering

Contacting Us
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 3
Contacting Us
There are several ways to contact us:
Ordering Information
For ordering information or sales support for HPLC products, contact
your local Thermo Fisher Scientific sales organization. For contact
information, go to Contact Us on http://www.thermofisher.com.
Technical Assistance
For technical support for HPLC products, contact your local Thermo
Fisher Scientific support organization. For contact information, go to
Contact Us on http://www.thermofisher.com.

Contacting Us
Page 4 Vanquish Pumps (VH-P10-A-02) Operating Manual

Contents
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 5
Contents
1 Using this Manual ...........................................................................11
1.1 About this Manual ................................................................................................12
1.2 Conventions ..........................................................................................................13
1.2.1 Safety Messages.......................................................................................13
1.2.2 Special Notices and Informational Notes.................................................13
1.2.3 Typographical Conventions......................................................................14
1.3 Reference Documentation....................................................................................15
2 Safety..............................................................................................17
2.1 Safety Symbols and Signal Words.........................................................................18
2.1.1 Safety Symbols and Signal Words in This Manual ...................................18
2.1.2 Observing this Manual .............................................................................19
2.1.3 Safety Symbols on the Pump ...................................................................19
2.1.4 Rating Plate ..............................................................................................20
2.2 Intended Use.........................................................................................................21
2.3 Safety Precautions ................................................................................................22
2.3.1 General Safety Information .....................................................................22
2.3.2 Qualification of the Personnel .................................................................23
2.3.3 Personal Protective Equipment ...............................................................23
2.3.4 Electrical Safety Precautions....................................................................24
2.3.5 General Residual Hazards ........................................................................25
2.3.6 In Case of Emergency...............................................................................26
2.4 Solvent and Additive Information.........................................................................27
2.5 Compliance Information .......................................................................................29
3 Pump Overview...............................................................................31
3.1 Pump Features......................................................................................................32
3.2 Operating Principle ...............................................................................................33
3.3 Interior Components.............................................................................................35
3.4 Piston Seal Wash System ......................................................................................37
3.5 Purge Unit .............................................................................................................38
3.6 Leak Detection ......................................................................................................39
3.7 Operation..............................................................................................................40

Contents
Page 6 Vanquish Pumps (VH-P10-A-02) Operating Manual
4 Unpacking.......................................................................................41
4.1 Unpacking ............................................................................................................ 42
4.2 Scope of Delivery ................................................................................................. 45
5 Installation......................................................................................47
5.1 Safety Guidelines for Installation......................................................................... 48
5.2 Installing the Pump .............................................................................................. 49
5.3 Site Requirements................................................................................................ 51
5.4 Accessing the Interior Components..................................................................... 53
5.5 Setting Up the Hardware ..................................................................................... 54
5.5.1 System Arrangement............................................................................... 54
5.5.2 Connecting the Pump.............................................................................. 56
5.6 Setting Up the Flow Connections......................................................................... 59
5.6.1 General Information and Guidelines....................................................... 59
5.6.2 Guiding Capillaries and Tubing Through the System .............................. 60
5.6.3 Connecting Fittings, Capillaries, and Tubing ........................................... 62
5.6.4 Guiding Liquids to Waste ........................................................................ 64
5.6.5 Connecting the Solvent Lines.................................................................. 65
5.6.6 Setting Up the Seal Wash System ........................................................... 69
5.6.7 Connecting the Pump and Autosampler................................................. 77
5.7 Turning On the Pump........................................................................................... 78
5.8 Setting Up the Pump in the Software .................................................................. 79
6 Operation .......................................................................................81
6.1 Introduction to this Chapter ................................................................................ 82
6.2 Safety Guidelines for Operation .......................................................................... 83
6.3 Control Elements.................................................................................................. 84
6.3.1 Keypad..................................................................................................... 84
6.3.2 Status Indicators...................................................................................... 86
6.4 Power On/Off Control.......................................................................................... 88
6.5 Use of Solvents and Additives.............................................................................. 89
6.6 Preparing the Pump for Operation ...................................................................... 91
6.7 Important Operating Parameters ........................................................................ 93
6.8 Purging the Pump................................................................................................. 98

Contents
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 7
6.9 Optimizing the Performance of the Pump..........................................................101
6.9.1 General Guidelines.................................................................................101
6.9.2 Gradient Delay Volume, Dwell Volume, and Ripple ..............................102
6.9.3 Installing Solvent Shut Off Valves ..........................................................109
6.10 Shutting Down the Pump....................................................................................111
6.10.1 Short-Term Shutdown (Interruption of Operation)...............................111
6.10.2 Long-Term Shutdown.............................................................................112
7 Maintenance and Service ..............................................................115
7.1 Introduction to Maintenance and Service..........................................................116
7.2 Safety Guidelines for Maintenance and Service.................................................117
7.3 General Rules for Maintenance and Service ......................................................119
7.4 Routine and Preventive Maintenance ................................................................120
7.4.1 Maintenance Plan ..................................................................................120
7.4.2 Flushing the Pump .................................................................................122
7.4.3 Cleaning or Decontaminating the Pump................................................124
7.4.4 Predictive Performance .........................................................................126
7.5 Seal Wash System ...............................................................................................128
7.5.1 Testing the Seal Wash System for Leakage............................................128
7.5.2 Replacing the Seal Wash Lines...............................................................129
7.5.3 Replacing the Seal Wash Detector.........................................................132
7.6 Y-Connector ........................................................................................................134
7.7 Pump Head..........................................................................................................136
7.7.1 Overview of Pump Head Parts...............................................................137
7.7.2 Replacing the Pump Head......................................................................138
7.7.3 Replacing the Pistons .............................................................................142
7.7.4 Cleaning the Piston ................................................................................145
7.7.5 Replacing the Piston Seals or Support Ring ...........................................146
7.7.6 Recommendations for New Piston Seals ...............................................151
7.7.7 Replacing the Seal Wash Seals...............................................................153
7.7.8 Replacing the Pump Head Seals.............................................................158
7.7.9 Testing the Piston Seals for Leakage......................................................161
7.8 Check Valves .......................................................................................................163
7.8.1 Replacing the Inlet Check Valves ...........................................................163
7.8.2 Replacing the Outlet Check Valves ........................................................165
7.8.3 Cleaning the Check Valves .....................................................................166

Contents
Page 8 Vanquish Pumps (VH-P10-A-02) Operating Manual
7.9 Inline Filter ......................................................................................................... 167
7.9.1 Testing the Inline Filter for Permeability .............................................. 167
7.9.2 Replacing the Inline Filter or Capillary Mixer........................................ 168
7.10 Mixing System.................................................................................................... 170
7.10.1 Testing the Static Mixer for Permeability ............................................. 170
7.10.2 Replacing the Static Mixer or Capillary Mixer....................................... 171
7.11 Solvent Lines and Solvent Line Filters................................................................ 173
7.11.1 Emptying the Solvent Lines ................................................................... 173
7.11.2 Replacing Solvent Lines......................................................................... 173
7.11.3 Replacing the Solvent Line Filter........................................................... 176
7.12 Testing the Pump for Leakage ........................................................................... 178
7.13 Replacing the Main Power Fuses ....................................................................... 180
7.14 Updating the Pump Firmware............................................................................ 182
7.15 Replacing the Doors ........................................................................................... 184
7.16 Transporting or Shipping the Pump................................................................... 186
7.16.1 Preparing the Pump for Transport ........................................................ 187
7.16.2 Transporting the Pump to a New Location ........................................... 188
7.16.3 Shipping the Pump ................................................................................ 188
7.17 Replacing the Slide-In Module ........................................................................... 190
7.17.1 Removing the Slide-In Module.............................................................. 190
7.17.2 Installing the Slide-In Module ............................................................... 192
8 Troubleshooting............................................................................195
8.1 General Information about Troubleshooting .................................................... 196
8.2 Messages............................................................................................................ 199
8.3 Testing From Chromeleon ................................................................................. 207
8.4 Resolving Leakage .............................................................................................. 208
8.5 Pressure Problems or Shifts in Retention Time ................................................. 210
8.5.1 Introduction .......................................................................................... 210
8.5.2 Resolving Pressure Pulsation or Shifts In Retention Time .................... 211
8.5.3 Performing Pressure Recalibration ....................................................... 213
8.5.4 Testing the Inline Filter/Static Mixer for Permeability.......................... 214
9 Specifications................................................................................215
9.1 Performance Specifications ............................................................................... 216
9.2 Physical Specifications ....................................................................................... 218

Contents
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 9
10 Accessories, Consumables and Replacement Parts......................219
10.1 General Information ...........................................................................................220
10.2 Ship Kit ................................................................................................................221
10.3 Optional Accessories...........................................................................................222
10.4 Consumables and Replacement Parts ................................................................223
11 Appendix.....................................................................................227
11.1 Compliance Information.....................................................................................228
11.1.1 Declarations of Conformity....................................................................228
11.1.2 WEEE Compliance ..................................................................................229
11.1.3 FCC Compliance .....................................................................................229
11.1.4 Manual Release History .........................................................................229
11.2 Digital I/O............................................................................................................230
12 Index ...........................................................................................233

Contents
Page 10 Vanquish Pumps (VH-P10-A-02) Operating Manual

1•Using this Manual
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 11
1Using this Manual
This chapter provides information about this manual, the conventions used
throughout the manual, and the reference documentation that is available
in addition to this manual.

1•Using this Manual
Page 12 Vanquish Pumps (VH-P10-A-02) Operating Manual
1.1 About this Manual
This manual describes the functional features and operating principle of
your Vanquish™ pump and provides instructions for installation, set up,
start up, shut down, operation, maintenance and troubleshooting.
The layout of this manual is designed to provide quick reference to the
sections of interest to the user. To obtain a full understanding of your
pump, read this manual thoroughly.
This manual also contains safety messages, precautionary statements,
and special notices that can prevent personal injury, damage to the
pump, or loss of data when followed properly.
Note the following:
•The pump configuration may vary; therefore, not all descriptions
necessarily apply to your particular pump.
•If some detail applies to only one model or variant, the model or
variant is identified by name.
•Illustrations in this manual are provided for basic understanding.
They can vary from the actual model of the pump or component.
However, this does not influence the descriptions. No claims can be
derived from the illustrations in this manual.
The descriptions in this manual assume that the pump is installed in the
Vanquish system stack. If this is not the case, additional hardware is
required and must be ordered separately. The information in this
manual applies correspondingly.

1•Using this Manual
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 13
1.2 Conventions
This section describes the conventions that are used throughout this
manual.
1.2.1 Safety Messages
The safety messages and precautionary statements in this manual
appear as follows:
•Safety messages or precautionary statements that apply to the
entire manual and all procedures in this manual are grouped in the
Safety chapter.
•Safety messages or precautionary statements that apply to an entire
section or to multiple procedures in a section appear at the
beginning of the section to which they apply.
•Safety messages that apply to only a particular section or procedure
appear in the section or procedure to which they apply. They appear
different from the main flow of text.
Safety messages are often preceded by an alert symbol and/or alert
word. The alert word appears in uppercase letters and in bold type.
Make sure that you understand and follow all safety messages
presented in this manual.
1.2.2 Special Notices and Informational Notes
Special notices and informational notes in this manual appear different
from the main flow of text. They appear in boxes and a note label
identifies them. The label text appears in uppercase letters and in bold
type.
NOTICE Highlights information necessary to prevent damage to the
pump or invalid test results.
TIP Highlights information of general interest or helpful information that
can make a task easier or optimize the performance of the pump.

1•Using this Manual
Page 14 Vanquish Pumps (VH-P10-A-02) Operating Manual
1.2.3 Typographical Conventions
These typographical conventions apply to the descriptions in this
manual:
Data Input and Output
•The following appears in bold type:
♦Input that you enter by the keyboard or that you select with the
mouse
♦Buttons that you click on the screen
♦Commands that you enter by the keyboard
♦Names of, for example, dialog boxes, properties, and parameters
•For brevity, long expressions and paths appear in the condensed
form, for example: Click Start > All Programs > Thermo
Chromeleon 7 > Services Manager > Start Instrument Controller.
References and Messages
•References to additional documentation appear italicized.
•Messages that appear on the screen are identified by quotation
marks.
Viewpoint
If not otherwise stated, the expressions left and rightin this manual
always refer to the viewpoint of a person that is facing the pump from
the front.
Particularly Important Words
Particularly important words in the main flow of text appear italicized.
Electronic Manual Version (PDF)
The electronic version (PDF) of the manual contains numerous links that
you can click to go to other locations within the manual. These include:
•Table of contents entries
•Index entries
•Cross-references (in blue text), for example, to sections and figures

1•Using this Manual
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 15
1.3 Reference Documentation
In addition to this operating manual, other documentation is available
for reference.
Hardware Documentation
Additional hardware documentation includes the following:
•Operating manuals for the other modules of the Vanquish system
A printed version of the manual is shipped with the device.
•Vanquish System Operating Manual
A printed version of the manual is shipped with the Vanquish system
base and solvent rack.
•Instrument Installation Qualification Operating Instructions
TIP Electronic versions of these manuals are available as PDF (Portable
Document Format) files. To open and read the PDF files, Adobe™
Reader™ or Adobe™ Acrobat™ is required.
Software Documentation
Additional software documentation includes the following:
•Chromeleon™ 7 Help and documents
The Chromeleon 7 Help provides extensive information and
comprehensive reference material for all aspects of the software.
For basic information about device installation and configuration,
refer to the Installation Guide; for specific information about a
certain device, refer to the Instrument Configuration Manager Help.
In Chromeleon 7, devices are called modules.
For information about the main elements of the user interface and
step-by-step guidance through the most important workflows, refer
to the Quick Start Guide.
For a concise overview of the most important workflows, refer to
the Reference Card.
•Chromeleon™ 6.8 Help
The Chromeleon 6.8 Help provides extensive information for all
aspects of the software, including device installation and
configuration.

1•Using this Manual
Page 16 Vanquish Pumps (VH-P10-A-02) Operating Manual
TIP The Chromeleon Help and documents are included in the software
shipment.
Third-Party Documentation
Refer also to the user documentation provided by the manufacturers of
third-party components and materials, for example, Safety Data Sheets
(SDSs).

2•Safety
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 17
2Safety
This chapter provides general and specific safety information and informs
about the intended use of the pump.

2•Safety
Page 18 Vanquish Pumps (VH-P10-A-02) Operating Manual
2.1 Safety Symbols and Signal Words
2.1.1 Safety Symbols and Signal Words in This Manual
This manual contains safety messages to prevent injury of the persons
using the pump. The safety symbols and signal words in this manual
include the following:
Always be aware of the safety information. Do not proceed until you
have fully understood the information and consider the consequences of
what you are doing.
CAUTION Indicates a hazardous situation that, if not avoided, could
result in minor or moderate injury.
WARNING Indicates a hazardous situation that, if not avoided, could
result in serious injury.

2•Safety
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 19
2.1.2 Observing this Manual
Observe the following:
•Before installing or operating the pump, read this manual carefully
to be familiar with the pump and this manual. The manual contains
important information with regard to user safety as well as use and
care of the pump.
•Always keep the manual near the pump for quick reference.
•Save this manual and pass it on to any subsequent user.
Read, understand, and comply with all safety messages and
precautionary statements presented in this manual.
2.1.3 Safety Symbols on the Pump
The table lists the safety symbols that appear on the pump or on labels
affixed to the pump. Follow the safety notices in this manual to prevent
the risk of operator injury or damage to the pump.
Symbol Description
Indicates a potential hazard. Refer to this manual to avoid the risk of
personal injury and/or to prevent damage to the device.
—
Ο
Power supply is on
Power supply is off
Indicates alternating current.
˜

2•Safety
Page 20 Vanquish Pumps (VH-P10-A-02) Operating Manual
2.1.4 Rating Plate
The rating plate is present on the pump near the electrical connections.
The rating plate indicates the serial number, part number, module
name, revision number (if any), line and fuse rating, and the
manufacturer's address.
TIP An additional type label on the leak tray of the pump indicates the
module name, serial number, part number, and revision number (if any).
To facilitate device identification have the information from this label
available when communicating with Thermo Fisher Scientific.