Argonaut Quest 210 User manual

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User Manual
Quest 2 1 0 Manual Synthesizer
part number 900 1 14 Rev 3
ARGONAUT
TECHNOLOGIES
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Table of Contents
Introduction
System Overview
Operating the Quest
2 10
Maintenance
Troubleshooting
(To be supplied)
Appendix A. Glossary of Terms
Appendix B. Control Box Display Screens
Appendix C. Quest Plumbing Schematic
ARGONAUT
TECHNOLOGIES
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Introduction
This manual is intendedto assist you with operating and maintaining the Quest 210
Manual Synthesizer.This manual is organized into the following chapters:
Chapter 1,Introduction, contains general information on the Quest 210
Manual Synthesizer,warranties, and a brief description of the instrument.
Chapter 2, System Overview, provides a definition of the Quest 210
hardware parts and an overview of how these parts work together.
Chapter
3, Operating the Quest 210, provides step-by-step
instructionsforperformingsolidphaseorsolutionphasereactions on
the Quest 210.
Chapter
4, Maintenance, provides step-by-step instructions on
maintenanceprocedures for optimum instrument performance.
Chapter
5, Troubleshooting,explains how to identify and resolve
problems that might occur.
Appendix A,,Glossaryof Terms.
Appendix
B, Controller Unit Display Screens, provides a list of the
possible display screens.The display screensprovide information on
and allows you to change the reaction temperature, time, and
agitation frequency.
QUEST 210 User Manual
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Introduction
Quest 21 0 Specifications
Quest 21 0 Specifications
REACTION VESSELS
AGITATION
COLLECTION
RACK
DIMENSIONS
Reactor Assembly
(W xdx h)
Weight
Controller Unit
(w xdx h)
Weight
Electrical Ratings
1-20 disposable with frit
5 or 10 mL transparent teflon
Proprietary vertical oscillation mechanism
-40°C to 130°C
(requiresrecirculating chiller for temperature
control below ambient)
Accommodates
20 and 40 mL scintillation
vials,
13 x 100 rnrn, 20 x 125 mm, SPE
cartridges
18" (45 cm) x 14" (36 cm) x 29" (74 cm)
75 lbs
10"
(25 cm) x 16.5" (42 cm) x 12" (30 cm)
20 lbs
15°C to 35°C Ambient Temperature
30-70% Relative Humidity
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Symbols
Symbols
The following hazard symbols are found on the Quest 210 Instrument:
When heating, the Reactor Assembly will
become hot. The symbol at the right is to warn
of hot surface. Use caution when working near
or on the Reactor Assembly. Allow it to cool
before attempting to access RVs.
This symbolindicates a shock hazard. Use care
when working around an area with this symbol.
QUEST 210 User Manual
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Introduction
User Supplied ltems - Quest 21 0 Manual Synthesizer
User Supplied ltems - Quest 210 Manual Synthesizer
30 - 40 psi house nitrogen supply or other inert gas.
110 VAC line supply for the Quest Controller Unit (The Quest will
also operate on 90-240
VAC without any modification required.)
User suppliedchiller.
Solvents and Reagents
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Quest 210 Limited WarrantyAgreement
Quest 21 0 LimitedWarranty Agreement
HOW LONG IS THE WARRANTY (TERM)
ThisWarranty Agreement begins on the invoice date of the Quest 210 and terminates
either
3 months or 1year from that date, depending on the type of warranty purchased.
WHO IS PROTECTED
This warranty may only be enforced only by the original purchaser.
LIMITEDWARRANTY (WHAT IS COVERED)
1. Argonautwarrantsthe Quest 210systemand options against defects in materials and
workmanship for the term of the Warranty Agreement. Argonaut will use reasonable
efforts to repair or replace theproduct, at its sole discretion, such defective hardware at
no chargeprovidedthat Argonaut isnotifiedof defectswithinthe warrantyperiod. The
following Quest 210 systems and options are protected by this warranty:
Reactor Assembly
Controller
Automated SolventWash Station
2. Argonaut makes and Buyer receives no other warranty expressed or implied and all
warranties of merchantabilityand fitness for a particular purpose are expressly
excluded. Neitherparty shallhave any liabilitywith respect to its obligations under this
agreement for consequential,exemplary, or incidental damages even if it has been
advised of the possibility of such damages.
3. Consumableproducts or the like are only warranted to conform to the quantity and
content stated on the label at the time of delivery.
QUEST 21 0 User Manual
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Introduction
Quest 21 0 LimitedWarranty Agreement
EXCLUSIONS (WHAT IS NOT COVERED)
This warranty covers normal use and is limited in scope to loss or damage to the
warranted product. Argonaut does not warrant and will not be held responsible for loss
or damages resulting from a cause other than defects in material or worlunanshlp,
including damage or loss causedby:
1. Servicing or modificationby the customer other than what is recommended in the
customer servicing and maintenance documentation, or which has not been recom-
mended by a qualified Argonaut technical support representative.
2. Neglect, accident or any natural disaster, including earthquake, lightning, flood, or
fire; electrical surges or use of improper power sources.
3. Failure to perform routine preventative maintenance as specified in the user
operation manual.
4. Non-conformance to recommendedinstrument operation procedures.
5. Any product on which the serial number has been defaced, modified or removed.
6. Any shipment of the product (claims must be presented to the carrier).
7. Any accessories used in connection with the product which are not covered under
warranty.
COVERED EXPENSESAND NOT COVERED EXPENSES
We will pay for:
1. Labor and materials for covered items.
2. Shipping of repaired systems and accessoriesback to the customer after service.
3. Shipment costs for repair parts sent to the customer for customer repair
We will not pay for:
1. Removal or installation of the system or accessories.
2. Costs of initial technical adjustments (set-up),including adjustment of user controls.
3. Shipment costs to return systems or accessories to the factory for repair, or returned
for "core" credit.
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SITE PREPARATION
4. Shipment boxes or packaging used to package systems and accessories which are
returned to the factory for repair. It is the customer's responsibility to retain original
system packaging.
SITE PREPARATION
It is the responsibility of the customer to prepare the site environmentally and provide
for the required space and services such as power, venting, bottled and compressed
gases, permits, licenses, approvals,etc. Argonaut will supply the customer with pre-
installation information detailing important site requirements prior to shipment.
INSTALLATION
Installation services are not included in the purchase price of the Quest 210.Unless
othercontractualagreementshavebeen arranged,it is theresponsibility of the customer
to perform the installationas describedin the manualprovided, as well as provide what
is required to unpack and move the equipment to its location. Contact your local
Argonaut representative for pricing of installation services by a qualified Argonaut
Service Engineer.
After installation, it is the responsibility of the customer to retain any shipment boxes
in the event a system or accessoryneeds to be shipped for repair.
HOW YOU CAN GET WARRANTY SERVICE ON YOUR QUEST 210
Argonaut has a fully staffed technical support hot line to help you repair minor
problems over the phone,
FAX or email. Major repairs which cannot be handled over
the phone are typically repaired at the nearest Quest
210 repair center. Argonaut does
not perform on site repair of the Quest unless other contractual agreements have been
pre-arranged.
To establish your Quest 210 warranty, you must fill out and mail the warranty return
card, provided in the shipmentbox, after you have finished the installation.
To qualify for warranty repair you must first contact the appropriate repair center
detailed in the following section.
QUEST 21 0 User Manual
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Introduction
lnterferenceInformation
lnterferenceInformation
Thisequipmentgenerates anduses radio frequencyenergy and,if not installed and used
in strict accordance with the manufacturer's instructions, may cause interference to
radio and television reception. It has been type tested and found to comply with the
limits for a Class
B computing device in accordance with the requirements set forth in
the European Standard
EN 5501 1: 1997. Class B equipment is equipment suitable for
use in domestic establishments and in establishments directly connected to a low
voltage power supply network which supplies buildings used for domestic purposes.
However, there is no guarantee that interference will not occur in a particular
installation. If this equipment does cause interference to radio or television reception,
which can be determined by turning the equipment off and on, the user is encouraged
to try to correct the interference by one or more of the following measures:
Reorient the receiving antenna
Relocate the equipment with respect to the receiver
Move the equipment away from the receiver
Plug the equipment into a different outlet so that the computer and
receiver are on different branch circuits
Immunity Information
Thisequipment has been type tested and found tocomply with the Requirements of the
Generic Immunity Standard:
EN50082- 111997.
If the equipment is used in a manner not specified by the manufacturer, the protection
provided by the equipment may be impaired.
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Safety
Safety
Thisequipment hasbeen tested and found to comply with the requirements as set forth
in the European Immunity Standard:
EN5OO82- 111 997.
The following hazard symbols are found on the Quest 210 Instrument:
When heating, the Reactor Assembly will
become hot. The symbol at the right is to warn
of hot surface.Use caution when working near
or on the Reactor Assembly.Allow it to cool
before attemptingto accessRVs.
This symbol indicates a shock hazard. Use care
when working around an area with this symbol.
Maintenance
Each time you finish a chemistry procedure, follow the maintenance procedures
described in
Chapter 4, Maintenance.
QUEST 210 User Manual
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Introduction
Contact lnformation
Contact Information
In the United States:
Argonaut Technologies
887 Industrial Road, Suite
G
San Carlos, CA 94070
PHONE: [phone]
888.598.1350(TollFree
U.S. Outside California)
FAX: [phone]
In Europe:
Argonaut TechnologiesA.G.
St. Jakobsstrasse 148
Postfach 43
4132Muttenz 2
Switzerland
PHONE: [phone]
FAX: [phone]
In Japan:
Argonaut TechnologiesK.K.
MK Komachi Bldg. 4-2-1
Kojimachi Chiyoda-Ku
Tokyo 102Japan
PHONE: [phone]
FAX: [phone]
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Quest 21 0 TechnicalSupport Contact Information
Quest 210 Technical Support Contact lnformation
Quest 210 Repair Center and Technical Support Hotline
PHONE: [phone]
FAX: [phone]
Quest Technical Supportemail: [email protected].
Use this email addressas an optionforcommunicationof service and support questions
or comments
The Marketing Department at Argonaut Technologies should be contacted via e-mail
at [email protected]or at the number above with questions or comments on the
content of this user manual.
This equipment has been type tested and found to be in accordance with the
requirements for Laboratory Instruments set forth in the European Standard
EN 6 10 10- 1 : l993IA2:1995.Copies of the TUV certificates are available upon
request from Argonaut Technologies Inc.
QUEST 21 0 User Manual
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Introduction
Quest 21 0 Overview
Quest 210 Overview
WARNING The Quest 210 Manual Synthesizer is designed for use in chemical
synthesisincluding potentially hazardous chemical reactions.The potential hazardsof
chemicalsynthesisincludebut arenotlimitedtoburns,explosions,andexposuretotoxic
chemicalsand carcinogens.Always wear eye protectionand suitablegloves.Operatethe
instrument in a fume hood.
The Quest 210Manual Synthesizerallowsyou to run in parallel up to 20 liquid or solid
phase organic chemistry reactions. The unique design of the Quest 210incorporates
heatinglcooling, agitation,andthe inert environmentneeded to run these reactions. The
mechanical features of the Quest 210 also provide for simple operation of the
instrument.
The Quest 210 consists of four main parts:
Reactor Unit
Controller Unit
Solvent Bottle Assembly
Umbilicus
The Reactor Unit contains Teflon reaction vessels, manual solvent and gas control
valves, and heating, cooling and agitation components. Solvents can be added to the
RVs in parallel using the manual rotary valves. Reagents can be added via luer ports
located at the top of each reaction vessel. Agitation is accomplished by pneumatically
moving a magnet bar, positioned between 2 banks of 10RVs, vertically up and down.
Small magnets, located in the RVs, move vertically with the magnet bar, effecting
mixing of reaction contents.
The Controller Unitcontainsthe controlsthat allowyou to setthe reaction temperature,
time, and agitation conditions. Also, the Controller Unit contains connections for
system power and gas, and interface connections for the Reactor Assembly agitation
control valves, manualrotary valves, and gas distributionmanifolds. A serial computer
port is included on the Controller Unit for download of firmware upgrades.
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Quest 21 0 Overview
The solvent bottle assemblyconsists of a cap to interface to a 4 L solvent bottle. The
Cap assembly will alternativelypressurize or vent the
4 L bottle. The Solvent Bottle
assembly connects to the Quest Reactor Unit and contains solvent for parallel delivery
to the RVs for resin washing and system cleaning.
The umbilicus links the Control Unit to the Reactor Unit. Solvent, gas pressure,
agitation and temperaturecontrol information are supplied/communicated through the
umbilicus. The umbilicus consists of the following lines:
Solvent - provides a pathway for solvent to move from the solvent
bottletothereactorassembly.Thesolventisthen deliveredinparallel
to the reaction vessels.
Drain Gas - provides a pathway for 30psi gas to move from the
Controller Unit pressureregulator to the reactor assembly. This gas
allows you to drain liquid from the reaction vessels.
Metered Gas - provides a pathway for 10psi gas to move from the
Controller Unit to the reactor assembly. The metered gas line
provides
an adjustablegas flow to the reaction vessel, providing an
inert environment for the reactions and is also useful when adding
reagent through the luer ports. The metered gas flow is adjusted via
a needle valve located on the top of the Reactor Unit.
Agitation - provides two 30psi lines which run to the pneumatically
controlled mixing bar. Valves in the control unit, alternately supply
pressure to the two lines to cause the mixer to oscillate vertically.
Electrical - provides power and data connections for the system.
NOTE You directthe solvent,drain gas,and metered gas movementby meansof the
mechanicalreactor assembly controls. You set the agitationand heating (electrical)
parametersby meansof theControllerUnitcomponents.Theagitationandtemperature
parametersthat you set are then carried out by the firmware.
QUEST 210 User Manual
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Introduction
Quest Installation Procedure
Quest Installation Procedure
Installation of the Quest involves connecting the system to a gas source, and making
some simple tubing connections. The process should take less than
1 hour.
Parts -
Quest Reactor Unit
Quest Controller Unit
Umbilicus (Shipped with one end connected to the Quest Reactor Unit)
Starter Kit
Glass Waste Tank
Solvent Bottle Cap
Safety Carrier for
4L SolventBottle
InstallationGlossary -
Teflon Tubing - The semi-transparenttubing (118 " OD) used for gas and liquid connec-
tions. Semi-rigid.
Tygon Tubing
- This flexible tubing has a slight yellow color to it. Used for gas
connections within the Quest controller unit.
Bushing
- Thetan coloredthreadedfittings (PEEK)used forTeflon tubing connections.
Ferrule
- The yellow, conical shaped piece which mates to the PEEK bushings. Used
for Teflon tube connections.
Bulk Head Fitting
- The female threaded ports found on the front of the Quest
Controller, and on various places of the Quest Reaction Unit.
Umbilicus
- The bundle of tubing and electrical wires which connects the Quest
Controller to the Quest Reaction Unit.
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Installation Procedure -
Installation Procedure -
Clear a space in a fume hood for the Quest. The space shouldbe about 3 ft. wide by 2
ft. deep and be at the left edge of the fume hood. Also, clear a space on the lab bench
adjacent to the fume hood for the controller.
Carefully unpackthe instrumentand place the Quest Reaction Unit in the hood and the
Quest Controller on the lab bench next to the hood. Remove any packaging material
from the units.
Theumbilicuswill be connectedtothe QuestReactor Unit.Free the umbilicus from any
packing material and lay it out sothe free end is placed in front of the Quest Controller
Unit.
Figure 1-1
Quest Controller Unit
QUEST
210 User Manual
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