Asus TUF GAMING B450M-PRO S User manual

Motherboard
TUF GAMING
B450M-PRO S

ii
E17226
Revised Edition v3
August 2020
Copyright © 2020 ASUSTeK COMPUTER INC. All Rights Reserved.
No part of this manual, including the products and software described in it, may be reproduced,
transmitted, transcribed, stored in a retrieval system, or translated into any language in any form or by any
means, except documentation kept by the purchaser for backup purposes, without the express written
permission of ASUSTeK COMPUTER INC. (“ASUS”).
Product warranty or service will not be extended if: (1) the product is repaired, modied or altered, unless
such repair, modication of alteration is authorized in writing by ASUS; or (2) the serial number of the
product is defaced or missing.
ASUS PROVIDES THIS MANUAL “AS IS” WITHOUT WARRANTY OF ANY KIND, EITHER EXPRESS
OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OR CONDITIONS OF
MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. IN NO EVENT SHALL ASUS, ITS
DIRECTORS, OFFICERS, EMPLOYEES OR AGENTS BE LIABLE FOR ANY INDIRECT, SPECIAL,
INCIDENTAL, OR CONSEQUENTIAL DAMAGES (INCLUDING DAMAGES FOR LOSS OF PROFITS,
LOSS OF BUSINESS, LOSS OF USE OR DATA, INTERRUPTION OF BUSINESS AND THE LIKE),
EVEN IF ASUS HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES ARISING FROM ANY
DEFECT OR ERROR IN THIS MANUAL OR PRODUCT.
SPECIFICATIONS AND INFORMATION CONTAINED IN THIS MANUAL ARE FURNISHED FOR
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AND SHOULD NOT BE CONSTRUED AS A COMMITMENT BY ASUS. ASUS ASSUMES NO
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Products and corporate names appearing in this manual may or may not be registered trademarks or
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owners’ benet, without intent to infringe.

iii
Contents
Safety information...................................................................................................... iv
About this guide.......................................................................................................... v
Package contents....................................................................................................... vi
TUF GAMING B450M-PRO S specifications summary............................................ vi
Connectors with shared bandwidth .......................................................................... x
Chapter 1 Product introduction
1.1 Before you proceed...................................................................................... 1-1
1.2 Motherboard overview .................................................................................1-1
1.3 Central Processing Unit (CPU).................................................................... 1-8
1.4 System memory............................................................................................ 1-9
1.5 M.2 installation............................................................................................1-10
Chapter 2 BIOS and RAID Support
2.1 Knowing BIOS...............................................................................................2-1
2.2 BIOS Setup program ....................................................................................2-2
2.3 ASUS EZ Flash 3...........................................................................................2-3
2.4 ASUS CrashFree BIOS 3.............................................................................. 2-4
2.5 RAID configurations..................................................................................... 2-5
Appendix
Notices ..................................................................................................................... A-1
ASUS contact information...................................................................................... A-6

iv
Safety information
Electrical safety
• To prevent electrical shock hazard, disconnect the power cable from the electrical outlet
before relocating the system.
• When adding or removing devices to or from the system, ensure that the power cables
for the devices are unplugged before the signal cables are connected. If possible,
disconnect all power cables from the existing system before you add a device.
• Before connecting or removing signal cables from the motherboard, ensure that all power
cables are unplugged.
• Seek professional assistance before using an adapter or extension cord. These devices
could interrupt the grounding circuit.
• Ensure that your power supply is set to the correct voltage in your area. If you are not
sure about the voltage of the electrical outlet you are using, contact your local power
company.
• If the power supply is broken, do not try to x it by yourself. Contact a qualied service
technician or your retailer.
Operation safety
• Before installing the motherboard and adding components, carefully read all the manuals
that came with the package.
• Before using the product, ensure all cables are correctly connected and the power cables
are not damaged. If you detect any damage, contact your dealer immediately.
• To avoid short circuits, keep paper clips, screws, and staples away from connectors,
slots, sockets and circuitry.
• Avoid dust, humidity, and temperature extremes. Do not place the product in any area
where it may be exposed to moisture.
• Place the product on a stable surface.
• If you encounter technical problems with the product, contact a qualied service
technician or your retailer.
• Your motherboard should only be used in environments with ambient temperatures
between 0°C and 40°C.

v
About this guide
This user guide contains the information you need when installing and conguring the
motherboard.
How this guide is organized
This guide contains the following parts:
• Chapter 1: Product Introduction
This chapter describes the features of the motherboard and the new technology it
supports. It includes descriptions of the switches, jumpers, and connectors on the
motherboard.
• Chapter 2: BIOS and RAID Support
This chapter tells how to boot into the BIOS, upgrade BIOS using the EZ Flash Utility
and support on RAID.
Where to find more information
Refer to the following sources for additional information and for product and software
updates.
1. ASUS website
The ASUS website provides updated information on ASUS hardware and software
products. Refer to the ASUS contact information.
2. Optional documentation
Your product package may include optional documentation, such as warranty flyers,
that may have been added by your dealer. These documents are not part of the
standard package.
Conventions used in this guide
To ensure that you perform certain tasks properly, take note of the following symbols used
throughout this manual.
CAUTION: Information to prevent damage to the components and injuries to
yourself when trying to complete a task.
IMPORTANT: Instructions that you MUST follow to complete a task.
NOTE: Tips and additional information to help you complete a task.

vi
TUF GAMING B450M-PRO S specifications summary
CPU
AMD Socket AM4 for 3rd/2nd/1st Gen AMD Ryzen™/2nd/1st Gen AMD
Ryzen™ with Radeon™ Vega Graphics/ Athlon™ with Radeon™ Vega
Graphics Processors*
*Refer to www.asus.com for CPU support list.
Chipset AMD B450 Chipset
Memory
3rd/2nd/1st Gen AMD Ryzen™/2nd/1st Gen AMD Ryzen™ with Radeon™
Vega Graphics/ Athlon™ with Radeon™ Vega Graphics Processors
4 x DIMM, Max. 128GB, DDR4 4400(O.C)/3533(O.C)/3466(O.C.)/ 3200(O.
C.)/3000(O.C.)/2800(O.C.)/2666/2400/2133 MHz Un-buffered Memory*
Dual Channel Memory Architecture
*ECC Memory (ECC mode) support varies by CPU.
*Refer to www.asus.com for the Memory QVL (Qualified Vendors Lists).
Graphics
Integrated Graphics in the 2nd/1st Gen AMD Ryzen™ with Radeon™ Vega
Graphics/ Athlon™ with Radeon™ Vega Graphics Processors
1 x DisplayPort 1.2
1 x HDMITM 2.0b
*Graphics specifications may vary between CPU types.
Expansion Slots
3rd/2nd/1st Gen AMD Ryzen™ Processors
1 x PCIe 3.0/2.0 x16 slot (supports x16 mode)
2nd and 1st Gen AMD Ryzen™ with Radeon™ Vega Graphics
Processors
1 x PCIe 3.0/2.0x16 slot (supports x8 mode)
AMD Athlon™ with Radeon™ Vega Graphics Processors
1 x PCIe 3.0/2.0 x16 (max. at x4 mode)
AMD B450 Chipset
1 x PCIe 2.0 x16 slot (supports x4 mode)*
1 x PCIe 2.0 x1 slot
*PCIEX16_2 shares bandwidth with M.2_2. When PCIEX16_2 runs, M.2_2 will be
disabled.
Multi-GPU Support Supports AMD 2-Way CrossFireX™ Technology
(continued on the next page)
Package contents
Check your motherboard package for the following items.
Motherboard 1 x TUF GAMING B450M-PRO S motherboard
Cables 2 x SATA 6Gb/s cables
Miscellaneous
1 x I/O Shield
1 x M.2 Rubber package
1 x M.2 SSD screw package
1 x TUF Gaming sticker
Application DVD 1 x Support DVD
Documentation 1 x TUF Certication card
1 x User manual
If any of the above items is damaged or missing, contact your retailer.

vii
TUF GAMING B450M-PRO S specifications summary
Storage
Total supports 2 x M.2 slots and 4 x SATA 6Gb/s ports
3rd/2nd/1st Gen AMD Ryzen™/ 2nd and 1st Gen AMD Ryzen™ with
Radeon™ Vega Graphics
1 x M.2_1 slot (Key M), type 2242/2260/2280 (supports PCIe 3.0 x4 &
SATA modes)
AMD Athlon™ with Radeon™ Vega Graphics Processors
1 x M.2_1 slot (Key M), type 2242/2260/2280 (supports SATA mode)
3rd/2nd/1st Gen AMD Ryzen™/ 2nd and 1st Gen AMD Ryzen™ with
Radeon™ Vega Graphics/ Athlon™ with Radeon™ Vega Graphics
Processors
Support Raid 0, 1, 10
AMD B450 Chipset
1 x M.2_2 slot (Key M), type 2242/2260/2280/22110 (PCIe 2.0 x4 mode)*
4 x SATA 6Gb/s ports
*M.2_2 shares bandwidth with PCIEX16_2. When M.2_2 runs, PCIEX16_2 will be
disabled.
Ethernet 1 x Realtek RTL8125B-CG 2.5Gb Ethernet
USB
Rear USB (Total 8 ports)
2 x USB 3.2 Gen 2 ports (1 x Type-A + 1 x USB Type-C®)
4 x USB 3.2 Gen 1 ports (4 x Type-A)
2 x USB 2.0 ports (2 x Type-A)
Front USB (Total 6 ports)
1 x USB 3.2 Gen 1 header supports additional 2 USB 3.2 Gen 1 ports
2 x USB 2.0 headers support additional 4 USB 2.0 ports
Audio
Realtek ALC S1200A 7.1 Surround Sound High Definition Audio
CODEC
- Supports Jack detection, Multi-streaming, Front Panel Jack-retasking
- Supports up to 24-Bit/192 kHz playback
Audio Features
- Rear optical S/PDIF out port
- Premium Japanese audio capacitors
- Audio Shielding
- Dedicated audio PCB layers
- Audio cover
Back Panel I/O Ports
2 x USB 3.2 Gen 2 ports (1 x Type-A + 1 x USB Type-C®)
4 x USB 3.2 Gen 1 ports (4 x Type-A)
2 x USB 2.0 ports (2 x Type-A)
1 x DisplayPort
1 x HDMITM port
1 x Realtek RTL8125B-CG 2.5Gb Ethernet port
5 x Audio jacks
1 x Optical S/PDIF out port
1 x BIOS FlashBack™ button
1 x PS/2 Keyboard/Mouse combo port
(continued on the next page)

viii
TUF GAMING B450M-PRO S specifications summary
Internal I/O
Connectors
Fan and cooling related
1 x 4-pin CPU Fan header
1 x 4-pin CPU OPT Fan header
2 x 4-pin Chassis Fan headers
Power related
1 x 24-pin Main Power connector
1 x 8-pin +12V Power connector
Storage related
2 x M.2 slots (Key M)
4 x SATA 6Gb/s ports
USB
1 x USB 3.2 Gen 1 header supports additional 2 USB 3.2 Gen 1 ports
2 x USB 2.0 headers support additional 4 USB 2.0 ports
Miscellaneous
2 x AURA RGB headers
1 x Clear CMOS header
1 x COM Port header
1 x Front Panel Audio header (AAFP)
1 x Speaker header
1 x SPI TPM header (14-1pin)
1 x 10-1 pin System Panel header
Special Features
ASUS TUF PROTECTION
- ASUS DIGI+ VRM (Digital power design with DrMOS)
- ASUS Enhanced DRAM Overcurrent Protection
- ASUS ESD Guards
- TUF LANGuard
- ASUS Overvoltage Protection
- ASUS SafeSlot
- ASUS Stainless-Steel Back I/O
ASUS Q-Design
- ASUS Q-DIMM
- ASUS Q-LED (CPU [red], DRAM [yellow], VGA [white], Boot Device
[yellow green])
- ASUS Q-Slot
ASUS Thermal Solution
- Aluminum heatsink design
ASUS EZ DIY
- BIOS FlashBack™ button
- BIOS FlashBack™ LED
- ProCool
AURA Sync
- AURA RGB headers
(continued on the next page)

ix
TUF GAMING B450M-PRO S specifications summary
Software
Features
ASUS Exclusive Software
Armoury Crate
- Aura Creator
- Aura Sync
- AI Noise-Canceling Microphone
AI Suite 3
- Performance And Power Saving Utility
TurboV EVO
EPU
Digi+ VRM
Fan Xpert 2+
- EZ update
TUF GAMING CPU-Z
AI Charger
ASUS Turbo LAN
DAEMON Tools
DTS Custom for GAMING Headsets
Norton Anti-virus software (Free Trial for 60 days)
WinRAR
UEFI BIOS
ASUS EZ DIY
- ASUS CrashFree BIOS 3
- ASUS EZ Flash 3
- ASUS UEFI BIOS EZ Mode
BIOS 256 Mb Flash ROM, UEFI AMI BIOS
Manageability WOL by PME, PXE
Operating
System
Windows 10 64 - bit
Windows 7 64 - bit *
*To support Windows 7 64-bit, please install an AMD Ryzen™ 2nd Generation or
Ryzen™ 1st Generation Processor.
Form Factor mATX Form Factor
9.6 inch x 9.6 inch (24.4 cm x 24.4 cm)
Specications are subject to change without notice. Refer to the ASUS website for the
latest specications.

x
Connectors with shared bandwidth
TUF GAMING B450M-PRO S
A
A
DDR4 DIMM_A1 (64bit, 288-pin module) DDR4 DIMM_A2* (64bit, 288-pin module) DDR4 DIMM_B1 (64bit, 288-pin module)
BOOT
VGA
CPU
DRAM
DDR4 DIMM_B2* (64bit, 288-pin module)
DIGI+
VRM
CPU_FAN
CHA_FAN2
CPU_OPT
RGB_HEADER1
RGB_HEADER2
COM_DEBUG
CHA_FAN1
SPI TPM
F_PANEL
SPEAKER
AAFP
SATA6G_4
CLRTC
SATA6G_3 SATA6G_2 SATA6G_1
256Mb
BIOS
EATX12V
BIOS_FLBK
FLBK_LED1
EATXPWR
U32G1_12
AMD
B450
BATTERY
HDMI_DP
LAN_U32G2_1
U32G2_C2
KBMS
_USB78
U32G1_3-6
RTL
8125B-CG
Super
I/O
PCIEX1
M.2_1(SOCKET3)
M.2_2(SOCKET3)
22110
2280 2260 2242
2280 2260 2242
PCIEX16_1
PCIEX16_2
USB910 USB1112
SOCKET AM4
COM
AUDIO
Configuration 1 2
APCIEX16_2 x4 -
M.2_2 -PCIe 2.0 x4
PCIEX16_2 shares bandwidth with M.2_2. When PCIEX16_2 runs, M.2_2 will be disabled.

ASUS TUF GAMING B450M-PRO S 1-1
Product introduction
1
1.1 Before you proceed
Take note of the following precautions before you install motherboard components or change
any motherboard settings.
• Unplug the power cord from the wall socket before touching any component.
• Before handling components, use a grounded wrist strap or touch a safely grounded
object or a metal object, such as the power supply case, to avoid damaging them due
to static electricity.
• Before you install or remove any component, ensure that the ATX power supply is
switched off or the power cord is detached from the power supply. Failure to do so
may cause severe damage to the motherboard, peripherals, or components.
Unplug the power cord before installing or removing the motherboard. Failure to do so can
cause you physical injury and damage motherboard components.
1.2 Motherboard overview
Place this
side towards
the rear of the
chassis
TUF GAMING B450M-PRO S
DDR4 DIMM_A1 (64bit, 288-pin module) DDR4 DIMM_A2* (64bit, 288-pin module) DDR4 DIMM_B1 (64bit, 288-pin module)
BOOT
VGA
CPU
DRAM
DDR4 DIMM_B2* (64bit, 288-pin module)
DIGI+
VRM
CPU_FAN
CHA_FAN2
CPU_OPT
RGB_HEADER1
RGB_HEADER2
COM_DEBUG
CHA_FAN1
SPI TPM
F_PANEL
SPEAKER
AAFP
SATA6G_4
CLRTC
SATA6G_3 SATA6G_2 SATA6G_1
256Mb
BIOS
EATX12V
BIOS_FLBK
FLBK_LED1
EATXPWR
U32G1_12
AMD
B450
BATTERY
HDMI_DP
LAN_U32G2_1
U32G2_C2
KBMS
_USB78
U32G1_3-6
RTL
8125B-CG
Super
I/O
PCIEX1
M.2_1(SOCKET3)
M.2_2(SOCKET3)
22110
2280 2260 2242
2280 2260 2242
PCIEX16_1
PCIEX16_2
USB910 USB1112
24.4cm(9.6in)
24.4cm(9.6in)
SOCKET AM4
COM
AUDIO 8
11
14
6
5
17
1213 410
3
5 1 2104 15 4
7169
6
18

1-2 Chapter 1: Product introduction
1.2.1 Layout contents
1. CPU socket
The motherboard comes with an AMD Socket AM4 designed for 3rd/2nd/1st Gen AMD
Ryzen™/2nd/1st Gen AMD Ryzen™ with Radeon™ Vega Graphics/ Athlon™ with Radeon™
Vega Graphics Processors.
For more details, refer to Central Processing Unit (CPU).
2. DDR4 DIMM slots
The motherboard comes with Dual Inline Memory Modules (DIMM) slots designed for DDR4
(Double Data Rate 4) memory modules.
For more details, refer to System memory.
3. Expansion slots
This motherboard supports two PCIe x16 graphics cards and one PCIe 3.0 x1 network card,
SCSI card or other card that comply with the PCI Express specication. Please refer to the
following table for the Hyper M.2 conguration.
Hyper M.2 x16 series card configuration
Slot PCIe bifurcation settings in PCIe x16 slots with different Ryzen™ CPUs
PCIEX16_1
3rd/2nd/1st Gen AMD Ryzen™ Processors (Support PCIe Gen 3 SSDs)
Supported SSDs
4
• Hyper M.2 X16 series cards are sold separately.
• When using 3rd/2nd/1st Gen AMD Ryzen™ Processors and a Hyper M.2 X16 series
card with 4 M.2 SSDs, if you wish to connect a display, we suggest installing a VGA
card to PCIe X16_2, which will run at x4.
• Set PCIEX16_1 to [PCIe RAID Mode] under BIOS settings to enable the Hyper M.2
X16 series card.
4. Fan headers
The Fan headers allow you to connect fans to cool the system.
Header Max.
Current
Max.
Power Default Speed Shared Control
CPU_FAN 1A 12W Q-Fan Controlled A
CPU_OPT 1A 12W Q-Fan Controlled A
CHA_FAN1 1A 12W Q-Fan Controlled -
CHA_FAN2 1A 12W Q-Fan Controlled -
5. Power connectors
These Power connectors allow you to connect your motherboard to a power supply. The
power supply plugs are designed to t in only one orientation. Find the proper orientation and
push down rmly until the power supply plugs are fully inserted.
Ensure to connect the 8-pin power plug.
GND
FAN PWR
FAN IN
FAN PWM
GND FAN PWR FAN IN FAN PWM

ASUS TUF GAMING B450M-PRO S 1-3
• For a fully congured system, we recommend that you use a power supply unit
(PSU) that complies with ATX 12V Specication 2.0 (or later version) and provides a
minimum power of 350 W.
• We recommend that you use a PSU with a higher power output when conguring a
system with more power-consuming devices. The system may become unstable or
may not boot up if the power is inadequate.
• If you are uncertain about the minimum power supply requirement for your system, we
recommend you to refer to online resources for Power Supply Wattage Calculator.
6. M.2 Slots (Key M)
The M.2 slots allow you to install M.2 devices such as M.2 SSD modules.
• For 3rd/2nd/1st Gen AMD Ryzen™/ 2nd and 1st Gen AMD Ryzen™ with Radeon™ Vega
Graphics, M.2_1 slot supports PCIe 3.0 x4 mode and SATA mode M Key design and
type 2242 / 2260 / 2280 storage devices.
• For AMD Athlon™ with Radeon™ Vega Graphics Processors, M.2_1 slot supports
SATA mode M Key design and type 2242/ 2260/ 2280 storage devices.
• For AMD B450 chipset, M.2_2 slot supports PCIe 2.0 x4 mode M Key design and type
2242/ 2260/ 2280 / 22110 storage devices.
• M.2_2 shares bandwidth with PCIEX16_2. When M.2_2 runs, PCIEX16_2 will be
disabled.
7. SATA 6Gb/s ports
The SATA 6Gb/s ports allow you to connect SATA devices such as optical disc drives and
hard disk drives via a SATA cable.
8. USB 3.2 Gen 1 header
The USB 3.2 Gen 1 header allows you to connect a USB 3.2 Gen
1 module for additional USB 3.2 Gen 1 ports. The USB 3.2 Gen 1
header provides data transfer speeds of up to 5 Gb/s.
The USB 3.2 Gen 1 module is purchased separately.
9. USB 2.0 headers
The USB 2.0 headers allow you to connect a USB module for additional USB
2.0 ports. The USB 2.0 headers provide data transfer speeds of up to 480
Mb/s.
DO NOT connect a 1394 cable to the USB connectors. Doing so will
damage the motherboard!
The USB 2.0 module is purchased separately.
10. AURA RGB headers
The RGB headers allow you to connect RGB LED strips.
The RGB headers support 5050 RGB multi-color LED strips (12V/G/R/B), with a maximum
power rating of 3A (12V), and no longer than 3 m.
USB3+5V
IntA_P1_SSRX-
IntA_P1_SSRX+
GND
IntA_P1_SSTX-
IntA_P1_SSTX+
GND
IntA_P1_D-
IntA_P1_D+
GND
PIN 1
USB3+5V
IntA_P2_SSRX-
IntA_P2_SSRX+
GND
IntA_P2_SSTX-
IntA_P2_SSTX+
GND
IntA_P2_D-
IntA_P2_D+
USB+5V USB_P9- USB_P9+ GND NC
USB+5V
USB_P10-
USB_P10+
GND
PIN 1

1-4 Chapter 1: Product introduction
Before you install or remove any component, ensure that the ATX power supply is switched
off or the power cord is detached from the power supply. Failure to do so may cause severe
damage to the motherboard, peripherals, or components.
• Actual lighting and color will vary with LED strip.
• If your LED strip does not light up, check if the RGB LED extension cable and the
RGB LED strip are connected in the correct orientation, and the 12V connector is
aligned with the 12V header on the motherboard.
• The LED strip will only light up when the system is powered on.
• The LED strip is purchased separately.
11. Clear CMOS header
This header allows you to clear the CMOS RTC RAM data of the system setup
information such as date, time, and system passwords.
To erase the RTC RAM:
1. Turn OFF the computer and unplug the power cord.
2. Use a metal object such as a screwdriver to short the two pins.
3. Plug the power cord and turn ON the computer.
4. Hold down the <Del> key during the boot process and enter BIOS setup to re-
enter data.
If the steps above do not help, remove the onboard battery and short the two pins again to
clear the CMOS RTC RAM data. After clearing the CMOS, reinstall the battery.
12. COM Port header
This header is for a serial (COM) port. Connect the serial port module cable
to this header, then install the module to a slot opening at the back of the
system chassis.
13. Front panel audio header
This header is for a chassis-mounted front panel audio I/O module that
supports HD audio standard. Connect one end of the front panel audio
I/O module cable to this header.
• We recommend that you connect a high-denition front panel
audio module to this header to avail of the motherboard’s high-
denition audio capability.
• If you want to connect a high-denition front panel audio
module to this header, set the Front Panel Type item in the
BIOS setup to [HD Audio]. By default, this header is set to [HD
Audio].
14. Speaker header
The 4-pin header is for the chassis-mounted system warning speaker. The
speaker allows you to hear system beeps and warnings.
CLRTC
+3V_BAT GND
PIN 1
PIN 1
COM
DCD
TXD
GND
RTS
RI
RXD
DTR
DSR
CTS
AAFP
AGND NC SENSE1_RETUR SENSE2_RETUR
PORT1 L
PORT1 R PORT2 R
SENSE_SEND
PORT2 L
HD-audio-compliant
pin definition
+5V GND GND Speaker Out
SPEAKER
PIN 1

ASUS TUF GAMING B450M-PRO S 1-5
15. SPI TPM header
This header supports a Trusted Platform Module (TPM) system with a
Serial Peripheral Interface (SPI), allowing you to securely store keys, digital
certicates, passwords, and data. A TPM system also helps enhance
network security, protects digital identities, and ensures platform integrity.
16. 10-1 pin System Panel header
This header supports several chassis-mounted functions.
• System power LED (2-pin +PWR_LED-)
This 2-pin header is for the system power LED. Connect the chassis
power LED cable to this header. The system power LED lights up
when you turn on the system power, and blinks when the system is in
sleep mode.
• Hard disk drive activity LED (2-pin +HDD_LED-)
This 2-pin header is for the HDD Activity LED. Connect the HDD
Activity LED cable to this header. The HDD LED lights up or flashes
when data is read from or written to the HDD.
• Power button/Soft-off button (2-pin PWR_BTN)
This header is for the system power button.
• Reset button (2-pin RESET)
This 2-pin header is for the chassis-mounted reset button for system reboot without
turning off the system power.
17. Q-LEDs
The Q-LEDs check key components (CPU, DRAM, VGA, and booting devices) during the
motherboard booting process. If an error is found, the critical component’s LED stays lit up
until the problem is solved.
The Q-LEDs provide the most probable cause of an error code as a starting point for
troubleshooting. The actual cause may vary from case to case.
18. BIOS FlashBackTM LED
The FlashBack™ LED lights up or blinks to indicate the status of the
BIOS FlashBack™.
Scan the QR code for more information on BIOS FlashBackTM
function.
TPM
PIN 1
T_SPI_MOSI
T_SPI_CLK
GND
F_BIOS_WP#_R
S_SPI_TPM_CS2#
S_SPI_TPM_IRQ#
F_SPI_HOLD#_R T_SPI_MISO F_SPI_CS0#_R +3V_SPI F2_SPI_CS1#_R S_PLTRST# VCCSPI
PIN 1
PWR_BTN
PWR_LED+ PWR_LED- PWR GND
HDD_LED+
HDD_LED-
Ground
HWRST#
(NC)
F_PANEL
+PWR_LED-
+HDD_LED- RESET

1-6 Chapter 1: Product introduction
1.2.2 Rear panel connectors
1. PS/2 keyboard/mouse combo port. This port is for a PS/2 mouse or keyboard.
2. USB 3.2 Gen 1 (up to 5Gbps) ports. These 9-pin Universal Serial Bus (USB) ports
connect to USB 3.2 Gen 1 devices.
3. USB 3.2 Gen 1 (up to 5Gbps) port with BIOS FlashBackTM function. Insert a USB
storage device to this 9-pin Universal Serial Bus (USB) port to run BIOS FlashBackTM.
4. DisplayPort. This port is for a DisplayPort-compatible device.
5. 2.5G Ethernet port. This port allows 2.5Gbps Ethernet connection to a Local Area
Network (LAN) through a network hub. Refer to the table below for the Ethernet port
LED indications.
Realtek RTL8125B-CG 2.5G Ethernet port LED indications
10 13 151412
2 4 5 61
811
7 8 9
16
3
Activity Link LED Speed LED
Status Description Status Description
OFF No link OFF No link
GREEN Linked GREEN 2.5 Gbps connection
BLINKING Data activity ORANGE 1 Gbps / 100 Mbps /
10 Mbps connection
ACT/LINK
LED SPEED
LED
LAN port
6. USB 3.2 Gen 2 (up to 10Gbps) port (teal blue, Type A). This 9-pin Universal Serial
Bus 3.2 (USB 3.2) port is for USB 3.2 Gen 2 devices.
7. Center / Subwoofer port (orange). This port connects the center/subwoofer speakers.
8. Rear Speaker Out port (black). This port connects the rear speakers in a 4 channel,
5.1 channel, or 7.1 channel audio conguration.
9. Line In port (light blue). This port connects the tape, CD, DVD player, or other audio
sources.
10. USB 2.0 ports. These 4-pin Universal Serial Bus (USB) ports are for USB 2.0 devices.
11. BIOS FlashBackTM button. Press the BIOS FlashBackTM button for three seconds until
the FlashBackTM LED blinks three times, indicating that the BIOS FlashBackTM function
is enabled.

ASUS TUF GAMING B450M-PRO S 1-7
12. HDMITM port. This port is for a High-Denition Multimedia Interface (HDMITM)
connector, and is HDCP compliant allowing playback of HD DVD, Blu-ray, and other
protected content.
13. USB 3.2 Gen 2 (up to 10Gbps) port (USB Type-C®). This 9-pin Universal Serial Bus
3.2 (USB 3.2) port is for USB 3.2 Gen 2 Type-C®devices.
14. Optical S/PDIF Out port. This port connects to the optical S/PDIF devices.
15. Microphone port (pink). This port connects a microphone.
16. Line Out port (lime). This port connects a headphone or a speaker. In 4-channel,
5.1-channel, and 7.1-channel congurations, the function of this port becomes Front
Speaker Out.
Refer to the audio conguration table for the function of the audio ports in 2, 4, 5.1, or
7.1-channel conguration.
Audio 2, 4, 5.1 or 7.1-channel configuration
Port Headset
2-channel 4-channel 5.1-channel 7.1-channel
Light Blue Line In Line In Line In Side Speaker Out
Lime Line Out Front Speaker Out Front Speaker Out Front Speaker Out
Pink Mic In Mic In Mic In Mic In
Orange – – Center/Subwoofer Center/Subwoofer
Black – Rear Speaker Out Rear Speaker Out Rear Speaker Out

1-8 Chapter 1: Product introduction
1.3 Central Processing Unit (CPU)
This motherboard comes with an AMD Socket AM4 designed
for 3rd/2nd/1st Gen AMD Ryzen™/2nd/1st Gen AMD Ryzen™ with
Radeon™ Vega Graphics/ Athlon™ with Radeon™ Vega Graphics
Processors.
Unplug all power cables before installing the CPU.
The AM4 socket has a different pinout design. Ensure that you use a CPU designed for the
AM4 socket. The CPU ts in only one correct orientation. DO NOT force the CPU into the
socket to prevent bending the connectors on the socket and damaging the CPU!
Installing the CPU
Apply the Thermal Interface Material to the CPU heatsink and CPU before you install the
heatsink and fan if necessary.
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ASUS TUF GAMING B450M-PRO S 1-9
1.4 System memory
This motherboard comes with four Double Data Rate 4 (DDR4) Dual Inline Memory Module
(DIMM) sockets. The gure illustrates the location of the DDR4 DIMM sockets:
Channel Sockets
Channel A DIMM_A1 & DIMM_A2*
Channel B DIMM_B1 & DIMM_B2*
DIMM_A2*
DIMM_A1
DIMM_B2*
DIMM_B1
• You may install varying memory sizes in Channel A and Channel B. The system
maps the total size of the lower-sized channel for the dual-channel conguration. Any
excess memory from the higher-sized channel is then mapped for single-channel
operation.
• Always install DIMMs with the same CAS latency. For optimal compatibility, we
recommend that you install memory modules of the same version or date code (D/C)
from the same vendor. Check with the retailer to get the correct memory modules.
• A DDR4 memory module is notched differently from a DDR, DDR2, or DDR3 module.
DO NOT install a DDR, DDR2, or DDR3 memory module to the DDR4 slot.
• The default memory operation frequency is dependent on its Serial Presence Detect
(SPD), which is the standard way of accessing information from a memory module.
Under the default state, some memory modules for overclocking may operate at a
lower frequency than the vendor-marked value.
• For system stability, use a more efcient memory cooling system to support a full
memory load.
• Refer to www.asus.com for the latest Memory QVL (Qualied Vendors Lists).
Recommended memory configurations
DIMM_B2*
DIMM_A1
DIMM_A2*
DIMM_B2*
DIMM_A2*
DIMM_B1
DIMM_B2*

1-10 Chapter 1: Product introduction
To remove a DIMM
B
A
1.5 M.2 installation
• Ensure to install the bundled M.2 rubber pad before installing your single sided M.2
storage device.
• DO NOT install the bundled M.2 rubber pads when installing a double-sided M.2
storage device. The rubber pad installed by default is compatible with double sided
M.2 storage devices.
• The diagrams in this section are for reference only.
• The M.2 is purchased separately.
OPTIONAL
1 2
Installing a DIMM
1 2
B
A
A