Milestone HistosMATE User manual
HistosMATE
Automatic cleaner
Operator Manual - MM063
HistosMATE
MM063-010 – Operator Manual
3
Thank you for choosing one of our systems and welcome to the increasingly crowded club of Milestone
laboratory instrumentation users.
We feel confident that you will be fully satisfied adding this new device to your laboratory.
We recommend you read this operator manual carefully and always keep it within reach for convenient and
quick referencing.
For any clarification or request for assistance, please contact our representative in your country:
Or contact
Milestone s.r.l.
Via Fatebenefratelli, 1/5
24010 Sorisole (BG) Italy
Tel. +39.035.412 8264
Fax +39.035.575498
web site www.milestonemed.com
e-mail marketing@milestonemedsrl.com
Read this manual carefully before using the instrument.
MM063-010 – HistosMATE – Operator Manual
2021-01
HistosMATE
MM063-010 – Operator Manual
4
SUMMARY
SUMMARY ........................................................................................................................................................ 4
1. INTRODUCTION ........................................................................................................................................ 5
1.1. Symbol used ...................................................................................................................................... 5
1.2. Designated use .................................................................................................................................. 6
1.3. Technical specifications ..................................................................................................................... 6
1.3.1. Cabinet ....................................................................................................................................... 7
1.3.2. Touch screen terminal ............................................................................................................... 7
1.3.3. Cavity ......................................................................................................................................... 7
1.4. Transportation and storage conditions .............................................................................................. 8
1.5. Warning information ........................................................................................................................... 8
1.5.1. Personal Data Safety ................................................................................................................. 9
1.6. Label ................................................................................................................................................ 10
1.7. Compatible reagents ........................................................................................................................ 10
1.8. Waste disposal of the equipment .................................................................................................... 11
1.8.1. Waste disposal of reagents ..................................................................................................... 12
2. INSTALLATION ........................................................................................................................................ 13
2.1. Space requirements ......................................................................................................................... 13
2.2. Unpacking and checking list ............................................................................................................ 15
2.3. Placement ........................................................................................................................................ 17
2.4. Unit overview ................................................................................................................................... 17
2.5. Fumes extraction system ................................................................................................................. 19
2.6. Power supply ................................................................................................................................... 20
2.7. Reagents.......................................................................................................................................... 21
3. USING HistosMATE ................................................................................................................................. 22
3.1. Main page ........................................................................................................................................ 24
3.2. Settings Page .................................................................................................................................. 26
3.2.1. Settings .................................................................................................................................... 27
3.2.2. Info ........................................................................................................................................... 28
3.2.3. Date and Time ......................................................................................................................... 29
3.2.4. Languages ............................................................................................................................... 29
3.2.5. Service ..................................................................................................................................... 30
3.2.6. Events Log ............................................................................................................................... 30
3.3. Running a cleaning cycle ................................................................................................................. 31
4. REAGENT MANAGEMENT ..................................................................................................................... 35
4.1. How to change the reagent.............................................................................................................. 35
5. DOCUMENTATION .................................................................................................................................. 37
5.1. Display logs in HistosMATE............................................................................................................. 37
5.2. Export logs from the terminal ........................................................................................................... 37
5.3. Install and operate with LogVIEWER .............................................................................................. 38
6. MAINTEINANCE ...................................................................................................................................... 40
6.1. Laboratory personnel ....................................................................................................................... 40
6.2. Authorized service personnel .......................................................................................................... 40
6.3. Yearly ............................................................................................................................................... 40
6.4. Customer support intervention/sending the unit to the manufacturer for repairs ............................ 40
7. CLEANING ............................................................................................................................................... 41
7.1. Safety precautions ........................................................................................................................... 41
7.2. HistosMATE cleaning up ................................................................................................................. 41
8. OPTIONAL AND SPARE PARTS ............................................................................................................ 42
9. ALLARMS- How to manage an alarm ...................................................................................................... 43
9.1. How to manage an alarm ................................................................................................................. 43
10. TROUBLESHOOTING ......................................................................................................................... 44
The manufacturer reserves the right to change and/or improve specifications without
notice and without incurring any obligation.
HistosMATE
MM063-010 – Operator Manual
5
1. INTRODUCTION
1.1. Symbol used
An instruction accompanied by this symbol provides a quite important and require
more attention.
An instruction accompanied by this symbol provides a cautionary statement: failure
to follow the instruction may endanger the operator or cause damage to the
instrument.
An instruction accompanied by this symbol provides a caution against electric shock.
Be sure to follow the instruction to prevent accidents resulting from electric shock.
Biohazard: be careful when you execute the procedure marked with this symbol:
danger of biohazard contamination.
CE logo: this instrument complies to European Community directives.
Specifies the manufacturer’s serial number.
Replaceable fuse
Fragile.
WEEE European directive symbol (2012/19/EC):
Electric/electronic device do not throw out in the environment.
Only authorized and qualified SERVICE personnel.
Manufacturer.
HistosMATE
MM063-010 – Operator Manual
6
1.2. Designated use
The new HistosMATE unit is an innovative, safe, rapid solution for the efficient cleaning of wax contaminated
racks, moulds and forceps.
HistosMATE has been specifically designed to accommodate Milestone processors racks as well as the
most common conventional histoprocessors racks.
It is of fundamental importance to remember that proper cleaning of the tools and processing racks has
important repercussions on the quality of tissue processing and the duration of the processors. Paraffin in
improperly cleaned processing baskets can cause damage to pipelines, processor valves, and can pollute
reagents.
For this reason, the use of HistosMATE is recommended not only for users of Milestone processors but for
all histology laboratories
HistosMATE is a system that must be operated by trained personnel, such as: laboratory technicians and
pathologists.
The system and its accessories have been engineered for laboratory use (indoor use) and they can therefore
withstand the harshest laboratory conditions.
The Milestone HistosMATE must be operated exclusively with the reagents listed in Compatible reagents
(see chapter 1.7).
1.3. Technical specifications
The technical specifications for the main components of the HistosMATE system are described in the
following sections.
- CODE 65280: HistosMATE 220-240V~ 50/60Hz-450W
- CODE 65281: HistosMATE 100-120V~ 50/60Hz-450 W
Working Temperature: 15°C – 30°C (59°F – 86°F)
Humidity (relative): From 10% to 80% - Non condensation
Maximum altitude: 2000m
Indoor use only.
The instrument is intended for use in histological laboratory (indoor use) only.
Any other use of the instrument is considered improper and may void the warranty
provided by the manufacturer.
HistosMATE
MM063-010 – Operator Manual
7
1.3.1. Cabinet
- Heavy duty industrial grade external chassis white painted by antimicrobial powder coatings to inhibit
microorganisms growth, formulated with silver ionic technology
- Built-in exhaust fan.
1.3.2. Touch screen terminal
- Characteristics: TFT-LCD 4.3” widescreen color display
Resolution 480x272
Resistive Touchscreen
Mass storage 512MByte
1CPU 600-700MHz
Microsoft Windows CE Version 6.00
- Programs: Customizable time and temperature
- I/O-Interface: 1x USB port 2.0
- Dedicated Milestone software with icon-based graphic interface
- “Time and Temperature” control Software.
1.3.3. Cavity
- Stainless steel.
- Resistance heating elements (400W) controlled by PID technology.
- Magnetic stirrer
- Built-in PT100 Temperature sensor.
- Draining tube with quick coupling.
- Sound Pressure <65db
HistosMATE
MM063-010 – Operator Manual
8
1.4. Transportation and storage conditions
Temperature: –20°C up to +60°C (-4°F up to 140°F)
Humidity: Humidity: up to 80% (up to 50% at 40°C (104°F)) non-condensation
1.5. Warning information
Should the equipment be used in ways different than those specified by the manufacturer, the warranty
provided by the manufacturer may be void.
Main power plugs are considered disconnecting device. Disconnect all plugs from the socket outlet before
assembling the system, connection of the optional parts and cleaning.
Equipment shall be connected to a main power socket outlet which is accessible and visible by the operator.
All parts of the equipment and all optional parts must be supplied only by the manufacturer.
DO NOT OPEN THE CHASSIS. Failure to follow the instruction in the documentation
might lead to a reduction of device safety. If the equipment is not working properly,
contact your supplier or the manufacturer.
Do not remove the instrument panels. Only authorized and qualified SERVICE
personnel may repair the instrument and access the instrument’s internal
components.
The instrument is supplied with replaceable fuses, but their replacement must be
effected by trained and authorized SERVICE personnel. If the system is still not
properly working, contact the local authorized and trained SERVICE representative
or the manufacturer.
It is important that normal standards for safety and good laboratory practices are
applied. Always use common sense and the best-known practice when operating the
instrument. Failure to follow the instructions in the documentation might lead to a
reduction of device safety.
The Competent Authority owning the instrument has primary responsibility for
accident-free operation together with designated personnel who operates SERVICE
or repair it.
To avoid damage to the instrument, use only the reagents listed in chapter 1.7
“Compatible Reagents”. Failure to follow the instructions in the documentation
might lead to a reduction of device safety.
The use of naked flames that can cause accidental sparks in the areas adjacent to
the unit is prohibited.
Be careful: exhaust reagents are toxic.
Handle with care and follow the local standard regulations.
Use caution when handling hot, warm reagent.
Never install HistosMATE unit under a fume hood. The presence of acids or caustic
reagents might contaminate the air flow used for ventilating the electronic
components, exposing them to possible corrosion or shorting of circuits.
HistosMATE
MM063-010 – Operator Manual
9
1.5.1. Personal Data Safety
The Device described herein is not intended for managing personal data of natural persons. Personal data of
natural persons shall not be inserted into the Device during the use of the Device. The organization that uses
the Device shall implement appropriate measures to ensure that no personal data of natural persons is
inserted into the Device. All the data referring to a person and inserted into the device shall use, at least, the
“pseudonymization”, in such a manner that the personal data can no longer be attributed to a specific data
subject without the use of additional information, provided that such additional information is kept separately
and is subject to technical and organizational measures to ensure that the personal data are not attributed to
an identified or identifiable natural person.
HistosMATE
MM063-010 – Operator Manual
10
1.6. Label
For symbols explanation see chapter 1.1.
1.7. Compatible reagents
Milestone MileGREEN, Milestone Rack Cleaning Solution, Isoparaffin.
Do not use XYLENE, acetone, benzene, or trichlorethane in the instrument. They can
seriously damage the unit.
DO NOT USE REAGENTS DIFFERENT FROM THOSE LISTED ABOVE.
In case of doubts contact: application@milestonemedsrl.com.
It is necessary to put 13L of cleaning reagent in the HistosMATE cavity.
HistosMATE
MM063-010 – Operator Manual
11
1.8. Waste disposal of the equipment
HistosMATE is a device typically installed in a laboratory where specimens and other biological tissues are
present. For your safety, it is therefore required to clean and disinfect before entering in contact with it. You
must also wear gloves when operating the system.
In case of return it is required that the unit is cleaned and disinfected before sending it back to Milestone.
Non-disinfected devices will be no longer accepted and you will be contacted to pay the relative disinfection
cost.
International health rules require that shipments of biohazard materials are not done in standard packages
(risk of sanctions).
Do not remove the side panels of the unit during the cleaning operations.
Before doing any operation disconnect the power supply.
Do not use direct or high-pressure water to clean the instrument.
For safety reason, any operation without the individual protective devices must be
avoided.
It is recommended to use alcohol-based detergents and polyphenolic-based disinfectants to clean and
disinfect the instrument.
For further information, contact the manufacturer at application@milestonemedsrl.com.
Removal of equipment from use for disposal:
1) Switch OFF the unit. Disconnect the power supply.
2) Disconnect all the optional, if available.
3) Clean and disinfect all parts of the equipment.
4) Dispose all electric and electronic parts of the equipment.
Complying with directive 2012/19/EC of the European Parliament and of the Council of 04 July 2012 on
waste electrical and electronic equipment (WEEE), the separate collection environmental managed of
equipment is mandatory.
It is necessary to return the used equipment to the distributor or to inquire about the presence of a local
empowered system for collection and disposal of WEEE.
The in-observance of Directive 2012/19/EC or of the local law which acknowledge it can have potential
effects on the environment and human health.
This symbol indicates separate collection
for electrical and electronic equipment
If additional requirements on accident prevention and environmental protection exist in the country of
operation, this instruction manual must be supplemented by appropriate instructions to ensure compliance to
such requirements.
HistosMATE
MM063-010 – Operator Manual
12
1.8.1. Waste disposal of reagents
For further information refer to the SDS (Material Safety Data Sheet) provided by your supplier.
Handle with care and store in a cool dry space using a tightly closed container.
Vapors may build up in empty containers. Treat empty containers as hazardous.
Waste material should be disposed of in an approved incinerator or in a designated landfill
site, in compliance with all federal, provincial and local government regulations.
Some reagents can have potential health hazard and cause environmental pollution if not
correctly disposed.
HistosMATE
MM063-010 – Operator Manual
13
2. INSTALLATION
Before switching the unit on (when coming from a storage area), allow the instrument
to reach environment operating conditions (at least 30 minutes).
2.1. Space requirements
HistosMATE is delivered in a wood box (43kg-94lb) with these dimensions:
Width: 430mm (16.92”)
Height: 680mm (26.77”)
Depth: 650mm (25.59”)
Unit dimensions:
Width: 300mm (11.81”)
Height: 465mm (18.30”)
Depth: 515mm (20.27”)
Space dimensions required to locate the Milestone HistosMATE:
Width: 600mm (23.62”)
Height: 1000mm (39.37”)
Depth: 771mm (30.36”)
Make sure that the unit has not been placed against any lateral surfaces that might limit the intake/outlet of
cooling air: allow at least a distance of 20cm (7.9in) for each side and behind.
HistosMATE
MM063-010 – Operator Manual
14
HistosMATE Weight (read carefully):
The weight of the HistosMATE is approximately 35kg (77.16lb); at least 2 persons should
remove the unit from its box and locate it on the bench.
If it is necessary to move the HistosMATE after its first installation, it is always
recommended to empty it before proceeding with the move
Never install HistosMATE unit under a fume hood. The presence of acids or caustic
reagents might contaminate the air flow used for ventilating the electronic components,
exposing them to possible corrosion or shorting of circuits.
HistosMATE
MM063-010 – Operator Manual
15
2.2. Unpacking and checking list
Check if your HistosMATE code corresponds to the voltage supply of the laboratory:
- CODE 65280: HistosMATE 220-240V~ 50/60Hz
- CODE 65281: HistosMATE 100-120V~ 50/60Hz
All parts of the equipment and all optional parts shall be supplied only by Milestone.
When unpacking, check that all parts correspond to the packing list included in the shipment.
Utmost care must be made during unpacking of the HistosMATE to avoid any scratch or damage to the
external coating.
HistosMATE codes 65280 e 65281 includes the following items:
1. HistosMATE unit
2. Items indicate in the table below
CODE
DESCRIPTION
Q.ty
IMAGE
50036
Power cord for units at
230V 50/60Hz
(Schuko)
1
50391
Power cord for units 100-
120V 50/60Hz (NEMA
5-15P).
1
50331
Black plastic tube 2.5 m
(8ft) long with metal
cable clamp to be used
to fix the hose to the
exhaust fume pipeline
1
62499
Draining Tube. This tube
must be connected to the
quick coupling to drain
exhausted reagents
1
65237
Stainless steel basket to
automatically remove
wax traces from metal
moulds and forceps
placed inside it
1
HistosMATE
MM063-010 – Operator Manual
17
2.3. Placement
HistosMATE unit can be positioned in its final place of use. Make sure it is firmly placed and the bench is
level.
During the setup, the HistosMATE must be disconnected from the main power supply.
A proper location of the HistosMATE is near and connected to any vapors extractor
system using the hose supplied. Make sure the unit is not placed against any back surface
limiting the air-cooling inlet/exhaust.
2.4. Unit overview
The picture shows the front view of the HistosMATE system.
1) ON/OFF button
2) USB port
3) Touch terminal
4) Ventilation button
5) Ventilation
6) Holder
7) Reagent substitution door
3
1
2
4
5
7
6
HistosMATE
MM063-010 – Operator Manual
18
The following picture shows the back side of HistosMATE:
1) Fume extractor connectors
2) Spare fuses
3) Fuses
4) Power cord connection
1
2
3
4
HistosMATE
MM063-010 – Operator Manual
19
2.5. Fumes extraction system
1. Connect the black exhaust tube (CODE 50332) to the exhaust outlet located on the back panel of the
unit.
In case of connection to an external fume extraction system, the customer is required to adapt the hose
connector. The plastic hose supplied has these characteristics:
• Length: 2.5m (98”)
• External diameter: 55mm (2.16”)
• Internal diameter: 50mm (1.96”)
• Fan air flow range:23–27m3/h (cube meter per hour).
2. Use the metal cable clamp (CODE 64757) to fix the hose to the exhaust outlet connection. Use a
screw driver to tighten the metal cable clamp.
3. The other end of the exhaust hose is normally connected to any vapors extractor system.
DO NOT connect the HistosMATE unit to the main power supply during the installation.
The external fume extraction system must be properly installed at all times, according to
local regulations on the safety of laboratory in force.
The external fume extraction system must permit an air flux 27m3/h (cube meter per hour).
HistosMATE
MM063-010 – Operator Manual
20
2.6. Power supply
• A ground connection is available in the lab to assure the unit works correctly (yellow/green, green or
bare wire). Do not connect a Milestone unit without ground connection. Do not use the blue/white
wire (neutral of power line).
• Power supply neutral has to be referred to ground.
• Power supply line wires (their size and distance from the switch board) used in the laboratory are
compliant with the label positioned on the back side of our units.
• Plug/socket is visible during the normal use and easily accessible.
Power supply line needs to have a ground connection (Class I device).
Power supply line protection:
115V version: miniature circuit breaker curve C, 15A, differential: 30mA.
230V version: miniature circuit breaker curve C, 10A, differential: 30mA.
Before connecting the plug to the laboratory’s socket, check that the power supply
voltage of the unit matches the power supply line of the laboratory.
Damages occur when wrong power supplies the instrument.
The power supply must be protected by a residual current circuit breaker with over
current protection, residual current 30mA. Power line must have potential earth
connection.
CONNECTING CABLES: Never connect or remove cables when power to the unit is
switched on, this will avoid risk of damage.
Main plug is considered as disconnecting device
Equipment shall be connected to main socket outlet which is accessible and visible by the
operator.
Disconnect main plug from the socket outlet before setting up the system and before
cleaning.
Connect the power cord socket in the HistosMATE plug and the power cord plug to main power supply
socket.
See also the label on the back of the unit which provides some important information.
Always provide the S.N. of the unit to Customer Support.
Other manuals for HistosMATE
1
Table of contents
