B&W Tek NanoRam Series Instruction manual

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NanoRam®Series
Handheld Raman System
Quick Start Manual

NanoRam®Series Handheld Raman
19 Shea Way, Newark, DE 19713, USA •Tel: [phone] •Fax: [phone] •Web: www.bwtek.com
290020255-J (2017/07/28) Copyright 2017 B&W Tek
Table of Contents
1. OVERVIEW ................................................................................................................................................ 4
1. DIAGRAMS OF THE INSTRUMENTS ........................................................................................................ 8
1.1. NANORAM................................................................................................................................................. 8
1.2. NANORAM MINI......................................................................................................................................... 9
1.3. Warranty Seal Label.................................................................................................................................10
1.4. Manufacturer’s Identification Label.........................................................................................................10
2. KNOWING YOUR INSTRUMENT ..............................................................................................................11
2.1. Power Supply...........................................................................................................................................11
2.2. Battery Installation and Charging............................................................................................................11
2.3. Power On/Off............................................................................................................................................14
2.4. User Login................................................................................................................................................15
2.5. Home Key.................................................................................................................................................15
2.6. Using the Sampling Accessories ............................................................................................................15
2.7. Barcode Scanner Key..............................................................................................................................22
2.8. Laser Switch /Acquisition Key.................................................................................................................22
3. OPERATOR USER QUICK START............................................................................................................23
3.1. User Login................................................................................................................................................23
3.2. Perform Material Identification................................................................................................................24

NanoRam®Series Handheld Raman
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3.3. Perform Material Investigation ................................................................................................................27
3.4. Performance Validation............................................................................................................................30
3.5. Enable Data Transfer................................................................................................................................31
3.6. History Review.........................................................................................................................................32
4. NID SOFTWARE........................................................................................................................................33
4.1. About NID.................................................................................................................................................33
4.2. Device Connection on NID.......................................................................................................................33
4.3. Login NID Client.......................................................................................................................................34
4.4. Data Synchronization...............................................................................................................................37

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1. Overview
The NanoRam Series is a handheld Raman instrument designed for rapid identification of
sample material based on their Raman spectrum. The instrument has a touch screen
operation with intuitive software for easy operation by specialists and non-specialists alike.
Identification and Investigation modes of analysis are available based on qualitative analysis
of sample spectra that are compared to method and/or library spectra to provide Pass/Fail
and Match/No Match results. The operating software (NOS) has different user access levels,
and includes a complete audit trail of measurements. Data reporting, management and
account management are done by synchronizing the instrument data with the
data/library/user/report management software NID, loaded onto a PC. Library and method
transfer are supported between same type of units (NanoRam to NanoRam, NanoRam Mini
to NanoRam Mini). Both instruments are housed in durable IP6X-rated cases (IP64 for
NanoRam and IP65 for NanoRam Mini respectively) that provide different levels of protection
from ingress of dust and water.
Note: this quick start manual is applicable to both NanoRam and NanoRam Mini.
1.1. Safety Warning and Cautions
The system contains one Class 3B laser light source. The product complies with 21 CFR
1040.10, Laser products. Please read through this user manual before operating the
system.
1.2. Laser Emission Aperture and Beam Shutter
Located at the laser emission aperture, the laser emission label indicates that the laser
energy emission occurs at the corresponding port.
The NanoRam unit comes equipped with CDRH-compliant laser safety measures
including soft key switch, remote interlock, and emergency laser stop key button.

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The laser hazard zone is within 30cm (11.8 inches) to the tip of the point-and-shoot
adaptor.
1.3. Remote Interlock (for NanoRam only)
The remote interlock is located at the bottom of the unit next to the Ethernet port.
The remote interlock facilitates the laser ‘on’ and ‘off’ remote control function. When the
laser stop key is inserted into the slot, the interlock is closed and laser emission is enabled.
When the key is pulled out, the interlock is open and the laser does not emit and cannot
be turned on.
1.4. Laser Warning Label
The laser warning label is located on the rear panel of the system. The label displays the
laser safety class, wavelength and power of the laser source.
Remote Interlock

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1.5. Precautions
Sources for additional information and assistance on laser safety:
CDRH-Radiological Health Program
Office of communication, Education and Radiation Programs
•Never point the unit directly at a person.
•Never look directly into the laser beam path or scattered laser
light from any reflective surface.
•Never look directly into the laser source.
•Maintain low beam level when performing experimental setup
to prevent inadvertent beam-eye contact.
•As a precaution against accidental exposures to the laser
beam or its reflection, user should always wear laser safety
glasses (provided) with sufficient attenuation for the laser.

NanoRam®Series Handheld Raman
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Center for Devices and Radiological Health
Food and DrugAdministration
10903 New Hampshire Avenue W066-4613
Silver Spring, MD 20993 USA
Tel: [phone]
Fax: [phone]
dsmi[email protected]
Laser Institute of America
13501 Ingenuity Drive, Suite 128
Orlando, FL 32826 USA
Toll Free: 1-800-345-2737
Tel: [phone]
Fax: [phone]
www.lia.org

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1. Diagrams of the Instruments
1.1.NanoRam
Laser emission indicator
12V DC Power connector
Ethernet Port
Remote Interlock
Battery compartment
Barcode scan key
Home key
Power On/Off key
Laser emission aperture
/Sampling port
Laser
switch/Acquisition
key
Rubber Protection

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1.2. NanoRam Mini
2D Barcode scanner
Laser emission aperture
/Sampling port
Shaft
2D Barcode Scanner
Barcode Scan Key
Home Key
Power On/Off Key
Laser Switch/Acquisition
Key
Rubber Protection
Laser Emission
Aperture
/Sampling Port

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1.3. Warranty Seal Label
The warranty seal labels are positioned on both sides of the system under the blue jacket.
Any attempt to open the panel(s) of this device will break these seals and void the
warranty.
1.4. Manufacturer’s Identification Label
Laser Emission Indicator
18V DC Power Connector
Ethernet cable
Port
Battery Compartment
Laser Emission
Aperture and shaft
Rubber Jacket’s Ribs
2D Barcode Scanner

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Located on the rear panel of the system, the manufacturer’s general identification label
includes warning information and also displays the manufacturer name, address, model
number, serial number, and the manufacturing date.
2. Knowing Your Instrument
2.1. Power Supply
The unit can be run on either external power supply or on battery. Before using the unit
with the battery, make sure that the battery is fully charged. The battery status can be
found on the top right corner of the screen in ‘operation’ displays, or the center of the
screen when in charging only mode. The NanoRam battery can be charged with the
12VDC power adaptor or optional charging cradle. The NanoRam Mini battery can be
charged with the 18VDC power adaptor or optional charging cradle.
Note: It is recommended to charge the battery only when the unit is not in use.
2.2. Battery Installation and Charging
Locate and identify the battery cover at the bottom end of the unit.
Note:there are two versions of battery door design: version Aand B. To identify: version
Adoes not have any sign on the bottom cover while version B has an unlock sign near
the ring. Turn counterclockwise to unlock if you have versionA and turn clockwise to
unlock if you have version B.
Version A Version B

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Version A:
Hold the ring and turn it counterclockwise 1/8th turn to unlock.
Carefully pull out the battery cover and set aside.
Insert the provided NanoRam Lithium Ion battery pack
into the battery compartment as shown. Battery contacts
should be facing down (towards the back of the unit) and
to the right. The strap attached to the battery pack can be
used for battery insertion as well as removal.Assure that
the battery is fully inserted.
Install the battery cover back in the same position as removed.
Use thumbs and/or fingers to firmly press the cover into place to
assure correct positioning and to establish a tight seal.

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Turn the ring clockwise 1/8th turn till the ring is in a vertical
position.
The cover is now locked.
Version B:
Hold the ring. Turn it clockwise 1/8th turn to unlock.
Turn it counterclockwise 1/8th turn till the ring is in a vertical
position to lock.
Note: The battery can be charged either through the supplied external power adaptor or using the optional charging
cradle.

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2.3. Power On/Off
To power on the system, press and hold the power on/off key for at least 3 seconds.
An initial screen will display, followed by a NanoRam OS (Operating System) screen
indicating that the system initialization is in process with a count up in percentage of
completion. After the initialization of the system is completed, the user login screen will be
displayed. The unit is now operational.
There are two ways to turn off the system
•Soft power down: press the power On/Off key for about one second. A message
appears confirming the shutdown request. Press OK to confirm the operation and the
system will turn off. Press Cancel to cancel the request and return to the previous
menu.

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•Hard power down: press and hold the power On/Off key for about 3 seconds.
Note: The instrument cannot be hard powered down when it is being charged. Avoid hard
powered down unless necessary. An “abnormal power down” error message will be
shown if the unit was hard powered down or battery was pulled out during operation.
2.4. User Login
After logging in with the defined user name and password the Home Screen will be
displayed.
The Home screen for the NanoRam is displayed here for an Administrator. The same
home screen is displayed for an Operator-level user.
2.5. Home Key
Pressing the Home key one time on the front panel will:
•return user to the previous screen
•log out and return to the login screen if the user is in the main screen
•cancel the current operation (for example: an acquisition with laser in emission) and
return to the Home screen
Pressing the Home key twice at any stage of the operation will return user to the Login
screen.
2.6. Using the Sampling Accessories
The NanoRam unit standard package comes with four types of sampling accessories which
User type symbol
Time and date
Battery status

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will facilitate easy and fast sampling. Depending on the type and form of the materials to be
measured, the appropriate sampling accessory can be selected. The sample can be placed
directly against the adaptor.
Point-and-shoot adaptor
Liquid vial holder adaptor that
holds a 15mm(diameter)x 45mm(height) vial
Bottle adaptor for measurement through
a container
Calibration cap with built-in polystyrene
Right angle adaptor (optional)
Tablet holder adaptor (optional)
Immersion probe adaptor (for use with
NanoRam only)
The user needs to ensure that the sampling adaptor is installed properly before using the
NanoRam. Before installing any accessories the NanoRam should be at the log in screen
with the laser turned off to ensure safety. No operations are permitted without the lensed
shaft in full installed position with standard accessories, or an immersion probe, tablet
holder or right-angle adaptor properly installed with their shaft accessory.
For installation of the right angle adaptor, tablet holder or immersion probe please read
the guidelines for safe installation and use provided with the accessory. They are
included in theAppendix of the user manual as well.

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Never remove the lensed shaft when the instrument is on.
The following steps will guide the user to successful installation of the sampling
accessory:
Make sure the correct shaft is installed onto the laser emission aperture.
Locate the alignment key on the adaptor and the set pin position at the laser emission
aperture.
Push the adaptor onto the shaft until the O-ring just reaches the instrument surface.
Gently turn the adaptor clockwise until a click is felt or the sound of a click is heard, which
indicates that the key on the adaptor is set to the set pin at the laser emission aperture.
Once the alignment is reached, stop turning the adaptor.
Standard Lensed Shaft
Key
Set pin
Push in
O-ring

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Push the adaptor further in until the O-ring is fully inside the emission port. At this
point the adaptor should be positioned firmly into its position.
Using the Point-and-Shoot Adaptor
The Point-and-shoot adaptor can be used for powder, solid or liquid sample
measurements through a thin and transparent container. With the Point-and-shoot
adaptor in place, hold the NanoRam unit so that the adaptor is against the sample
container surface.
Note: B&W Tek does not recommend that the adaptor touch powder samples directly,
as they may contaminate the lens on the sampling adaptor. The use of a protective
transparent plastic film is recommended.
Precaution: to avoid accidental exposure to the laser beam
do not look directly into laser emission aperture.

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Using the Liquid Vial Holder Adaptor
The liquid vial holder can be used for liquid, gel, or powder samples. The liquid vial
holder holds a 15 mm (diameter) x 45mm (height) vial.
Using the Bottle Adaptor
The bottle adaptor can be used for the measurement of samples through transparent
containers of less than 5 mm in thickness, such as liquid samples inside bottles, or
containers. The bottle or container can be placed directly against this adaptor. The
measurement beam will then be ideally focused into the sample over 5 mm away
from the surface of the adapter.
The NanoRam Mini unit standard package comes with three types of sampling
accessories which will facilitate easy and fast sampling. Depending on the type and form
of the materials to be measured, the appropriate sampling accessory can be selected.
The sample can be placed directly against the adaptor.
Point-and-shoot adaptor
Bottle adaptor
Liquid vial holder adaptor

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Point-and-shoot adaptor
Liquid vial holder adaptor that
holds a 15mm(diameter)x 45mm(height) vial
Performance validation cap with built-in
polystyrene
Right Angle Adapter (optional)
The user needs to ensure that the sampling adaptor is installed properly before using the
NanoRam Mini. Before installing any accessories, the NanoRam Mini should be at the
log in screen with the laser turned off to ensure safety. No operations are permitted
without the lensed shaft in full installed position with standard accessories.
Using the Point-and-Shoot Adaptor
The point-and-shoot adaptor can be used for powder and other solid samples. With the
point-and-shoot adaptor in place, hold the NanoRam Miniunit so that the adaptor is
against the sample container or sample surface.
To install point-and-shoot adaptor, insert the adaptor onto the shaft, gently push it all the
way in until the adaptor is installed properly into position and secured by the rubber
jacket ribs.
Note: We do not recommend that the adaptor touch powder samples directly, as they
may contaminate the lens on the shaft. The use of a protective transparent plastic film is
recommended.