cytiva UNICORN 7.9 User manual

UNICORN™ 7.9
System Control Manual
cytiva.com

Table of Contents
1Introducing UNICORN System Control ............................................................ 3
1.1 About this manual ......................................................................................................................................... 4
1.2 About System Control of UNICORN ........................................................................................................ 5
1.3 Important user information ....................................................................................................................... 6
1.4 Associated documentation ....................................................................................................................... 7
2 General UNICORN operation ............................................................................. 8
2.1 Log on and log off routines ......................................................................................................................... 9
2.2 Help functions ................................................................................................................................................. 11
3 The System Control module .............................................................................. 12
3.1 System Control module overview ............................................................................................................ 13
4 How to perform a run .......................................................................................... 15
4.1 Connect to system ........................................................................................................................................ 16
4.2 Start a method run ........................................................................................................................................ 17
4.3 Monitor a run ................................................................................................................................................... 21
4.4 Manual system control ................................................................................................................................ 27
4.5 Method queue, Design of Experiments, Scouting and BufferPro runs ...................................... 29
5 System Settings .................................................................................................. 32
6 Troubleshooting ................................................................................................. 35
Table of Contents
UNICORN 7.9 System Control Manual 29722732 AA 2

1 Introducing UNICORN System
Control
About this chapter
This chapter contains:
•A general introduction to System Control using the UNICORN™ system control
software .
•Information about the user documentation for UNICORN, including an overview of
related documents describing the use of the software.
In this chapter
Section See page
1.1 About this manual 4
1.2 About System Control of UNICORN 5
1.3 Important user information 6
1.4 Associated documentation 7
Software declaration of conformity
UNICORN 7.9 is technically compatible with all relevant sections of FDA 21 CFR Part 11.
A part 11-system assessment checklist is available on request from your local Cytiva
representative.
1 Introducing UNICORN System Control
UNICORN 7.9 System Control Manual 29722732 AA 3

1.1 About this manual
Purpose of this manual
The purpose of the UNICORN System Control Manual is to provide a guide describing
the general system control functions in UNICORN. It includes general operation,
system settings and instructions on how to perform a chromatography run. It covers
the features and tools included in the System Control module of the UNICORN soft-
ware with practical instructions.
The manual covers the following:
•general UNICORN operation, including log on and log off.
•how to perform a run
•how to change system settings.
Refer to the instrument's Operating Instructions for further information on how to
perform a run.
Note: The UNICORN System Control Manual does not describe the functions of
every command in all panes and dialog boxes of the user interface. Refer to
the online help for information about commands that are not described in
this manual. The online help in the System Control module is accessed
either by clicking help buttons in software dialog boxes, by pressing the F1
key, or clicking Help for System Control on the Help menu.
Typographical conventions
Menu commands, field names and other text items from the software are quoted
exactly as they appear on the screen, in a bold italic typeface:
Example: Result Navigator, Method Navigator, Method Navigator, UNICORN
User Setup etc.
Menu paths are shown in a bold italic typeface with a separating colon between each
level:
Tools →UNICORN User Setup i.e., the menu option UNICORN User Setup from the
Tools menu.
Controls on the instrument, computer or keyboard keys are shown with a bold, regular
typeface:
Example: Press the Delete key.
Text that the user must either type exactly as shown in the manual, or that UNICORN
displays as a response (not a regular part of the graphic user interface), is represented
by a monospaced typeface:
Example: Connection change
File system paths are represented by a monospaced typeface:
Example: C:\Program Files\Cytiva\UNICORN\
1 Introducing UNICORN System Control
1.1 About this manual
UNICORN 7.9 System Control Manual 29722732 AA 4

1.2 About System Control of UNICORN
Introduction
This section is a brief introduction to the control system used in UNICORN.
What is UNICORN?
UNICORN is a complete software package for:
•control and supervision of chromatography systems.
•evaluation and analysis of the results from separation runs.
Description of the System Control
module
The System Control module is used to start, monitor and control a chromatography
run.
Runs can be performed in three different ways, as listed below:
•Using a preprogrammed method without any manual interactions.
•Interact with the instrument during a method run by performing manual instruc-
tions.
•Perform manual runs. This approach may be useful for simpler procedures such as
priming tubing with buffer.
1 Introducing UNICORN System Control
1.2 About System Control of UNICORN
UNICORN 7.9 System Control Manual 29722732 AA 5

1.3 Important user information
Read this before running System
Control
All users must read the entire Operating Instructions before installing, oper-
ating or maintaining the chromatograpy system, and running System Control.
Always keep the Operating Instructions at hand when operating System Control.
Do not operate the chromatograpy system in any other way than described in the user
documentation. If you do, you may be exposed to hazards that can lead to personal
injury and you may cause damage to the equipment.
1 Introducing UNICORN System Control
1.3 Important user information
UNICORN 7.9 System Control Manual 29722732 AA 6

1.4 Associated documentation
Introduction
This section describes the user documentation that is delivered with UNICORN.
User documentation
The user documentation listed in the table below is available from the Help menu in
UNICORN and as printed books.
Document Main contents
UNICORN Method
Manual
Overview and detailed descriptions of the method
creation features in UNICORN. Instructions on how to
use the software. Workflow descriptions for common
operations.
UNICORN Evaluation
Manual
UNICORN Administration
and Technical Manual
Overview and detailed description of network setup
and complete software installation. Administration of
UNICORN and the UNICORN database.
UNICORN System
Control Manual
Overview and detailed description of the system
control features in UNICORN. Includes general opera-
tion, system settings and instructions on how to
perform a run.
UNICORN Contextual
Help
Dialog box descriptions for UNICORN (from the Help
menu).
1 Introducing UNICORN System Control
1.4 Associated documentation
UNICORN 7.9 System Control Manual 29722732 AA 7

2 General UNICORN operation
About this chapter
This chapter includes a description of general UNICORN operation which includes log
on and log off UNICORN, how to structure files and folders and how to use the Online
Help.
In this chapter
Section See page
2.1 Log on and log off routines 9
2.2 Help functions 11
2 General UNICORN operation
UNICORN 7.9 System Control Manual 29722732 AA 8

2.1 Log on and log off routines
Start UNICORN and log on
Follow the instructions to start UNICORN and log on to the program. A valid e-license
must be available for the workstation. See UNICORN Administration and Technical
Manual for more information about e-licenses.
Step Action
1Double-click the UNICORN icon on the desktop.
Result:
The Log On dialog box opens.
Note:
If there is no connection to the database it is still possible to log on to
UNICORN and control a running system. The Log On dialog box will give the
option to start System Control without a database. Click Start System
Control to proceed to the next Log On dialog box.
2In the Log On dialog box:
a. Click a user name in the User Name list
and
b. enter the password in the Password field.
Note:
It is also possible to select the Use Windows Authentication check box
and enter a network ID in the User Name box.
2 General UNICORN operation
2.1 Log on and log off routines
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Step Action
c. select which UNICORN modules to start.
d. click OK.
Result:
The selected UNICORN modules open.
Log off or exit UNICORN
Follow the instruction to log off or exit UNICORN. This can be performed from any of the
UNICORN modules.
If you want to... then...
log off UNICORN on the File menu, click Log off.
ResultAll open UNICORN modules close and the Log On
dialog box opens.
exit UNICORN on the File menu, click Exit UNICORN.
ResultAll open UNICORN modules close.
Note: If an edited method or result is open and not saved when you try to exit or
log off UNICORN, you will see a warning. Click Yes to save, No to exit without
saving, or Cancel to stay logged on.
2 General UNICORN operation
2.1 Log on and log off routines
UNICORN 7.9 System Control Manual 29722732 AA 10