EVER Pharma D-mine Care User manual

A guide for patients, families
and carers

CARE SERVICE
Our dedicated and highly experienced D-mine®Care nurse
advisers are here to help you during your apomorphine journey
with EVER Pharma. Our service is available to all people in the
UK on Dacepton®(apomorphine hydrochloride) and is free of
charge. Our aim is to support you with information and advice
at the key points in your journey and to be available to answer
any questions you may have.
This booklet will take you through the key information relating
to your D-mine®Care Pen. Have a read and don’t hesitate to
contact us with any questions.
Apomorphine is NOT morphine and does not have any pain
killing properties, nor is it addictive. Please note that Dacepton®
will leave a green stain on any surface or material it comes into
contact with.
For people who have been prescribed Dacepton®

USING YOUR D- MINE
®PEN
What will you need?
D-mine®Care Pen
Dacepton®cartridge
(5 per pack)
Pen needles* (100 per box)
The dosage wheel clearly shows the dose you want
to inject. Simply dial up or down to the right dose
*BD Micro-Fine Ultra™ needles are
recommended for use with the D-mine®
Care Pen. Pen needles from other
manufacturers can be used according
to their stated compatibility details.
The D-mine®Care Pen has been designed to be easy to use and
we will take you through everything you will need to do to use
your Pen. Let’s show you what your Pen looks like:
Pen needle
Pen cap
Cartridge sleeve
Outer needle protective cap
Dacepton®cartridge
Inner needle
protective cap
Display window
Hold down the
push button to
deliver your dose

At this stage you may feel a little overwhelmed by the idea of
having to inject yourself and we want you to know that together
with your healthcare professional we will help you get used to
your D-mine®Care Pen.
When you receive your Pen, you will find comprehensive
instructions inside. Please refer to these instructions should
you have any questions regarding using your Pen.
Before you Inject
• Wash your hands and always handle the device and
medication with clean hands.
• Clean your skin as per the advice given by your healthcare
professional.
• Use a new needle each time you inject.
• Inject into sites such as your abdomen or your outer thighs
as shown by your healthcare professional.
• Change your injection site each time.
• Do not inject in to a skin fold or scar tissue.
• Do not inject into an area of skin that is sore, red, infected
or damaged.
• See the Skincare section for more information.
• Always check the expiry date of your medicine.
• Do not use if the solution has turned green.
BEFORE YOU START

CHANGING THE CARTRIDGE ATTACHING THE PEN NEEDLE
Remove the Pen cap.
Twist the cartridge sleeve
until you hear a click. Remove
empty cartridge if necessary.
Insert new cartridge.
Push threaded rod back
completely.
Push the cartridge sleeve into
the housing and turn to lock.
You will hear a click.
Pull off the peel foil.
Push on and twist the Pen
needle onto the cartridge
sleeve.
Remove the outer needle
protective cap.
Remove and dispose the
inner needle protective cap.
1
2
3
4
5
1
2
3
4

PRIMING AND FUNCTION CHECK
“tap-tap”
For the function test, hold
the Pen pointing upwards
and gently tap the cartridge
sleeve, so that the
air can rise to the top.
Press the push-button.
A few drops of medicine will
emerge. If no drops emerge,
repeat steps 1-4.
Dial the required dose by turning the dosage wheel
clockwise. You can correct the dose by dialling anti-
clockwise if needed. Look at the display to see if you
have dialled the required dose.
Dial the test dose forward by
turning the dosage wheel.
Check the dose by looking
at the display, so that the
symbol is clearly displayed.
1
2
3
4
SETTING THE DOSE
INJECTING
Press and hold the push-button fully down during the
medication discharge.
After the medication has been
completely discharged, wait for
6 seconds and ONLY then pull
out the Pen needle.
Check that the display is as the 0.0 position to confirm
full dose delivery.
1
2
3
AFTER YOUR INJECTION
1
2
Attach the outer needle protective cap to the needle,
remove the Pen needle and dispose in accordance
with local regulations.
Attach the Pen cap securely after each use.
1
3After you have removed the needle, you can change
your cartridge if needed.

CARING FOR YOUR SKIN
Medications that are administered under the skin
may cause skin reactions leading to redness,
tenderness, itching and the development of
nodules (hardening of the skin at the injection
site). These skin reactions are not dangerous and
can be managed through good skincare practise
and by altering the injection site
• Inject at least 1 inch (2.5 cm) away from your belly button
and any recent injection sites.
• Insert the needle at 90 degrees to the surface of your skin.
• Keep your skin dry and be sure to wipe away any drops of
Dacepton®.
• Massage your skin by hand or with a massage device, as
this may help prevent the formation of skin nodules.
• Do not inject into a skin fold or scar tissue and do not
inject into an area of skin that is red, sore, infected or
damaged.
If persistent skin reactions occur, please consult your
healthcare professional or your D-mine®Care nurse.
Date Started Date Changed
/ /20 / /20
/ /20 / /20
/ /20 / /20
/ /20 / /20
/ /20 / /20
/ /20 / /20
/ /20 / /20
/ /20 / /20
/ /20 / /20
/ /20 / /20
RESPONSE TEST DETAILS
Response Test Date: / /20
Pen Response Test Dose: mg
BP Lying: mmHg
BP Standing: mmHg
Parkinson’s Specialist:
D-mine®Nurse Adviser:
CARTRIDGE CHANGE RECORD
DOSAGE RECORD
Date Daily Dose
/ /20 mg
/ /20 mg
/ /20 mg
/ /20 mg
/ /20 mg

or if you have questions regarding any of this information.
Can I travel with my Pen?
Parkinson’s should not prevent you from doing the things you
love. When you go travelling you need to ensure that you have
enough Dacepton®to last you during the period you will be
away. Don’t forget about your pen needles, make sure you take
enough of them to use a new pen needle every time you inject.
If needed, you could ask your GP to prescribe an additional
D-mine®Care Pen for you, so you have a spare pen when you
go away on holiday.
Please visit d-minecare.co.uk to download a copy of our Travel
Letter. This may be helpful to take with you on holiday to
explain what your Dacepton®therapy is.
Never stop taking any Parkinson’s treatment abruptly including
Dacepton®.
FAQS
How do I get hold of my medication?
There are different options available to get hold of your
Dacepton®.
Homecare – Our homecare is provided by our partner
Pharmaxo. Your GP or hospital will register you for
homecare, and your medication and pen needles will get
delivered straight to your home.
GP prescription (FP10)/hospital prescription – You can
also get your Dacepton®and Pen needles from your local
pharmacy. You can get your prescription from your GP or
hospital and take it to your pharmacy to be processed.
To use Dacepton®with your D-mine®Care Pen you will need the
following:
• D-mine®Care Pen – this is given to you free of charge at
the time you start your therapy.
• Pen needles for injection – a box of 100 pen needles are
given to you, free, every month. If you require additional
pen needles please phone [phone].
• Dacepton®cartridge which contains your medication –
this is the only item your healthcare professional has to
prescribe for you.
• You can phone your D-mine®Care nurse adviser for advice
FAQS

FAQS
What if I go to hospital?
• If it happens that you need to go to hospital, it is important
that you take this information leaflet with you. You will
need to explain to the healthcare professionals that you
have Parkinson’s and that this injection provides treatment
for your Parkinson’s.
How long does Dacepton®last after opening?
• Always check the expiry date of your medicine.
• Do not use if the solution has turned green.
• Dacepton®10mg/ml solution for injection in cartridge is
stable for 15 days at 25°C (room temperature), after first
opening. Ensure you handle Dacepton®and D-mine®
devices according to the instructions for use and the
guidance provided by your D-mine®nurse or treating
healthcare professional.
For additional information please visit:
• www.parkinsons.org.uk
• epda.eu.com
• cureparkinsons.org.uk
• nhs.uk/conditions/parkinsons-disease
NOTES

Dacepton®and D-mine®are registered trademarks of EVER Pharma. BD Mirco-Fine™is a registered
trademark of Beckton Dickinson.
EVP-114.03 Date of preparation: September 2021
Who to contact for support
For support related to your Dacepton®therapy, please contact your healthcare
professional or your D-mine®Care nurse adviser.
Technical Support
For technical support relating to your device:
0800 254 0175 (24 hours/day. During peak times, out of hours and weekends,
leave a message and you will be called back) or
email [email protected]
Prescriptions and ancillaries
For support relating to prescriptions, ordering and additional ancillaries such as
lines and pen needles:
0800 254 0176 (Monday-Friday: 08h00-16h00)
Adverse Events
Any adverse events should be reported to your healthcare professional. You can
also report adverse events directly via the Yellow Card Scheme at
www.yellowcard.mhra.gov.uk
Adverse events should also be reported to Medical Information on:
0800 254 0174 or
[email protected]
By reporting adverse events you can help provide more information on the safety
of this medicine.
Very common side effects include hallucinations and injection site reactions. If
you experience these side effects, please discuss them with your healthcare
professional.
Please visit d-minecare.co.uk for instructional videos and any further support
you may need during your Dacepton®journey.