Knauer Azura CT 2.1 User manual

Column Thermostat CT 2.1
Instructions
Document no. V6811
HPLCHPLC

Note: For your own safety, read the instructions and follow the warnings
and safety information on the device and in the instructions.
Keep the instructions for future reference.
Note: In case you require this instruction in another language, please
submit your request including the corresponding document number via
e-mail or fax to KNAUER.
Do you have questions about the installation or the operation of your
instrument or software?
International Support:
Contact your local KNAUER partner for support:
www.knauer.net/en/Support/Distributors-worldwide
Support in Germany
(Austria & Switzerland on case-to-case basis):
Phone: [phone] (workdays 9-17h CET)
Fax: [phone]
E-mail: [e-mail]
KNAUER Wissenschaftliche Geräte GmbH
Hegauer Weg 38
14163 Berlin
Germany
Phone: [phone]
Fax: [phone]
Internet: www.knauer.net
E-mail: [e-mail]
Document number: V6811
Version number: 1.5
Release date: June 26, 2023
Translation of the original edition
These instructions apply to products with the product number:
ATCXXYYZZ
The information in this document is subject to change
without prior notice. For the latest version of the instructions,
visit our website: www.knauer.net/library.
These instructions are printed on recycled paper that has been awarded
the Blue Angel.
This document contains confidential information and may not be
reproduced without written consent of KNAUER Wissenschaftliche
Geräte GmbH.
© KNAUER Wissenschaftliche Geräte GmbH 2023
All rights reserved.
AZURA® is a registered trademark of
KNAUER Wissenschaftliche Geräte GmbH.
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i
AZURA® Column Thermostat 2.1 Instructions, V6811
Table of contents
1. General ...........................................................................1
1.1 About these instructions..................................................1
1.2 Signal words ............................................................1
1.3 Additional typographical conventions ......................................1
1.4 Legal information ........................................................2
1.4.1 Liability limitation.................................................2
1.4.2 Transport damage ................................................2
1.4.3 Warranty conditions ..............................................2
1.4.4 Declaration of conformity..........................................2
2. Basic safety instructions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
2.1 Intended use ............................................................3
2.1.1 Operating ranges ................................................3
2.1.2 Foreseeable misuse...............................................3
2.2 User qualification ........................................................3
2.3 Operator responsibility ...................................................4
2.4 Personal safety equipment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
2.5 Safety features on the device ..............................................4
2.6 Working with solvents ....................................................5
2.6.1 General requirements.............................................5
2.6.2 Contamination by health-threatening solvents ........................5
2.6.3 Avoiding leakage.................................................5
2.7 Specific environments ....................................................5
2.7.1 Earthquake-endangered areas .....................................5
2.7.2 Explosive environment ............................................6
2.7.3 Cooling room ....................................................6
2.7.4 Wet room .......................................................6
2.8 Maintenance, care, and repair .............................................6
2.9 Service request form .....................................................6
3. Product information.................................................................7
3.1 General ................................................................7
3.1.1 Optional accessories..............................................7
3.1.2 GLP data ........................................................7
3.2 Scope of delivery ........................................................7
3.3 Views ..................................................................8
3.4 Symbols and signs .......................................................9
4. Installation and initial startup .......................................................11
4.1 Unpacking .............................................................11
4.2 Ambient conditions .....................................................11
4.2.1 Operation site ..................................................11
4.2.2 Ambient temperature ............................................11
4.2.3 Space requirements .............................................12

ii Table of contents
AZURA® Column Thermostat 2.1 Instructions, V6811
4.3 Power supply...........................................................12
4.4 Computer control.......................................................13
4.4.1 Setting up LAN..................................................13
4.4.2 Configuring LAN settings.........................................13
4.4.3 Connecting devices with LAN .....................................14
4.4.4 Configuring the router ...........................................14
4.4.5 Integrating LAN into the company network .........................15
4.4.6 Controlling several systems separately in LAN .......................15
4.5 Setting IP addresses via software .........................................16
4.5.1 Mobile Control: Setting a static IP address ..........................16
4.5.2 Mobile Control: Setting a dynamic IP address via device name.........17
4.5.3 Mobile Control: Setting a dynamic IP address via device serial number..17
4.5.4 Firmware Wizard: Setting a static IP address.........................18
4.5.5 Firmware Wizard: Setting a dynamic IP address ......................19
4.6 Installing cartridge for eluent pre-tempering ...............................20
4.6.1 Mounting column to precolumn tempering..........................20
4.7 Capillary guide .........................................................21
5. Operation ........................................................................22
5.1 Initial start-up ..........................................................22
5.2 Switching on ...........................................................22
5.3 Control with chromatography software ....................................22
6. Functionality tests .................................................................23
6.1 Installation Qualification (IQ) .............................................23
6.2 Operation Qualification (OQ).............................................23
7. Troubleshooting ...................................................................24
7.1 L AN...................................................................24
7.2 Possible problems and solutions ..........................................25
7.3 Error messages.........................................................25
7.4 Replacing fuses.........................................................26
8. Maintenance and care..............................................................27
8.1 Maintenance contract ...................................................27
8.2 Cleaning and caring for the device ........................................27
8.3 Removing a leak ........................................................27
8.4 Testing the leak sensor ..................................................28
9. Transport and storage..............................................................29
9.1 Taking the device out of operation ........................................29
9.2 Packing the device ......................................................29
9.3 Transporting the device .................................................29
9.4 Storing the device ......................................................29

Table of contents iii
AZURA® Column Thermostat 2.1 Instructions, V6811
10. Disposal ..........................................................................30
10.1 AVV-Marking Germany ..................................................30
10.2 WEEE registration number ...............................................30
10.3 Eluents and other operating materials .....................................30
11. Technical data.....................................................................31
11.1 Main features...........................................................31
11.2 Communication ........................................................31
11.3 General ...............................................................31
12. Repeat orders .....................................................................32
12.1 Device ................................................................32
12.2 Accessories and spare parts..............................................32
13. Index.............................................................................33

AZURA® Column Thermostat 2.1 Instructions, V6811

1
AZURA® Column Thermostat 2.1 Instructions, V6811
1. General
1.1 About these instructions
These operating instructions enable the safe and efficient operation of
the device. The user must have carefully read and understood these ope-
rating instructions before starting any work.
The basic prerequisite for safe operation is compliance with all safety
instructions (see “2 Basic safety instructions“, p. 3). In addition to the
safety and warning instructions in these operating instructions, the local
accident prevention regulations and the national industrial safety regulati-
ons apply.
These operating instructions are an integral part of the device. It must be
kept in the immediate vicinity of the device and accessible to the user at
all times.
You can download these and other instructions from the KNAUER web-
site: www.knauer.net/library
1.2 Signal words
Possible dangers related to the device are distinguished in personal and
material damages.
Symbol Meaning
DANGER (red) indicates a highly hazardous situation.
If not avoided, it will result in death or serious injury.
WARNING (orange) indicates a hazardous situation.
If not avoided, it could result in death or serious
injury.
CAUTION (yellow) indicates a moderate hazardous
situation. If not avoided, it could result in minor or
moderate injury.
NOTICE (blue) is used to address issues which are
not related to physical injury.
1.3 Additional typographical conventions
General equal treatment: When persons are described, this document
uses the male grammar form to keep the text easy to read. The form
has a neutral sense and speaks to people of any gender in the same
way.
Note: Specific information are prefixed with the word “Note” and an
information icon.
Note: This is an example.

AZURA® Column Thermostat 2.1 Instructions, V6811
2 General
1.4 Legal information
1.4.1 Liability limitation
The manufacturer is not liable for the following issues:
Non-compliance of these instructions
Non-observance of necessary safety precautions
Improper use
Operation of the device by unqualified personnel
(see “2.2 User qualification“, p. 3)
Use of non-approved spare parts
Technical changes by the user such as opening the device and
unauthorized modifications
Violations of General Terms and Conditions (GTC)
1.4.2 Transport damage
The packaging of our devices provides the best possible protection
against transport damage. However, check the packaging for transport
damage. In case you notice any damage, inform the Technical Support
and the shipping company within three workdays.
1.4.3 Warranty conditions
For information on warranty please refer to our general terms and condi-
tions on the website: www.knauer.net/terms
1.4.4 Declaration of conformity
The declaration of conformity is enclosed as a separate document with
the product and can be obtained online:
www.knauer.net/en/Support/Declarations-of-conformity

3
AZURA® Column Thermostat 2.1 Instructions, V6811
2. Basic safety instructions
The device has been developed and constructed in such a way that ha-
zards arising from its intended use are largely excluded. Nevertheless, the
following safety instructions must be observed in order to exclude residu-
al hazards.
2.1 Intended use
Only use the device for applications that fall within the range of the inten-
ded use. Otherwise, the protective and safety equipment of the device
could fail.
2.1.1 Operating ranges
The device is intended to be used for chromatographic applications in
the laboratory.
2.1.2 Foreseeable misuse
Refrain from the use of the device for the following purposes or
conditions:
Medical purposes. The device is not approved as a medical product.
Operating outside of a laboratory or measurement room. Otherwise,
the manufacturer does not guarantee the functionality and safety of
the device.
Operation in potentially explosive areas without special and additio-
nal explosion protection. Contact the KNAUER Customer Support for
more information.
2.2 User qualification
The user is qualified to handle the device if all of the following points
apply:
The user has at least a basic knowledge of liquid chromatography.
The user has knowledge about the properties of the used solvents and
their health risks.
The user is trained for the special tasks and activities in the laboratory
and knows the relevant standards and regulations.
Due to technical training and experience, the user can understand and
carry out all the work described in the operating instructions on the
instrument and recognize and avoid possible dangers independently.
The users ability to react is not impaired by the consumption of drugs,
alcohol or medication.
Participation in the installation of a device or a training by the company
KNAUER or an authorized company.
If the user does not meet these qualifications, the supervisor has to be
informed.

AZURA® Column Thermostat 2.1 Instructions, V6811
4 Basic safety instructions
2.3 Operator responsibility
The operator is any person who operates the device himself/herself or
leaves it to a third party for use and who bears the legal product responsi-
bility for the protection of the user or third parties during operation.
The obligations of the operator are listed below:
Know and follow the applicable work safety regulations.
Identify hazards arising from the working conditions at the place of use
in a risk assessment.
Set up operating instructions for the operation of the device.
Regularly check whether the operating instructions correspond to the
current status of the regulations.
Clearly regulate and specify responsibilities for installation, operation,
troubleshooting, maintenance and cleaning and set clear rules.
Ensure that all personnel who work with the device have read and
understood these operating instructions.
Train the personnel who work with the device at regular intervals and
inform them about the dangers.
Provide the necessary safety equipment to the employees working
with the unit (see section below).
2.4 Personal safety equipment
The protective measures required in the laboratory must be observed
and the following protective clothing worn during all work on the device:
Safety glasses with side protection.
Protective gloves in accordance with the prevailing ambient conditions
and used solvents (e.g. heat, cold, protection against chemicals).
Lab coat.
Personalised protective safety equipment which is specified in the
particular laboratory.
2.5 Safety features on the device
Power switch: Devices of the AZURA® L series may be switched off
using the power switch (toggle switch on the back side of housing) at
any time, this causes no damage to the device. To switch off devices of
the AZURA® S series, remove the plug from the power socket.
Front cover as a splash protection for the user.
Leak tray: Devices of the AZURA® L series have a leak tray on the front
side. The leak tray collects leaking solvents and protects components
from potential damage caused by discharging liquid.
For the detectors AZURA DAD 2.1L, DAD 6.1L und MWD 2.1L, the
lamp switches off automatically when the cover is opened.