Leica IP S User manual

Instructions for Use
Leica IP S -
Printer for slides
Leica IP S, V 1.9 RevD, English – 05/2013
Order No: 14 0601 85101, RevD

Leica IP S
Printer
for slides
Instructions for Use
Leica IP S
Order No. 14 0601 85101 RevD
V 1.9 RevD, English - 05/2013
Always keep this manual with the instrument.
Read carefully before working with the instrument.

3
Leica IP S
The information, numerical data, notes and value
judgments contained in this manual represent
the current state of scientific knowledge and
state-of-the-art technology as we understand it
following thorough investigation in this field.
We are under no obligation to update the pres-
ent manual according to the latest technical
developments, nor to provide our customers with
additional copies, updates etc. of this manual.
For erroneous statements, drawings, technical
illustrations etc. contained in this manual we
exclude liability as far as permissible accord-
ing to the national legal system applicable in
each individual case. In particular, no liability
whatsoever is accepted for any financial loss or
consequential damage caused by or related to
compliance with statements or other information
in this manual.
Statements, drawings, illustrations and other
information as regards contents or technical
details of the present manual are not to be
considered as warranted characteristics of our
products.
These are determined only by the contract
provisions agreed between ourselves and our
customers.
Leica reserves the right to change technical
specifications as well as manufacturing process-
es without prior notice. Only in this way is it pos-
sible to continuously improve the technology and
manufacturing techniques used in our products.
This document is protected under copyright laws.
All copyrights of this document are retained by
Leica Biosystems Nussloch GmbH.
Any reproduction of text and illustrations (or of
any parts thereof) by means of print, photocopy,
microfiche, web cam or other methods—includ-
ing any electronic systems and media—requires
express prior permission in writing by Leica
Biosystems Nussloch GmbH.
For the instrument serial number and year of
manufacture, please refer to the name plate at
the back of the instrument.
© Leica Biosystems Nussloch GmbH
NOTE
Leica Biosystems Nussloch GmbH
Heidelberger Str. 17 - 19
D-69226 Nussloch
Germany
Phone: [phone]
Fax: [phone]
Internet: http://www.LeicaBiosystems.com

4Instructions for Use V 1.9 RevD - 05/2013
Table of contents
1. Important Information ............................................................................................................... 6
1.1 Symbols in the text and their meanings.................................................................................... 6
1.1.1 Symbols on the transport packaging and their meanings..................................................... 7
1.2 Qualification of personnel........................................................................................................... 8
1.3 Intended use of instrument......................................................................................................... 8
1.4 Instrument type............................................................................................................................. 8
2. Safety ........................................................................................................................................... 9
2.1 Safety instructions........................................................................................................................ 9
2.2 Warnings...................................................................................................................................... 10
3. Instrument Components and Specifications....................................................................... 12
3.1 Overview—instrument............................................................................................................... 12
3.2 Technical data............................................................................................................................. 14
3.3 Print specifications..................................................................................................................... 16
3.3.1 Requirements for specimen slides .......................................................................................... 16
3.3.2 Print specifications..................................................................................................................... 18
3.3.3 Printing bar code ........................................................................................................................ 19
3.3.4 Resistance against reagents.................................................................................................... 21
4. Instrument Setup...................................................................................................................... 22
4.1 Site requirements ....................................................................................................................... 22
4.2 Unpacking the Instrument......................................................................................................... 22
4.3 Installing the printer................................................................................................................... 24
4.4 Standard delivery—packing list............................................................................................... 25
4.5 Installing the manual unload station ....................................................................................... 26
4.6 Automated unload station (optional)....................................................................................... 27
4.7 Installing/exchanging the flash bulb ....................................................................................... 28
4.8 Filling and inserting the magazines ......................................................................................... 30
4.9 Electrical connection................................................................................................................. 32
4.10 Exchanging the cartridge.......................................................................................................... 33
4.11 Installing the printer driver........................................................................................................ 37
5. Operation................................................................................................................................... 40
5.1 Control panel functions.............................................................................................................. 40
5.2 Display indications ..................................................................................................................... 45
5.3 Alarm functions........................................................................................................................... 47
5.4 Printer driver settings ................................................................................................................ 48

5
Leica IP S
Table of contents
6. Cleaning and Maintenance.................................................................................................... 51
6.1 Cleaning the instrument............................................................................................................. 51
6.2 Clean print head.......................................................................................................................... 53
6.3 General maintenance................................................................................................................. 54
6.4 Storing the printer....................................................................................................................... 55
7. Troubleshooting ....................................................................................................................... 59
7.1 Malfunctions................................................................................................................................ 59
7.2 Status messages......................................................................................................................... 60
7.3 Error messages........................................................................................................................... 61
7.4 Changing the flash bulb............................................................................................................. 64
7.5 Power failure............................................................................................................................... 64
7.6 Replacing the fuses.................................................................................................................... 65
8. Warranty and Service ............................................................................................................. 66

6Instructions for Use V 1.9 RevD - 05/2013
1.1 Symbols in the text and their meanings
(5)
LOAD
Manufacturer
CE labeling shows that the product
corresponds to one or more applicable
European directives.
Environmental protection symbol of the
China RoHS directive. The number in
the symbol indicates the "Environment-
friendly Use Period" of the product. The
symbol is used if a substance restricted
in China is used in excess of the maxi-
mum permitted limit.
Symbol for labeling electrical and elec-
tronic equipment in accordance with
Section 7 of the German Electrical and
Electronic Equipment Act (ElektroG). Ele-
ktroG is the law regarding the sale, re-
turn and environmentally sound disposal
of electrical and electronic equipment.
Warnings
appear in a gray box and are marked by
a warning triangle .
Notes
i.e. important user information appear
in a gray box and are marked by an in-
formation symbol .
Inflammable solvent and reagents are
marked with this symbol.
Instrument surfaces which become hot
during operation are marked with this
symbol.
Avoid direct contact with these surfac-
es - they may cause burns.
REF
SN
Observe the Instructions for Use.
Designates the serial number of the
instrument.
Order number for standard delivery or
accessories.
Symbol for alternating current
Warning – Dangerous electrical volt-
age.
Numbers and parentheses refer to item
numbers in the illustrations.
Function keys to be pressed on the
touch screen are written in bold-print
capital letters.
1. Important Information

7
Leica IP S
1. Important Information
The package contents are fragile and
must be handled with care.
Indicates the correct upright position of
the package.
The package must be kept in a dry
environment.
Example of labeling
in accordance with
IPPC
Package labeling in accor-
dance with German Hazard-
ous Freight Ordinance Road
and Rail (GGVSE)/European
Agreement concerning the
International Carriage of
Dangerous Goods by Road
(ADR) for transporting haz-
ardous goods.
Class 3: "FLAMMABLE
LIQUID" - Flammable liquid
substance.
Tip-n-Tell indicator to moni-
tor whether the shipment
has been transported and
stored in upright position
according to your require-
ments. With a pitch of 60° or
more, the blue quartz sand
flows into the arrow-shaped
indicator window and sticks
there permanently. Improp-
er handling of the shipment
is immediately detectable
and can be proven defini-
tively.
• IPPCsymbol
• Countrycode inaccordance withISO 3166,
e.g. DE for Germany
• Regionalidentifier,e.g.HEforHessen
• Producer/treatmentprovider code,unique
assigned number starting with 49
• Treatmentcode,e.g.HT(heattreatment),MB
(methyl bromide), and possibly DB (debarked)
1.1.1 Symbols on the transport packaging and their meanings

8Instructions for Use V 1.9 RevD - 05/2013
1.4 Instrument type
All information provided in these Instructions for
Use applies only to the instrument type indicated
on the cover page.
A name plate indicating the instrument serial
number is attached to the back of the instrument.
Fig. 1
1.2 Qualification of personnel
• TheLeicaIPSmay beoperatedby trained
laboratory personnel only.
• Alllaboratorypersonneldesignatedtooperate
this instrument must read these Instructions
for Use carefully and must be familiar with all
technical features of the instrument before
attempting to operate it.
Fig. 1 is provided as an example only
and shows a valid nameplate for this
instrument with the necessary in-
formation about instrument type and
power requirement. The precise data
for the various versions is specified in
Chapter 3.2, "Technical data".
1. Important Information
1.3 Intended use of instrument
Leica IP S printer system for standard specimen
slides.
• Theinstrumenthas beendesigned foruse
in pathology, histology, cytology, toxicology
and similar laboratories, and there only for
standard specimen slides.
• Imprintsofadequate qualityand resistance
to subsequent processing in tissue proces-
sors can only be guaranteed when using the
specimen slides and reagents specified in
Chapter 3.3.
• Theinstrumentmustbeusedexclusivelyac-
cording to the instructions contained in these
Instructions for Use.
Proper and intended use includes the
observance of all instructions in the
Instructions for Use and compliance
with all inspection and maintenance
instructions.
Any other use of the instrument is
considered improper!

9
Leica IP S
2. Safety
2.1 Safety instructions
These Instructions for Use include important
instructions and information related to the oper-
ating safety and maintenance of the instrument.
The Instructions for Use are an important part of
the product, and must be read carefully prior to
startup and use and must always be kept near
the instrument.
This instrument has been built and tested in ac-
cordance with the safety regulations for electri-
cal measuring, control, regulating and laboratory
devices.
To maintain this condition and ensure safe
operation, the user must observe all notes and
warnings contained in these Instructions for Use.
Make sure to comply with the safety instructions and warnings in this chapter.
Make sure to read these instructions, even if you are already familiar with the operation and
use of other products.
These Instructions for Use must be appropriately supplemented as required by the existing reg-
ulations on accident prevention and environmental safety in the operator's country.
The protective devices on both instrument and accessories may neither be removed nor modi-
fied. Only authorized and qualified service personnel may access and repair the internal com-
ponents of the instrument.
For current information about applicable guidelines, please refer to the CE declaration of con-
formity and on our Internet site at:
http://www.LeicaBiosystems.com
Use only the provided power cable - this must not be replaced with a different power cable. If
the power plug does not fit in your socket, contact our service.
Residual risks
The instrument has been designed and constructed with the latest state-of-the-art technology
and according to recognized standards and regulations with regard to safety technology. Op-
erating or handling the instrument incorrectly can place the user or other personnel at risk of
injury or can cause damage to the instrument or other property. The machine may be used only
as intended and only if all of its safety features are in proper working condition. Malfunctions
that impede safety must be remedied immediately.

10 Instructions for Use V 1.9 RevD - 05/2013
2. Safety
Warnings—Transport and Installation
• Once unpacked, the instrument may be transported only in an upright position.
• Do not expose the instrument to direct light (window, lamps with strong light)!
• Only connect the instrument to a grounded power socket. Do not interfere with the grounding
function by using an extension cord without a ground wire.
• Do not operate the instrument in rooms with explosion hazard.
• Condensation water may form in the instrument, if there is an extreme difference in tempera-
ture between the warehouse and the installation site and if air humidity is high at the same
time. If this is the case, wait at least two hours before switching on the instrument. Failure to
adhere to this waiting period may result in damage to the instrument.
• Markings on the instrument showing the warning triangle indicate that the correct operating
instructions (as defined in these Instructions for Use) must be followed when operating or
replacing the item marked.
• Failure to adhere to these instructions may lead to accidents causing personal injury and/or
damage to the instrument or accessories or destroyed, unusable slides.
• Some instrument surfaces become hot during operation. They are marked with this warning
label. Touching these surfaces may cause burns.
Warnings—Markings on the instrument itself
2.2 Warnings
The safety devices installed in this instrument by the manufacturer only constitute the basis for
accident prevention. Primarily responsible for accident-free operation is above all the institution
which owns the instrument and, in addition, the designated personnel who operates, services
or repairs the instrument.
To ensure trouble-free operation of the instrument, make sure to comply with the following
instructions and warnings.

11
Leica IP S
Warnings—Instrument operation
Warnings—Cleaning and maintenance
• Before any maintenance, switch off the instrument and unplug it from power supply.
• To clean the exterior surfaces, use a mild and ph-neutral commercial household cleaner.
You may NOT use: Alcohol, cleaning materials containing alcohol (glass cleaner!), abra-
sives, or solvents containing acetone or xylene!
• The painted surfaces and the control panel of the instrument are not resistant to xylene or
acetone!
• While working and during cleaning, no liquid may get into the interior of the instrument.
2. Safety
• The instrument may be operated by trained laboratory personnel only. It must only be operat-
ed for the purpose of its designated use and according to the instructions contained in these
Instructions for Use.
• The instrument is de-energized after disconnection of the power supply through the power
cable (power supply circuit breaker) - in emergencies, disconnect the power plug.
• Do not touch the chute during operation. Risk of injury.
• Do not open the reflector flap of the flashlight while the instrument is ON—risk of burns and
blinding.
• The device operator is obligated to conform to the local workplace limit values and to docu-
ment them.

12 Instructions for Use V 1.9 RevD - 05/2013
3. Instrument Components and Specifications
Fig. 2
2
3
5
1
3.1 Overview—instrument
1 - Basic instrument
2 - Slide Magazines
2.1- Magazine no. 1
3 - Control panel
4 - Lid
5 - Cover—cartridge slot
6 - Unload station (manual)
4
6
2.1

13
Leica IP S
3. Instrument Components and Specifications
Fig. 4Fig. 3
Rear panel and electrical connectionsFront view without lid
9
12
7 8 10
13
2.1 -2.3
11
3
2
1
2.1-2.3- Magazine receptacles nos. 1 - 3
7 - Drying module
8 - Cover—flash bulb
9 - Cassette carrier
10 - Print head
11 - Magazine holder
12 - Feeding chute with cover
13 - Transfer point: chute --> cassette
carrier, with sensor
14 - Location plate
15 - External alarm jack
16 - Socket for printer cable
17 - DIL switch
18 - Power supply connection
19 - Power switch
20 - Cleaning cartridge
21 - Secondary fuses
22 - Drawer for broken glass
21 19 18 20 22
16
15
17
14
Attention for pos. 20.
The instrument is delivered with the
storage cartridge installed!
Prior to operation, the cleaning car-
tridge must be exchanged for an ink
cartridge - see Chapter 4.10, "Exchang-
ing the cartridge".

14 Instructions for Use V 1.9 RevD - 05/2013
3. Instrument Components and Specifications
3.2 Technical data
General
Approvals: The instrument-specific approval marks are located at the rear panel
of the instrument, next to the name plate.
Nominal supply voltages: 100 to 120 V ~ +/- 10 %
200 to 240 V ~ +/- 10 %
Nominal frequency: 50 to 60 Hz
Power fuse: 2x T 3.15 A L250 V
Maximum power draw at 100 - 120 V: 4.0 A
Maximum power draw at 200 - 240 V: 2.8 A
Leakage current at 240 V/50 Hz: ca. 2.4 mA
Nominal power: 700 VA
IEC 1010 classification: Protection class 1, pollution degree 2
Overvoltage installation category II
Operating elevation: up to max. 2000 m NN
A-weighted noise level: < 70 dB (A)
IP protection class (IEC 60529) IP20
Climatic conditions for the operation of the instrument:
Temperature: +15 °C to +30 °C
Relative humidity: 20 - 80 % - non-condensing
Climatic conditions for the storage and transport of the packaged instrument:
Storage temperature range: +5 °C to +40 °C
Transport temperature range: -29 °C to +40 °C
Relative humidity: 10 - 85 % - non-condensing
Dimensions and weight
Dimensions of basic instrument
Width x depth: 475 x 650 mm
Height with magazine: 560 mm
Dimensions with unload station connected
Width x depth: 548 x 650 mm
Height with magazine: 655 mm
Basic instrument empty weight: approx. 28 kg
Weight, packed: approx. 65 kg
Unload station empty weight: approx. 14 kg
Weight, packed: approx. 32 kg

15
Leica IP S
Performance
Load capacity: up to 3 magazines,
up to 150 slides per magazine
Printing speed 1:
Printing batch jobs: 14 slides/minute
(two-line printing)
Single-cassette printing: 10 s per slide
Ink cartridge capacity 2: approx. 60,000 printouts or 3.5 months
Flash bulb lifetime: approx. 150,000 flashes
Printing
Print resolution 3: 360 x 360 dpi / 180 x 180 dpi, adjustable
Printing medium: Glass specimen slide with coated field
76 x 26 mm, max. 1.2 mm thick
Print format: Slide
Pressure surfaces: max. 25.4 x 18.0 mm
PC system requirements
IBM-compatible PC
Processor clock frequency: min. 800 Mhz
Main memory (RAM): min. 256 MB
Hard disk: min. 6 GB
CD-ROM drive
1 free serial port
Operating system: Windows NT, Windows 2000, Windows XP
Windows VISTA, Windows 7 (32 bit and
64 bit)
1) Average value—exact speed in each individual case depending on system configuration and the
software used.
2) Average value—exact number of cassettes in each individual case depending on quantity being
imprinted and on density of imprint.
3) Measured in addressable dots per inch
3. Instrument Components and Specifications

16 Instructions for Use V 1.9 RevD - 05/2013
The texture of the slide print surface is extremely
important for optimal print quality and durability.
The print surface varies considerably between
manufacturers, color selection and coated (posi-
tively charged) versus uncoated surfaces.
They can even vary greatly from slide to slide in
the same lot. Colored print surfaces, other than
pure white, contain pigments that help the ink
spread evenly and adhere strongly.
3. Instrument Components and Specifications
Fig. 5
3.3 Print specifications
Only standard specimen slides with imprint-
able colored edges (23) can be imprinted in the
Leica IP S (see Fig. 5).
Printing directly onto the glass is not possible.
Specimen slides with the following dimensions
can be processed: 76 x 26 mm, max. 1.2 mm thick.
23
3.3.1 Requirements for specimen slides
• Toreducetheamountofglassdustandthe
risk of mechanical failures, use only clipped
corner slides (45° angle on each corner, Fig. 5).
• Slides tobe usedin theprintersmust be
stored appropriately in closed containers and
protected from dust and moisture.
• Positivelychargedslidesareinherentlysticky
so they require special handling to insure reli-
able mechanical handling by the instrument.
• Whentheprintjobiscomplete,theprintedsur-
face of the slide may be handled immediately.
Please be aware, however, that the special
ink is alcohol-based and exposure to alcohol
in combination with physical contact (rub-
bing) could cause the print quality to degrade
significantly.
Specimen slides with a white printed surface
should be checked for print quality and ink resis-
tance before purchase.
Some slides have been coated over the print
surface as well as the glass, which can create
problems with the adherence of the ink. These
slides should also be tested for print quality and
ink adherence before purchase.

17
Leica IP S
3. Instrument Components and Specifications
Tested and recommended print media for the Leica IP S ink jet printer
Specimen slides recommended by Leica are:
• LeicaSnowcoat® Clipped Corner Slide
• LeicaClipped Corner X-tra ®Adhesive Slides
Important!
The use of other print media may result in unsatisfactory print quality and/or jamming of slides/
cassettes during the printing process!
If the specimen slides you are currently using are not listed above, please contact your local
Leica Biosystems representative.
Caution!
Slides made by other manufacturers must be tested before use.
The test must include the following steps:
Mechanical compatibility with the instrument.
Imprint quality.
Chemical and mechanical resistance of the imprints against the reagents the slides will be
exposed to during the subsequent processing steps (see also Chapter 3.3.4).
Important!
Leica Biosystems assumes no responsibility whatsoever for any damages suffered as a conse-
quence of imprints of poor quality or imprints made with non-reagent-resistant ink.

18 Instructions for Use V 1.9 RevD - 05/2013
3.3.2 Print specifications
3. Instrument Components and Specifications
Width Height
Format Dots mm Dots mm
Slide 360 25.4 256 18.0
Print resolution
The print head of the instrument has a preset
resolution of 360 dpi in both directions (vertical
and horizontal).
Each printed line has a maximum height of
128 dots.
This corresponds to a value of 9.03 mm.
Therefore, a maximum of 2 lines can be printed
on the slides.
In horizontal direction, the printable surface is
limited only by the size of the object to be im-
printed (Fig. 6).
The above values must be taken into consider-
ation when defining the print area ("paper size")
in the application you are going to print from.
Printing area
The printing area parameters listed in the table
below are defined in the printer driver.
24
Fig. 6
Print quality
Quality and resolution of the imprints depend on:
• thematerialoftheimprintablesurface/thedyesusedtocolortheimprint-
able surface.
• thestructureoftheimprintablesurface(24).
The final resolution of the imprints is not determined only by the resolution
of the print head.
If the slide surface is not capable of 360 dpi resolution, "running" ink will
lead to poor printing results. In such cases it is better to work at a lower
resolution.
The printer driver allows you to change the resolution from 360 dpi to
180 dpi.
(For more information, see Chapter 5.4).