MABTECH ASTOR 2 User manual

Operating Instructions
Mabtech ASTOR™ 2
ELISpot reader
© 2023 Mabtech

Table of Contents
Introduction ��������������������������������������������������������������������������������� 3
Intended use ������������������������������������������������������������������������������������������������������ 3
Symbols��������������������������������������������������������������������������������������������������������������� 3
Labels ������������������������������������������������������������������������������������������������������������������ 3
Contact information ������������������������������������������������������������������������������������������ 3
Regulatory information �������������������������������������������������������������� 4
Quality Management System (QMS) ��������������������������������������������������������������� 5
Safety �������������������������������������������������������������������������������������������� 6
Product description��������������������������������������������������������������������� 8
Overview ������������������������������������������������������������������������������������������������������������� 8
In this package ��������������������������������������������������������������������������������������������������� 8
Cleaning/Decontamination������������������������������������������������������������������������������� 9
Disposal��������������������������������������������������������������������������������������������������������������� 9
Warranty�������������������������������������������������������������������������������������������������������������� 9
Technical specications ������������������������������������������������������������ 10
Setup and installation ��������������������������������������������������������������� 11
How to use the Mabtech ASTOR™ 2 reader ��������������������������� 14
Service, maintenance, and transport�������������������������������������� 16
To replace the fuses����������������������������������������������������������������������������������������� 17

3
Introduction
Intended use
Mabtech ASTOR™ 2: Detection of secreting cells in ELISpot assay� For research use only�
Symbols
These symbols are shown on the reader:
Symbols Description
Complies with the directives
listed under “Regulatory
information”
S/N Serial number
Electronic waste, disposal
according to WEEE
Warning! The operating
instructions must be consulted
in all cases where this symbol
is marked�
Labels
Machine label:
Contact information
Mabtech AB
Augustendalstorget 9
SE-131 52 Nacka Strand
Sweden
Customer service:
Phone: +46 8 716 27 00
E-mail: mabtech@mabtech�com
Mabtech ASTOR™ 2 ELISpot reader
P/N: 2001
100-240 VAC, 50-60 Hz, 0.5 A max, 100 W
Fuse: F4A H, 250 VAC, 5x20 mm
Inputs: USB 3.0
2023-XX-XX Made in Sweden
S/N: #XX
Revision: XXX
Box 1233, SE-131 28 Nacka Strand, SWEDEN
www.mabtech.com

4
Regulatory information
The Mabtech ASTOR™ 2 ELISpot reader complies with the following directives:
Directive Applied standards
CE mark for the European Economic Area (EEA)
2014/30/EU – Electromagnetic
Compatibility Directive (EMC)
• EN IEC 61326-1, edition 4:2021-06-04 & edition 3:2013-01-11
• EN 55011, edition 5:2016-04-01+A1:2017-04-21 +A11:2020-
03-06+A2:2021-04-09
• EN IEC 61000-3-2, edition 5:2019-03-01+A1:2021-04-09 &
edition 4:2014-08-22
• EN 61000-3-3, edition 3:2013-08-23+A1:2019-08-
02+A2:2021-11-05
2014/35/EU – Low Voltage Directive
(LVD)
• EN 61010-1, edition 3:2010-10-15+ A1:2019-02-22
• EN 62471, edition 1:2008-09-12
2011/65/EU – Restriction of
Hazardous Substances Directive
(RoHS)
• CENELEC EN IEC 63000, edition 1:2018-12-07
2006/42/EC – Machinery Directive
(MD)
North America
FCC Part 2 • §2�906 SDoC:2019-10-01
FCC Part 15* • §15�107:2019-10-01
• §15�109:2019-10-01
ICES-003 • Issue 7: 2020-10-15
International Standards
EMC • IEC 61326-1, edition 3:2020-10-26 & edition 2:2012-07-10
• CISPR 11, edition 6:2015-06-09+A1:2016-06-
23+A2:2019-01-18
• IEC 61000-3-2, edition 5:2018-01-26+A1:2020-07-14 &
edition 4:2014-05-26
• IEC 61000-3-3, edition 3:2013-05-14+A1:2017-05-
18+A2:2021-03-25
Safety • IEC 61010 -1, edition 3:2010-06-10+A1:2016-12-16
• IEC 62471, edition 1:2006-07-26
*This equipment has been tested and found to comply with the limits for a Class B
digital device, pursuant to part 15 of the FCC Rules� These limits are designed to provide
reasonable protection against harmful interference in a residential installation� This
equipment generates, uses, and can radiate radio frequency energy and, if not installed
and used in accordance with the instructions, may cause harmful interference to radio
communications� However, there is no guarantee that interference will not occur in a
particular installation� If this equipment does cause harmful interference to radio or
television reception, which can be determined by turning the equipment o and on, the
user is encouraged to try to correct the interference by one or more of the following

5
measures:
• Reorient or relocate the receiving antenna�
• Increase the separation between the equipment and the receiver�
• Connect the equipment into an outlet on a circuit dierent from that to which the
receiver is connected�
• Consult the dealer or an experienced radio/TV technician for help�
Quality Management System (QMS)
Standard Description
EN ISO 13485:2016, Edition 4:2016-03-02
+A11:2021-09-08
• Medical devices - Quality management systems -
Requirements for regulatory purposes
EN ISO 9001:2015, Edition 5:2015-09-15 • Quality management systems – Requirements

6
Safety
Before you install or operate the system, you must read the safety information� There
is a risk of user injury or damage to the system if the instructions in this manual are not
followed�
Warning! Risk of personal injury if instructions are not followed�
Caution! Risk of material damage if instructions are not followed�
Note: General information or advice on optimal use of the system�
Warning! The Mabtech ASTOR™ 2 ELISpot reader must only be used by
trained persons�
Warning! Do not keep or use ammable or non-ammable liquids near the
system. Risk of re.
Warning! Use caution when you eject the plate holder� The plate holder
protrudes 12 cm from the machine when fully ejected� Risk of physical injury�
Warning! Follow the instructions in this manual when you lift or move the
reader� Risk of injury to the persons or damage to the system�
Warning! Do not use the instrument near sources of strong
electromagnetic radiation (e�g� unshielded intentional RF sources), as these
can interfere with the operation of the instrument�
Warning! Do not connect faulty equipment to the system� Risk of electrical
shock and damage to the system�
Warning! Connect all cables correctly when you install the system� Risk of
electrical shock�
Warning! To disconnect power, unplug either end of the power cable� Place
the reader so that the plug can be easily separated from the wall socket�
Caution! Only use the microtiter plate types specied under “Technical
specications.” Other plates can cause malfunction and electrical failure.

7
Caution! Do not insert microtiter plates that contain liquid� Risk of short
circuit in the reader�
Caution! Do not place objects near or on the reader� Vibrations from the
reader can make objects fall�

8
Product description
Overview
Number Description Number Description
1Cover 4Programming switch*
2Power button 5USB port
3 Door to plate loader 6 IEC inlet with fuse holder
*Programming switch should be set downwards
In this package
The following parts are included in the package:
• Mabtech ASTOR™ 2 ELISpot reader
• USB cable
• Power cable
• Spare fuse
• Operating Instructions (this manual)
• MAIPSWU adapter
1
2
3
4
5
6

9
Cleaning/Decontamination
Clean the outside of Mabtech ASTOR™ 2 ELISpot reader with a damp cloth when needed�
Before you send the system to any third party, ll out a certicate of decontamination to
ensure that the instrument does not contain any potential contaminants.
Warning! The instrument may not be used with biohazardous substances�
Please note that Mabtech cannot accept any instrument or parts that may be
contaminated with biohazardous substances such as viable biological agents, harmful
quantities of chemicals, or radioactive materials.
Disposal
By the end of the reader life, recycle at a designated local reception point for
Waste Electrical and Electronic Equipment (WEEE)� You must not discard the
reader as household waste�
Warranty
Refer to the Mabtech General Terms & Conditions of Sale found on
http://www�mabtech�com/terms-and-conditions or the contractual agreement between
the seller and the buyer�
Caution! Failure to obey the instructions in this manual will void the warranty�
Caution! The safety of any system or equipment that incorporates the Mabtech
ASTOR ELISpot™ 2 reader is the responsibility of the person connecting the
reader to that system or equipment�

10
Technical specifications
Power supply
AC input voltage 100 to 240 VAC
AC input current Max 0�5 A @100–240 VAC
AC frequency 50 to 60 Hz
Power consumption 40 W max
Fuses Quick-Acting F4A H, 250 V(H = High Breaking Capacity
(Ceramic Tube))
Operation and Maintenance
Interfaces 1 USB 3�0 port
Dimensions (H × W × D) 315 mm × 430 mm × 480 mm
Weight 19�1 kg
Environmental specications For indoor use only, +5ºC to +40ºC (+41ºF to +104ºF)
Altitude up to 2000 m
Relative humidity range: 5–95%
Pollution Degree 2
Mains supply tolerance (%) or
absolute mains supply values
(voltage uctuations of the nominal
voltage)
+/-10%
Transient overvoltages Overvoltage Category II
Surge Level 3 (CM 12 ohm) & 4 (DM 2 ohm): 2 kV–
1.2/50 μs
IP class IP20
Key features
Read/calculation speed 2 min / plate
Analyze speed 3 min from system start-up to excel export
Resolution (H × W) 1200 × 1200 pixels
Approved 96-well plate types ELISpot
• MSIPS45 (ELISpot, clear)
• MSIPS4W (ELISpot, white)
• M8IPS4510 (ELISpot, strip)
• MAIPSWU10 (ELISpot, white, w/o underdrain
• MAIPS4510 (ELISpot, clear, w/o underdrain)
The Mabtech ASTOR™ 2 ELISpot reader must be connected to a computer equipped with
the Mabtech Apex™-software�

11
Setup and installation
Warning! Follow the instructions in this manual when you lift or move the
reader� Risk of injury to person or damage to the system�
Warning! Do not use or keep ammable liquids near the system. Risk of
re.
Caution! The reader is heavy� Place it on a solid table� Use two people to lift
or move the reader�
Caution! Keep other equipment more than 10 cm away from the reader�
Risk of malfunction caused by overheating�
Note: Keep the packaging in case the system needs to be sent back to
Mabtech for service�
1. Lift the Mabtech ASTOR™ 2 ELISpot
reader out of the box by the handles�
2. Place the Mabtech ASTOR™ 2 ELISpot
reader upright on a solid table� Remove
the inner packaging� Make sure that
you have received all components
specied in the section “In this
package” on page 8�

12
3. Connect the USB and power cables�
Number Description Number Description
1 Power cord ASTOR 5 Mouse cord
2USB cord 6Power cord monitor
3HDMI/ DisplayPort cable 7Power cord computer
4Keyboard cord
Warning! Do not connect faulty equipment to the system� Risk of electrical
shock and damage to the system�
Caution! Connect the Mabtech ASTOR™ 2 ELISpot reader to a grounded
outlet� The input voltage must be between 100 to 240 VAC, 50-60 Hz�
Note: In the event of power failure, the reader might have to be re-started�
1
3
2
5
6
7
4
2=

13
Note: Connect Mabtech ASTORTM 2 to the USB 3�0/3�1 port on the computer�
4. Push the button to turn on the Mabtech ASTOR™ 2 ELISpot reader�

14
How to use the Mabtech ASTOR™ 2 reader
1. Start the computer and double-click on the program symbol�
The login screen is shown�
2. Select a prole and enter your password. Click Login�
3. Double-click on the type of assay you wish to run�
4. Click Eject� The reader ejects the plate loader�

15
5. Put the microtiter plate in the plate loader�
6. In Mabtech Apex™ click Read� The reader retracts the plate loader� The microtiter plate
is read and the spots are counted�
7. Click Save and select a folder� Click Save�

16
Service, maintenance, and transport
Caution! Only use shielded signal cables that are shorter than 3 m to comply
with applicable EMC requirements� If the USB cable is longer than 2m, the
connection between the reader and the computer can stop working�
Caution! Use only the parts specied below. Using other parts will void the
warranty�
Return the equipment in the same box that it arrived in for repair/service/transport�
Environmental conditions for transport and storage should be according to IEC 60068-2
and IEC 60721-3:
• Public transportation: -40 to +70ºC
• Storage locations: -25 to +55ºC�
Only the following parts can be replaced by the user:
Part Description
Power cable • 240 V/10 A (international) or 100 V/15 A (North America)
• IEC 60320-1 C13 connector
USB cable • Shielded USB cable
• Type A 3�0 male – type B 3�0 male
• ≤2m
Fuses x 2 • Cartridge fuses SP 5×20
• 250V 4A
• IEC 60127-2
• Quick-Acting F4A, H (H = High Breaking Capacity (Ceramic Tube))
Note: All components in Mabtech ASTOR™ are compliant with RoHS(Restriction
of Hazardous Substances Directive, 2011/65/EU)�

17
To replace the fuses
Warning! Disconnect the power before replacing the fuses� Risk of electrical
shock�
1
2
3
1. Pull out the power cable from the IEC inlet�
2. Remove the fuse holder from the IEC inlet with a at screwdriver or similar tool.
3. Replace the fuses�
4. Plug the fuse holder and the power cable back in�

18

19

www�mabtech�com
Mabtech AB (Head Oce)
Sweden
Tel: +46 8 716 27 00
mabtech@mabtech�com
Mabtech, Inc.
USA
Tel: +1 513 871-4500
mabtech�usa@mabtech�com
The products are for research use only.
MABTECH shall not be liable for the use or handling of the product or for
consequential, special, indirect or incidental damages there from�
Developed and manufactured by MABTECH AB, Swe-
den, whose quality management system complies
with the standards
ISO 9001:2015 & ISO 13485:2016�
CERTIFIED
ISO 13485
Medical devices
Quality management systems
CERTIFIED
ISO 9001
Quality management systems
Operating instructions, rev� 2023-08
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