ORENCIA ClickJect User manual

Read these instructions before you use the ClickJect Autoinjector
and each time you get a refill. There may be new information. Before you use the Autoinjector for the first time,
make sure your healthcare provider shows you the right way to use it.
Important:
• Keep the ClickJect Autoinjector in the refrigerator until ready to use.
• Do not freeze.
INSTRUCTIONS FOR USE
ORENCIA®ClickJect™
(abatacept) Injection
125 mg/mL, Single-Dose Autoinjector, For Subcutaneous Use Only
eyers Squibb Company n, NJ 08543 USA e
LOT: EXP:
For Position Only
N(01)1 03 XXXX XXXX XX C
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F
N(01)
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Indication/Usage
Adult Rheumatoid Arthritis (RA): ORENCIA®(abatacept) is a prescription medicine that reduces signs and
symptoms in adults 18 years or older with moderate to severe RA, including those who have not been helped
enough by other medicines for RA. ORENCIA may prevent further damage to your bones and joints and may help
your ability to perform daily activities. In adults, ORENCIA may be used alone or with other RA treatments other
than tumor necrosis factor (TNF) antagonists.
Adult Psoriatic Arthritis (PsA): ORENCIA is a prescription medicine that reduces signs and symptoms in adults
with active psoriatic arthritis (PsA). In adults, ORENCIA may be used alone or with other PsA treatments.
Please read Important Safety Information on pages 16-18.

2
Before You Begin
Before Use
Grip
Get to know the ClickJect Autoinjector
• The Autoinjector automatically delivers the medicine. The transparent tip locks over the
needle once the injection is complete and the Autoinjector is removed from the skin.
• Do not remove the orange needle cover until you are ready to inject.
Viewing Window
Activation Button (Blue)
Expiration Date
Needle Cover (Orange Cap)

3
• Alcohol
swab
• Adhesive
bandage
• Cotton ball or gauze
• ClickJect
Autoinjector
• Sharps disposal
container
Gather supplies for your injection on a clean, flat surface
(only the ClickJect Autoinjector is included in the package):
Transparent Tip
After Use
Blue Indicator
Go to Step 1
3

4
WAIT
Minutes
30
Let your ClickJect Autoinjector warm up.
Remove one Autoinjector from the refrigerator
and let it rest at room temperature for
30 minutes.
Do not remove the Autoinjector needle cover while
allowing it to reach room temperature.
Step 1: Prepare Your Autoinjector

LOT:
EXP:
For Position Only
N(01)1 03 XXXX XXXX XX C
Liquid
Expiration Date
Examine the ClickJect Autoinjector:
• Check expiration date printed on the label.
Do not use if past the expiration date.
• Check the Autoinjector for damage.
Do not use if it is cracked or broken.
• Check the liquid through the viewing window.
It should be clear and colorless to pale yellow.
You may see a small air bubble. You do not need
to remove it. Do not inject if the liquid is cloudy,
discolored, or has particles in it.
Wash your hands well with soap and water.
Go to Step 2
5

6
Outer area of
upper arms
Caregiver ONLY
Front of thighs
Abdomen,
avoid 2 inches
around navel
Injection Areas
Self-Injection
and Caregiver
Choose your injection site
in either the stomach (abdomen), front of
the thighs, or outer area of upper arm (only
if caregiver administered).
Rotate injection site.
•Each week you can use the same area of
your body, but use a different injection site
in that area.
•Do not inject into an area where the skin is
tender, bruised, red, scaly, or hard. Do not
give the injection in any areas with scars or
stretch marks.
•Record the date, time, and site where you inject.
Step 2: Prepare for Injection
6

7
Gently clean injection site:
•Wipe the injection site with an alcohol swab and let it air dry.
•Do not touch the injection site again before giving the injection.
•Do not fan or blow on the clean area.
LOT:
EXP:
For Position Only
N(01)1 03 XXXX XXXX XX C
Remove
Needle Cover
Pull orange needle cover
STRAIGHT off.
• DO NOT RECAP the Autoinjector.
• Throw away (discard) the needle cover in your
household trash.
•Do not use the Autoinjector if it is dropped
after the needle cover is removed.
Note: It is normal to see a drop of fluid
leaving the needle.
Go to Step 3
7

8
90°
Window
Skin Pinch
Position the Autoinjector so you can see the viewing
window and it is at a 90ºangle to the injection site. With
your other hand, gently pinch the cleaned skin.
Complete all steps to deliver your full dose of medicine:
WAIT
until blue
indicator
stops
moving
P
R
E
S
S
&
H
O
L
D
Seconds
15
PUSH
DOWN
on skin
Step 3: Inject Your Dose
8

9
Press button, HOLD for 15 seconds AND watch window.
• You will hear a click as the injection begins.
• To deliver the full dose of medicine, hold the Autoinjector
in place for 15 seconds AND wait until the blue indicator
stops moving in window.
Remove the ClickJect Autoinjector from the injection site by
lifting it straight up. After you remove it from your skin, the transparent tip will
lock over the needle. Release skin pinch.
Push DOWN
on skin to unlock
the Autoinjector.
Go to Step 4
9

10
Adhesive bandage
Cotton ball or gauze
Care of injection site:
•There may be a little bleeding at the injection site. You
can press a cotton ball or gauze over the injection site.
• Do not rub the injection site.
• If needed, you may cover the injection site with an
adhesive bandage.
Step 4: After the Injection
Disposing of used ClickJect Autoinjectors:
• Put your used ClickJect Autoinjector in an FDA-cleared Sharps disposal container right away after use.
Do not throw away (dispose of) loose needles and prefilled syringes in your household trash.
• If you do not have an FDA-cleared Sharps disposal container, you may use a household container that is:
º made of a heavy-duty plastic,
º can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
º upright and stable during use,
º leak resistant, and
ºproperly labeled to warn of hazardous waste inside the container.