Qiagen Q-Base User manual

Sample to Insight__
March 2019
Q-Base
User Manual

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Contents
1Introduction .............................................................................................................4
1.1 About this user manual ...............................................................................4
1.2 Intended use of the QIAcube Connect ............................................................5
1.3 Requirements for QIAcube Connect users.......................................................6
2Safety Information....................................................................................................7
3General Description..................................................................................................7
3.1 External features of Q-Base .........................................................................8
4Installation Procedures ..............................................................................................9
4.1 Site requirements........................................................................................9
4.2 Power requirements ....................................................................................9
4.3 Connecting Q-Base to your network..............................................................9
4.4 Connecting additional tablets to an existing Q-Base......................................22
4.5 Administration of Q-Base via the Q-Base Administration Portal ......................22
4.6 Factory reset of Q-Base .............................................................................27
4.7 Insert/remove the microSD card .................................................................27
5QIAcube Connect App Features................................................................................28
5.1 Instrument status ......................................................................................28
5.2 Run setup ................................................................................................29
5.3 Maintenance ............................................................................................30
5.4 History ....................................................................................................30
5.5 In-App notification ....................................................................................30
6Troubleshooting.....................................................................................................31
6.1 General information..................................................................................31
6.2 Contacting QIAGEN Technical Services ........................................................31
6.3 FAQs ......................................................................................................31
7Glossary ...............................................................................................................33
8Appendix A – Technical Details ................................................................................34
8.1 Technical data..........................................................................................34
8.2 Declaration of Conformity..........................................................................34

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8.3 Certificates...............................................................................................34
8.4 Waste Electrical and Electronic Equipment (WEEE) .........................................34
8.5 FCC Declaration........................................................................................34
9Appendix B – Ordering Information..........................................................................35
Ordering Information..............................................................................................35
10 Revision History .....................................................................................................35

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1Introduction
Before using the Q-Base, it is essential that you read this user manual carefully and pay attention to
the safety information. The instructions and safety information must be followed to ensure safe
operation of the instrument and to maintain the instrument in a safe condition.
QIAGEN brings the QIAcube Connect customer experience to the next level with remote instrument
monitoring through the Q-Base (an IoT gateway) and the QIAcube Connect tablet application. The
gateway can be connected to one or more QIAcube Connect instruments and serves as an interface
between the instrument and the QIAcube Connect tablet application.
Schematic view of connection and data flow between Q-Base, QIAcube Connect and a tablet device
1.1 About this user manual
This user manual provides information about the QIAcube Connect in the following sections:
1. Introduction
2. Safety Information
3. General Description
4. Installation Procedures
5. QIAcube Connect App Features
6. Troubleshooting
7. Glossary
8. Appendix A – Technical Details
9. Appendix B – Ordering Information
10.Revision History

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1.1.1 Technical assistance
At QIAGEN®we pride ourselves on the quality and availability of our technical support. Our
Technical Services Departments are staffed by experienced scientists with extensive practical and
theoretical expertise in molecular biology and the use of QIAGEN products. If you have any
questions or experience any difficulties regarding the QIAcube Connect or QIAGEN products in
general, do not hesitate to contact us.
QIAGEN customers are a major source of information regarding advanced or specialized uses of
our products. This information is helpful to other scientists as well as to the researchers at QIAGEN.
We therefore encourage you to contact us if you have any suggestions about product performance
or new applications and techniques.
For technical assistance and more information, please see our Technical Support Center at
www.qiagen.com/support/technical-support or call one of the QIAGEN Technical Service
Departments or local distributors (see back cover or visit www.qiagen.com).
1.1.2 Policy statement
It is the policy of QIAGEN to improve products as new techniques and components become
available. QIAGEN reserves the right to change specifications at any time.
To produce useful and appropriate documentation, we appreciate your comments on this user
manual. Please contact QIAGEN Technical Services.
1.2 Intended use of the QIAcube Connect
Q-Base enables users to connect the QIAcube Connect App running on a tablet to their QIAcube
Connect instrument(s) via local intranet. The Q-Base interface manages the instrument data transfer
from QIAcube Connect to the QIAcube Connect App. Q-Base is connected to the user’s intranet,
for example via Wi-Fi. Once installed, Q-Base does not require regular operation or maintenance
activities.
The QIAcube Connect App and Q-Base are to be used in a laboratory setting by trained personnel.
The QIAcube Connect App and Q-Base are intended for molecular biology applications. These
products are not intended for the diagnosis, prevention or treatment of a disease.

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1.3 Requirements for QIAcube Connect users
The table below covers the general level of competence and training necessary for transportation,
installation, use, maintenance and servicing of the QIAcube Connect.
Task Personnel Training and experience
Delivery No special requirements No special requirements
Installation, routine use and
maintenance
Laboratory technicians or
equivalent
Appropriately trained
and experienced
personnel familiar with
use of computers and
automation in general
Servicing QIAGEN Field Service
Specialists only
Trained and authorized
by QIAGEN

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2Safety Information
Before installing or using Q-Base, it is essential that you carefully read the user manual provided by
the hardware supplier Eurotech and pay attention to their safety information. The instructions and
safety information in this user manual must be followed to ensure safe operation of the instrument
and to maintain the instrument in a safe condition.
The safety information for Q-Base (Eurotech – ReliaGATE 10-12) can be found at the following site:
https://www.eurotech.com/en/products/iot/multi-service-iot-edge-gateways/reliagate-10-12
3General Description
The Q-Base hardware enables connection of the QIAcube Connect App running on a tablet to
QIAcube Connect instruments via a local intranet connection. The Q-Base interface manages the
transfer of data from the QIAcube Connect instrument(s) to the QIAcube Connect App on tablet.
Q-Base can be connected to the intranet via Wi-Fi or LAN. The initial network settings of Q-Base
are configured via the QIAcube Connect App using a Bluetooth®connection between Q-Base and
the tablet or via your personal computer
The QIAcube Connect App provides real-time status monitoring of one or multiple QIAcube Connect
instrument(s). It also displays the QIAcube Connect run setup including the selected protocol and
sample number.

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3.1 External features of Q-Base
Front view of Q-Base Rear view of Q-Base
Top view of Q-Base Q-Base Wi-Fi/ Bluetooth dongle
1 RJ-45 Ethernet port (ETH 1)
Note:
The ETH1 port can be used to connect
Q-Base to your local network (LAN).
5Power cord socket
6 USB port
2 RJ-45 Ethernet port (ETH 0)
Note:
The ETH0 port can be used to
configure Q-Base from a personal computer.
Important:
Do not connect to your LAN.
7 Green LED indicator for Bluetooth on/off (first LED; USER1 LED)
8 Blue LED indicator for power on/off (last LED; POWER)
3 Two USB ports 9 Wi-Fi/Bluetooth dongle (to be inserted into one of the USB ports)
4 Service panel (includes micro SD card slot,
factory reset button and backup battery)
For more details regarding hardware features, refer to the user manual provided by Eurotech:
https://www.eurotech.com/en/products/iot/multi-service-iot-edge-gateways/reliagate-10-12
9
7
8
1
2
3
4
6
5

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4Installation Procedures
This section provides instructions to install Q-Base and connect it to the local network.
4.1 Site requirements
Q-Base must be connected to the same network as the QIAcube Connect instrument and the tablet.
Q-Base does not need to be located in close proximity to enable proper connection to the QIAcube
Connect.
4.2 Power requirements
Q-Base requires the following power supply: 100–240 V AC, 50/60 Hz
The included power supply transforms the voltage to the operational voltage of 6-36 V DC. Ensure
that the voltage rating of the Q-Base is compatible with the AC voltage available at the installation
site. Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages.
Important: The power connector is NOT protected against short circuit. Always include an external
fuse to protect the product.
Details about power supply specifications and how to supply power can be found in user manual
from Eurotech:
https://www.eurotech.com/en/products/iot/multi-service-iot-edge-gateways/reliagate-10-12
4.3 Connecting Q-Base to your network
4.3.1 Connecting Q-Base to your network using QIAcube Connect App on the tablet
This section describes how to initially set up Q-Base within your network and ensure the connection
to the QIAcube Connect instrument.
Note: If you intend to connect Q-Base to LAN, and your LAN does not support automatic assignment
of IP addresses (not supporting DHCP), support from an IT professional might be required.

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1. Insert the Wi-Fi/Bluetooth dongle into one of the Q-Base USB ports (see Section 3.1, “External
features of Q-Base”).
2. If you want to connect your Q-Base to a wired network, plug the LAN cable into ethernet
port ETH1.
Important: Do not use Ethernet port ETH0 for the LAN connection.
3. Power up the Q-Base by plugging the power cord into an appropriate power socket.
4. Turn on the tablet and activate Bluetooth function.
5. Launch the QIAcube Connect App.
Read and accept “Terms and Agreement” to proceed. “Terms and Agreement” only appears
during the first launch of the application.
6. On the tablet, press the Configuration icon ( ) to start Bluetooth scanning for Q-Base
devices.
Note: For successful Bluetooth communication between Q-Base and tablet, the devices must be
within a maximum distance of 10 meters.
7. After a few seconds, the Q-Base name will be listed under Available Q-Base devices for
configuration of network settings.
Note: If the Q-Base cannot be found, refresh the Bluetooth search by pressing the
Configuration icon again.
Note: Q-Base Bluetooth is automatically turned off after 10 minutes. The USER1 LED is
powered off (see Section 3.1, “External features of Q-Base“). To restart the initial Q-Base
configuration, restart the Q-Base by unplugging the power cord for 5 seconds.
8. Select the Q-Base name from the list to pair Q-Base with the tablet.

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9. Enter the default login details. The User Name is Admin and the Password is Qiagen123.
10.The QIAcube Connect App will prompt you to change the password. Choose a new password
according to the password guidelines described by the information box on the screen, and
then press Reset.
11.Enter the LAN or Wi-Fi settings as described in sections 4.3.1.1 or 4.3.1.2 before proceeding
with step 12.
Note: Do not press Finish Configuration before you have entered the IP address of Q-Base into
the QIAcube Connect instrument. The Q-Base IP address can be found in the information
panel on the right-hand side of the screen.

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12.Switch on the QIAcube Connect instrument and log in as an admin user.
13.On the QIAcube Connect touchscreen, select the Configuration tab, and then select the
Q-Base tab as shown below.
14.Make sure that the box next to Communication enabled is checked.

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15.Enter the Q-Base IP address in the Q-Base URL field on the QIAcube Connect touchscreen. The
IP address is shown in the QIAcube Connect App (see step 11, above, and screenshot
below). Type the IP address into the field or scan the 2-D barcode (see screenshot below).
Note: The IP address shown above is just an example.
16.Once you have entered the Q-Base IP address on the QIAcube Connect touchscreen, press
Apply to continue.
17.Press Finish Configuration on the tablet.
Important: If you don’t press Finish Configuration, the connection will only be established after
10 minutes, automatically.
Note: The first time Q-Base is configured for LAN, there may be a delay of approximately
2—4 minutes to reach the provided Q-Base URL through the tablet app.
18.Optional: Wait for 10 seconds and press Test on the QIAcube Connect touchscreen to test for
a functional connection.
19.Reboot the QIAcube Connect instrument to start the connection and receive the instrument
status.

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4.3.1.1 Connecting to WLAN/Wi-Fi
Note: Q-Base only supports connection to Wi-Fi networks with visible SSIDs and WPA2.
1. Press the WLAN tab in the QIAcube Connect App to configure the Wi-Fi connection.
2. Select the desired Wi-Fi network from the list of Available networks.
3. Once selected, enter the Wi-Fi password in the Password field.
Note: The server, SSID and security type details will be automatically filled.
4. Press Connect.
5. Proceed with step 12 in Section 4.3.1 (page 12).

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4.3.1.2 Connecting to LAN (static IP or DHCP)
•LAN Connection with static IP
Note: If you intend to connect Q-Base to a LAN that does not support automatic assignment of IP
addresses (i.e., does not support DHCP), you might require additional support from an IT
professional.
Note: When entering details into the screen above, Static IP Manual is selected by default.
1. In the IP address field in the QIAcube Connect App, enter the IP address that should be used
for the Q-Base.
2. In the Subnet mask field, enter the subnet mask that should be used for the Q-Base.
3. Optional: Enter the DNS server in the DNS server field.
4. Optional: In the Gateway field, enter the IP address of the gateway.
5. Press Connect.
6. Proceed with step 12 in Section 4.3.1 (page 12).

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•LAN connection using DHCP
1. To use DHCP-configured LAN, select DHCP in the Device network settings area of the QIAcube
Connect App.
Note: When using DHCP-configured LAN, the network settings for Q-Base will be obtained
automatically from the DHCP server. No further input is required.
2. Proceed with step 12 in Section 4.3.1 (page 12).
4.3.2 Connecting Q-Base to your network using personal computer
This section describes how to initially set up Q-Base within your network and ensure the connection
to your QIAcube Connect instrument, without using Bluetooth.
Note: If you intend to connect Q-Base to your LAN, and your LAN does not support automatic
assignment of IP addresses (not supporting DHCP), you might require support from an IT
professional.
1. To connect your Q-Base to a wired network, plug the LAN cable into ethernet port ETH1.
To connect your Q-Base to a wireless network, insert the Wi-Fi/Bluetooth dongle into one of
the Q-Base USB ports (see Section 3.1, “External features of Q-Base”).
2. Use a LAN cable to directly connect Q-Base to your personal computer using ETH0 (see
Section 3.1, “External features of Q-Base”).
Important: Do not use Ethernet port ETH0 for the LAN connection.

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3. Power up the Q-Base by plugging the power cord into an appropriate power socket.
Wait for 20 seconds. Then open a web browser (e.g., Chrome™ or Mozilla®Firefox) on your
personal computer.
Enter the URL: https://172.16.0.1.
Note: Use a recent browser. Older browsers (like Internet Explorer®) may not correctly display
all features of the Q-Base Administration Portal.
Note: Q-Base uses a self-signed certificate for the https connection. Therefore, the browser
may issue a security warning. Ignore the warning or add an exception to access the Q-Base
configuration.
The screen shown below will appear on the personal computer.
4. Enter the User Name: Admin and Password: Qiagen123.
5. The Change password screen appears as shown below. Choose a new password according
to the provided password guidelines, and then press Change Password.

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6. Once the password is changed successfully, you will be redirected to the main page of the
Q-Base Administration Portal.
7. Select Network Settings from the menu on the left-hand side.
Note: You will not be able to change any other Q-Base settings while you are connected via
ETH0 port. To access other settings, finish the network setup and then access the Q-Base
Administration Portal through your local network, as described in Section 4.5.
8. Enter the LAN or Wi-Fi settings as described in sections 4.3.2.1 or 4.3.2.2 before proceeding
with step 11.

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9. Switch on the QIAcube Connect instrument and log in as an admin user.
10.On the QIAcube Connect touchscreen, select the Configuration tab, and then select the
Q-Base tab as shown below.
11.Make sure that the box next to Communication enabled is checked.
12.Enter the Q-Base IP address in the Q-Base URL field on the QIAcube Connect touchscreen
(marked in red in the screenshot below).
Note: The IP address shown above is just an example.
13.Once you have entered the Q-Base IP address, press Apply to continue.
14.Optional: Press Test on the QIAcube Connect touchscreen to test for a functional connection.
15.Reboot the QIAcube Connect instrument to start the connection and receive the complete
instrument data.

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16.Connect your tablet to the Q-Base (refer to section 4.4).
17.In the browser: Select Sign Out on the left-hand side.
18.Close the browser.
19.Remove the cable between ETH0 and your PC.
4.3.2.1 Connecting to WLAN/Wi-Fi
Note: Q-Base only supports connection to Wi-Fi networks with visible SSIDs and WPA2.
1. Press the WLAN tab of the Q-Base Administration Portal to configure the Wi-Fi connection.
2. Press Scan to search for available Wi-Fi networks.
3. Select the desired Wi-Fi network from the list of Available networks.
4. Once selected, enter the Wi-Fi password in the Password field.
Note: The server, SSID and security type details will be automatically filled.
5. Click Connect.
6. Proceed with step 10 in Section 4.3.2 (page 19).
4.3.2.2 Connecting to LAN (static IP or DHCP)
•LAN Connection with Static IP
Note: If you intend to connect Q-Base to a LAN that does not support automatic assignment of IP
addresses (i.e., does not support DHCP), you might require additional support from an IT
professional.
Note: When entering details into the screen above, Static IP Manual is selected by default