ThermoFisher Scientific Vanquish VC-D11 User manual

thermoscientific
Vanquish
Diode Array/Multiple-
Wavelength Detectors
VC-D11, VC-D12, VF-D11
Operating Manual
4820.8302-EN Revision 2.0 •December 2019

Copyright © 2019 Thermo Fisher Scientific Inc. All rights reserved.
Original Operating Manual
The hardware descriptions in this manual revision refer to devices VC-D11-A-01, VC-D12-A-01,
VF-D11-A-01.
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Contacting Us
Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual
Page 3

Contacting Us
Page 4 Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual

Contents
Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual
Page 5
Contents
1 Using this Manual ...................................................................... 11
1.1 About this Manual ................................................................................................12
1.2 Conventions..........................................................................................................13
1.2.1 Safety Messages....................................................................................... 13
1.2.2 Special Notices and Informational Notes ................................................. 13
1.2.3 Typographical Conventions ...................................................................... 14
1.3 Reference Documentation ...................................................................................15
2 Safety......................................................................................... 17
2.1 Safety Symbols and Signal Words.........................................................................18
2.1.1 Safety Symbols and Signal Words in This Manual .................................... 18
2.1.2 Observing this Manual ............................................................................. 18
2.1.3 Safety Symbols on the Device .................................................................. 19
2.1.4 Rating Plate .............................................................................................. 19
2.2 Intended Use ........................................................................................................20
2.3 Safety Precautions................................................................................................21
2.3.1 General Safety Information...................................................................... 21
2.3.2 Qualification of the Personnel ................................................................. 22
2.3.3 Personal Protective Equipment................................................................ 22
2.3.4 Electrical Safety Precautions .................................................................... 23
2.3.5 General Residual Hazards......................................................................... 24
2.3.6 In Case of Emergency ............................................................................... 26
2.4 Solvent and Additive Information ........................................................................27
2.4.1 General Compatibility .............................................................................. 27
2.4.2 Allowed pH Ranges................................................................................... 28
2.4.3 Allowed Concentrations ........................................................................... 28
2.4.4 Further Information ................................................................................. 29
2.5 Compliance Information.......................................................................................30
3 Device Overview ........................................................................ 31
3.1 Device Features ....................................................................................................32
3.2 Operating Principle...............................................................................................34
3.3 Interior Components ............................................................................................36
3.4 Flow Cell ...............................................................................................................37
3.5 Lamps ...................................................................................................................39

Contents
Page 6 Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual
3.6 Leak Detection......................................................................................................40
3.7 Operation .............................................................................................................41
4 Unpacking .................................................................................. 43
4.1 Unpacking.............................................................................................................44
4.2 Scope of Delivery..................................................................................................47
5 Installation................................................................................. 49
5.1 Safety Guidelines for Installation .........................................................................50
5.2 Installing the Device .............................................................................................51
5.3 Site Requirements ................................................................................................53
5.3.1 Power Considerations .............................................................................. 53
5.3.2 Power Cord............................................................................................... 54
5.3.3 Condensation ........................................................................................... 54
5.4 Accessing the Interior Components .....................................................................55
5.5 Setting Up the Hardware......................................................................................56
5.5.1 System Arrangement................................................................................ 56
5.5.2 Connecting the Device ............................................................................. 57
5.5.3 Connecting the Power Cord ..................................................................... 58
5.6 Installing a VIS Lamp (Tungsten Lamp) (Optional)................................................59
5.7 Installing a Flow Cell .............................................................................................62
5.8 Setting Up the Flow Connections .........................................................................67
5.8.1 General Information and Guidelines........................................................ 67
5.8.2 Guiding Capillaries and Tubing Through the System................................ 69
5.8.3 Installing the Partition Panel Plugs........................................................... 70
5.8.4 Connecting Fittings, Capillaries, and Tubing ............................................ 72
5.8.5 Flow Connections to the Flow Cell ........................................................... 74
5.8.6 Guiding Liquid Leaks to Waste ................................................................. 78
5.9 Turning On the Device..........................................................................................79
5.10 Setting Up the Device in the Software .................................................................80
6 Operation................................................................................... 81
6.1 Introduction to this Chapter.................................................................................82
6.2 Safety Guidelines for Operation ...........................................................................83
6.3 Control Elements..................................................................................................84
6.3.1 Keypad...................................................................................................... 84
6.3.2 Status Indicators....................................................................................... 86

Contents
Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual
Page 7
6.4 Power On/Off Control ..........................................................................................87
6.5 Preparing the Device for Operation .....................................................................88
6.5.1 Guidelines for Use of Flow Cells ............................................................... 90
6.5.2 Guidelines for Use of the Lamps .............................................................. 93
6.6 Important Operating Parameters.........................................................................95
6.7 Optimizing the Performance of the Device ..........................................................99
6.7.1 General Guidelines ................................................................................... 99
6.7.2 Overview of Optimization Parameters................................................... 100
6.8 Shutting Down the Device ................................................................................. 108
6.8.1 Short-Term Shutdown (Interruption of Operation) ............................... 108
6.8.2 Long-Term Shutdown............................................................................. 109
6.8.3 Restart after Long-Term Shutdown........................................................ 112
7 Maintenance and Service ......................................................... 113
7.1 Introduction to Maintenance and Service......................................................... 114
7.2 Safety Guidelines for Maintenance and Service................................................ 115
7.2.1 General................................................................................................... 115
7.2.2 Flow Cells................................................................................................ 117
7.3 General Rules for Maintenance and Service ..................................................... 118
7.4 Routine and Preventive Maintenance............................................................... 119
7.4.1 Maintenance Plan .................................................................................. 119
7.4.2 Cleaning or Decontaminating the Device............................................... 119
7.4.3 Predictive Performance.......................................................................... 121
7.5 Performing a Wavelength Validation and Calibration....................................... 122
7.6 Lamps ................................................................................................................ 124
7.6.1 Replacing the UV Lamp (Deuterium Lamp) ............................................ 124
7.6.2 Replacing the VIS Lamp (Tungsten Lamp) .............................................. 128
7.7 Flow Cell ............................................................................................................ 131
7.7.1 Guidelines for Handling Flow Cells......................................................... 131
7.7.2 Preparing the Flow Cell for Storage ....................................................... 132
7.7.3 Cleaning the Flow Cell ............................................................................ 134
7.7.4 Removing the Flow Cell.......................................................................... 134
7.8 Diagnostic Cell ................................................................................................... 137
7.8.1 Installing the Diagnostic Cell .................................................................. 137
7.8.2 Removing the Diagnostic Cell................................................................. 139
7.9 Replacing the Waste Line .................................................................................. 140
7.10 Replacing the Main Power Fuses....................................................................... 142

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Page 8 Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual
7.11 Updating the Device Firmware.......................................................................... 144
7.12 Replacing the Doors........................................................................................... 146
7.13 Transporting or Shipping the Device ................................................................. 148
7.13.1 Preparing the Device for Transport........................................................ 148
7.13.2 Transporting the Device to a New Location ........................................... 149
7.13.3 Shipping the Device................................................................................ 150
7.14 Replacing the Slide-In Module........................................................................... 152
7.14.1 Removing the Slide-In Module ............................................................... 152
7.14.2 Returning the Slide-In Module ............................................................... 154
7.14.3 Installing the Slide-In Module ................................................................ 154
7.14.4 Setting Up the Slide-In Module .............................................................. 156
8 Troubleshooting....................................................................... 157
8.1 General Information about Troubleshooting .................................................... 158
8.2 Messages ........................................................................................................... 160
8.3 Checking the Flow Cell....................................................................................... 166
8.4 Resolving Liquid Leaks ....................................................................................... 167
9 Specifications ........................................................................... 169
9.1 Performance Specifications............................................................................... 170
9.1.1 Detector ................................................................................................. 170
9.1.2 Flow Cells................................................................................................ 173
9.2 Physical Specifications....................................................................................... 174
10 Accessories, Consumables and Replacement Parts ................... 175
10.1 General Information.......................................................................................... 176
10.2 Ship Kit............................................................................................................... 177
10.3 Optional Accessories ......................................................................................... 178
10.4 Consumables and Replacement Parts ............................................................... 179
11 Appendix.................................................................................. 181
11.1 Compliance Information.................................................................................... 182
11.1.1 Declarations of Conformity .................................................................... 182
11.1.2 WEEE Compliance .................................................................................. 183
11.1.3 FCC Compliance...................................................................................... 183
11.1.4 NIST Compliance .................................................................................... 183
11.1.5 Manual Release History.......................................................................... 184

Contents
Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual
Page 9
11.2 UV Cutoff Wavelengths of Solvents................................................................... 185
Index........................................................................................ 187

Contents
Page 10 Diode Array/Multiple-Wavelength Detectors (VC-D11, VC-D12, VF-D11)
Operating Manual