health hazard presented by such agents and should use, store,and dispose
of such samples according to the required safety regulations.
• The laboratory manager must take the necessary precautions to ensure
that the surrounding workplace is safe, and that UPHO operators are
suitably trained and not exposed to hazardous levels of infectious agents.
• When working with volatile solvents, toxic substances, etc., you must
provide an efficient laboratory ventilation system to remove steams that
may be produced.
Personal Protective Equipment (PPE)
• Operators must wear the appropriate level of personal protective
equipment as required for the particular laboratory environment in which
the System will be used. This may include: laboratory coat, gloves, safety
glasses and safety shoes.
• Operators must not operate the equipment if feeling unwell.
3. Introduction
The traditional sample grinding with a Pestle & Mortar is a very slow
method, that can only process one single sample at a time and has a high
risk of causing cross-contamination. Besides that, after such a procedure, it
is necessary to clean and disinfect the equipment. Efficient sample
disruption/grinding is a prerequisite for nucleic acid, protein and other
biomolecules extraction and purification procedures.
Incomplete sample disruption can lead to significantly reduced recovery
yields of the molecules of interest and can increase the risk of clogging
when using purification columns or magnetic particles later in the
workflow.
UPHO is a versatile bead mill device designed for rapid, efficient and
simultaneous disruption of up to 64 samples. A wide range of sample
adapters are available for UPHO providing sample flexibility and leading to
reliable and quality results.
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