Milestone HistosMATE User manual

HistosMATE
Automatic cleaner
Operator Manual
MM063
MILESTONE
HELPING
PATIENTS

Milestone s.r.l.
MM063-008 –HistosMATE –Operator Manual
3
Thank you for having selected our system and welcome to the ever growing world club of users for Milestone
laboratory instrumentation.
We are sure that you will be completely satisfied with this new tool entering your laboratory.
We invite you to read carefully this operator manual and to keep it in reach for convenient and fast
consulting.
For any possible clarification or any request for assistance please contact either our Representative in your
country:
Or contact
Milestone s.r.l.
Via Fatebenefratelli, 1/5
24010 Sorisole (BG) Italy
Tel. +39.035.412 8264
Fax [phone]
web site www.milestonemedsrl.com
e-mail [e-mail]
Please read the user manual before using the device.
MM063-008 –HistosMATE –Operator Manual
2015-03

Milestone s.r.l.
MM063-008 –HistosMATE –Operator Manual
4
SUMMARY
SUMMARY ........................................................................................................................................................ 4
1. INTRODUCTION........................................................................................................................................ 5
1.1. Symbol used...................................................................................................................................... 5
1.2. Designated uses................................................................................................................................ 6
1.3. Technical specifications..................................................................................................................... 6
1.3.1. Cabinet....................................................................................................................................... 6
1.3.2. LCD touch screen...................................................................................................................... 6
1.3.3. Cavity......................................................................................................................................... 6
1.4. Transportation and storage conditions .............................................................................................. 7
1.5. Warning information........................................................................................................................... 7
1.6. Instrument labeling explanation......................................................................................................... 8
1.7. Compatible reagents.......................................................................................................................... 8
1.8. Waste disposal of the equipment ...................................................................................................... 8
1.9. Waste disposal of reagents ............................................................................................................... 9
2. INSTALLATION........................................................................................................................................ 10
2.1. Space requirements......................................................................................................................... 10
2.2. Unpacking and checking list............................................................................................................ 10
2.3. Placement........................................................................................................................................ 12
2.3.1. Unit overview ........................................................................................................................... 12
2.4. Fumes extraction system................................................................................................................. 13
2.5. Power supply ................................................................................................................................... 14
2.6. Reagents.......................................................................................................................................... 14
3. OPERATE WITH HistosMATE................................................................................................................. 15
3.1. LCD touch screen............................................................................................................................ 16
3.2. Running a cleaning cycle................................................................................................................. 17
3.3. Owner setting................................................................................................................................... 20
3.4. System settings ............................................................................................................................... 21
4. REAGENT MANAGEMENT ..................................................................................................................... 22
4.1. How to change the reagent:............................................................................................................. 22
5. MAINTEINANCE ...................................................................................................................................... 23
5.1. Laboratory personnel....................................................................................................................... 23
5.2. Authorized service personnel .......................................................................................................... 23
6. TROUBLESHOOTING ............................................................................................................................. 24

Milestone s.r.l.
MM063-008 –HistosMATE –Operator Manual
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1. INTRODUCTION
1.1. Symbol used
An instruction accompanied by this symbol provides a quite important and require
more attention.
An instruction accompanied by this symbol provides a cautionary statement: failure to
follow the instruction may endanger the operator or cause damage to the instrument.
An instruction accompanied by this symbol provides a caution against electric shock.
Be sure to follow the instruction to prevent accidents resulting from electric shock.
Biohazard: be careful when you execute the procedure marked with this symbol:
danger of biohazard contamination.
CE logo: this instrument complies to European Community directives.
Fragile.
WEEE European directive symbol (2002/96/EC):
Electric/electronic device do not throw out in the environment.
Only authorized and qualified SERVICE personnel.
Manufacturer.

Milestone s.r.l.
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1.2. Designated uses
The new HistosMATE unit is an innovative, safe, rapid solution for the efficient cleaning of wax contaminated
racks, moulds and forceps.
HistosMATE has been specifically designed to accommodate Pathos, Histos, Logos series of racks as well
as the most common conventional histoprocessors racks.
The system and its accessories have been engineered for laboratory use and they can therefore withstand
the harshest laboratory conditions.
The Milestone HistosMATE must be operated exclusively with the reagents listed in Compatible reagents
(see chapter 1.7).
1.3. Technical specifications
The technical specifications for the main components of the HistosMATE system are described in the
following sections.
CODE 65200/SY: Power Supply: 230 VAC –50/60 Hz –400W
CODE 65201/SY: Power Supply: 115 VAC –60 Hz –400W
Working Temperature: 15°C –30°C (59°F –86°F)
Humidity (relative): up to 80%
Maximum altitude: 2000m
Indoor use only.
1.3.1. Cabinet
- Heavy duty industrial grade external chassis.
- Built-in exhaust fan.
1.3.2. LCD touch screen
Monochrome touch screen LCD. Resolution 320x240 3.8".
“Time and Temperature” control Software.
1.3.3. Cavity
Stainless steel.
Resistance heating elements (400 W) controlled by PID technology.
Magnetic stirrer with speed control (200÷600 RPM).
Built-in PT100 Temperature sensor.
Draining tube with quick coupling.
The instrument is intended for use in histological laboratory (indoor use) only.
Any other use of the instrument is considered improper and may void the warranty
provided by the manufacturer.

Milestone s.r.l.
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1.4. Transportation and storage conditions
Temperature: -20°C to +60°C.
Humidity: up to 80% (up to 50% at 40°C –104°F) non-condensing.
Before using HistosMATE (when coming from a storage room), let the unit reach working
environmental conditions (at least half an hour).
1.5. Warning information
Should the equipment be used in ways different than those specified by the manufacturer, the warranty
provided by the manufacturer may be void.
Main power plugs are considered disconnecting device. Disconnect all plugs from the socket outlet before
assembling the system, connection of the accessories and cleaning.
Equipment shall be connected to a main power socket outlet which is accessible and visible by the operator.
All parts of the equipment and all accessories must be supplied only by the manufacturer.
DO NOT OPEN THE CHASSIS. Failure to follow the instruction in the documentation
might lead to a reduction of device safety. If the equipment is not working properly,
please contact your supplier or the manufacturer.
Do not remove the instrument panels. Only authorized and qualified SERVICE
personnel may repair the instrument and access the instrument’s internal
components.
It is important that normal standards for safety and good laboratory practices are
applied. Always use common sense and the best known practice when operating the
instrument. Failure to follow the instructions in the documentation might lead to a
reduction of device safety.
The Competent Authority owning the instrument has primary responsibility for
accident-free operation together with designated personnel who operates SERVICE
or repair it.
To avoid damage to the instrument, use only the reagents listed in chapter 1.7
“Compatible Reagents”. Failure to follow the instructions in the documentation
might lead to a reduction of device safety.
Be careful: exhaust reagents are toxic.
Handle with care and follow the local standard regulations.
Use caution when handling hot, warm reagent.
Never install the HistosMATE unit under a fume hood. The presence of acids or
caustic reagents might contaminate the air flow used for ventilating the electronic
components, exposing them to possible corrosion or shorting of circuits.

Milestone s.r.l.
MM063-008 –HistosMATE –Operator Manual
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1.6. Instrument labeling explanation
For symbols explanation see chapter 1.1.
1.7. Compatible reagents
Regenx® or Diasolv® or MicroClean® or Clear Rite3® or Soltrol® or other xylene substitutive solution,
(made of isoparaffins).
1.8. Waste disposal of the equipment
In case this system needs to be returned to the manufacturer for any repair, it is necessary to clean and
disinfect the unit before return. Non-disinfected devices will not be accepted and you will be contacted to pay
the relative disinfection cost.
International health rules require that shipments of biohazard materials are not done in standard packages
(risk of sanctions).
It is recommended to use enzymatic detergents and polyphenolic based disinfectants or chlorine substitutes
to clean and disinfect the instrument. Alternatively use of a solution of 1:10 Bleach (recommended by the
CDC for disinfecting) is also allowed to decontaminate the instrument.
Do not use XYLENE, acetone, benzene, or trichlorethane in the instrument. They can
seriously damage the unit.
DO NOT USE REAGENTS DIFFERENT FROM THOSE LISTED ABOVE.
In case of doubts please contact: [e-mail].
It is necessary to put 10 L of cleaning reagent in the HistosMATE cavity.
Do not remove the side panels of the unit during cleaning operations.
Disconnect the power supply before any operation.
Do not use direct or high-pressure water to clean the instrument.
For safety reason, any operation without the individual protective devices must be
avoided.

Milestone s.r.l.
MM063-008 –HistosMATE –Operator Manual
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For further information, please contact the manufacturer: [e-mail].
In addition, complying with directive 2002/96/EC of the European Parliament and of the Council of 27
January 2003 on waste electrical and electronic equipment (WEEE), the separate collection environmental
managed of equipment is mandatory.
It is necessary to return the used equipment to the distributor or to verify the presence of a local empowered
system for collection and disposal of WEEE.
The in-observance of Directive 2002/96/EC or of the local law which acknowledges it can have potential
effects on the environment and human health.
This symbol indicates separate collection
for electrical and electronic equipment.
If additional requirements on accident prevention and environmental protection exist in the country of
operation, this instruction manual must be supplemented by appropriate instructions to ensure compliance to
such requirements.
1.9. Waste disposal of reagents
For further information please refer to the MSDS (Material Safety Data Sheet) provided by your supplier.
Handle with care and store in a cool dry space using a tightly closed container.
Vapors may collect in empty containers. Treat empty containers as hazardous.
Waste material should be disposed of in an approved incinerator or in a designated landfill
site, in compliance with all federal, provincial and local government regulations.
Some reagents can have potential health effects and cause environmental pollution if not
correctly disposed.

Milestone s.r.l.
MM063-008 –HistosMATE –Operator Manual
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2. INSTALLATION
2.1. Space requirements
Unit dimensions:
WIDTH
HEIGHT
DEPTH
300mm (11.81inch)
465mm (18.3 inch)
515mm (20.27inch)
Space dimensions required to locate the Milestone HistosMATE:
500mm (19.68 inch)
1000mm (3 ft-4inch)
700mm (2ft-4inch)
HistosMATE Weight (read carefully):
2.2. Unpacking and checking list
Check if your HistosMATE part number corresponds to the voltage supply of the laboratory:
HISTOSMATE CODE 65200/SY: 230 VAC –50/60 Hz –400W
HISTOSMATE CODE 65201/SY: 115 VAC –60 Hz –400W
HistosMATE is delivered in a wood box (43kg –94lb) with these dimensions:
Depth 65cm (25.6inch)
Width 43cm (17inch)
Height 68cm (26.8inch)
When unpacking, check that all parts correspond to the packing list included in the shipment.
Utmost care must be made during unpacking of the HistosMATE to avoid any scratch or damage to the
external coating.
PACKING OF HISTOSMATE
The weight of the HistosMATE is approximately 35 Kg ( 77 lbs); at least 2 persons should
remove the unit from its box and locate it on the bench.
Never install the HistosMATE unit under a fume hood. The presence of acids or caustic
reagents might contaminate the air flow used for ventilating the electronic components,
exposing them to possible corrosion or shorting of circuits
All parts of the equipment and all accessories shall be supplied only by Milestone.