REPLIGEN XCell C410:V3 User manual

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XCell™ C410:V3 Controller
User Guide
For use with:
•XCell ATF® 4 Device
•XCell ATF® 6 Device
•
XCell ATF® 10 Device

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The information contained in this document is subject to change without notice.
With respect to documentation accompanying product, Repligen makes no warranty, express or
implied. Any and all warranties related to the documentation accompanying product are expressly
disclaimed. Customer shall refer to the terms and conditions of sale governing the transaction for
any and all warranties for the Product.
Repligen Corporation shall not be liable for errors contained herein or for incidental or
consequential damages in connection with the furnishing, performance, or use of this material.
No part of this document may be photocopied, reproduced, or translated to another language
without the prior written consent of Repligen Corporation.
Products are not intended for diagnostic or therapeutic use or for use in vivo with humans or
animals.
For further information, please contact Repligen Corporation at www.repligen.com.
©2021 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property
of Repligen Corporation and/or its affiliate(s) or their respective owners.
Customer Support
customerserv[email protected]om
[phone] (Option 1)
Repligen Corporation
111 Locke Drive
Marlborough, Massachusetts 01752
www.repligen.com

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Contents
2.1.1 Filtration assembly......................................................................................................14
4.3.1 S-Line HFM insertion...................................................................................................43
4.3.2 I-Line HFM insertion....................................................................................................43
7.4.1 Bi-annual maintenance...............................................................................................48
7.4.2 Every four years ..........................................................................................................49

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List of tables
Table 1. XCell ATF® pump housing and controller pairings..............................................................10
Table 2. Utility requirements............................................................................................................12
Table 3. Size and weight ...................................................................................................................13
Table 4. Primary screen information................................................................................................18
Table 5. Main screen display parameters.........................................................................................21
Table 6. The Basic Set-up screen display parameters ......................................................................24
Table 7. Advanced Set-up screen display parameters .....................................................................25
Table 8. The Start-up Guide screen display parameters ..................................................................26
Table 9. Calibration screen display parameters ...............................................................................27
Table 10. LPM min/max .....................................................................................................................29
Table 11. Trend screen controls.........................................................................................................29
Table 12. The Alarm screen display parameters ................................................................................32
Table 13. Two (2) Pump controller status relay states ......................................................................32
Table 14. Two (2) Pump interlock relay states...................................................................................32
Table 15. Administration screen display parameters ........................................................................34
Table 16. Batch Information overview screen display parameters ...................................................35
Table 17. Batch Info Algorithm display parameters...........................................................................36
Table 18. Batch Set-up screen values.................................................................................................39
Table 19. Advanced Set Up screen values..........................................................................................39
Table 20. Field: P-Flow and E-Flow values .........................................................................................40
Table 21. Cycle time vs. Flow rate......................................................................................................49
Table 22. Access levels to the XCell™ C410:V3 Controller .................................................................50
Table 23. Monitor points list ..............................................................................................................62
Table 24. Input/Output list.................................................................................................................64
Table 25. Alarm list.............................................................................................................................66
Table 26. Spare parts..........................................................................................................................67
List of figures
Figure 1. Filtration assembly connection to C410:V3 Controller and a bioreactor side port ............8
Figure 2. XCell ATF® Device pump cycles ...........................................................................................9
Figure 3. XCell™ C410:V3 Controller, XCell ATF® 10 SS pump housing and pressure relief valve....11
Figure 4. Pneumatic Enclosure .........................................................................................................14
Figure 5. Electric Box (E-Box) connections .......................................................................................15
Figure 6. Log on screen.....................................................................................................................19
Figure 7. Log on screen and password .............................................................................................19
Figure 8. Main screen .......................................................................................................................20
Figure 9. Basic Set-up screen............................................................................................................23
Figure 10. Advanced Set-up screen....................................................................................................25
Figure 11. Start-up Guide screen .......................................................................................................26
Figure 12. Calibration screen..............................................................................................................27
Figure 13. Trending screen.................................................................................................................28
Figure 14. Process Trend screen ........................................................................................................29
Figure 15. PV, PRV, P2, P3, P4, P5, W1 Trend screens .......................................................................30
Figure 16. Alarm screen .....................................................................................................................31
Figure 17. Users screen ......................................................................................................................33
Figure 18. Basic Administration screen..............................................................................................34
Figure 19. Batch Info overview screen...............................................................................................35
Figure 20. Algorithm screen ...............................................................................................................36
Figure 21. Instrument flow control schematic of XCell™ C410:V3 Controller ...................................38
Figure 22. Types of filter housings .....................................................................................................43
Figure 23. Filtration assembly prepared for autoclaving ...................................................................46

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Abbreviations
ATF Alternating tangential flow
DF Driving force
DP Driving pressure
HFM Hollow fiber filter module
HMI Human machine interface
PA Pump air
PL Pump liquid
PRV Pressure regulator valve
SM Screen module
SUBs Single-use bioreactors
TFDF® Tangential flow depth filtration
California Proposition 65 Warning
WARNING
This product can expose you to chemicals including Cadmium, which is
known to the State of California to cause cancer and birth defects or other
reproductive harm. For more information go to www.P65Warnings.ca.gov.

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1. Description of XCell ATF® Device and process
The XCell ATF® Device provides an efficient means for fractionation of various mixtures. It may
include separation of large particles such as microcarriers (~ 200 microns in size) from a suspending
medium. It may include separation of mammalian cells (~ 10 microns in size) from culture medium;
or it may include separation of some molecules from other molecules or from a suspending solvent.
The focus in this manual will be on the use of the XCell ATF® Device and process for separation of
these constituents by filtration, based primarily on size.
The XCell ATF® Device consists of the following primary components (see also Figure 1):
•Controller: a dedicated controller used to control and monitor XCell ATF® Device activity. It
also provides the means for connecting to and controlling utility services.
•Filtration assembly: a stainless-steel assembly of two major elements, a filter housing and a
diaphragm pump:
oFilter Housing: steel housing containing the filtration element, either a hollow fiber
module (HFM) or screen module (SM).
oDiaphragm pump : steel spherical housing in which a diaphragm membrane is
moved up and down by pressurized air or vacuum, creating alternating flow.
•The filtration assembly includes the following components for each process application:
oConnection Assembly: tubing assembly connecting the filtration assembly to a
bioreactor or process vessel
oBioreactor Adaptor: adaptor between the Connection Assembly and bioreactor
port. Typical ports/connectors/adaptors for stainless steel bioreactors include an
Ingold-type port or, if a single use bioreactor (SUB), then, a disposable aseptic
connector (DAC) or equivalent.
A typical configuration of the XCell ATF® Device is shown in Figure 1. The filter housing accepts
either a HFM, with pore sizes from 30 kD to ~0.5 micron, or a SM for fractionation of larger particles,
> 70 microns. The separating element, the HFM or SM, is positioned between a process vessel or a
bioreactor at one end and the diaphragm pump at the other end. The vessel serves as a storage
container for the content to be filtered. The diaphragm pump provides the means for generating
alternating tangential flow, back and forth, between the vessel and pump, through the hollow fibers
of the HFM or through the SM. The XCell ATF® process provides the means for generating rapid, low
shear, tangential flow. A filtrate pump as shown in Figure 1 is used for controlled removal of a
filtered stream. The unfiltered material remains in the system. The XCell ATF® Device provides the
means for confining the process. The entire process is enclosed. Only a single connection is required
between the XCell ATF® Device and the vessel. As shown in Figure 1, that connection can be either
through a head plate of the vessel or through a side or bottom port. Placing the filtration assembly
next to the vessel requires only a short tubing to complete the connection between the two. That
connection can be hard piped or soft piped. Either one may be used to make a sterile connection
between vessel and the filtration assembly, as will be discussed further on.

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Figure 1. Filtration assembly connection to C410:V3 Controller and a bioreactor side port
1.1 XCell ATF® Device pump cycle
The diaphragm pump is the heart of the XCell ATF® Device process. It produces an alternating flow
through the HFM (lumen side) or SM. The XCell ATF® Device provides a pulsating, reversible, flow of
liquid, back and forth, between the process vessel and the diaphragm pump. The following is a
description of that process:
The diaphragm pump is partitioned into two chambers with a flexible diaphragm, Figure 2. One of
the pump chambers, the pump liquid (PL) chamber is connected to the Filter Housing, which, in
turn, is connected to the process vessel. Therefore, any flow between the diaphragm pump and
process vessel will be through the filtration device. The second pump chamber, the pump air (PA)
chamber, is connected to the pump flow control system. Typically, controlled addition of
compressed air into the PA chamber increases the pressure in the chamber relative to the process
vessel, forcing the flexible diaphragm partitioning the two chambers to move into the PL chamber
and towards the vessel. Liquid in the PL chamber is forced through the filter to the process vessel.
The flow through the HFM (lumen side) generates tangential flow in one direction. This pumping
phase (or cycle) is called the pressure cycle. Inversely, with a pressurized process vessel relative to
PA or PL, or with an external vacuum supply, liquid will flow in the reverse direction, from process
vessel, through the HFM (lumen side), to the PL chamber, generating tangential flow in the other
direction. This pumping phase (or cycle) is called the exhaust cycle. These alternating pump cycles
are then repeated continuously. See also Figure 2.

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Figure 2. XCell ATF® Device pump cycles
Note on the exhaust cycle:
Therefore, to increase the pressure in the vessel relative to the diaphragm pump, a vacuum service
is required. The PA chamber can then be alternately pressurized and evacuated to produce XCell
ATF® Device flow while maintaining the process vessel at atmospheric pressure. On the other hand,
when using a vessel that can be pressurized, vessel pressure can be used to drive the liquid from the
vessel to the PL chamber. When vessel pressure is limited, it may be supplemented with vacuum. In
either of the above schemes, one is driving the liquid from the vessel to the diaphragm pump by
increasing the pressure in the vessel relative to the diaphragm pump.
WARNING: Glass bioreactors or single-use bioreactors (SUBs), unless
otherwise specified by the manufacturer of the vessel, should
not be pressurized. Such vessels can explode if pressurized.
WARNING: When using a glass vessel or SUB, be sure to maintain an
unrestricted vent from the vessel. In the case a diaphragm fails,
the air flow into the diaphragm pump will proceed through the
HFM or SM into the vessel. A free exhaust from the vessel will
minimize the buildup of pressure in the vessel.

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1.2 XCell ATF® Device control scope and objectives:
The XCell™ C410:V3 Controller provides the process control functionality of the XCell ATF® 4, XCell
ATF® 6, and XCell ATF® 10 Devices.
XCell™ C410:V3 Controller is designed to:
1. Control ATF flow rates in both pressure and exhaust phases.
2. Provide a user interface capability for XCell ATF® Device control and monitoring.
3. Set-up and select operation parameters.
4. Display real-time process data.
5. Alarm for error conditions.
6. Provide batch control and user hierarchy.
7. Have PLC software upgrades in the field by replacing memory modules.
8. Have two major components, an Electronics Box (E-Box) and a Pneumatics Box (P-Box).
9. Allow the E-Box to operate an XCell ATF® 4, XCell ATF® 6, or XCell ATF® 10 Device using
specific software and modules.
10. Allow the P-Box hardware and process parameters to be specific to the size of the particular
XCell ATF® Device being controlled.
Table 1. XCell ATF® pump housing and controller pairings
XCell ATF®
pump housing
XCell™ Controller Description
XCell ATF® 4 Stainless
Steel
XCell™ C410:4V3
XCell™ C410:V3 C410 Controller for XCell ATF® 4
Device with air tubing.
XCell™ C410:4V3-GMP
XCell™ C410:V3 C410 controller for XCell ATF® 4 Device
with air tubing and standard GMP documentation and
FAT.
XCell™ C410:4V4B-GMP
Profibus configured XCell™ C410-V4B Controller with
power separation for XCell ATF® 4 Device with air
tubing, standard GMP documents and FAT.
XCell ATF® 6 Stainless
Steel and Single-use
XCell™ C410:6V3
XCell™ C410:V3 C410 Controller for XCell ATF® 6
Device with air tubing.
XCell™ C410:6V3-GMP
XCell™ C410:V3 C410 Controller for XCell ATF® 6
Device with air tubing, standard GMP documents and
FAT.
XCell™ C410:6V4B-GMP
Profibus configured XCell™ C410-V4B Controller with
power separation for XCell ATF® 4 Device with air
tubing, standard GMP documents and FAT.
XCell ATF® 10
Stainless Steel and
Single-use
XCell™ C410:10V3
XCell™ C410:V3 C410 Controller for XCell ATF® 6
Device with air tubing.
XCell™ C410:10V3-GMP
XCell™ C410:V3 C410 Controller for XCell ATF® 10
Device with air tubing, standard GMP documents and
FAT.
XCell™ C410:10V4B-GMP
Profibus configured XCell™ C410-V4B Controller with
power separation for XCell ATF® 10 Device with air
tubing and standard GMP documentation and FAT.

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1.3 XCell ATF® Device interconnectivity drawing
Figure 3. XCell™ C410:V3 Controller, XCell ATF® 10 SS pump housing and pressure relief valve

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Table 2. Utility requirements
Utility Requirement Additional considerations
Primary compressed air
Maximum 90 psig /
6.1 bar
Oil free, dry, filtered gas, i.e., medical grade air
Secondary pressure Typically: 35 psi / 2.4bar, Regulated oil free, dry, filtered air
Vacuum service Minimum -12.5 psig
Vacuum supplied by a Repligen or customer
supplied local pump capable of maintaining ~-
12.5 psig with nominal flow as follows:
XCell ATF® 4 - 40L/min
XCell ATF® 6 - 60L/min
XCell ATF® 10 - 200L/min
Pump should be clean room compatible
Exhaust Untreated discharge or user specified
Steam (SIP) ~30lbs/hr.
Applicable only to a steamable connection
between XCell ATF® Device and bioreactor vessel
Condensate drain
For SIP condensate drainage
Altitude 2000 m
This product has been assessed for a maximum
altitude of 2000 m.
Pollution degree Pollution degree 2
This product is intended to be used in an
environmental of pollution degree 2. Pollution
degree 2 area is normally where only
nonconductive pollution can be present.
Temporary conductivity that is caused by
condensation is to be expected.
Current
0.6 AMP
Frequency
50/60Hz
Supply voltage
100 - 240VAC (+10%, -10%)
Main supply voltage fluctuation +/- 10%
Environment
temperature humidity
Ambient Temperature (0-
50° C) Low Humidity (0-
80% RH) Indoor (Dry)
Environmental specifications only apply to
controller. Controller is designed to be used
indoor (dry) and low humidity location

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The size of a filtration assembly may vary slightly based on XCell ATF® Device configuration and
accessories. The XCell™ C410:V3 Controller dimensions are fixed.
Table 3. Size and weight
Component Dimensions (H, W, D) Comments
C410V3 Controller
Pneumatic Box 17 in 15 in 8 in
Includes all plugs
and connectors.
Electric Box 24 in 20 in 9 in
Includes all plugs
and connectors.
Filtration
Assembly
Fully assembled
system
XCell ATF® 4 SS
Pump Housing
24 in 6 in 6X10 in
XCell ATF® 6 SS
Pump Housing
44 in 10 in 8X10 in
XCell ATF® 10 SS
Pump Housing
44 in 14 in 14x20 in
XCell ATF® 6
Single-use Device
38 in 12 in 10 in
XCell ATF® 10
Single-use Device
38 in 18 in 16 in
Note: Indicated dimensions are estimates for the filtration assembly, as the connection to the
bioreactor, the connections to the controller and to accessories can affect height and effective
area.
Component Estimated weight Comments
C410V3 Controller
Pneumatic Box ~13 Kg
Weight of the P-Box will vary depending
on the particular XCell ATF® Device it is
configured to control.
Electric Box ~23 Kg
Filtration assembly
XCell ATF® 4 SS Pump Housing ~6 kg Weight does not include the weight of any
liquid, filter or connection between the
filtration assembly and the vessel
XCell ATF® 6 SS Pump Housing ~14 kg
XCell ATF® 10 SS Pump Housing ~40 kg
XCell ATF® 6 Single-use Device ~ 5 kg Does not include the weight of liquid and
A2B connectors
XCell ATF® 10 Single-use Device ~ 18 kg

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2. XCell™ C410:V3 Controller layout
2.1 General layout
The XCell™ Controller consists of two parts: The P-Box, Figure 4 and E-Box, Figure 5. The two are
interconnected with a cable that relays signal and power. A general layout of the two boxes with the
XCell ATF® Device is shown in Figure 1. The primary design objective is to produce a modular system
that will maximize adaptability of the system to the various space requirements of the user’s
facilities. The Interconnect Cable, I-Cable, connecting the E-Box and the P-Box can be selected to the
required lengths to facilitate positioning and handling of the boxes within the facility. One can
envision the P-Box in proximity to the filtration assembly, while the E-Box positioned distant to the
filtration assembly, possibly mounted on a wall or a skid.
2.1.1 Filtration assembly
This includes the diaphragm pump , Filter Housing, connection to the bioreactor, harvest line, pump
air inlet assembly, stand, plus all the housing accessories as specified in the part list.
Figure 4. Pneumatic Enclosure
a. System STOP switch
b. Interconnect cable plug
c. Plugs for sensor inputs (4x4-20mA)
d. Connection for diaphragm pump
e. Connection for compressed air
f. Connection for vacuum supply
g. Pressure regulator (0 to 60 psi, 0 to 4.1 bar)
h. Vacuum gauge (0 to -14psi, o to -0.95 bar)
i. Pressure gauge (0 to 60psi, 0 to 4.1 bar
(Not pictured in Figure13) Pressure relief assembly - set to 40 psi, 2.8 bar.
Electric enclosure
The Electric enclosure contains the HMI and PLC components, including:

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the Siemens S7 - 1200 PLC. It is programmed using Siemens Step 7 Basic v13. The Operator Interface
Terminal (OIT or HMI) is a Siemens SIMATIC TP 1200 Comfort, programmed using Siemens WinCC
Advanced v13.
Figure 5. Electric Box (E-Box) connections
The Electronic enclosure includes the following connections:
j. 120/220vac power cable with plug
k. Interconnect cable plug
l. Operator Interface Terminal (OIT or HMI)
m. Illuminated POWER ON/OFF selected switch
n. Illuminated system STOP push button
o. Alarm relay outputs (2)
p. Harvest pump relay outputs (2)
q. Ethernet plug
2.2 Primary pneumatic services
Air inlet (e) - Located on the P-Box and provides an inlet to house compressed air source.
Recommended minimum air pressure requirement is ~50 psi / 3.4bar. Somewhat higher inlet
pressures may be required, as needed, to generate higher flow rates or to drive pneumatic
instruments.
Exhaust/ vacuum line (f) - Located on the P-Box. This line is connected to a vacuum source. A
vacuum source should always be connected to the exhaust line to ensure reliable operation of the
WARNING: Do not exceed 90 psi / 6.1 bar on the Air inlet.

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XCell ATF® Device. In addition to vessel pressure, the hydrostatic pressure generated by the height
difference between vessel liquid level and pump level may assist or hamper the exhaust flow
Pump line (d) -Located on the P-Box. The line connects the P-Box to the diaphragm pump. A
hydrophobic 0.2 micron filter in this line provides both a sterile barrier and also a potential barrier to
the back flow of liquid from diaphragm pump to controller should a diaphragm rupture. Be sure to
use the hydrophobic filter in the pump line to prevent accidental flow of liquid from the filtration
assembly to the P-Box.
Air pressure regulator - Typical range of regulator is 0-60 psi/ 4.1bar. This is a second stage pressure
regulator for regulating service air inlet pressure to a specified, user required, value. Typically, the
secondary air pressure is regulated to 35psi/2.4bar. That value is selected because that pressure is
recommended to drive the proportional pressure control valve PRV1 and it is generally the upper
limit of the pressure required to achieve set flow rates.
Air pressure gauge (i) - Located on the upper side of the P-Box. Typical range of gauge is 0-60psi. It
shows second stage system pressure.
Vacuum gauge (h) - Located on the upper side of the P-Box. Typical range of gauge is 0 to -30inHg / -
0.95 bar. It shows primary vacuum pressure status.
2.3 Primary electric services
Electric plug (j) -Located on the E-Box. Electric power (standard 100-240V AC, 50/60Hz).
Power switch (m) - Located on E-Box.
Power indicator Light - same as the power switch. Lights green when power is ON.
Stop button (a, n) - Located on the P-Box and E-Box.
Either Stop button, causes the system cease operation and default to Standby mode, when the
diaphragm pump defaults to Exhaust.
2.4 Signal
A total of 4 Sensor input plugs (c) are provided on the P-Box. All inputs are analogue 4-20 mA. Three
plugs P3, P4 and P5 are for pressure inputs. One plug W1 is for a load cell input.
Ethernet (q) -communication port for data acquisition on E-Box.
Relays – Two relay outputs are for relaying alarm conditions (o). Two relays for driving a harvest
pump (p).
Interconnect (Signal) Cable (I-Cable) - to relay signal and DC power between E-Box and P-Box.
2.5 C410:V3 Ethernet set-up and connectivity
Ethernet infrastructure
The communication link between the Windows environment and the XCell™ ATF Controller is based
on Profinet® communication protocol. The Profinet® platform is an open Industrial Ethernet
standard developed by the PROFIBUS Organization and is standard Ethernet (IEEE802.3). The
Profinet® communication protocol sends and receives data using the open Ethernet TCP/IP standard
at a bandwidth of 100 Mbit/s and functions identical to traditional industrial Ethernet in providing
“real-time” channel for time-critical communications (i.e. process data).

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Ethernet configuration
The communications interface between the controller HMI and PLC is based on Profinet® platform
(Industrial Ethernet). The controller is factory set to the following IP settings:
IP address Subnet mask Default gateway
HMI 192.168.1.167 255.255.255.0 None
PLC 192.168.1.168 255.255.255.0 None
This factory default setting has the HMI and PLC on the same subnet allowing proper
communications to take place. If ‘####’ appears in input fields and the software version is not
displayed on the administration screen, the HMI and PLC may not be properly connected, and the
connection may need to be reset. See Appendix 5 for instructions on how to set IP Addresses and
connections.
XCell ATF® operations- Remote monitoring and data acquisition
The following diagram shows the network architecture for controlling XCell ATF® Technology from
an OPC Server and OPC Client Software over Profinet®:
The OPC Client Software is any OPC capable program that will connect through the OPC Server to
the XCell ATF® Device. The OPC Client Software will control the XCell ATF® Device remotely and/or
read the status of the XCell ATF® Device. Examples of OPC Client Software include Microsoft Excel,
WinCC HMI by Siemens, and FTView HMI by Rockwell Automation.
•The acronym "OPC" comes from "OLE (Object Linking and Embedding) for Process Control".
Since OLE is based on the Windows COM (Component Object Model) standard, under the
hood OPC is essentially COM. Over a network, OPC relies on DCOM (Distributed COM),
which was not designed for real-time industrial applications and is often set aside in favor of
OPC tunneling.
•OPC is implemented in Server/Client pairs. The OPC Server is a software application that
bridges the communication of the PLC with the Windows environment and then with the
OPC Client Software application. Some common OPC Server program suppliers include Delta
Logic (OPC Server and Data Logger) and Siemens (WinCC Siemens).
•OPC also comprises several standards including OPC Data Access (OPC DA) and other
standards for alarms and events, historical data, batch data and XML.
Proceed to Appendix 6 for details on OPC Integration for Remote Data Logging.
2.6 Disconnecting the controller
1. The controller must stay connected to the power supply in order to function.

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2. Controller must be placed clear from the any other cord in the workstation/ bench top for
safety.
3. Filters and tubing must be connected away from the appliance inlet for power supply for
operator safety in case of disconnecting device.
4. Press ON to allow the controller to continue its previous status, following a power failure.
5. On the switch adjacent to the power cord, Press OFF to allow the controller status to default
to STOPPED status, following a power failure or in need for a disconnect.
6. Supply cord is detachable and must be kept clear behind the product to avoid operator from
safety hazards.
3. XCell™ C410:V3 Controller process and control
3.1 Interface and screens
A Siemens Operator Interface Terminal (OIT) provides the user with the following features:
1. Pump status including cycle rate, flow rate, pressures, controller status and total batch
cycles
2. Setup parameters
3. Acknowledge and clear machine faults (i.e. warning and alarms)
4. Process trending
When an input box is highlighted and pressed; a number pad or keyboard will appear on screen to
enable data input.
For numerical entries as the value is being typed, a Min and Max range dialog box appears, showing
the user the acceptable value range. Any value outside the min/max range, or any text strings or
letters is not accepted.
The OIT will display the following Primary screens:
Primary screens - Main, Set-up, Alarms, Trending, Batch, Admin., Log Off.
Secondary screens - Screens within the Primary screens.
Table 4. Primary screen information
Screen Description
LOG ON Initial system log on which appears when the C410:V3 controller first powers up
MAIN
Main diaphragm pump Control and monitoring displays real time pump status
access to all Primary screens
SET UP Users Set-up p of process parameters, calibration, and diaphragm pump parameters
ALARMS Display diaphragm pump warnings and faults
TRENDING
Graphical real time display of flow set point, exhaust set points, flow process value,
vessel weight.
BATCH INFO Batch Set-up screen
ADMINISTRATOR Setting of users ID, security level and passwords, close application, PLC ON/OFF
LOG OFF Users log off

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3.2 Description of screens and buttons
Figure 6. Log on screen
Log on screen appears when the C410:V3 controller is powered up. Click on LOG ON to bring up
User/Password Dialog Box and Keyboard. For first time use, enter ADMIN for USER and 1234 for
PASSWORD.
Figure 7. Log on screen and password

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Figure 8. Main screen
The Main screen provides an overview of the process. It displays a pneumatic process schematic, an
animated diaphragm movement /cycle, valve transition between pressure and exhaust cycles and
flow direction. From the Main screen, an operator can:
1. Monitor and control XCell ATF® Device processes. In the Main screen and all subsequent
screens, all data fields with a white background are for display only. The operator, based
upon security levels, can change data fields with a beige background.
2. Start/Stop diaphragm pump.
a. When starting the diaphragm pump, a dialog box will appear to enable the user to
start with current settings, start with default settings or cancel and return to the
main screen.
b. When stopping the diaphragm pump, a dialog box will appear that enables the user
to confirm the stop command, or to cancel and return to the main screen.
3. Access other screens based upon password security levels.
4. Observe P2 trending. A P2 Trend button hides/reveals this screen.
5. Observe an animated diaphragm pump showing inflation and deflation cycles of the
diaphragm pump.
6. Monitor Overtime condition- displayed in FLOW status sub screens, by change of actual
cycle time field to red.
7. Monitor Overflow condition- displayed in FLOW status sub screens, by change of actual cycle
time field to orange.