SCIEX C100HT User manual

C100HT Biologics Analyzer System
Installation Guide
June 2018RUO-IDV-09-3829-A

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1 Introduction..............................................................................................................................................4
Hardware Overview...........................................................................................................................................................5
Cartridge............................................................................................................................................................................7
Decommissioning and Disposal..........................................................................................................................................8
Chemical Precautions.........................................................................................................................................................8
2 Installation Instructions.........................................................................................................................10
Unpack and Place the System..........................................................................................................................................10
Unpack the System....................................................................................................................................................10
Unpack the Controller and Monitor...........................................................................................................................10
Remove the Transport Lock..............................................................................................................................................11
Connect the Cables..........................................................................................................................................................12
Configure the Controller and the Software......................................................................................................................13
Set the Instrument ID.......................................................................................................................................................14
Install the Cartridge in the System...................................................................................................................................15
Verify the Alignment of the Transport System ................................................................................................................16
Configure the Photomultiplier Tube (PMT) Voltage.........................................................................................................18
Inject a Sample and Determine the Detector Counts..................................................................................................18
Set the Photomultiplier Voltage.................................................................................................................................19
Test the Detector........................................................................................................................................................20
Review the Default Users.................................................................................................................................................21
Complete the Qualifications.............................................................................................................................................21
3 Troubleshooting.....................................................................................................................................22
Troubleshooting Tables....................................................................................................................................................22
Run a Test Sample...........................................................................................................................................................28
Export Log Files for Troubleshooting................................................................................................................................29
4 Service Kit Bill of Materials...................................................................................................................31
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Contents

WARNING! Personal Injury Hazard. Use SCIEX-recommended parts only. Use of parts
not recommended by SCIEX or use of parts for any purpose other than their intended
purpose can put the user at risk of harm or negatively impact system performance.
CAUTION: Potential System Damage. Follow the instructions in the service documentation
when servicing the system. Do not perform unauthorized procedures.
This guide is intended solely for a trained and qualified Field Service Employee (FSE). It contains information
required to install and troubleshoot the C100HT Biologics Analyzer system.
This capillary electrophoresis system and its components meet or exceed the applicable regulatory requirements.
For safety and regulatory information about the system refer to the C100HT Biologics Analyzer System
Operator Guide.
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1
Introduction

Hardware Overview
Figure 1-1 Front and Side Panel
DescriptionItem
Service door1
Cartridge door2
Sample door3
LED power indicator; green when the system is on, blue when it is off.4
Access cover5
Right side cover6
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Introduction

Figure 1-2 Back Panel
DescriptionItem
Name plate1
FCC Compliance label2
Waste Electrical and Electronic Equipment label3
No User-serviceable Parts label4
For Research Use only label5
RoHS label6
RS-232 connector7
Voltage switch8
Power switch, mains supply connection, and fuse holder9
High Voltage label10
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Introduction

Cartridge
Note: Always allow the cartridge to stand in the cartridge stand at room temperature for at least 20 minutes
before use.
Figure 1-3 Cartridge in Cartridge Stand
DescriptionItem
Gel reservoir1
Cartridge purge port2
Cartridge data key3
Capillary windows4
Cartridge stand5
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Introduction

Decommissioning and Disposal
WARNING! Environmental Hazard. Do not dispose of system components in municipal
waste. Follow local regulations when disposing of components.
Before decommissioning, decontaminate the entire system following local regulations. Follow the SCIEX Red Tag
process and complete an instrument Decontamination Form for instrument and parts returns.
When removing the system from service, separate and recycle different materials according to national and local
environmental regulations.
Note: SCIEX will not accept any system returns without a completed Decontamination Form.
Chemical Precautions
WARNING! Ionizing Radiation Hazard, Biohazard, or Toxic Chemical Hazard.
Determine whether decontamination is required prior to cleaning or
maintenance. The customer must decontaminate the system prior to cleaning
or maintenance if radioactive materials, biological agents, or toxic chemicals
have been used with the system.
WARNING! Environmental Hazard. Do not dispose of system components in municipal
waste. Follow local regulations when disposing of components.
•Determine which chemicals have been used in the system prior to service and regular maintenance. Refer to
the Safety Data Sheets for the health and safety precautions that must be followed with chemicals. SCIEX
Safety Data Sheets can be found at sciex.com/tech-regulatory.
•Always wear laboratory-required personal protective equipment. For associates, SCIEX recommends the use
of powder-free neoprene or nitrile gloves, safety glasses, and a laboratory coat.
•Avoid ignition sources when working with flammable materials, such as isopropanol, methanol, and other
flammable solvents.
•Take care in the use and disposal of any chemicals. Potential risk of personal injury if proper procedures for
handling and disposing of chemicals are not followed.
•Avoid skin contact with chemicals during cleaning and wash hands after use.
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Introduction

•Collect all spent liquids and dispose of them as hazardous waste.
•Comply with all of the local regulations for the storage, handling, and disposal of biohazardous, toxic, or
radioactive materials.
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Introduction

Unpack and Place the System
Refer to the “Checklists”in the Site Planning Guide for more information.
Unpack the System
WARNING! Lifting Hazard. Make sure that at least three people or a lifting device
are available to lift the CE system. Follow established safe lifting procedures. Refer
to the Site Planning Guide for the weights of system components.
WARNING! Electrical Shock Hazard. Make sure that the system can be
disconnected from the mains supply outlet in an emergency. Do not block
the mains supply outlet.
1. Inspect the shipping box for damage or evidence of mishandling. If external damage is evident, notify the
carrier before opening the crate.
2. Cut the straps on the box and then open the box.
3. Remove the cartridge stand and the ship kit containing cables from the packaging foam.
4. Remove the boxes containing the controller and monitor.
5. (For customers with the cart) Remove the cart from the box and then lock the wheels on the cart.
6. Lift the C100HT Biologics Analyzer system out of the box and then put it on the bench or the cart.
7. Instruct the user to store the packaging in a safe location for later use when moving the system.
Unpack the Controller and Monitor
1. Open the controller carton, remove the controller, and then put it on the cart or a table close to the C100HT
Biologics Analyzer system.
2. Open the monitor carton, remove the monitor, and then put it on the cart or the table close to the controller.
3. Instruct the user to store the packaging in a safe location for later use when moving the system.
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2
Installation Instructions