2mag bioMIXdrive 1 User manual

Operation Manual
English
bioMIXdrive 1 Order no.: 80001
bioMIXdrive 2 Order no.: 80002
bioMIXdrive 3 Order no.: 80003
bioMIXdrive 4 Order no.: 80004
with
bioMIXcontrol Order no.: 98400
bioMIXcontrol S Order no.: 98500
bioMIXcontrol 4MS Order no.: 98604
Includes:
Quick start
Operation Manual
Technical Documentation
Specifications
Version 6.0 Issue 08/2019 www.2mag.de

© 2mag AG Page 2 of 25 Version: 6.0
Thank you for your confidence shown in us!
Congratulations to the purchase of your new product.
For any enquiries, questions or suggestions please do not hesitate to
contact us at [email protected].
2mag
Main competence of 2mag is based upon mixing, tempering and
measuring/controlling. In these fields we are offering support with our
products to the modern laboratory within the standardized daily business
as well as for the implementation of highly complex processes in the
state-of-the-art research. Due to the fact that 2mag is developing
according to customer’s needs, is manufacturing self-contained and under
permanent quality control and is also selling on-site together with
competent contact persons, we can guaranty our customer an outstanding
quality and product performance.

© 2mag AG Page 3 of 25 Version: 6.0
Contents
A Quick start _________________________________________ 4
1. Overview of your product__________________________________ 4
2. Application fields ________________________________________ 5
2.1 Operator ____________________________________________ 5
2.2 Basic functions _______________________________________ 5
2.3 Product combinations __________________________________ 5
2.4 Application not for the intended use _______________________ 5
2.5 Combinations of vessels ________________________________ 6
2.6 Stirring bars _________________________________________ 7
2.7 Tips and hints to the topic stirring ________________________ 7
3. Installation _____________________________________________ 8
3.1 Safety advice ________________________________________ 8
3.2 Installation, connection to control unit bioMIXcontrol (S)_______ 9
3.3 Installation, connection to control unit bioMIXcontrol 4MS _____ 10
4 Operating of the control units ______________________________ 12
4.1 Operating of the control unit bioMIXcontrol (S) _____________ 12
4.1.1 Description operating elements bioMIXcontrol (S)__________ 12
4.1.2 Stirring operation and stirrer control bioMIXcontrol (S)______ 13
4.2 Operating of the control unit bioMIXcontrol 4MS ____________ 15
4.2.1 Description operating elements bioMIXcontrol 4MS _________ 15
4.2.2 Stirring operation and stirrer control bioMIXcontrol MS4_____ 16
4.3 Accessory –Extension Cord for bioMIXdrive ________________ 18
5. External heating operation in incubators and water baths ________ 19
6. Maximum operation temperatures __________________________ 19
B Maintenance, Cleaning and Care _______________________ 20
C Service case and customer service _____________________ 21
D Errors ____________________________________________ 22
E Technical details____________________________________ 23

© 2mag AG Page 4 of 25 Version: 6.0
A Quick start
1. Overview of your product
Magnetic stirrer bioMIXdrive with control unit bioMIXcontrol
Image 1: 1-position magnetic stirrer bioMIXdrive 1 with control unit bioMIXcontrol
Your product contains at despatch:
A modern inductive magnetic stirring system (bioMIXdrive)
consisting of a stainless steel stirring plate with 1, 2, 3 or 4
stirring points with fixed stirrer control cable (8-pin plug, with
screw nut)
An external control unit with one connector socket
(bioMIXcontrol /bioMIXcontrol S) for connection of 1
bioMIXdrive or with 4 connector sockets (bioMIXcontrol 4MS)
for using up to 4 bioMIXdrive 1.
With pluggable power cable (country-specific).

© 2mag AG Page 5 of 25 Version: 6.0
2. Application fields
2.1 Operator
The maintenance- and wear-free magnetic stirrers bioMIXdrive are used
in the fields of chemistry, medicine, pharmacy and mainly microbiology
and biotechnology.
The operators are generally working in research and development,
production and quality assurance.
2.2 Basic functions
Basic function is stirring of liquids in suitable and chemically resistible and
biological applicable vessels.
The stirrer housing is hermetically close and therefore immersible.
The maximum ambient temperature is +50°C in air and +50°C in water
immersed.
2.3 Product combinations
In addition to the use at the conventional laboratory desk our products
have also been tested for the application in
Laminar flow devices
Safety cabinets
Safety cabins
Water baths
Incubators
Please note: For using the stirrer in incubators please set the adjustable
stirring power to the minimum usable power to reduce the additional
heating effect caused by the magnetic stirring drive. Please see chapter “5
External heating operations in incubators and water baths” at page 13.
2.4 Application not for the intended use
The magnetic stirrer bioMIXdrive is explicitly not intended for the
application:
Stirring and warming of flammable liquids
Warming of pressure-tight closed and NOT pressure-
resistant vessels or glasses
(e.g. Erlenmeyer flasks, lab flasks)
At general atmosphere or danger of explosion

© 2mag AG Page 6 of 25 Version: 6.0
The 2mag is offering special products for the just mentioned application
combinations. More information for this can be found at www.2mag.de or
at [email protected]
2.5 Combinations of vessels
Please use round, chemical resistant and biological applicable and where
required heat-resistant vessels made of glass or non-magnetic metal. You
can use vessels up to the maximum size stated in the spreadsheet 1.
The vessels should have a thin, even wall thickness. Flat glass bottoms
(without any curve to the inside) and smooth surfaces will improve the
operating characteristic of the magnetic stirring bar. Uneven surfaces
would reduce the stirring power and would cause reaming up of the
stirring bar’s gliding surface.
In case you intend to stir large amount of liquids, please chose such
stirring flasks that have a comparatively small diameter and thin bottom.
The magnetic stirring bar can then be centred better.
We recommend using of commercial cell culture- and tissue culture flasks
with integrated hanging stirring bar or propeller systems as well as cell
culture flasks with hanging pendulum systems (single or double spinner
systems).
The magnetic stirring systems bioMIXdrive are optimized for both cell
culture vessel types.
Stirring System
Stirring Vessels
Nominal
Volume
Max.
Quantity
bioMIXdrive 1
Culture- and Tissue Culture
flasks
max. 5.000 ml
1
bioMIXdrive 2
Culture- and Tissue Culture
flasks
max. 5.000 ml
2
bioMIXdrive 3
Culture- and Tissue Culture
flasks
max. 5.000 ml
3
bioMIXdrive 4
Culture- and Tissue Culture
flasks
max. 5.000 ml
4
Spreadsheet 1: Volumes and vessels

© 2mag AG Page 7 of 25 Version: 6.0
Please always place the flasks in the magnetic
centre of the magnetic stirrer. This will ensure the
optimum stirring effect!
Do never use any pressure-tight closed flasks.
RISK OF BURSTING!
Do only use temperature-resistant vessels.
Be careful with plastic flasks!
2.6 Stirring bars
In general, all stirring bars matching the length and diameter can be used.
But we recommend using the commercial stirring bars with Samarium
Cobalt magnetic core (SmCo). By using this highly energetic magnetic
material the maximum stirring power of the magnetic stirrer can be
achieved, especially when mixing viscose media.
We recommend using of commercial cell culture- and tissue culture flasks
with integrated hanging stirring bar or propeller systems as well as cell
culture flasks with hanging pendulum systems (single or double spinner
systems).
The magnetic stirring systems bioMIXdrive are optimized for using both
cell culture vessel types.
2.7 Tips and hints to the topic stirring
The culture flasks should be filled max. up to the middle or up to the
marked filling level.
Place one magnetic stirring bar in each stirring flask or use the stirring
system of the cell- resp. tissue culture system.
Place the stirring flasks right in the centre of the stirring point.

© 2mag AG Page 8 of 25 Version: 6.0
3. Installation
3.1 Safety advice
Please ensure the following basic conditions prior to installation:
The magnetic stirrer works with permanent magnets.
Cardiac pacemakers, data storage mediums,
magnetic cards and other devices, which can be
affected by magnetic fields, have to be kept away from
the fields of the stirring unit as well as from the stirring
bars.
The device must not be used in explosive rooms.
The control unit bioMIXcontrol must not be dipped in
water or any cleaning solutions.
Your supply voltage has to comply with the label of the
control unit. The control unit has to be switched off
before any power connection or power disconnection.
To increase the operation safety, the control unit should
be placed apart from chemical materials and reactions
as well as away from thermal influences.
For special requirements please contact [email protected].
ATTENTION!
The control unit has to be switched off, BEFORE
you connect or disconnect the plugs.
Always turn off the power switch first before
handling the connection cables.

© 2mag AG Page 9 of 25 Version: 6.0
3.2 Installation, connection to control unit bioMIXcontrol (S)
Step by step instruction (please also see image 2)
Switch off the control unit bioMIXcontrol BEFORE you
handle the connection cables with the power switch (5)
and disconnect the power cable (4)!
The stirrer control cable (1) of the magnetic stirrer bioMIXdrive
has now to be connected to the 8-pin socket of the control unit
(2).
Please secure this plug connection by turning the screw
nut situated at the plug. Only by this a trouble-free operation
can be guaranteed.
Connect the power cable (4) to the power input (3) rear-side and
afterwards to the power socket.
The control unit is now connected to the magnetic stirrer and
ready for operation.
Image 2: Installation, rear side of the control unit bioMIXcontrol
Description functional elements of control unit - backside
1 Connector of the stirrer control cable
2 Socket for the stirrer control cable
3 Power socket
4 Power cable
5 Power switch
6 Control unit 2mag –bioMIXcontrol
X Stirring drive unit 2mag –bioMIXdrive 1 (or bioMIXdrive 2/3/4)
3
4
1
2
5
6
x

© 2mag AG Page 10 of 25 Version: 6.0
3.3 Installation, connection to control unit bioMIXcontrol 4MS
Step by step instruction (please also see image 3)
Control unit with Master-Slave function, up to 4x bioMIXdrive 1
Switch off the control unit bioMIXcontrol 4MS BEFORE you
handle the connection cables with the power switch (5)
and disconnect the power cable (4)!
The stirrer control cable (1a-d) of the magnetic stirrer
bioMIXdrive 1 has now to be connected to the 8-pin socket of the
control unit (2a-d).
Please secure this plug connection by turning the screw
nut situated at the plug. Only by this a trouble-free operation
can be guaranteed.
Connect the power cable (4) to the power input (3) rear-side and
afterwards to the power socket.
The control unit is now connected to the magnetic stirrer and
ready for operation.
Please note:
The control unit bioMIXcontrol 4MS is made for using
bioMIXdrive 1 ONLY!
DO NOT use the stirring drives
bioMIXdrive 2/3/4 with the
control unit bioMIXcontrol 4MS!
Risk of damage of the controller!

© 2mag AG Page 11 of 25 Version: 6.0
Image 3: Installation, rear side of the control unit bioMIXcontrol 4MS
Description functional elements of control unit - backside
1a-d Connectors of the stirrer control cable, stirrer no. 1-2-3-4
2a-d Sockets for the stirrer control cable, stirrer no. 1-2-3-4
3 Power socket
4 Power cable
5 Power switch
6 Control unit 2mag –bioMIXcontrol
Please note:
Up to 4x stirring drive bioMIXdrive 1 can be connected.
Please do not connect bioMIXdrive 2, bioMIXdrive 3, bioMIXdrive 4 or
bioMIXdrive 6 with control unit bioMIXcontrol 4MS.
Risk of damage of the controller!
3
4
1a
2a
5
6
1b
1c
1d
2b
2c
2d

© 2mag AG Page 12 of 25 Version: 6.0
4 Operating of the control units
4.1 Operating of the control unit bioMIXcontrol (S)
Image 4: Control unit bioMIXcontrol
Image 5: Close-up, operating elements control unit bioMIXcontrol and bioMIXcontrol S
4.1.1 Description operating elements bioMIXcontrol (S)
7 Control unit 2mag - bioMIXcontrol
Stirrer control
8 ON/OFF key for magnetic stirrer
9 MODE-key (M) for power adjustment of the magnetic stirrer
10 Display for speed indicator and power indicator
11 MINUS-key (-) for reduction of stirrer speed
12 PLUS-key (+) for increase of the stirrer speed
7
8
9
11
12
10
7
8
9
11
12
10

© 2mag AG Page 13 of 25 Version: 6.0
Operating of the control unit
After the cables have been installed correctly according to “Installation,
connection to the control unit bioMIXcontrol”, the magnetic stirrer
system MIXdrive will be ready for operation.
4.1.2 Stirring operation and stirrer control bioMIXcontrol (S)
Turning On and Off
Please turn on the main power switch (5) at the rear side of the control
unit bioMIXcontrol.
Please press the ON/OFF-key (8) once. The magnetic stirrer will be
switched on by that. The current stirring speed will be shown in the
display (10).
By pressing the ON/OFF-key (8) once more, the magnetic stirrer will be
switched off again. The display indicator (10) expires.
SoftStart
After the magnetic stirrer was switched on, the stirring bars in the flasks
will be smoothly accelerated to the set speed accurately.
The accelerating phase will be shown by the illumination of a dot at the
right segment of the LED-display (10).
Stirrer speed adjustment
The speed of the magnetic stirrer can be adjusted by pressing the MINUS-
(11) resp. the PLUS-key (12).
The adjusted speed will be shown in the display (10) when the magnetic
stirrer is switched on. The speed range can be adjusted between 5 and
250 rpm in steps by 1.
By constantly pressing the MINUS- resp. the PLUS-keys, an accelerated
adjustment of the speed can be achieved.
QuickSet
To enter the start- respectively maximum speed directly and quickly there
is the Quickset-function available.
The use of the following described keys will be made with the stirrer
turned on.
Setting the Start Speed
Press the MINUS-key (11) permanently and press shortly the ON/OFF-key
(8) afterwards. The start speed “5” will be set.
Setting the Maximum Speed
Press the PLUS-key (12) permanently and press shortly the ON/OFF-key
(8) afterwards. The maximum speed “250” will be set.

© 2mag AG Page 14 of 25 Version: 6.0
Power adjustment
A newly developed and extremely efficient magnetic stirrer will come into
operation.
The modern stepper-motor drive concept causes a minimized operational
heat output by the magnetic stirrer. Nevertheless the magnetic stirrer
emits a low lost energy to the ambience caused by physics. To reduce the
heat output the power of the magnetic stirrer can be adjusted.
A high power setting is necessary to move viscose media and large
volumes.
A low power setting guaranties a warming-free long-term use for
example operation in incubators.
The stirring power can be adjusted in four steps by using the MODE-key
(9). By pressing the MINUS-key (11) respectively the PLUS-key (12) just
after pressing the MODE-key, the power can be adjusted between 10-
100%.
The current value is now shown on the display (10). The display (10) will
turn back to the current speed indicator after approx. 5 seconds.
The power adjustment is finished again at the time the speed range is
shown.
The power adjustment can also be finished immediately by pressing the
MODE-key (9) again.
Display, Magnetic Stirrer
The display (10) provides as described above a description of:
Current stirring speed (always with switched on magnetic stirrer)
Set power (after pressing the MODE-key (9))
To check, whether the magnetic stirrer is switched on. The display
will not be illuminated in case the stirrer is switched off.
The magnetic stirrer works with permanent magnets.
Cardiac pacemakers, data storage mediums,
magnetic cards and other devices, which can be
affected by magnetic fields, have to be kept away from
the fields of the stirring unit as well as from the stirring
bars.

© 2mag AG Page 15 of 25 Version: 6.0
4.2 Operating of the control unit bioMIXcontrol 4MS
Control unit with Master-Slave function, up to 4x bioMIXdrive 1
Image 6: Control unit bioMIXcontrol 4MS
Image 7: Close-up, operating elements control unit bioMIXcontrol 4MS
4.2.1 Description operating elements bioMIXcontrol 4MS
7 Control unit 2mag –bioMIXcontrol 4MS
Stirrer control
8 ON/OFF key for magnetic stirrer
9 MODE-Taste (M) for switching between the stirrer no. 1-2-3-4
10 Display for speed indicator
11 MINUS-key (-) for reduction of stirrer speed
12 PLUS-key (+) for increase of the stirrer speed
7
8
9
11
12
10
7
8
9
11
12
10

© 2mag AG Page 16 of 25 Version: 6.0
Operating of the control unit
After the cables have been installed correctly according to “Installation,
connection to the control unit bioMIXcontrol 4MS”, the magnetic
stirrer system MIXdrive will be ready for operation.
4.2.2 Stirring operation and stirrer control bioMIXcontrol 4MS
Turning On and Off
Please turn on the main power switch (5) at the rear side of the control
unit bioMIXcontrol 4MS.
Please press the ON/OFF-key (8) once. The magnetic stirrer will be
switched on by that. The current stirring speed will be shown in the
display (10) as well as the number of the actual stirrer which is in the set
mode.
Example:
Display shows: “1.150”stirrer no. 1set speed is 150 rpm
By pressing the ON/OFF-key (8) once more, the magnetic stirrer will be
switched off again. The display indicator (10) expires.
SoftStart
After the magnetic stirrer was switched on, the stirring bars in the flasks
will be smoothly accelerated to the set speed accurately.
The accelerating phase will be shown by the illumination of a dot at the
right segment of the LED-display (10).
Stirrer speed adjustment
The speed of the magnetic stirrer can be adjusted by pressing the MINUS-
(11) resp. the PLUS-key (12).
The adjusted speed will be shown in the display (10) when the magnetic
stirrer is switched on. The speed range can be adjusted between 5 and
250 rpm in steps by 1.
By constantly pressing the MINUS- (11) resp. the PLUS-keys (12), an
accelerated adjustment of the speed can be achieved.
Switching between the stirrer no. 1-2-3-4 (Master-Slave function)
The stirrer no. 1-2-3-4 can be addressed by using the MODE-key (9).
The display shows as follows:
“1.150”stirrer no. 1set speed is 150 rpm
“2.150”stirrer no. 2set speed is 150 rpm
“3.150”stirrer no. 3set speed is 150 rpm
“4.150”stirrer no. 4set speed is 150 rpm
“A.150”ALL stirrers (synchronous mode) set speed is 150 rpm

© 2mag AG Page 17 of 25 Version: 6.0
“A.--- ”ALL stirrers are active, but the stirrers are running with
independent speeds until the MINUS-key (11) or PLUS-key (12) is
pressed. In this case ALL stirrers will be synchronized.
The speed and ON/OFF of each stirrer (no. 1-2-3-4) can be set separately
and independent in a range from 5 to 250 rpm. The active unit is indicated
with the number1-2-3-4 of the first digit of the LED display.
In the case that “A. ” is displayed all stirrers can be set to the same
speed synchronous mode of all stirrers.
In this case all stirrers can be stopped and turned on again with ON/OFF
key (8) at the same time.
Stirring power adjustment
To reduce the operating complexity of the bioMIXcontrol 4MS the stirring
power is fixed. The stirring power is optimized regarding minimized heat
lost of the stirring drive and solid rotation of the motor to get reliable
mixing movement of the cell cultures.
The stirring power is variable and depending on the speed. It can not be
adjusted from outside and is in the controller software fixed.
Display, Magnetic Stirrer
The display (10) provides as described above a description of:
Current stirring speed (always with switched on magnetic stirrer)
Current active stirrer (switching after pressing the MODE-key (9))
To check, whether the magnetic stirrer is switched on. The display
will not be illuminated in case the stirrer is switched off.
Displays:
“1.150” stirrer no. 1set speed is 150 rpm
“2.150” stirrer no. 2set speed is 150 rpm
“3.150” stirrer no. 3set speed is 150 rpm
“4.150” stirrer no. 4set speed is 150 rpm
“A.150” ALL stirrers (synchronous mode) set speed is 150 rpm
“A.--- ”ALL stirrers are active, but the stirrers are running with
different speeds.
The magnetic stirrer works with permanent magnets.
Cardiac pacemakers, data storage mediums,
magnetic cards and other devices, which can be
affected by magnetic fields, have to be kept away from
the fields of the stirring unit as well as from the stirring
bars.

© 2mag AG Page 18 of 25 Version: 6.0
4.3 Accessory –Extension Cord for bioMIXdrive
With the accessory Extension Cord for bioMIXdrive series (order no.
46200) the control wire of the stirrer can be extended by 3m.
Other lengths on request.

© 2mag AG Page 19 of 25 Version: 6.0
5. External heating operation in incubators and water
baths
Do not heat up liquids whose flashpoint is lower than
the set temperature.
Explosion hazard! Fire hazard!
Do never use any pressure-tight closed vessels
RISK OF BURSTING!
Please use only temperature-resistant vessels
Beware of plastic vessels!
6. Maximum operation temperatures
Incubator operation
Please note the maximum operation temperature +50 °C
in air for the standard versions
Water bath operation:
Please note the maximum operation temperature +50 °C
in water immersed for the standard versions

© 2mag AG Page 20 of 25 Version: 6.0
B Maintenance, Cleaning and Care
Do not use any cleaning agent or cleaning rag that is
based on chlorine with metallic components or
ammoniac.
These agents may harm the surface.
The control unit must not be dipped in water or any
cleaning solutions.
2mag devices are generally maintenance-free.
Due to their construction the 2mag devices are very robust and designed
for the professional daily use.
We recommend cleaning the devices’ surfaces with e.g. cleaning agents
containing tensides or isopropyl alcohol regularly.
BEFORE cleaning the surfaces, switch off the device with the power
switch and pull out the power cable afterwards.