illumina Infinium LiHa User manual

Infinium LiHa and Infinium RoMa Operating Manual - Document # 1000000110155 v00
Operating Manual
Infinium LiHa and Infinium RoMa

© 2020, Illumina, Inc. All rights reserved.
All trademarks are the property of Illumina, Inc. or their respective owners.
I

0 - Preface
Manufacturer
Infinium LiHa and Infinium RoMa Operating Manual - Document # 1000000110155 v00 0 - 1
0 Preface
For Your Safety Before performing any work on or with the Infinium LiHa and Infinium RoMa,
first read the Operating Manual - Document # 1000000110155 v00 carefully,
in particular chapter 2 “Safety”.
0.1 Manufacturer
Address of
Manufacturer
0.2 Use of the Product
0.2.1 Intended Use
Intended Use The Infinium LIHA/ROMA is an automated robotic solution for sample preparation.
Note: This product is intended for research use only (RUO) and will not be for
clinical use.
0.2.2 Improper Use
Improper Use The Infinium LiHa and Infinium RoMa must not be used with options or
components which are not approved by Illumina.
WARNING
The use of non approved options may impair the safety concept of the Infinium
LiHa and Infinium RoMa.
This means that the safety and compliance to national and international
standards, as required for UL/CSA certification, by EC directives, etc. cannot be
ensured any more.
Illumina Inc.
5200 Illumina Way
San Diego, CA 92122
United States

0 - 2 Infinium LiHa and Infinium RoMa Operating Manual - Document # 1000000110155 v00
0 - Preface
CE Conformity
0.3 CE Conformity
Declaration of
Conformity
The Infinium LiHa and Infinium RoMa is designed and built in compliance with the
basic safety and health requirements of applicable EC Directives. With the
declaration of conformity the manufacturer declares conformity with the provisions
of the Directives.
CE Label
0.4 CSA Certification
The Infinium LiHa and Infinium RoMa is tested and certified by the Canadian
Standards Association (CSA).
CSA Marking The CSA marking is affixed to the Infinium LiHa and Infinium RoMa.
Canada IC Compliance
This Class A digital apparatus meets all requirements of the Canadian
Interference - Causing Equipment Regulations.
This device complies with Industry Canada license - exempt RSS standards.
Operation is subject to the following 2 conditions:
1 This device may not cause interference.
2 This device must accept any interference, including interference that may
cause undesired operation of the device.
The CE label is affixed to the Infinium LiHa and Infinium RoMa.

0 - Preface
FCC Rules
Infinium LiHa and Infinium RoMa Operating Manual - Document # 1000000110155 v00 0 - 3
0.5 FCC Rules
FCC
Compliance
This device complies with Part 15 of the FCC Rules. Operation is subject to the
following 2 conditions:
This device may not cause harmful interference.
This device must accept any interference received, including interference that
may cause undesired operation.
CAUTION
Changes or modifications to this unit not expressly approved by the party
responsible for compliance could void the user’s authority to operate the
equipment.
Note: This equipment has been tested and found to comply with the limits for a
Class A digital device, pursuant to Part 15 of the FCC rules. These limits are
designed to provide reasonable protection against harmful interference when the
equipment is operated in a commercial environment. This equipment generates,
uses, and can radiate radio frequency energy and, if not installed and used in
accordance with the instrumentation manual, may cause harmful interference to
radio communications. Operation of this equipment in a residential area is likely to
cause harmful interference in which case users will be required to correct the
interference at their own expense.

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0 - Preface
FCC Rules

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Infinium LiHa and Infinium RoMa Operating Manual - Document # 1000000110155 v00 1 - 1
Table of Contents
0Preface
0.1 Manufacturer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0-1
0.2 Use of the Product . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0-1
0.2.1 Intended Use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0-1
0.2.2 Improper Use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0-1
0.3 CE Conformity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0-2
0.4 CSA Certification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0-2
0.5 FCC Rules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0-3
1 About This Manual
1.1 Reference Documents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-2
1.2 Trademarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-2
1.3 Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-3
2Safety
2.1 Safety Message Conventions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-1
2.1.1 Signal Words . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-1
2.1.2 Safety Symbols . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-1
2.2 General Safety Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-3
2.3 Operating Company . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-5
2.4 User Qualification. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-6
2.4.1 Operator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-6
2.4.2 Key Operator . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-6
2.5 Safety Elements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-7
2.6 Product Safety Signs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-9
2.7 Laser Radiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-10
2.8 Decontamination Declaration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-13

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3 Technical Data
3.1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-1
3.1.1 Infinium LiHa and Infinium RoMa Overview . . . . . . . . . . . . . . . . . . . . . 3-1
3.1.2 Product Identification and Labeling . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-2
3.2 Technical Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-3
3.2.1 Dimensions and Weights . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-3
3.2.2 Supplies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-4
3.2.3 Status Lamp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-5
3.2.4 Environmental Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-6
3.2.5 Emissions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-7
3.2.6 Electromagnetic Compatibility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-7
3.2.7 I/O Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-7
3.3 Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-8
3.3.1 Computer Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-8
3.3.2 Software Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-8
3.3.3 System Liquid Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-8
3.3.4 Sample Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-8
3.4 System Modules. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-9
3.4.1 Liquid Handling Arm (LiHa) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-9
3.4.2 Robotic Manipulator Arm Standard (RoMa) . . . . . . . . . . . . . . . . . . . . . 3-12
3.4.3 Positive Identification (PosID) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-13
3.5 Chemical Resistance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-17
3.5.1 Standard Materials Resistance Table . . . . . . . . . . . . . . . . . . . . . . . . . 3-17
4 Description of Function
4.1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-1
4.2 Structure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-2
4.2.1 Mechanical Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-2
4.2.2 The Infinium LiHa and Infinium RoMa Worktable. . . . . . . . . . . . . . . . . 4-3
4.2.3 Liquid System Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-3
4.3 Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-4
4.3.1 Liquid Handling Arm (LiHa) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-4
4.3.2 Robotic Manipulator Arm Standard (RoMa Standard) . . . . . . . . . . . . . 4-6
4.3.3 Barcode Scanner on RoMa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-7
4.3.4 Safety Elements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-8
4.4 Positive Identification (PosID) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-10
4.5 Liquid System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-14
4.5.1 Tubing Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-15
5 Putting into Operation
5.1 Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5-1
5.1.1 Initial Installation of the Instrument. . . . . . . . . . . . . . . . . . . . . . . . . . . . 5-1
5.2 Startup . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5-1

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6 Operation
6.1 Operating and Display Elements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-1
6.1.1 Operating Elements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-1
6.2 Operating Modes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-3
6.3 Operating in Routine Operation Mode . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-3
6.3.1 Safety Instructions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-3
6.3.2 Enclosed Work Area . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-7
6.3.3 Switching the Instrument On . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-7
6.3.4 Instrument Preparation and Checks . . . . . . . . . . . . . . . . . . . . . . . . . . 6-9
6.3.5 Checks and Terminating Tasks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-17
6.3.6 Switching the Instrument Off . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-17
6.3.7 When a Crash Occurred . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-18
6.4 Maintenance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-18
7 Preventive Maintenance and Repairs
7.1 Tools and Consumables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-1
7.1.1 Cleaning Agents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-1
7.2 Maintenance Schedule. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-5
7.2.1 Maintenance: Immediate Maintenance . . . . . . . . . . . . . . . . . . . . . . . . 7-5
7.2.2 Maintenance Table: Daily Maintenance. . . . . . . . . . . . . . . . . . . . . . . . 7-6
7.2.3 Maintenance Table: Weekly Maintenance . . . . . . . . . . . . . . . . . . . . . . 7-8
7.2.4 Maintenance Table: Yearly Maintenance. . . . . . . . . . . . . . . . . . . . . . . 7-8
7.3 Maintenance Tasks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-10
7.3.1 Liquid System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-10
7.3.2 Syringe. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-14
7.3.3 Fixed Tips of LiHa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-15
7.3.4 Wash Station . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-16
7.3.5 Worktable. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-17
7.3.6 Safety Panels. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-17
7.3.7 Liquid Containers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-17
7.3.8 Carriers and Racks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-18
7.3.9 Positive Identification (PosID) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-19
7.3.10 Arm Guide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-21
7.4 Precision and Function Tests. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-22
7.4.1 Liquid Handling Performance Verification Testing . . . . . . . . . . . . . . . . 7-22
7.5 Decontamination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7-22
8 Troubleshooting
8.1 Troubleshooting Table . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8-1
9 Shutdown, Transport and Storage
9.1 Shutdown . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-1
9.1.1 Instrument . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-1
9.1.2 Reporting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-3
9.2 Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-4
9.2.1 Unpacking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-4
9.2.2 Packaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-4
9.3 Storage. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-5

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10 Disposal
10.0.1 Local Requirements European Union . . . . . . . . . . . . . . . . . . . . . . . . . 10-1
10.0.2 Local Requirements People’s Republic of China . . . . . . . . . . . . . . . . . 10-1
11 Spare Parts and Accessories
11.1 Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-1
11.2 Documentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-1
11.3 Infinium LiHa and Infinium RoMa Basic Accessories Kit . . . . . . . . . . . . . . 11-1
11.4 Carriers, Racks, Troughs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-2
11.4.1 Carriers for Microplates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-2
11.4.2 Carriers for Tubes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-3
11.4.3 Wash Stations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-4
11.5 Tips and Accessories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-5
12 Customer Support
12.1 Contacts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12-1