Leica Aperio GT 450 DX User manual

Aperio GT 450 DX
IT Manager and
Lab Administrator Guide
MAN-0483, Revision B | May 2022

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 20222
Aperio GT 450 DX IT Manager and Lab Administrator Guide
This document applies to Aperio GT 450 DX Controller, Aperio GT 450 DX Console, and Aperio GT 450 DX SAM DX
versions 1.1 and later.
Copyright Notice
ÌCopyright © 2022 Leica Biosystems Imaging, Inc. All Rights Reserved. LEICA and the Leica logo are registered trademarks of Leica
Microsystems IR GmbH. Aperio, GT, and GT 450 are trademarks of Leica Biosystems Imaging, Inc. in the USA and optionally in other
countries. Other logos, products, and/or company names might be trademarks of their respective owners.
ÌThis product is protected by registered patents. For a list of patents, contact Leica Biosystems.
Customer Resources
ÌFor the latest information on Leica Biosystems Aperio products and services, please visit www.LeicaBiosystems.com/Aperio.
Contact Information – Leica Biosystems Imaging, Inc.
Headquarters Customer Support General Information
Leica Biosystems Imaging, Inc.
1360 Park Center Drive
Vista, CA 92081
USA
Tel: [phone] (toll free)
Direct International Tel: [phone]
Contact your local support
representative with any query and
service request.
https://www.leicabiosystems.com/
service-support/technical-support/
US/Canada Tel: [phone] (toll free)
Direct International Tel: [phone]
Email: [email protected]
European Union Authorized Representative United Kingdom Responsible Person
CEpartner4U
Esdoornlaan 13
3951 DB Maarn
The Netherlands
Leica Microsystems (UK) Limited
Larch House, Woodlands Business Park
Milton Keynes, England, United Kingdom, MK14 6FG
Importers
Leica Biosystems Deutschland GmbH
Heidelberger Straße 17-19
69226 Nussloch, Germany
Leica Microsystems (UK) Limited
Larch House, Woodlands Business Park
Milton Keynes, England, United Kingdom, MK14 6FG
00815477020297, 00815477020389
23GT450DXIVD, 23SAMSWDXIVD

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 3
Notices ................................................................................................................................ 5
Revision Record .................................................................................................................................................... 5
Cautions and Notes............................................................................................................................................... 5
Symbols ............................................................................................................................................................... 6
Customer Service Contacts ..................................................................................................... 8
1 Introduction................................................................................................................... 10
About This Guide................................................................................................................................................. 11
Related Documents ............................................................................................................................................. 12
Log Into SAM DX................................................................................................................................................. 12
The SAM DX User Interface.................................................................................................................................. 12
2 Aperio GT 450 DX Network Architecture ............................................................................. 15
Image Types Supported....................................................................................................................................... 15
General Information ............................................................................................................................................ 15
Network Bandwidth Requirements........................................................................................................................ 16
How the Aperio GT 450 DX Fits into Your Network................................................................................................. 16
Secure Access .................................................................................................................................................... 16
Aperio GT 450 DX Recommended Network Conguration ...................................................................................... 17
3 Conguring the Aperio GT 450 DX ..................................................................................... 19
General Instructions ........................................................................................................................................... 19
Basic Scanner Settings.................................................................................................................................... 20
Scanner System Information: Info Page............................................................................................................ 21
Scanner System Information: Settings Page ..................................................................................................... 22
Scanner Conguration Settings............................................................................................................................ 23
Images Page....................................................................................................................................................... 25
Image File Name Format ................................................................................................................................. 25
Barcode Management ..................................................................................................................................... 26
PIN Management ............................................................................................................................................ 27
Conguring a PIN and Timeout .................................................................................................................... 27
Enabling DICOM Image Output......................................................................................................................... 28
Contents

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 20224
Contents
4 Viewing System Information............................................................................................. 30
Displaying Scanner Information and Settings........................................................................................................ 30
Displaying Scanner Statistics............................................................................................................................... 31
Working with the Event Log.................................................................................................................................. 31
Back Up Log Files ........................................................................................................................................... 31
Login Alerts .................................................................................................................................................... 31
5 User Management .......................................................................................................... 32
Understanding Roles ........................................................................................................................................... 32
Managing Users.................................................................................................................................................. 33
Add a User...................................................................................................................................................... 33
Edit a User...................................................................................................................................................... 34
Delete a User .................................................................................................................................................. 34
Unlock a User Account .................................................................................................................................... 34
Changing Your User Password ............................................................................................................................. 34
6 Cybersecurity and Network Guidelines............................................................................... 36
Aperio GT 450 DX and Aperio SAM DX Cybersecurity Features............................................................................... 36
Data Protection................................................................................................................................................... 37
Physical Safeguards for Aperio GT 450 DX ........................................................................................................... 37
Protecting the SAM DX Server.............................................................................................................................. 37
Password, Login, and User Conguration Safeguards........................................................................................ 37
Physical Safeguards for the SAM DX Server...................................................................................................... 37
SAM DX Server Administrative Safeguards ....................................................................................................... 38
Use of Off the Shelf Software............................................................................................................................... 39
Support and Cybersecurity Patches...................................................................................................................... 39
A Troubleshooting............................................................................................................. 40
Scanner Administration Manager DX (SAM DX) Server Troubleshooting ................................................................. 40
Restart the DataServer .................................................................................................................................... 41
Verify Mirth is Running .................................................................................................................................... 41
IIS Conguration Error ..................................................................................................................................... 41
B Summary of Scanner Setting and Conguration Options ....................................................... 42
Basic Scanner Information................................................................................................................................... 42
Scanner Conguration......................................................................................................................................... 43
C Binding an SSL Certicate to Aperio SAM DX ...................................................................... 45
Assign the SSL Certicate to Your Website ........................................................................................................... 45
Bind the SSL Certicate....................................................................................................................................... 46
Index ................................................................................................................................. 49

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 5
Notices
Revision Record
Rev. Issued Sections
Affected Detail
B May 2022 All Corrected several typographical errors.
A April 2022 All New version for Aperio GT 450 DX product. Based on existing
Aperio GT 450 DX IT Manager and Lab Administrator Guide,
MAN-0459, Revision B
Cautions and Notes
`Serious Incidents Reporting - Any serious incident that has occurred in relation to the Aperio GT 450 DX shall be
reported to the manufacturer and the competent authority of the member state in which the user and/or the patient
is established.
`Specications and Performance - For device specications and performance characteristics, refer to the document
Aperio GT 450 DX Scanner Specications.
`Installation - Aperio GT 450 DX must be installed by a trained Leica Biosystems Technical Services representative.
`Repair - Repairs may be done only by a trained Leica Biosystems Technical Services representative. After repairs
are done, ask the Leica Biosystems technician to perform operation checks to determine the product is in good
operating condition.
`Accessories - For information on using Aperio GT 450 DX with third-party accessories such as a Laboratory
Information System (LIS) not provided by Leica Biosystems, contact your Leica Biosystems Technical Services
representative.
`Quality Control -For information on image quality checks, see the Aperio GT 450 DX User’s Guide.
`Maintenance and Troubleshooting -For information on maintenance, see the Aperio GT 450 DX User’s Guide.
`Cybersecurity - Be aware that workstations and servers are susceptible to malware, viruses, data corruption, and
privacy breaches. Work with your IT administrators to protect workstations by following your institution’s password
and security policies.
For Aperio recommendations on protecting your SAM DX server, see “Chapter 6: Cybersecurity and Network
Guidelines” on page 36.
If a suspected Aperio GT 450 DX cybersecurity vulnerability or incident is detected, contact Leica Biosystems
Technical Services for assistance.
`Training - This manual is not a substitute for the detailed operator training provided by Leica Biosystems or for other
advanced instruction.
`Safety - Safety protection may be impaired if this device is used in a manner not specied by the manufacturer.

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 20226
Symbols
The following symbols appear on your product label or in this user guide.
Symbol Regulation/
Standard Description
ISO 15223-1 - 5.4.3 Consult the instructions for use.
ISO 15223-1 - 5.1.1 Manufacturer
ISO 15223-1 - 5.1.3 Date of manufacture
ISO 15223-1 - 5.1.2 European Union Authorized Representative
ISO 15223-1 - 5.1.8 Importer
AS/NZS 4417.1
Device is in compliance with with the Australian Communications Media
Authority (ACMA) requirements (safety and EMC) for Australia and New
Zealand.
ISO 15223-1 - 5.1.7 Serial number
ISO 15223-1 – 5.5.1 In Vitro Diagnostic medical device.
ISO 15223-1 – 5.1.6 Catalog number
ISO 15223-1 – 5.7.10 Unique Device Identier
EU 2017/746
Article 18
Device carries the CE (Conformité Europëenne) Mark and fullls the
requirements of EU Regulation 2017/746.
Medical Devices
Regulations 2002 Device is in compliance with UK Conformity Assessment requirements.
ISO 15223-1 - 5.4.4 Caution
SO 7010 – W001 General warning

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 7
Symbol Regulation/
Standard Description
IEC 61010-1 TÜV Product Services have certied that the listed products comply with
both U.S. and Canadian safety requirements.
IEC 60417 - 5031 This device is suitable for direct current only.
IEC 60417 - 5007 On. To indicate connection to the mains, at least for mains switches or their
positions, and those cases where safety is involved.
IEC 60417 - 5008 Off. To indicate disconnection from the mains, at least for mains switches,
and all those cases where safety is involved.
ISO 15523-1 5.7.3 Temperature limitation
ISO 15223-1 5.3.8 Humidity limitation
2012/19/EU
Device is regulated under 2012/19/EU (WEEE Directive) for Electrical
and Electronic Equipment Waste and must be discarded under special
conditions.
People’s Republic
of China Electronic
Industry Standard SJ/
T11364
Device contains certain toxic or hazardous elements and can be used safely
during its environmental protection use period. The number in the middle of
the logo indicates the environmental protection use period (in years) for the
product. The outer circle indicates that this product can be recycled.
IEC 60825-1 Device is a Class 1 Laser Product that is in compliance with international
standards and U.S. requirements.
CA Proposition 65
This product can expose you to chemicals known to the State of California
to cause Cancer qnd Reproductive Harm. For more information, go to
https://www.P65Warnings.ca.gov.
N/A Device is made in the USA of U.S. and foreign components.

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 20228
Customer Service Contacts
Please contact the oce for your country for technical assistance.
Australia:
96 Ricketts Road
Mount Waverly, VIC 3149
AUSTRALIA
Tel: [phone] (toll free)
Between 8:30 AM-5 PM, Monday-Friday, AEST
Email: [email protected]
Austria:
Leica Biosystems Nussloch GmbH
Technical Assistance Center
Heidelberger Strasse 17
Nussloch 69226
GERMANY
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
België/Belgique:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
Canada:
Tel: [phone] (toll free)
Direct International Tel: [phone]
Email: T[email protected]
China:
17F, SML Center No. 610 Xu Jia Hui Road, Huangpu
District
Shanghai, PRC PC:200025
CHINA
Tel: [phone]
Fax: [phone]
Email: [email protected]
Remote Care email: [email protected]
Danmark:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
Deutschland:
Leica Biosystems Nussloch GmbH
Technical Assistance Center
Heidelberger Strasse 17
Nussloch 69226
GERMANY
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
Eire:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
España:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
France:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
Italia:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
Japan:
1-29-9 Takadanobaba, Shinjuku-ku
Tokyo 169-0075
JAPAN
Nederland:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 9
New Zealand:
96 Ricketts Road
Mount Waverly, VIC 3149
AUSTRALIA
Tel: [phone] (toll free)
Between 8:30 AM-5 PM, Monday-Friday, AEST
Email: [email protected]
Portugal:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
The Russian Federation
BioLine LLC
Pinsky lane 3 letter A
Saint Petersburg 197101
THE RUSSIAN FEDERATION
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: [email protected]
Sweden:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
Switzerland:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
United Kingdom:
Tel: [phone] (toll free)
In-country Tel: [phone]
Email: suppor[email protected]
USA:
Tel: [phone] (toll free)
Direct International Tel: [phone]
Email: T[email protected]

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 202210
This chapter introduces the Scanner Administration Manager DX (SAM DX) for use with one or more Aperio GT 450 DX
scanners.
The Aperio GT 450 DX is a high performance, brighteld whole slide scanner that includes continuous loading with 450-slide
capacity across 15 racks, priority rack scanning, automated image quality check and a scan speed of ~32 seconds at 40x
scanning magnication for a 15 mm x 15 mm area. The Aperio GT 450 DX was designed to t into your network environment
and offer the best in security and performance.
The Aperio GT 450 DX is intended for use by trained clinical pathology histotechnicians, while the Aperio GT 450 SAM DX
software is intended for use by IT professionals and laboratory administrators.
The Aperio GT 450 DX is intended for use in medium- to high-volume clinical pathology laboratories that support the
pathology services of a hospital, reference laboratory or other clinical facility.
Ensure you follow appropriate good laboratory practices and the policies and procedures required by your institution for slide
preparation, processing, storage, and disposal. Use this equipment only for this purpose and in the manner described in the
Aperio GT 450 DX User’s Guide.
Component Description
Scanner Administration Manager DX (SAM DX)
Server
The SAM DX server connects to multiple Aperio GT 450 DX scanners and
runs the SAM DX Client Application Software.
Scanner Administration Manager DX (SAM DX)
Client Application Software
The SAM DX client application software enables IT implementation, PIN
conguration, and service access of multiple scanners from a single
desktop client location for IT professionals.
Workstation, monitor, and keyboard A workstation, monitor, and keyboard are required to be connected to
your Local Area Network (LAN) with access to the SAM DX server to use
SAM DX to manage the GT 450 DX scanners.
The Aperio GT 450 DX includes the Scanner Administration Manager DX (SAM DX) that enables IT implementation and service
access of up to 4 scanners from a single desktop client location. SAM DX facilitates setup, conguration, and monitoring
of each scanner. SAM DX is installed on a server that resides on the same network as the scanner(s) as well as other
components for image management.
Features of SAM DX include:
`Web-based user interface, compatible with most current browsers to allow access throughout your facility network.
`Role-based user access. An operator role allows users to view conguration settings, while an administrative role
allows the user to change the settings.
1 Introduction

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 11
Chapter 1: Introduction
`Scanner-specic conguration settings for user-access PINs and timeouts. Access to each scanner on the system
can be congured with separate access PINs.
`Central display of statistics and event logs. Information for each scanner on the system can be displayed and
reviewed from the SAM DX interface for comparison.
`Support for multiple scanners, with centralized conguration and monitoring.
`Immediate display of scanner status. The home page displays which scanners are online and which are not.
`Services to process log data and events via Mirth Connect to a database on the le system.
About This Guide
This guide is intended for laboratory administrators, IT managers, and anyone else responsible for managing the Aperio GT
450 DX on their facility network. For general information on how to use the scanner, refer to the Aperio GT 450 DX User’s
Guide.
The next chapter of this guide explains the Aperio GT 450 DX network architecture and shows how data ows from one
component of the system to another.
Chapters that follow discuss using the Scanner Administration Manager DX (SAM DX) application to congure the Aperio GT
450 DX scanner(s), including how to add user accounts to SAM DX, and congure access PINs for each scanner. Tasks that
are only available to Leica Support personnel are beyond the scope of this manual.
For information on specic tasks, use the following table.
Task See…
Learn how the GT 450 DX scanners and the Scanner
Administration Manager DX (SAM DX) server t into your
network
“Chapter 2: Aperio GT 450 DX Network Architecture” on
page 15
Learn how data ows between the Aperio GT 450 DX, the
SAM DX server, and optional image and data management
servers.
“Aperio GT 450 DX Recommended Network Conguration” on
page 17
Log in to the Scanner Administration Manager DX (SAM
DX) client application software
“Log Into SAM DX” on page 12
Adjust conguration settings for DICOM or DSR
communication with the SAM DX server and scanner
“Scanner Conguration Settings” on page 23
Display information about a scanner on the system “Chapter 3: Conguring the Aperio GT 450 DX” on page
19
Check to see if a scanner is online “The SAM DX User Interface” on page 12
Display the serial number, software version, or rmware
version for a scanner on the system
“Scanner System Information: Info Page” on page 21
Review scanner statistics and history “Displaying Scanner Statistics” on page 31
Review advanced conguration options such as camera
settings
“Displaying Scanner Information and Settings” on page 30

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 202212
Chapter 1: Introduction
Task See…
Add a new user for Scanner Administration Manager DX
(SAM DX)
“Add a User” on page 33
Delete a user account from SAM DX “Delete a User” on page 34
Change the password for a user “Changing Your User Password” on page 34
Unlock a locked user account “Unlock a User Account” on page 34
Diagnose a problem by reviewing the event and error logs “Working with the Event Log” on page 31
Check for updates to the software “Displaying Scanner Information and Settings” on page 30
Review cybersecurity and network recommendations for
the Aperio GT 450 DX
“Chapter 6: Cybersecurity and Network Guidelines” on page
36
Related Documents
Videos available through the Aperio GT 450 DX touchscreen provide instructions for basic scanning tasks such as loading and
unloading racks.
For additional information on operating the Aperio GT 450 DX, refer to the following documents:
`Aperio GT 450 DX Quick Reference Guide - Get started with the Aperio GT 450 DX.
`Aperio GT 450 DX User’s Guide - Learn more about the Aperio GT 450 DX.
`Aperio GT 450 DX Specications - Detailed specications on the Aperio GT 450 DX.
Log Into SAM DX
After the Aperio GT 450 DX is installed and congured, the next step is to use the Scanner Administration Manager DX (SAM
DX) to manage the Aperio GT 450 DX scanners and users.
1. Open an Internet browser and enter the address of the SAM DX server. (The Leica installation representative provides
this address to the IT representative at the facility when the system is installed. Contact your IT staff for this address
if you don’t have it.)
2. Enter your login (user) name and password. If this is the rst time you are logging in, use the login information
provided by your system administrator or the Leica Biosystems installer.
3. Click Log In.
The SAM DX User Interface
The SAM DX home page with the scanner list is shown below. Note that users with the Operator role will not see the
Conguration icons.

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 13
Chapter 1: Introduction
The four general areas of the page are described below.
Scanner List
This list displays each scanner in the system, including the custom or “friendly” name, and
the scanner model. Lab Admin users can click a scanner name in this area to display the Edit
Scanner options.
Scanner Status Area
This area displays the status of each scanner.

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 202214
Chapter 1: Introduction
User Login
This displays the user name for the current SAM DX user.
Select your login name to display links for changing the password and logging out.
Commands Area
The icons used to display System Information, Event Log, and Conguration pages are
included in this area.
Note that the Conguration icons are only available to users with the Lab Admin role.

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 15
This chapter presents a basic architectural overview of how the Aperio GT 450 DX and the SAM DX server t in your network.
iIT network failure may lead to delay in diagnosis/prognosis until the network is restored.
Aperio GT 450 DX Architecture
The Aperio GT 450 DX was designed with IT ease of use and security in mind. It is integration-ready for your image and data
management system (IDMS), an LIS, and other networked systems.
The Aperio GT 450 DX includes an Aperio GT 450 DX, Scanner Administration Manager DX (SAM DX) server, cables, and plugs.
Each instance of the SAM DX server can accommodate four Aperio GT 450 DX scanners and multiple SAM DX servers can
exist on your network.
The SAM DX client application software resides on the SAM DX server, and includes the following:
`SAM DX software for conguration of the scanner
`Web-based user interface for scanner administration and conguration
`Logging and messaging services for events and errors
`DICOM server to convert the DICOM image les to SVS and transfer them to the image storage system
Image Types Supported
The Aperio GT 450 DX creates SVS les or DICOM images. The .SVS image format is the default.
Before you can enable DICOM image output, your IT environment must meet the requirements detailed in the Aperio DICOM
Conformance Statement. Also, a Leica Biosystems Technical Services representative will need to log into SAM DX as a Leica
Admin and enable Optional Features for the scanner you want to congure for DICOM. See “Enabling DICOM Image Output” on
page 28 for details.
General Information
The following guidelines apply:
`The network share where images are stored (DSR) can exist on the same server as IDMS, or it may reside elsewhere
on the local network.
`Messaging includes an instance of Mirth Connect and the deployment of various channels used to transform and
route scanner messages (scan events and logs).
Before the installation of the Aperio GT 450 DX scanners, SAM DX client application software, and the SAM DX server, the
2
Aperio GT 450 DX Network
Architecture

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 202216
Chapter 2: Aperio GT 450 DX Network Architecture
Leica Biosystems technical representative determines the best architecture for the installation based on projected usage,
current network conguration, and other factors. This includes deciding which components are installed on each physical
server in the network. The various components and services can be installed on different servers, or co-located on a single
server.
Network Bandwidth Requirements
For the connection between the Aperio GT 450 DX and the SAM DX server, the required minimum bandwidth is a gigabit
ethernet with a speed equal to or greater than 1 gigabit per second (Gbps). For the connection between the SAM DX server
and the image repository (DSR), the required minimum bandwidth is 10 gigabits per second.
How the Aperio GT 450 DX Fits into Your Network
These are the major components of the Aperio GT 450 DX and SAM DX system:
`Aperio GT 450 DX - One or more Aperio GT 450 DX scanners can be connected to a SAM DX server through the
network. Each SAM DX server can support multiple scanners.
`Aperio Scanner Administration Manager DX (SAM DX) Server - The SAM DX server contains the Scanner
Administration Manager client application software, the subject of this guide. The SAM DX server provides the
DICOM Image converter to convert DICOM images to SVS image le format. (Aperio GT 450 DX scanners stream
encrypted DICOM images to the SAM DX server). SAM DX also manages scanner conguration settings, and
manages messaging using Mirth connections.
`Digital Slide Repository (DSR) Server - This server (also known as an Image Storage System server) contains the
whole slide images from the scanner and the infrastructure to manage them. The repository may be a network share
available through a server on your network, or may reside on an optional Aperio eSlide Manager Server.
`SAM DX Workstation/Console - Accessed through a web browser (Firefox, Chrome, or Edge) on PC or laptop on your
network, administrators and operators use the console to view event data and statistics. Administrators can also
add user accounts, congure PINs, and make conguration changes.
`Database - The MS SQL Server Database that contains user data, settings data, the data and events reported via the
statistical reports, and the errors reported in the logs.
`Network File Share - The location on your network where event logs are stored.
Secure Access
Access via the SAM DX user interface is secured using SSL. Self-signed SSL certicates are provided at installation. To avoid
security messages from the browser, customers may provide their own security certicates.
iTo protect your network from cybersecurity attacks, we recommend that you disable unused ports and services on your
network.

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 17
Chapter 2: Aperio GT 450 DX Network Architecture
Aperio GT 450 DX Recommended Network Conguration
This section describes the recommended way to connect your Aperio GT 450 DX in your IT environment for optimal
performance.
Con g Data
Port 44386
TLS
Image Data
TCP 2762
TLS
Image Metadata
Port 44386
TLS
Aperio GT 450 DX Scanner
Event Data Ports
6662, 6663
No sensitive data
SAM DataServer Mirth
DICOM Converter
SQL Server
Database
SAM Server File System
Log Data
Events
Events
Con g Data
Secured Port 443 SAM Web Page
Image Metadata
Port 44386
TLS
Image Data UDP 137, 138
TCP 139, 445
SMB3
Image and Data Management System
Image Server File System
DSR Server
SAM Server
Time
Synchronization Port 123
Viewing station
Viewing station

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 202218
Chapter 2: Aperio GT 450 DX Network Architecture
Data Type Description Port
Image Data The Scanner sends DICOM image data to the DICOM Converter. The data is sent using
TLS encryption.
Congure the communication between the scanner and the DICOM converter using the
Hostname and Port settings on the Images conguration page.
TCP 2762
The DICOM Converter sends the image data (either as a converted SVS le, or as raw
DICOM data) to the image and data management system (IDMS) on the DSR Server. The
data is sent using SMB3 Encryption.
Congure the communication between the DICOM converter and the DSR using the File
Location setting on the Images page.
UDP 137,
138
TCP 139,
445
Images can be sent to viewing stations connected to the DSR. 80, 443
Scanner
Conguration
Data
The scanner sends a call to the SAM DX DataServer to request conguration data. The
SAM DX DataServer returns the conguration data to the scanner. The data is sent using
TLS Encryption. Communication between the scanner and the SAM DX DataServer is
congured on the scanner.
44386
The SAM DX DataServer stores the conguration data on the SQL Server Database on the
SAM DX Server.
The SAM DX DataServer displays the conguration data through the SAM DX web page.
Time
Synchronization
Timeclock synchronization between SAM DX and Multiple Scanners is maintained using
network time protocol.
UDP 123
Image Metadata The Scanner sends Image Metadata to the SAM DX DataServer. The data is sent using
TLS encryption. Communication between the scanner and the SAM DX DataServer is
congured on the scanner.
44386
The SAM DX DataServer sends image metadata to the IDMS located on the DSR. The
data is sent using TLS encryption.
Congure the communication between the SAM DX DataServer and the scanner using
the Hostname and Port settings on the DSR page.
Messaging and
Event Data
The scanner sends logs and event data to the Mirth Connect Server. No sensitive data is
transferred.
Congure the communication between the scanner and the Mirth Connect Server on the
Event Handling conguration page.
6662, 6663
The Mirth Connect Server copies critical event and error data to the SAM DX DataServer,
and then the SAM DX DataServer sends this data to the SQL database. This is the data
reported out via the SAM DX Event Logs.
The SAM DX DataServer displays the event data through the SAM DX web page.
The Mirth Connect Server processes the Log data and appends the Event Log, which
resides on the le system. The communication between Mirth and the Event Log is
congured within the Mirth Application setup. It is not accessible through SAM DX.
“Scanner Conguration Settings” on page 23 provides information on how to congure the various connections between the
components and services through the SAM DX interface.

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 2022 19
This chapter provides information you will use if you need to change the scanner settings, system information, or
conguration. The scanner conguration denes how the scanner communicates with SAM DX, and how SAM DX, in turn,
communicates with the various components on the network, including the IDMS server, the DICOM Image converter, and
others. Also included are procedures for assigning scanner access PINs.
General Instructions
Only a user who is assigned the Lab Admin role can make conguration changes. Operators can view conguration settings,
but cannot change them.
Some of the conguration settings dene how the scanner communicates with SAM DX, such as the Mac
Address and Hostname. The Serial Number uniquely identies the scanner. Calibration settings dene
how the scanner operates. These settings can only be changed by Leica Support personnel, and are
displayed in shaded elds.
There are three sets of scanner conguration parameters:
`Basic Scanner settings, such as the network address, name, and display language
`Scanner System Information, such as general information and detailed scanner and camera settings
`Scanner Conguration settings, such as communication settings for the DICOM Image converter and the DSR server,
event management, time zone, and PIN management
Each set of parameters is discussed in this chapter.
3
Conguring the Aperio GT
450 DX

Aperio GT 450 DX IT Manager and Lab Administrator Guide, Revision B © Leica Biosystems Imaging, Inc. 202220
Chapter 3: Conguring the Aperio GT 450 DX
Basic Scanner Settings
To display the Edit Scanner dialog box:
1. Conrm that the Scanners icon in the banner is selected, and the page shows the list of scanners. Click the
Scanners icon to display the list, if necessary.
2. Hover over the name of the scanner until the edit symbol appears, then click the scanner name.
3. Customize the available settings as needed:
`Enter a Friendly Name to identify the scanner for your facility. (The friendly name is shown on the main page.)
`Select a new language for the scanner control panel messages, if you wish.
`Refer to “Appendix B: Summary of Scanner Setting and Conguration Options” on page 42 for additional
information on each option.
4. Click Save to save your changes.
If you are setting up a new scanner or need to change how the scanner communicates with other servers on the network,
continue with “Scanner Conguration Settings” on page 23.