Mundipharma NYXOID Manual
This leaflet tells you:
lHow to recognise symptoms of an opioid overdose
lWhat to do in the event of an opioid overdose
lHow to give Nyxoid
lHow to recognise acute withdrawal symptoms
For more information:
Visit www.nyxoid.com
or scan QR code
There is also a
Quick Start Guide
on the back of the
Nyxoid container.
Mundipharma Pharmaceuticals Limited,
Millbank House, Arkle Road, Sandyford, Dublin 18, Ireland.
Nyxoid®is a registered trade mark of
Mundipharma Corporation Limited.
Date of prep: April 2018
Job code: IRE/NYXO-18015a(1)
Date of item: July 2020
For full instructions, turn to the other side of the leaflet.
Take care: a person treated with Nyxoid may show acute
withdrawal symptoms, which can be dangerous.
ALWAYS call an ambulance immediately, even if the person
wakes up — they may become unconscious again, and stop
breathing.
Nyxoid contains naloxone. Nyxoid works for a short time only
to reverse the effects of opioids while you wait for emergency
medical attention. Naloxone works by displacing opioid drug
molecules from their receptors in the brain and body.
If you carry Nyxoid?
Set an alert in your calendar for 1 month before your Nyxoid is
due to expire. Then arrange for a replacement.
When to use Nyxoid?
If you know or suspect that someone has overdosed on an opioid
drug, use Nyxoid as described on the other side of this leaflet.
Nyxoid contains the active substance naloxone. Naloxone
temporarily reverses the effects of opioids such as heroin,
methadone, fentanyl, oxycodone, buprenorphine and morphine.
Nyxoid is a single-dose nasal spray used for the emergency
treatment of opioid overdose or possible opioid overdose in
adults and adolescents over 14 years.
Nyxoid is not a substitute for emergency medical care.
Nyxoid should be carried by anyone at risk of overdosing on an
opioid. Carers such as close family or friends should know where
to find Nyxoid in case of emergency.
opioid receptors in brain and body
Opioid overdose Naloxone treatment
Opioid drugs
fit into
receptors.
Naloxone fits more
strongly in the
receptors. Opioids are
temporarily displaced
from receptors.
Brain signals are
blocked. Breathing
slows and stops.
Theperson becomes
unconscious.
Brain signals
resume. The
person can
breathe again,
and wakes up.
opioid
naloxone
opioid receptors in brain and body
Opioid overdose Naloxone treatment
Opioid drugs
fit into
receptors.
Naloxone fits more
strongly in the
receptors. Opioids
are temporarily
displaced from
receptors.
Brain signals are
blocked. Breathing
slows and stops.
Theperson
becomes
unconscious.
Brain signals
resume. The
person can
breathe again,
and wakes up.
opioid
naloxone
What is Nyxoid? Quick reference
How does Nyxoid work?
1Check for signs of overdose
2Call an ambulance
3Give Nyxoid
5Monitor and give support
until the ambulance arrives
6Give 2nd dose of Nyxoid
if no improvement after 2–3 minutes
OR overdose symptoms come back
7Take care for your personal safety:
watch for acute withdrawal symptoms
8Dispose of used Nyxoid
and get a replacement
4Put into recovery position
Check for signs of overdose
Call an ambulance
Give Nyxoid
Put into recovery position
Monitor and give support
until the ambulance arrives
Dispose of used Nyxoid
and get a replacement
Give 2nd dose of Nyxoid
if no improvement after 2–3 minutes OR
overdose symptoms come back
Take care for your personal safety:
watch for acute withdrawal symptoms
!
!
Check for signs of overdose
Give 1 spray of Nyxoid Monitor until help arrives
No response? Give 2nd dose
Take care for your own safety
When the ambulance arrives
Disposal of used nasal sprays
If you forget to give the used sprays to the paramedics, pass
them to a healthcare professional or pharmacist, and arrange
for replacements. Never throw away the sprays in water waste
or household waste.
Put into recovery position
Call an ambulance
lApproach with care. Check for dangers, such as injecting
materials that might lying around
lCheck for a response, to see if the person is conscious.
You can:
l shout their name
l gently shake their shoulders
l talk loudly into their ear
l rub their breastbone (sternum)
l pinch their ear or the bed of their fingernail
lCheck airways and breathing.
l Clear the mouth and nose of any blockages
l For 10 seconds, check for breathing – Is the chest moving?
Canyouhearbreathingsounds?Canyoufeelbreathonthe
cheek?
lCheck for signs of overdose, such as:
l no response to touch or sounds
l slow, uneven breathing or no breathing
l snoring, gasping or gulping
l blue or purple fingernails or lips
lIf an overdose is suspected Nyxoid should be given
lStay with the person. Watch for an improvement in
breathing, and their response to sound and touch
lIf the person is unconscious and not breathing normally,
give basic life support (such as CPR) if you are trained to
do so
lBe aware — even if they wake up, they may become
unconscious again, and stop breathing
lIf there’s no improvement after 2–3 minutes, or if
overdose symptoms come back: use a new Nyxoid
spray in the other nostril. You can do this while the
person is in the recovery position
lIf patient does not respond to two doses, further doses
may be given (if available)
lNyxoid can cause acute withdrawal symptoms if
the person is dependent on opioid drugs. Symptoms
can include:
• body aches and stomach cramps
• feeling sick, vomiting, diarrhoea
• sneezing
• sweating, fever, shivering or trembling
• nervousness, restlessness or irritability
Some people may seem to act aggressively as they wake up.
Take care for your own safety.
lImmediately tell them what has happened and that you
have given Nyxoid. Give them any used Nyxoid spray(s).
lPut your phone in loudspeaker mode if possible
to keep your hands free
lGive emergency services as much information as
you can, including:
l your exact location and postcode (if known)
l what substances you think the person may have taken
l whether they are conscious and breathing
l that you plan to give Nyxoid spray
Nyxoid is not a substitute for emergency medical
care or basic life support (such as CPR).
Always call for emergency
services immediately, even
if the person wakes up.
What to do: step-by-step
CD
APlace nearest arm at
right angle
to body,
with arm
bent
BBring other arm
across chest
Place back of
person's hand
against cheek
Grasp far leg
just above knee
Lift knee
Roll person
towards you,
onto their
side
Support head, keeping
back of hand against cheek
Final position:
Hand supports
head
Top leg bent at hip and knee
Lay the person on their back.
Support the back of the neck,
and let the head tilt back.
Clear away anything you see
blocking their nose.
B
Peel off the back of the
Nyxoid container.
Remove the nasal spray and
place it within easy reach.
A
Hold the spray as shown —
first two fingers either side
of the nozzle, thumb ready
to push the plunger.
Don’t press to prime or
test before use.
C
Don’t
press yet
Gently insert the spray nozzle
into onenostril. Press firmly
on the plunger until it clicks
and gives the dose.
Remove the nozzle from
the nostril. If possible, note
which nostril you used.
Press
“Click”
D
1
3 5
6
7
8
4
2
!
!
Each nasal spray contains one dose only.
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet.
You can also report side effects directly via HPRA Pharmacovigilance,
Website: www.hpra.ie. By reporting side effects you can help provide more
information on the safety of this medicine.
