Planer MR7 User manual

®
MR7
INSTRUCTIONS FOR USE
© 2022 Planer Limited
Original instructions
MA200524-EN 5.0.430

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MR7 : INSTRUCTIONS FOR USE MA200524-EN 5.0.430
Table of contents
1. Introduction 7
1.1 Notices ............................................................................................................................ 8
1.2 Intended use statement ................................................................................................ 9
1.3 Symbols used in the manual ......................................................................................... 9
1.4 Symbols used on the equipment .................................................................................. 9
1.5 Symbols used in the application ................................................................................ 11
1.5.1 General symbols ..................................................................................................... 11
1.5.2 Welcome page symbols ......................................................................................... 12
1.5.3 Main options symbols ............................................................................................ 12
1.5.4 Alarm symbols ........................................................................................................ 13
1.5.5 Licensing symbols .................................................................................................. 13
1.5.6 Port symbols ........................................................................................................... 13
1.5.7 Profile symbols ....................................................................................................... 13
1.5.8 Manual override symbols ....................................................................................... 14
1.5.9 Kryofile symbols ..................................................................................................... 14
1.5.10 User symbols .......................................................................................................... 14
1.5.11 Settings symbols .................................................................................................... 15
1.6 Safety information ....................................................................................................... 15
1.6.1 First aid ................................................................................................................... 15
1.6.2 Safety ...................................................................................................................... 15
1.6.2.1 Equipment ................................................................................................................................................ 15
1.6.2.1.1 Warnings ........................................................................................................................................... 15
1.6.2.1.2 Precautions ....................................................................................................................................... 16
1.6.2.2 Liquid nitrogen and vessels ................................................................................................................. 17
1.6.3 EMC precautions .................................................................................................... 17
1.7 About the MR7 ............................................................................................................. 18
1.7.1 Theory of operation ................................................................................................ 18
1.7.2 Connection overview .............................................................................................. 20
1.7.2.1 MR7 Controller ....................................................................................................................................... 20
1.7.2.2 Chamber ................................................................................................................................................... 21
2. Getting started 23
2.1 Installing the equipment ............................................................................................. 24
2.1.1 Installing the liquid nitrogen supply ...................................................................... 25
2.2 Software installation ................................................................................................... 25
2.3 Basic configuration ...................................................................................................... 26
2.3.1 Configuring email and web access ........................................................................ 27
2.3.1.1 Sending email using Gmail ................................................................................................................... 28
2.3.2 Licensing the application ....................................................................................... 30
2.3.3 Adding users ........................................................................................................... 30
2.3.3.1 Access levels ........................................................................................................................................... 31
2.3.3.2 MR7 Controller specific access levels ............................................................................................... 32
2.3.4 Configuring the password constraints ................................................................... 32

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2.3.5 Adding the port ....................................................................................................... 33
2.3.6 Configuring alarms ................................................................................................. 33
2.3.6.1 System alarm types ................................................................................................................................ 34
2.3.6.1.1 Control deviation alarms ............................................................................................................... 34
2.3.6.2 Alarm notifications ................................................................................................................................ 34
2.3.7 Creating profiles ..................................................................................................... 34
2.3.7.1 Creating a warming profile .................................................................................................................. 35
2.3.8 Configuring the control coefficients ...................................................................... 36
2.3.9 Configuring the wired network ............................................................................... 37
2.3.10 Configuring the wireless network .......................................................................... 37
2.3.11 Setting date and time ............................................................................................. 38
2.3.12 HP USB printer installation ..................................................................................... 38
2.4 Switching off the system ............................................................................................. 40
3. Using a Planer pump and dewar 41
3.1 Filling a dewar .............................................................................................................. 42
3.2 Fitting the pump .......................................................................................................... 42
3.3 Testing and pressurising the pump ............................................................................ 44
3.4 Removing the pump .................................................................................................... 44
4. Profiles 47
4.1 Profile terms ................................................................................................................. 48
4.2 Profile stages ................................................................................................................ 48
4.3 Manual seeding ............................................................................................................ 48
4.4 Pulse seeding ................................................................................................................ 49
4.5 Automatic seeding ....................................................................................................... 50
4.6 Trigger on sample ........................................................................................................ 50
5. Running profiles 51
5.1 Preparing the nitrogen supply ................................................................................... 52
5.2 Starting the profile ...................................................................................................... 52
5.3 Loading samples ........................................................................................................... 52
5.4 Seeding samples ........................................................................................................... 53
5.5 Monitoring the run ...................................................................................................... 54
5.6 Removing samples at the end ..................................................................................... 54
5.7 Aborting a run .............................................................................................................. 55
5.8 Returning the freezer to ambient .............................................................................. 55
5.9 Viewing Kryofiles .......................................................................................................... 56
5.9.1 To view a stored Kryofile ........................................................................................ 56
5.9.2 Printing a Kryofile ................................................................................................... 56
5.9.2.1 Printer ....................................................................................................................................................... 57
5.9.2.2 PDF (File) .................................................................................................................................................. 57
5.9.2.3 PDF (Email) .............................................................................................................................................. 57

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5.9.3 To retrieve the backup Kryofile .............................................................................. 58
5.9.4 Resuming Kryofiles ................................................................................................. 58
6. Infrequent tasks 59
6.1 Web browser access .................................................................................................... 60
6.2 Viewing the audit trail ................................................................................................. 61
6.3 Changing the line colours ............................................................................................ 61
6.4 Advanced configuration .............................................................................................. 61
6.5 Changing your password ............................................................................................. 65
6.5.1 Resetting a password ............................................................................................. 65
6.6 Controlling the MR7 using a PC .................................................................................. 66
6.7 File locations ................................................................................................................. 68
6.8 Mirrored Kryofiles ........................................................................................................ 69
7. Equipment list 71
8. Routine maintenance and troubleshooting 73
8.1 MR7 service schedule .................................................................................................. 74
8.2 Routine maintenance .................................................................................................. 74
8.3 General cleaning .......................................................................................................... 75
8.4 Cleaning and disinfecting the system ......................................................................... 76
8.5 Battery replacement .................................................................................................... 77
8.6 Calibrating the system ................................................................................................. 78
8.6.1 Manual calibration ................................................................................................. 79
8.6.2 Emailing a calibration report .................................................................................. 79
8.7 Troubleshooting ........................................................................................................... 80
8.7.1 Troubleshooting ..................................................................................................... 80
8.7.2 MR7 Troubleshoooting ........................................................................................... 80
8.7.3 Unexpected reset ................................................................................................... 81
8.7.4 The run has stopped prematurely .......................................................................... 81
8.7.5 The chamber will not cool ...................................................................................... 81
8.7.6 The chamber will not heat ..................................................................................... 82
8.7.7 No response from the system ................................................................................ 82
8.7.8 Returning for service .............................................................................................. 82
8.8 Disposal ......................................................................................................................... 82
9. Additional information 83
9.1 Specifications ............................................................................................................... 84
9.1.1 System specifications ............................................................................................. 84
9.1.2 Power specifications .............................................................................................. 84
9.1.2.1 Series 300 ................................................................................................................................................ 84
9.1.2.2 Series 500 ................................................................................................................................................ 84
9.1.3 Controller specifications ........................................................................................ 85

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9.1.4 Chamber specifications .......................................................................................... 85
9.1.5 Fuses ...................................................................................................................... 86
9.1.5.1 Series 300 ................................................................................................................................................ 86
9.1.5.2 Series 500 ................................................................................................................................................ 86
9.1.6 Batteries ................................................................................................................. 86
9.2 External alarm connection .......................................................................................... 86
89
Index

Introduction

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MR7 : INSTRUCTIONS FOR USE MA200524-EN 5.0.430
Introduction
1 Introduction
This manual only applies to the following models: MR7 Series 300 and 500
This guide has been designed to help you install and use the MR7. The guide includes
important information regarding safe use of the equipment and it is important that you
familiarise yourself with this document before attempting to install or operate the
equipment.
The following symbols are used within this guide:
WARNING. Failure to follow these instructions could result in injury or loss of
samples.
CAUTION: This section contains important information. Failure to follow these
instructions could result in loss of data.
TIPS: This information is intended to help you use the application.
1.1 Notices
INSTRUCTIONS FOR USE: MR7 System
Issue: 5.0.430 2022-08-01
© 2022 Planer Limited
Original instructions
Planer Limited. 110 Windmill Rd., Sunbury-on-Thames, Middlesex,
TW16 7HD, UK. Tel: [phone]; email: [e-mail]
Good practice demands that in critical applications, reliance should not be placed on a
single source of data. Hard copies and backup copies should be routinely kept.
All equipment supplied by Planer Limited is subject to a Warranty Agreement and
Limited Liability. In addition, software products are not sold but are licensed for use and
are subject to a Licence Agreement.
You may freely copy and distribute this document for personal use in any form provided
that the document is reproduced in full and includes these notices. Individual pages and
forms may be freely copied for the purposes of implementing any instructions within the
documentation. You may not make modifications or create derivative works. Any
modification to these conditions requires the written permission of Planer Limited.
This information is provided without warranty, express or implied, and including but not
limited to any implied warranties in respect of merchantability or fitness for any purpose,
except to the extent that such provisions are held to be void, in violation of applicable
law, or unenforceable in a specific jurisdiction.
Planer Limited reserves the right to alter products and their specifications without notice.
Oracle and Java are registered trademarks of Oracle and/or its affiliates. Other names
may be trademarks of their respective owners.
DeltaTv7 powered by http://serialio.com
PDF Technology by Qoppa Software, LLC – www.qoppa.com

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Introduction
1.2 Intended use statement
The controlled-rate freezer is specifically designed for users who need to cool or heat
samples following a defined temperature-time profile, as part of patient treatment or
diagnosis and where the samples will subsequently be re-introduced into the body.
1.3 Symbols used in the manual
The following symbols are used within this guide:
WARNING. Failure to follow these instructions could result in injury or loss of
samples.
CAUTION: This section contains important information. Failure to follow these
instructions could result in loss of data.
NOTE: This information is intended to help you use the application.
1.4 Symbols used on the equipment
Refer to these instructions. Failure to follow these
instructions may result in personal or third-party injury.
Manufacturer
Consult instructions for use.
Swiss Representative
European Representative
Medical Device Model number
Product name
No tools
Direct current (DC) input.
Primary PT100 input.

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MR7 : INSTRUCTIONS FOR USE MA200524-EN 5.0.430
Introduction
Secondary PT100 input.
Serial port connection.
Ethernet connection.
USB connections.
SD card.
Controlled-rate freezer connector.
Alarm output connector.
Do not dispose of with general waste.

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MR7 : INSTRUCTIONS FOR USE MA200524-EN 5.0.430
Introduction
1.5 Symbols used in the application
1.5.1 General symbols
Help Open the application help
Back Go back to previous page
Done Close current page
Save as Save information to file
Store Store information in the controller's memory
Read Read information from the controller's memory
Print/PDF Print the information or generate a PDF
Move selection from right-hand list to left-hand list
Move selection from left-hand list to right-hand list
Move selection upwards in a list
Move selection downwards in a list
Add an item to a list
Remove an item from a list

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Introduction
1.5.2 Welcome page symbols
Menu Open main menu page
Run Run a profile
Log Out Log out
Log in Log in
Log in Log in
1.5.3 Main options symbols
Back Go back to previous page
Done Close current page
Alarm s Access alarms menu
Audit Trail Access the audit trail
Edit passw ord Edit your password
Licensing Access the licensing menu
Ports Access the ports menu
Profiles Access the profiles menu
Cool/Heat Access the manual override menu
Kryofiles View Kryofiles
Access the Users page
Settings Access the Settings page
Shut dow n Shut down the application

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Introduction
1.5.4 Alarm symbols
Active View active alarms
Setup Set up alarms
1.5.5 Licensing symbols
Edit Edit the licence
Icon identifying a valid licence
Icon identifying a valid licence
1.5.6 Port symbols
New Add a new port
Edit Edit the port configuration
Select freezer type
1.5.7 Profile symbols
New Create a new profile
View View a profile
Edit Edit a profile
Delete Delete a profile
Run Run a profile
Steps View the profile steps
Steps Edit the profile steps
Chart View profile steps as a graph

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Introduction
1.5.8 Manual override symbols
Active
Activate the freezer's solenoid valve to reduce the
temperature
Setup Activate the freezer's heater to increase the temperature
1.5.9 Kryofile symbols
View
Activate the freezer's solenoid valve to reduce the
temperature
Retrieve Retrieve the last freezing run from the controller's memory
Profile View profile steps as a graph
Chart View run data as a graph
Table Tabular information about the run
Calibrate Calibrate the controller using information from the Kryofile
Symbols used to show information about the profile are also available when viewing a
Kryofile; see Profile symbols .
1.5.10 User symbols
New Add a new user
View View users
Edit Edit your own details
Edit Edit a user
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Introduction
1.5.11 Settings symbols
Edit Edit settings
View Reset settings
Calibrate Calibrate the freezer
Netw ork Configure the wired network settings
WiFi Configure the wireless network settings
Coeffs Configure the freezer coefficients
Standard Select standard freezer coefficients
External Control the freezer externally
Internal Return control to the MR7
1.6 Safety information
WARNING
This section contains important information for the safe use of the system. Failure to
follow these instructions could result in injury or loss of samples.
1.6.1 First aid
IF IN DOUBT, SEEK IMMEDIATE MEDICAL ATTENTION. If any quantity of
liquid nitrogen comes into contact with the skin or eyes, immediately flood
that area of the body with large quantities of unheated water, apply cold
compresses and seek medical attention. If the skin is blistered or there is
any possibility that eyes have been affected, the patient should be taken
immediately to a doctor or hospital for treatment.
1.6.2 Safety
1.6.2.1 Equipment
1.6.2.1.1 Warnings
WARNING

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Introduction
Operating the equipment in a manner not specified within this document or under
conditions outside of the specifications may result in the protection offered by the
equipment being impaired.
Installation must only be undertaken by suitably trained personnel.
The equipment is classified as Class I equipment and must be earthed for safe
operation.
The mains lead must be properly fitted to a 3-way mains connector and connected to
an earthed mains outlet to maintain protection against electric shock,
The operator should be provided with additional protection against electric shock
because of the potentially wet laboratory environment.
oEnsure that the mains supply to the equipment is protected by a residual-current
circuit breaker (RCCB) operating at a differential of 30 mA.
oEnsure that the equipment is not compromised by faulty equipment sharing the
same supply and causing nuisance trips.
Any electrical devices connected to the equipment must comply with either IEC 950,
IEC 61010 or their equivalent.
The chamber and contents may get cold enough to cause frostbite when running a
profile.
The Series 500 chamber and contents can become hot enough to cause burns even
when the equipment is not running a profile.
The Series 500 chamber weighs 23 kg and requires at least two people for safe
handling.
oSupport the weight using the bottom plate.
oDo not attempt to lift using the edges of the case.
1.6.2.1.2 Precautions
CAUTION
The connectors on the equipment must only be used for connection to other
equipment described in this document.
When heating under manual control, check the chamber temperature at intervals of 30
seconds or less to avoid overheating.
User servicing is limited to cleaning and decontamination. All other servicing must
only be undertaken by suitably trained engineers.
For continued protection against risk of fire, fuses must always be replaced with fuses
of the same type and rating.
Do not move the equipment while it is still wet after a freezing run.
Switching off the chamber at sub-zero temperatures may cause serious damage to
the equipment.
If connected to a liquid nitrogen cylinder, allow the hose to thaw and warm up to room
temperature before shutting off the valve on the cylinder.
Do not switch on the LNP4 pump power supply while the chamber is heating.
The unit is designed for connection to information technology equipment compliant
with EN60950 or its equivalent. Use with other equipment may compromise the safety
of the device. The unit should only be connected to an Ethernet local area network
(LAN) internal to the building.

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Introduction
1.6.2.2 Liquid nitrogen and vessels
WARNING
Avoid nitrogen build up. Only use liquid nitrogen in well ventilated rooms. Small
volumes of liquid nitrogen convert to very large volumes of gas. This can result in
drowsiness or asphyxiation.
If liquid nitrogen is used in confined spaces, install oxygen-deficiency alarms.
Guidance on ventilation requirements are given in BCGA Code of Practice CP30, "The
safe use of liquid nitrogen dewars up to 50 litres".
If there is a risk of reduced or insufficient ventilation when a room is unoccupied,
oxygen deficiency alarms must be installed and positioned outside of the room so that
operators are aware of the hazard before entering. The operational status of alarms
should be visible from outside the room.
If liquid nitrogen is used in an area that requires forced ventilation, an alarm to indicate
failure of the ventilation must be fitted.
When dispensing or potentially being exposed to liquid nitrogen, wear protective
clothing.
oWear a face shield
oWear cryogenic protective gloves with your sleeves over the gloves.
oDo not wear short gauntlets. Liquid nitrogen can get caught in the cuffs.
Handle vessels containing liquid nitrogen carefully.
oLiquid nitrogen boils at -196 ºC and both liquid and gas can cause rapid and severe
frostbite.
oDelicate tissue such as the eyes can be damaged by exposure to cold gas, which
may be too brief to affect the skin of the hands or face.
Stand clear of boiling and splashing liquid nitrogen and its gas when filling a dewar or
when inserting objects, such as a pump, into the liquid.
Use tongs or wear suitable protective gloves when handling cold or hot objects.
Never remove a pump from a dewar until the pressure gauge reading has fallen to zero.
This is achieved by opening the pressure relief valve mounted on the side of the pump.
Avoid contact with cold nitrogen gas when depressurising the dewar.
The dewars used with this equipment must never be used to store any liquid other
than liquid nitrogen.
Only use vessels designed for working with liquid nitrogen.
Secure the liquid nitrogen container to prevent toppling.
Ensure that the delivery pipe connections are secure and leak-free before supplying
liquid nitrogen to the freezer.
The liquid nitrogen pressure must not exceed 1.7 bar (25 psi).
1.6.3 EMC precautions
CAUTION
The following precautions must be taken to ensure that the equipment is not damaged
by electrostatic discharge (ESD), and that its immunity to radio frequency interference is
not compromised.

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Introduction
Ensure that the equipment is not running and that the mains power is disconnected
before connecting or disconnecting any cable.
Fit the plastic covers and plugs provided to all unused connectors.
Immediately before touching the sample temperature probe, touch an earthed part
such as a metal part of the equipment's enclosure.
Do not touch any uncovered connectors with your hands or tools, even when the
equipment is switched off.
When connecting the equipment to a computer, always use a fully screened cable no
longer than 2 m.
Take care to avoid placing the equipment in environments influenced by sources of
electromagnetic interference, such as large transformers.
1.7 About the MR7
The key parts of the complete system are shown below.
Fig.1 Key parts of the MR7 system
1. Touchscreen
2. Power and alarm indication strip
3. Monitor stand
1.7.1 Theory of operation
The equipment is designed to cool samples by following a predefined time-temperature
profile. The temperature-time relationship is referred to as the profile.
The equipment comprises two main elements:

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Introduction
1. MR7 Controller: the user interface and temperature controller. This comprises two
internal subsystems:
a. IO Control Board: measures the current temperature and adjusts the amount of
liquid nitrogen or heat that is supplied to the chamber.
b. Host Board: provides the user interface and downloads profiles to the IO Control
Board to be executed.
2. Chamber: contains the samples being cooled and houses the heater and liquid
nitrogen injection components.
The simplified process is described below:
1. The user creates a profile using the user interface on the controller.
2. The user starts the profile.
3. The Host Board downloads the profile to the IO Control Board to be executed.
4. The IO Control Board monitors the temperature of the chamber and either injects
liquid nitrogen or applies the heater in order to ensure the temperature follows the
temperature-time profile.
5. At the end of the run, the Host Board informs the user that the run has ended so the
samples can be removed.

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Introduction
1.7.2 Connection overview
1.7.2.1 MR7 Controller
All connectors are at the bottom of the MR7 control box.
Fig.2 Connections on the MR7 control box
1 DC power input
2Controller rate freezer connector.
3 Primary temperature probe input
4 Secondary temperature probe input
5 Serial port. For use by trained service personnel only.
6 Alarm output
7 USB connection. For use by trained personnel only.
8 USB connection. For use by trained personnel only.
9 Micro SD card. For use by trained personnel only.
10 Network connection.