ZINEXTS MagPurix 24 EVO User manual

Automated Nucleic Acid Purification System
24 EVO
Catalog No.: ZP01019
Rev. Date: Sep. 07, 2022
Manual No. IFU-MP01-01019
Version: 2.7
Instruction Manual
Obelis s.a.
Bd Général Wahis 53
1030 Brussels Belgium
Tel: +(32) 2 732-59-54
Fax: +(32)2 732-60-03
[e-mail]

www.zinexts.com 2MagPurix 24 EVO Instruction Manual
Contents
Introduction ...................................................................................................................................3
Safety Information ........................................................................................................................4
1.0 Installation ...............................................................................................................................8
1.1 Composition of the MagPurix 24 EVO system ................................................................. 8
1.2 Contents of Reagent Kits....................................................................................................9
1.3 Operating Environment / Condition .................................................................................9
1.4 Unpack the MagPurix 24 EVO system.............................................................................11
1.5 Overall View .......................................................................................................................12
2.0 Getting Started ......................................................................................................................14
2.1 Turning ON the power......................................................................................................14
2.2 Touch Panel and User Interface.......................................................................................18
2.3 Preparation ........................................................................................................................18
Function Test............................................................................................................................19
2.5 Extraction ...........................................................................................................................19
3.0 Cleaning & Maintaining the MagPurix 24 EVO..................................................................24
4.0 Troubleshooting ....................................................................................................................28
5.0 Specifications.........................................................................................................................30
6.0 Warranty ................................................................................................................................31
7.0 Revision history .....................................................................................................................31

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Introduction
Thank you for purchasing the MagPurix 24 EVO which is a fully automated, standalone robot
that can purify nucleic acids within 30-45 minutes. With advanced magnetic bead separation
technology, it enables you to obtain high-quality extraction results. Moreover, the most user-
friendly interface makes users free from troublesome parameter settings and maintenance.
This guide contains important information regarding the safe use of the MagPurix 24 EVO.
Please read this manual carefully before you start to run the system for the first time, especially
for Safety Information.
If there is any question about how to install or operate the system, please contact our certified
distributors/agents or email our technical support center ( suppor[email protected] ).
Manufacturer Info:
Manufacturer: Zinexts Life Science Corp
Address: 16F., No. 93, Sec. 1, Xintai 5th Rd., Xizhi Dist.,
New Taipei City 221416, Taiwan (R.O.C)
Tel: [phone]
Fax: [phone]
Mail: [e-mail]
Product of Origin: Taiwan
MagPurix Magnetic Bead Purification Process

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Safety Information
The meaning of safety precaution marks are as follows:
WARNING:
“WARNING” indicates a dangerous condition that may lead to death or serious injury.
BIOHAZARD:
This symbol indicates that certain precautions must be taken when working with
potentially infectious material.
CAUTION:
This symbol indicates that non-compliance with instructions or procedures may lead to
physical injury or even death or could cause damage to the instrument.
Important:
“Important” points an important note for appropriate usage, as well as prohibited actions.
Note:
“Note” indicates the procedures that should be obeyed and supplementary information
for use.
HOT SURFACE:
This symbol labels potentially hot surfaces on the instrument.
IVD
This symbol shows this instrument is an “In vitro diagnostic”-certified medical device.
For your safety and that of others, follow the guidelines provided in the following pages
concerning the use of the MagPurix 24 EVO system.

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About Instrument
WARNING:
Ignoring the following notations may lead to fire or electric shock.
- In countries other than Taiwan, US and Canada, use a power cable that meets your
country’s standard or contact your local distributor.
- Do not use the MagPurix 24 EVO system with the voltage other than the voltage
specified on the device.
- Do not use the MagPurix 24 EVO system with a damaged power plug or a loose socket.
- If there is dust on the prongs of the power plug or on the plug socket, remove it with a
dry cloth.
- When you disconnect the plug from the outlet, be sure to hold the power plug itself.
Do not pull the power cable.
- For maintenance, disconnect the power plug from the outlet.
- Do not touch the power plug when you hear the crash of thunder.
Do not pour any liquid on the MagPurix 24 EVO system.
Do not place any objects containing liquid on the MagPurix 24 EVO system. Doing so
may cause device failure, fire, or electric shock.
If the device starts to smoke or smells strange, immediately unplug the power cable.
CAUTION:
Never attempt to remodel the MagPurix 24 EVO system without the manufacturer’s
permission. Doing so may cause fire or electric shock.
Do not place or drop objects on the MagPurix 24 EVO system. Also refrain from
bumping or knocking it, as doing so may cause a failure or malfunction of the
MagPurix 24 EVO system.
If any liquid materials are left inside the device, wipe it up with a soft paper tissue, etc.
Otherwise, the MagPurix 24 EVO system may be damaged.

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Repairs to the MagPurix 24 EVO system should only be performed by such agencies as
are specifically authorized by the ZINEXTS LIFE SCIENCE CORPORATION.
Only original the ZINEXTS LIFE SCIENCE CORPORATION replacement parts should be
used.
If the equipment is used in a manner not specified by the manufacturer, the protection
provided by the equipment may be impaired.
About Reagent Kits
CAUTION:
When handling any of the kits, refer to the respective handbook.
Reagents in each kit should be handled by observing the safety information and
precautions regarding the kit.
Extraction should be performed in an appropriate laboratory or workplace.
Note:
The kits are not supplied with the MagPurix 24 EVO system. Select the desired kit(s) and
order it (them) separately.

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About Samples
BIOHAZARD:
Always wear appropriate gloves, a mask, and safety goggles, etc. when handling any
infectious samples.
About Infectious Wastes
When handling or disposing of infectious materials, follow the laboratory guideline or
the law regarding infectious waste to perform proper incineration, fusion, sterilization,
and/or disinfection.
When you use a third party company to dispose of wastes, outsource this work to an
operator licensed to handle medical waste subject to special control, and give them the
medical waste manifest at the same time.
Zinexts Service Center
For technical problem and instrument maintenance
http://tw.dictionary.yahoo.com/dictionary?p=maintainceplease contact our service center:
Zinexts Life Science Corp.
www.zinexts.com
16F., No. 93, Sec. 1, Xintai 5th Rd., Xizhi Dist.,
New Taipei City 221416, Taiwan
Tel: [phone]
Fax: [phone]

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1.0 Installation
1.1 Composition of the MagPurix 24 EVO system
Check that the following items are included in the package. Contact your local
representative if you notice any missing part(s).
Caution: Please note that specific sample rack shall use along with device. Don't mix-use
sample rack on other device.
Caution: TURN OFF POWER BEFORE INSERT AND PICK UP SD CARD.
To insert the Un-locked SD card in right direction
Please make sure all the components are free from damages as
soon as you get the system. If any damage is found, please contact your local
representative for instant support.
Note:
Zinexts’ global warranty does not cover damages from transportation or improper
operation.
A. MagPurix 24 EVO X 1
B. Power Cord X 1
C. Sample Rack X 2
D. Barcode Reader X 1
E. SD card
(32GB X 1+64GB X 1 or above)
E. User Manual X 1
G. Fuse X 3 (1A,2A,4A)

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1.2 Contents of Reagent Kits
A B
C/D/E
F G
A.
Reagent Cartridge(s)
B. Reaction Chamber(s)
C. Tip Holder
D. Piercing pin
E. Filter tip
F. Sample tube
G. Elution tube
Note:
Reagent kits are to be purchased separately. Please contact your local agents or
representatives to get further info.
The contents of reagent kits will vary. Refer to the handbook of kits enclosed in
reagent box for details.
1.3 Operating Environment / Condition
Use the MagPurix 24 EVO system in a location that meets the following conditions:

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The MagPurix 24 EVO system must be place at a minimum distance of 5-10 cm
from all sidewalls to allow good air circulation. The space for the allocation of the
MagPurix 24 EVO system must remain 5-10 cm from instrument to sidewalls.
A location where power supply is provided with safety.
A location where the temperature ranges from 15 to 30°C and humidity ranges
from 30% to 80% RH. (non-condensing)
A location that is flat and stable, with no vibration.
A location away from direct sunlight. (Block the sunlight by closing curtains or
blinds as necessary)
A location which is well-ventilated and not dusty.
A location where the temperature does not go up and down suddenly. (Warming
a cold room suddenly or moving the MagPurix 24 EVO system from a room with
low temperature to a warm room may cause condensation inside the device,
resulting in abnormal extraction)
A location where the temperature and humidity are kept within the specified
range (far from water taps, water heaters, humidifiers, air-conditioners, and
heaters)
A location far from objects that generate strong magnetic fields. (motors,
transformers, TV, audio speakers, magnets, etc.) (Bringing the MagPurix 24 EVO
system close to any type of magnetic field may cause a malfunction)

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Warning:
Do not use the MagPurix 24 EVO system in a location where it is wet or can be splashed
with water. It may cause device failure, fire, or electric shock.
When relocating the MagPurix 24 EVO system, disconnect the plug from the outlet first.
If the power cable is damaged, this may cause device failure, fire, injury, or electric
shock.
Caution:
Do not use the MagPurix 24 EVO system in an unstable place such as a slanted surface
or a place subject to vibrations. It may cause injury or device failure.
Do not use the MagPurix 24 EVO system under direct sunlight or close to a heating
device. It may shorten the life of the MagPurix 24 EVO system, or cause troubles.
Do not open the maintenance door while performing the experiment.
Do not open the front door while performing the experiment.
Operating Conditions
1.4 Unpack the MagPurix 24 EVO system
Open the packing box and take out the instrument and related accessories.
Important:
The MagPurix 24 EVO system weights more than 100 kg. It should be lifted and
moved by two persons.
Items
Conditions
Temperature (°C)
During operation
15 – 30
During downtime
0 – 55
Humidity % (RH)
During operation
30 – 80
During downtime
10 – 80
Altitude, operating (m)
Less than 2000 m (1008
hPa)

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Hold the moving handler of the instrument from two sides to move it out from the
box. Handlers are located under the device, on the chassis’ bottom.

Do not hold the outer covering.
Do not hold the front panel.
Do not hold the door.
Caution:
Improper MagPurix 24 EVO system movement handling will lead to instrument
damages.
For correct and safe use of the MagPurix 24 EVO, install the device in a location
close to the electrical outlet and that has enough space for installation and main
switch operation .
1.5 Overall View
Front view with Door closed
Power Outlet
Scanner Port
Engineer Port
Smart view window
Door Handle
7” Touch Panel
Main power switch
Bottom lid-
rubbish Tray
Update Port (HMI)

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Front view with Door opened
Inside view
UV Lamp
Camera
Recorder
Operation Area
There is a total of 24strips
(from left to right)
Piston
Reagent kit holder
Heating module
Tip holder plate
M module
Holder lid
Sample rack

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2.0 Getting Started
Biohazard:
Always wear appropriate gloves, a mask, and safety goggles during any biohazardous
operation during the extraction process. Even when touching the device after any
operation with a biohazard risk, wear appropriate gloves and a mask since the device
may be contaminated.
Important:
Before starting extraction, put on appropriate gloves, a mask, and safety goggles if
required by the operation. During the operation, from sample preparation to extraction
completion, be careful not to expose the samples to foreign contaminants such as
sweat, saliva, etc.
2.1 Turning ON the power
Follow the steps below to release the fixed part inside the instrument
i. Plugin the power cord to the instrument and connect to the electric outlet.
ii. Connect the barcode reader to instrument. Turn the power ON and log in
with User ID ( Display will delay startup to read the SD card)
“Service” (as distributor) without password. You can set your Distributor
“Service” password to lock access to end user to certain “service” options)
(Please refer to System Status for the operate information)
iii. Set up the local time.
(Please refer to System Status for operating information)

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iv. System will start to do the initialization and device will release transportation
fixing parts automatically.
..
Dashcam time adjustment
Dashcam time adjustment is suggested for the first use. Fallow the steps
below to set the dashcam time:

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Step 1, remove the dashcam as below.
Step 2, turn on instrument and find
System from Settings.
Step 3, click Camera to turn off the sensor.
Step 4, find each button from left side of
camera and follow below steps.
Step 5, the dashcam will automatically
start recording after turn off sensor.
Press “OK “button to pause.
Step 6, long press “M” button access to
menu.

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As an end user, please log in with User ID “Admin” (as end user/top authority
in the laboratory) without password. You can set your Top authority “Admin”
password to lock access to user to certain “Admin” options
Step 7, press “M” button again to move to
the next page.
Step 8, select Date/Time and press OK
Step 9, use the ▲▼ button to adjust time
to the current time and press OK
Step 10, after adjustment, press “M”
button to return to the main
screen.
Step 11, back to panel and click camera to
open sensor. And then hang
camera back follow the same way.

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v. Once logged in, you will able to set up at least 10 other users with their own
password.
Important:
Keep the shipping box and fixing block materials. They will be needed again
when transporting the MagPurix 24 EVO system.
2.2 Touch Panel and User Interface
2.3 Preparation
The following preparations are required for extraction operation.
For Sample preparation, please refer to the handbook of each kit.
Function Bar
Homepage
Status Bar
- Gloves
- Mask
- Safety Goggles
- MagPurix Kit

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Function Test
Enter the settings menu and check the position of each axis (Y/Z/P/M).
1. Press button first then axis will go back to home position
2. Press button then system will going to check the position automatically.
(Please refer to System Status for the operate information)
1. 2.
3. 4.
5. 6.
2.5 Extraction
(1) Plastic consumable set up:

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Insert Sample Tube Insert Elution Tube Load the sample(s)
(On Sample Rack) (On Sample Rack) (To Sample Tube)
Insert the cartridges Push down each cartridges Insert Reaction Chambers Insert Tip Holder
(ST cartridges with “click” sound) (push down each wells)
Close the tip holder lids Insert Piercing Pins Insert Filter tipsStick the barcode label