3D Histech Pannoramic 1000 User manual

Pannoramic 1000
2.0
User’s Guide
May 23, 2019
Rev. 1

Pannoramic 1000 2.0 – User’s Guide
Contents
Disclaimer....................................................................................................................... 4
Declaration Of Conformity............................................................................................... 6
Character Formats and ymbols....................................................................................... 7
Notes Regarding Operational afety................................................................................8
Notes on Warranty........................................................................................................ 10
Terms and Abbreviations...............................................................................................11
1 Product Description.................................................................................................... 12
1.1 Product Overview....................................................................................................................12
1.1.1 Intended Use..................................................................................................................................................12
1.1.2 Features and Benefits.....................................................................................................................................13
1.1.3 arning and Information Labels....................................................................................................................15
1.1.4 Main Parts of the Device................................................................................................................................16
1.1.5 Connector panel.............................................................................................................................................19
1.2 System Overview......................................................................................................................19
1.2.1 Pannoramic 1000 system...............................................................................................................................19
1.2.2 Hardware Options..........................................................................................................................................20
1.2.3 Control Software............................................................................................................................................21
2 Installation................................................................................................................. 22
2.1 Control computer ports...........................................................................................................22
2.2 Connectors and cables.............................................................................................................23
3 Preparing lides and Magazines..................................................................................24
3.1 Affixing Barcode Stickers to Slides...........................................................................................25
3.2 Preparing Magazines................................................................................................................26
4 oftware and Work-flow............................................................................................. 30
5 Using Profiles.............................................................................................................. 47
6 Troubleshooting and Maintenance..............................................................................49
6.1 Safety Information...................................................................................................................49
6.1.1 Cleaning the device........................................................................................................................................49
6.1.2 Cleaning the condenser..................................................................................................................................50
6.1.3 Preventive maintenance.................................................................................................................................51
6.2 Troubleshooting.......................................................................................................................51
6.3 Maintenance............................................................................................................................53
6.3.1 Removing the protective cover......................................................................................................................53
6.3.2 Replacing fuses of the main power switch.....................................................................................................54
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Pannoramic 1000 2.0 – User’s Guide
6.3.3 Removing a slide.............................................................................................................................................55
7 Transporting Pannoramic 1000....................................................................................57
8 Packaging instructions for Pannoramic 1000................................................................58
8.1 Preparations.............................................................................................................................58
8.2 Main parts and their accessories.............................................................................................66
8.3 Packaging.................................................................................................................................68
8.3.1 Packing the P1000 scanner.............................................................................................................................68
8.3.2 Closing the package........................................................................................................................................71
8.3.3 Packing the accessories..................................................................................................................................71
8.4 Handling of the package..........................................................................................................71
8.5 Construction of the wooden box.............................................................................................73
9 Technical Data............................................................................................................. 76
Index............................................................................................................................. 79
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Pannoramic 1000 2.0 – User’s Guide
Disclaimer
Copyright © 2001-2019 3DHISTECH Ltd.
All rights reserved.
Intellectual property related to the 3DHISTECH products are as follows:
EP 1,789,831; US 7,663,078; EP 2,024,772; JP 2009-512685; US 12/301,781; EP 1,644,767; JP 2007-
516451; US7,327,515; EP 1,994,398; JP 2008-557835; US 12/281,566; U0700210; US 6,246,785;
HU0900142; HU0700404; PCT/HU2007/000065; EP 08762668.5; US 12/663,537;
PCT/AT2006/000492; JP 2008-542552; EP 06817469; US 12/095,545; PCT/AT2006/000493; EP
06817470.5; US 12/095,596; HU0900741; US 61/264,732; US 11/826,752; P0401870;
PCT/IB2005/050344; US 11/662,976; HU0700409; US 12/042,050; US 77/636,144 and 007502032.
The above mentioned granted patents, granted utility model, registered trademarks, pending
international and national patent applications and the other corresponding IP are the sole properties
of the 3DHISTECH Ltd.
3DHI TECH Ltd. is not liable for damage of whatever nature (including, but not limited to, general
or specific damage, indirect damage, consequential damage or incidental damage, including the
results of the analysis of the digitized slides, for example, change of health status related to
erroneous diagnosis from the digitized slide(s)) that stems from or is associated with use of
Product, digitized slides, quality of staining, quality of stained slides, quality of used method of
staining. 3DHI TECH Ltd. assumes no responsibility for the functionality and fault-free condition of
your “application programs” (Workflows, VBA macros, Commander scripts).
CAUTION
The system is available for research purposes and has not been approved as a medical device in the
European Union.
Do not use this device in close proximity to sources of strong electromagnetic radiation (e.g.
unshielded intentional RF sources), as these may interfere with the proper operation.
THE OFTWARE I PROVIDED “A I ” AND WITHOUT WARRANTY OF ANY KIND, EXPRE ED,
IMPLIED OR OTHERWI E, INCLUDING WITHOUT LIMITATION, ANY WARRANTY OF
MERCHANTABILITY OR FITNE FOR A PARTICULAR PURPO E.
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Pannoramic 1000 2.0 – User’s Guide
Further Information
For the latest information on 3DHISTECH products and services, please visit our website at the
following URL: http ://www.3dhistech.com.
Company Address: 3 Öv street
1141 Budapest – HUNGARY
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Pannoramic 1000 2.0 – User’s Guide
Declaration Of Conformity
3DHISTECH Ltd. declares that the product Pannoramic 1000 digital slide scanner is designed and
produced with consideration of specified requirements according to the ISO13485 Medical devices.
Quality management systems. Requirements for regulatory purposes (ISO 13485:2016).
IEC 61010-1:2010 – “ Safety requirements for electrical equipment for measurement, control, and
laboratory use. General requirements ”
IEC 61010-2-081:2015 – “ Safety requirements for electrical equipment for measurement, control and
laboratory use. Part 2-081: Particular requirements for automatic and semi-automatic laboratory
equipment for analysis and other purposes ”
IEC 61010-2-101:2002, “ Safety Requirements for Electrical Equipment for Measurement, Control,
and Laboratory Use – Part 2-101: Particular requirements for in vitro diagnostic (IVD) medical
equipment ”
IEC 55011:2016 – Group 1, Class B – “Industrial, scientific and medical (ISM) equipment – Radio-
frequency disturbance characteristics - Limits and methods of measurement ”
Conformity with Directive IEC 61010-2-101 is marked by on the product labeling.
There is no further operator (user) action required in case of residual risks.
Further information may be obtained from the manufacturer:
3DHISTECH Ltd.
3 Öv street
1141 Budapest – HUNGARY
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Pannoramic 1000 2.0 – User’s Guide
Character Formats and ymbols
Example ords or characters that appear on the screen. These include field names, screen
and window titles, push-button and menu names, paths or options.
Keys on the keyboard. For example, function keys (such as F11) or the Ctrl+M key
combination.
Example Cross-references within this document or to other documents.
Warning! It might cause irreversible damage or harm to the user of the product or the
product itself if this instruction is not followed.
Caution! It might cause the product to not work properly if this instruction is not followed
and alerts to a potentially critical situation.
Note: Calls attention to some important information or feature.
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Pannoramic 1000 2.0 – User’s Guide
Notes Regarding Operational afety
The below section of this User’s Guide contains information and warnings of a kind that must be
followed by owner/operator personnel.
arning and advisory symbols which are used on the base unit of the Pannoramic 1000 and in the
section 2.0 Warning and Information Labels have the following meanings:
CAUTION
Disconnect mains plug before any kind of intervention into the device!
CAUTION
Crush hazard!
The Pannoramic 1000, including any of its original accessory components, should not be operated in
any other way than described in section 1.1.1 Intended Use.
Any of the following notes should be strictly observed:
Warning!
If operating the device other than specified by the manufacturer, the level of
safety will decrease.
Caution!
In the event of any non-conforming type of use, including non-conforming use
of assemblies or single parts, no liability will be assumed by the Manufacturer.
This shall also apply to service or repair work of any kind, which is performed by
other than authorized service personnel. All claims for warranty and warranty
services will be null and void in any such case.
Warning!
Use of this instrument in a dry environment, especially if synthetic materials are
present (synthetic clothing, carpets, etc.) may cause damaging electrostatic
discharges that may cause erroneous results.
Warning!
Insert the power cord plugs only into a grounding outlet. The protective action
must not be rendered ineffective by extension cables without protective
conductor. The Pannoramic 1000 has a built-in protection which must not be
rendered ineffective by extension cables without protective (earth-ground)
conductor.
Warning!
The operation of the instrument in explosion-risk environments is not allowed.
Warning!
If protective devices are found to be ineffective, the Pannoramic 1000 must be
shut down and precautions must be taken to prevent unintended usage. For
necessary repair work or work to restore proper operating condition, you
should contact the 3DHISTECH Customer Service.
Warning!
Check that your local line voltage is compatible with Pannoramic 1000
specifications before you turn power on.
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Pannoramic 1000 2.0 – User’s Guide
Disconnect plug!
Remember to unplug the power cord before you open the Pannoramic 1000
device.
Warning!
Only connect external devices that are safety extra low voltage rated to the
instrument to avoid the risk of electrical shock.
Warning!
The Pannoramic 1000 does not include any special facilities to protect from
samples with an etching, potentially infectious, toxic, radioactive or other
health-damaging effect. You are under obligation to comply with all currently
binding legislation, notably, national accident prevention rules when handling
samples of this kind.
Caution!
Dirt or dust may adversely impact the operating capability of the Pannoramic
1000. For this reason, measures must be taken to eliminate such influences to a
maximum possible degree. During periods of non-use, the Pannoramic 1000
must be protected with a dust cover. Check that power is turned off before you
put the cover on.
Crush hazard!
Never open the front door unless prompted accordingly by software. hen you
open the door at any other time, make sure not to reach with your hands into the
instrument to avoid the risk of crushing your fingers.
Warning!
The front door is equipped with an interlock switch. If the door is opened while a
digitization process is running, the process will be stopped instantly.
Warning!
A defective Pannoramic 1000 is not classified as domestic waste. It must be
properly disposed in accordance with currently valid legal requirements.
Warning!
The Pannoramic 1000 may not be operated by other than properly instructed
persons. Operating personnel must be fully aware of the potential dangers
which a particular field of application involves. The Pannoramic 1000 is a
precision instrument which may suffer a significant reduction in operational
functions or even physical destruction following intervention performed in any
nonconforming manner.
Caution!
Do not position the equipment so that it is difficult to operate and to
disconnect the device if necessary.
Note:
The safety level of the equipment after servicing will be identical with level of
the original equipment.
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Pannoramic 1000 2.0 – User’s Guide
Notes on Warranty
3DHISTECH Ltd. – as the Product Manufacturer – warrants the Pannoramic 1000 to be free from faults
in material and workmanship at the moment of installation. Defects must be notified immediately on
identification and maximum efforts must be undertaken in order to the amount of damage as small
as possible. On receiving notice of a fault, the Product Manufacturer will be under obligation to
remove the fault, at his own option, either by providing adequate repair services or by delivering a
faultless product for replacement. No warranty will be accepted in cases of natural wear (notably,
wear and tear parts) or improper product handling.
The Product Manufacturer will refuse any liability in the event of damage resulting from faulty
operation, negligence or unauthorized intervention into the product, notably, from the replacement
of product parts or the usage of accessory parts from other manufacturers. Any such case will void
the user’s claim for warranty.
Except for action which is explicitly described in this User’s Guide, you are prohibited from
performing any kind of maintenance or repair work at the Pannoramic 1000. Only 3DHISTECH Service
personnel or specifically authorized representatives are allowed to handle repair work. In case of
malfunction, contact the 3DHISTECH Service Support first.
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Pannoramic 1000 2.0 – User’s Guide
Terms and Abbreviations
C V Comma Separated Value
FOV Field of View
NA Numerical Aperture
Virtual lide / lide A digital image of a thin glass plate on which specimens are mounted for
microscopic study:
a dynamic, interactive image that you can manage, save, magnify, zoom, name,
evaluate, annotate, mark and comment, send to a colleague electronically for co-
operation or advice, and so on.
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Pannoramic 1000 2.0 – User’s Guide 1 Product Description
1 Product Description
1.1 Product Overview
1.1.1 Intended Use
Pannoramic 1000 is designed to digitize histology slides using high-numerical aperture objectives
through illumination of transmitted light (Brightfield illumination). The target users of the product can
work for example, in education, research, industrial, or medical sectors.
Warning!
After each scanning make sure to inspect the digital slide for over-exposed
areas. If the slide has been scanned based on improperly set parameters, it can
highly affect the diagnostic result because of information loss.
Warning!
Any modification to a hardware or software component of the PC will highly
affect the functionality of the scanner program.
Warning!
The Pannoramic 1000 device must be operated by a properly instructed person
only. Operating personnel must be fully aware of the potential dangers which a
particular field of application involves. The Pannoramic 1000 scanner is a
precision instrument which may suffer a significant reduction in operational
functions or even physical destruction following intervention performed in any
nonconforming manner.
Warning!
Do NOT install any other application than the Pannoramic 1000 canner
control software application and its auxiliary drivers on the control computer.
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Pannoramic 1000 2.0 – User’s Guide 1.1.2 Features and Benefits
1.1.2 Features and Benefits
The Pannoramic 1000 offers world-class brightfield whole slide scanning. An outstanding 0.12
µm/pixel resolution in Brightfield mode is achieved with the 40×/0.95 NA (equivalent to 80×
magnification) Plan-Apochromat objective. The Pannoramic 1000 is a high-level automatic scanner
with low maintenance, simple and easy use. Optimal for those customers, who want to begin with
digitizing of their tissue samples and intend to use the scanner for high-volume batch processing.
Key features of the Pannoramic 1000 Scanner
Hardware
•The largest capacity whole-slide scanner on the market: up to 1000 slides
•Fully automatic loading and scanning
•Fastest whole-slide scanner on the market: 2000 slides per day (20x objective, 40x optical
equivalent magnification, 0.24 μm/pixel resolution, 15 x 15 mm single layer)
•Innovative hardware design
•Anti-vibration granite base for maximum stability and image quality
•Dual slide stage
•Robust construction for heavy duty use
•Automated slide handling
•Flexible slide processing, scanning in arbitrary order
•Parallel operation: slide loading and preview in parallel with scanning
•Rapid loading
•Double-width slide (mega slide) support
•Mixed (single and double-width) batch scanning
•Non-sequential magazine loading
•Priority magazine handling
•Magazine panels supporting slide magazines from a range of stainer devices (up to 5 per
device) – default magazine is Sakura
•High-resolution imaging
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Pannoramic 1000 2.0 – User’s Guide 1.1.2 Features and Benefits
•Different objectives are exchangeable automatically during scanning: Two dry, 20x / 40x
objectives with 40x / 80x optical equivalent magnification and 0.24 / 0.12 μm/pixel resolution
oftware
•PANNORAMIC® P1000 Scanner Control software developed for PANNORAMIC® 1000
•New, flexible, Touch Mode ready[TH1], easy-to-use software user interface
•Direct scanning to CaseCenter server
•Advanced scanning profile features:
◦Multiple scanning profiles, auto selection
◦Temporary scanning profile option
•Advanced image management:
◦Batch preview function
◦Multiple image compression options
◦Multiple color profile and schemes
•Z-Stack and Extended scanning functions
•Automated tissue detection and coverslip detection
•1D and 2D type barcode reading and parsing
•Advanced operational information management:
◦Scanning history file
◦Automatic saving of scanning settings
•indows 10 compatible
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Pannoramic 1000 2.0 – User’s Guide 1.1.3 Warning and Information Labels
1.1.3 Warning and Information Labels
The following figure contains the labels used on the Pannoramic 1000 main unit.
Figure 1 – Warning and information labels
NOTE: The symbol refers to the possibility of exposure to biological hazards whenever
handling slides.
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Pannoramic 1000 2.0 – User’s Guide 1.1.4 Main Parts of the Device
1.1.4 Main Parts of the Device
The following figure shows the main outer parts of the base unit.
Figure 2 – Main outer parts of the base unit
1. Sliding door of slide compartment
2. Service door
3. Service door opener
4. Door open request button
5. Power ON/OFF button
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Pannoramic 1000 2.0 – User’s Guide 1.1.4 Main Parts of the Device
The below image shows the main inner components of the base unit.
Figure 3 – Main inner components of the base unit
1. Magazine compartment
2. Slide loader/grabber
3. Preview unit
4. Camera
5. Objectives
6. Slide stage
7. Condenser
8. Pipetting unit
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Pannoramic 1000 2.0 – User’s Guide 1.1.4 Main Parts of the Device
Figure 4 – Illumination component of the Pannoramic 1000
9. PAX 10 FLASH illumination unit
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Pannoramic 1000 2.0 – User’s Guide 1.1.5 Connector panel
1.1.5 Connector panel
The following figure details the sub-assemblies of the connector panel.
Figure 5 – ub-assemblies of the connector panel
1. USB port for controller PC, camera cable port, HUB port
2. Main power inlet
3. Main power switch
4. Fuse box
1.2 ystem Overview
The standard scope of delivery of the product includes the following hardware and software items.
1.2.1 Pannoramic 1000 system
The main components of the Pannoramic 1000 system are the following:
1. Pannoramic 1000 base unit
2. Monitor
3. Mouse
4. Control computer
5. Keyboard
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Pannoramic 1000 2.0 – User’s Guide 1.2.2 Hardware Options
1.2.2 Hardware Options
The configuration of the control computer and monitor can vary depending on the product order.
Camera
Adimec QUARTZ Q-12A180
1 CMOS camera for high-quality Brightfield
applications allowing fast scanning
Camera adapter
1.6× adapter
Warning!
The installation of the cameras in Pannoramic 1000 must be carried out
by trained professionals!
In any other case the warranty will be automatically voided.
The supplier or distributor is not liable for any damages caused by an
installation carried out by an unauthorized person.
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