Biosense BREATH KETONE METER User manual

Patient Guide
Biosense Device and App

The Biosense® devi e measures breath a etone or BrA e, whi h is produ ed as a byprodu t of
fatty a id oxidation and the resulting formation of energy-yielding ketone bodies. Ketones are
produ ed during times of glu ose insuf ien y and are released into the blood to be taken up
by tissues to be metabolized for energy. The on entration of a etone in the breath indi ates
your level of ketone produ tion resulting from fatty a id oxidation. The devi e represents
breath a etone in s aled units alled ACEs, from 0-40. The higher your ACEs, the more
ketones are being produ ed. Ketosis is the term used to des ribe a state in whi h there is an
a umulation of ketones in the body tissues and uids.
The Biosense Device

There are three different ketone bodies: Acetoacetate (AcAc), Beta-hydroxybutyrate (BhB) and
Acetone (BrAce) Ketones represent a third class of energy substrates for your metabolism 
Under conditions of insufcient glucose, your liver converts fats into the ketones AcAc and BhB
for energy BrAce is a direct by-product of AcAc and a volatile organic compound measurable in
the breath AcAc and BhB both circulate in the blood and can interconvert within cells Urinary
dipsticks measure AcAc as unused AcAc is excreted in the urine Urine tests provide a range of
ketone levels rather than a discrete value Further, AcAc levels in the urine decline after several
weeks of keto-adaptation limiting their utility to track nutritional ketosis over time BhB measured
in venous blood provide the highest level of accuracy but must be done in a lab At-home BhB
nger prick tests measure BhB in capillary blood but are inconvenient and costly over time
Three types of Ketone Bodies and Why it Matters
As ketone levels often vary greatly throughout the day, a single ketone measurement provides a
limited view of an individual's metabolic state To capture cumulative progress over time, our
clinical study calculated a daily area under the curve (AUC ) The AUC is a summary of the
accumulated depth and duration of nutritional ketosis each day It answers the question, "how
deeply and for how long have I been in ketosis?" with a single number Our clinical data
showed a very high correlation between breath and blood AUCs (R2 = 0 83) when both
measurements were taken 3 times daily Stated differently, using a breath or a blood device to
take multiple measurements per day captures the high variability of daily ketone levels and
provides very similar indications of overall ketone activity
Measuring breath acetone allows you to track if you are producing ketones and indicates your
level of fatty acid oxidation Ketosis may result in many health benets for you such as, fat loss,
glucose control, blood pressure regulation, improved cognitive function, and has been studied
for its role in increasing longevity Ketosis is inuenced primarily by diet and fasting Exercise,
stress (increasing cortisol and insulin), and sleep have also been shown to impact levels of
ketosis As diet plays a primary role in fatty acid oxidation and ketone formation, it is important
for you to follow a dietary plan resulting in lowering glucose and increasing ketones Research
has shown a variety of dietary plans to be effective, including carbohydrate restriction, calorie-
restriction, and more Though following a plan may be easy for some patients, people often
react very differently to the same lifestyle change, making it challenging to identify which food
choices and in which quantities affect each patient's ketone production rate Therefore,
measuring matters When you track ketones, it allows your practitioner to be better informed
about how you react to interventions in not only diet, but also exercise, stress and sleep
Why Measure Multiple Times Daily
What Breath Acetone Measurements Tell You
About Your Health

Downloading the app
Pairing device to phone
Click one of the links below to download the iosense app to
your mobile device, or search iosense in the app store.
Turn on the Biosense device and enable Bluetooth on your 
phone. Open the Biosense app and turn on your Biosense 
by pressing the check button for three seconds. 
If the device is not on this screen, the device can still be 
paired as long as it is not asleep. Select “Pair a Device”, 
then select your device from the device list. Your device
name will appear as “B” or “BiosenseXXXX”(example: 
Biosense1234). If you have successfully paired, you will see 
a message that says Device Connected. After the Biosense 
device and app are manually paired for the rst time, they 
will automatically connect each time the app is open and 
the Biosense device is on and nearby

iosense has a simple two-button interface and an onboard 
LED screen that guides the user through the measurement 
process. To begin taking a measurement, the rst thing you 
need to do is power on your device. To do so, press and 
hold the check button until you see the blue iosense logo.
The optimal blow technique consists of a normal inhale and 
then a full exhale with medium force (think blowing up a 
balloon or blowing a bubble).The device waits until the end 
of the exhalation to begin measuring. Keep breathing until 
you hear two short vibrations from the device. Finally, after a 
brief analysis period (around 15 seconds), the measurement 
result is displayed on the device screen. The result is also 
placed on a color scale that indicates where the your fat 
burn rate lies on the overall spectrum of ketosis.
Once the device is on, it will immediately enter into a preparation stage as
indicated by the Preparing Device screen, vibrating as it warms up and
calibrates. This process can take up to 120 seconds to warm up. After
device preparation is complete, you will see a new screen that says Press
Start. At this point, you can press the check button to take a 
measurement. You will then be prompted to blow into the device.
Using the device