Buchi S-300 User manual

MiniSprayDryer S-300
Operation Manual
11594255 | A en

Imprint
Product Identification:
Operation Manual (Original) MiniSprayDryer S-300
11594255
Publication date: 06.2022
Version A
BÜCHI Labortechnik AG
Meierseggstrasse 40
Postfach
CH-9230 Flawil 1
E-Mail: [email protected]
BUCHI reserves the right to make changes to the manual as deemed necessary in the light of experience,
especially with respect to structure, illustrations and technical details.
This manual is copyrighted. Information from it may neither be reproduced, distributed, or used for
competitive purposes, nor made available to third parties. The manufacture of any component with the
aid of this manual without prior written agreement is also prohibited.

Büchi Labortechnik AG Table of contents
Operation Manual MiniSprayDryer S-300 iii
Table of contents
1 About this document...........................................................................................................8
1.1 Mark-ups and symbols ..........................................................................................................8
1.2 Trademarks ...........................................................................................................................8
1.3 Connected devices ................................................................................................................8
2 Safety....................................................................................................................................9
2.1 Proper use .............................................................................................................................9
2.2 Use other than that intended .................................................................................................9
2.3 Staff qualification ...................................................................................................................9
2.4 Personal protective equipment ............................................................................................10
2.5 Warning notices in this document........................................................................................10
2.6 Warning symbols .................................................................................................................11
2.7 Residual risks ......................................................................................................................11
2.7.1 Faults during operation...........................................................................................12
2.7.2 Hot surfaces ...........................................................................................................12
2.7.3 Dangerous vapors ..................................................................................................12
2.7.4 Dangerous particles................................................................................................12
2.7.5 Glass breakage ......................................................................................................12
2.7.6 Malfunction of a connected instrument (option)......................................................12
2.8 Modifications........................................................................................................................13
3 Product description...........................................................................................................14
3.1 Description of function .........................................................................................................14
3.2 Configuration .......................................................................................................................15
3.2.1 Front view ...............................................................................................................16
3.2.2 Rear view................................................................................................................17
3.2.3 Connections on the side .........................................................................................18
3.2.4 Cylinder holder and sensor plugs ...........................................................................18
3.2.5 Spray drying nozzle (Two fluid nozzle)...................................................................19
3.3 Type plate............................................................................................................................19
3.4 Scope of delivery .................................................................................................................20
3.5 Technical data .....................................................................................................................20
3.5.1 MiniSprayDryer S-300 ............................................................................................20
3.5.2 Ambient conditions .................................................................................................21
3.5.3 Materials .................................................................................................................21
3.5.4 Installation site........................................................................................................22
4 Transport and storage ......................................................................................................23
4.1 Transport .............................................................................................................................23
4.2 Storage ................................................................................................................................23
4.3 Lifting the instrument ...........................................................................................................23

Table of contents Büchi Labortechnik AG
iv Operation Manual MiniSprayDryer S-300
5 Installation..........................................................................................................................25
5.1 Before installation ................................................................................................................25
5.2 Establishing electrical connections......................................................................................25
5.3 Securing against earthquakes .............................................................................................25
5.4 Installing the spray gas supply ............................................................................................26
5.5 Installing peristaltic pump 2 (option) ....................................................................................26
5.6 Installations for remote services (option).............................................................................26
5.7 Installations for a spray drying mode...................................................................................27
5.8 Installing the outlet filter holder............................................................................................27
6 Interface..............................................................................................................................29
6.1 Layout of the interface .........................................................................................................29
6.2 Navigation bar .....................................................................................................................29
6.2.1 Menu bar ................................................................................................................30
6.2.2 Control panel ..........................................................................................................30
6.3 Function buttons ..................................................................................................................32
6.4 System settings ...................................................................................................................32
6.4.1 Changing the display settings.................................................................................32
6.4.2 Changing the language settings .............................................................................32
6.4.3 Changing the sound settings ..................................................................................32
6.4.4 Changing date and time .........................................................................................33
6.5 Customizing options ............................................................................................................33
6.5.1 Changing the home screen background.................................................................33
6.5.2 Customize the control panel ...................................................................................33
6.5.3 Customize the report ..............................................................................................34
6.5.4 Changing the measurement units...........................................................................35

Büchi Labortechnik AG Table of contents
Operation Manual MiniSprayDryer S-300 v
7 Preparing for a spray drying process..............................................................................36
7.1 Preparing the outlet filter .....................................................................................................36
7.1.1 Preparing the outlet filter with filter bag (Option) ....................................................36
7.1.2 Preparing the outlet filter with PTFE membrane (Option).......................................37
7.2 Preparing the glass assembly .............................................................................................39
7.3 Preparing the product vessel...............................................................................................41
7.4 Preparing the spray drying nozzle .......................................................................................41
7.5 Preparing the peristaltic pump.............................................................................................43
7.5.1 Preparing the peristaltic pump for manual mode.................................................... 43
7.5.2 Preparing the peristaltic pump for auto mode (option) ...........................................43
7.6 Preparing the sensors .........................................................................................................44
7.6.1 Preparing the product temperature sensor (option)................................................44
7.6.2 Preparing the outlet temperature sensor ................................................................45
7.7 Preparing the grounding (if no product sensor is used).......................................................46
7.8 Adjusting the peristaltic pump bed.......................................................................................46
7.9 Preparing the instrument for remote services (option) ........................................................47
7.10 Editing a method (Advanced and Corrosive only) ...............................................................48
7.10.1 Creating a new method ..........................................................................................48
7.10.2 Deleting a method ..................................................................................................49
7.10.3 Changing the name of a method ............................................................................49
7.10.4 Changing the description for a method...................................................................49
7.10.5 Changing the drying gas volume for a method....................................................... 50
7.10.6 Changing the inlet temperature for a method ......................................................... 50
7.10.7 Changing the dispersion gas volume for a method ................................................50
7.10.8 Changing the pump volume for a method ..............................................................51
7.10.9 Changing the outlet temperature for a method....................................................... 51
7.10.10 Changing the product temperature for a method.................................................... 51
7.10.11 Changing the nozzle deblock frequency for method ..............................................52
7.10.12 Importing a method.................................................................................................52
7.10.13 Exporting a method ................................................................................................52
7.10.14 Loading a method...................................................................................................53
7.11 Editing a job list (Advanced and Corrosive only) ................................................................. 53
7.11.1 Creating a new job list ............................................................................................53
7.11.2 Adding an entry to a job list ....................................................................................53
7.11.3 Deleting a job list ....................................................................................................54
7.11.4 Deleting a job list entry ...........................................................................................54
7.11.5 Loading a job list.....................................................................................................54
7.12 Editing an auto mode sequence (Advanced and Corrosive only)........................................55
7.13 Tagging table entries ...........................................................................................................55

Table of contents Büchi Labortechnik AG
vi Operation Manual MiniSprayDryer S-300
8 Carrying out a spray drying process...............................................................................56
8.1 Preparing the instrument for monitoring ..............................................................................56
8.2 Carrying out a spray drying process in open mode ............................................................. 56
8.2.1 Preparing the instrument for open mode ................................................................ 56
8.2.2 Starting a spray drying process in open mode .......................................................56
8.2.3 Tasks during spray drying (manual mode only)......................................................58
8.2.4 Ending a spray drying process in open mode ........................................................58
8.2.5 Shutting down the instrument ................................................................................. 58
8.3 Carrying out a spray drying process in closed mode...........................................................59
8.3.1 Preparing the instrument for closed mode..............................................................59
8.3.2 Starting a spray drying process in closed mode..................................................... 59
8.3.3 Tasks during spray drying (manual mode only)......................................................61
8.3.4 Ending a spray drying process in closed mode ...................................................... 61
8.3.5 Shutting down the instrument ................................................................................. 61
8.4 Exporting run data ...............................................................................................................61
8.5 Deleting run data .................................................................................................................62
8.6 Disconnecting the remote services......................................................................................62
9 Cleaning and servicing .....................................................................................................63
9.1 Regular maintenance work..................................................................................................63
9.2 Calibrating the peristaltic pumps .........................................................................................63
9.3 Cleaning the aspirator .........................................................................................................64
9.4 Opening and closing the lower rear door.............................................................................64
9.5 Opening and closing the upper rear door ............................................................................ 65
9.6 Cleaning and servicing the drying gas hoses ...................................................................... 65
9.7 Cleaning the filter.................................................................................................................66
9.8 Cleaning the heater .............................................................................................................66
9.9 Cleaning the glass component ............................................................................................66
9.10 Cleaning the nozzle .............................................................................................................67
9.11 Cleaning and servicing the warning and directive symbols ................................................. 68
9.12 Cleaning the housing...........................................................................................................68
10 Help with faults ..................................................................................................................69
10.1 Troubleshooting...................................................................................................................69
10.1.1 Troubleshooting general......................................................................................... 69
10.1.2 Troubleshooting heater...........................................................................................71
10.1.3 Troubleshooting aspirator....................................................................................... 72
10.2 Nozzle does not atomize .....................................................................................................72
10.3 Changing the fuse ...............................................................................................................72
10.4 Sending instrument data to BUCHI customer service .........................................................73
10.5 No liquid delivery .................................................................................................................73
11 Taking out of service and disposal..................................................................................74
11.1 Taking out of service ...........................................................................................................74
11.2 Disposal...............................................................................................................................74
11.3 Returning the instrument .....................................................................................................74

Büchi Labortechnik AG Table of contents
Operation Manual MiniSprayDryer S-300 vii
12 Appendix ............................................................................................................................75
12.1 Material information .............................................................................................................75
12.1.1 Feeding tube...........................................................................................................75
12.1.2 Drying gas hoses.................................................................................................... 75
12.2 Spare parts and accessories ...............................................................................................76
12.2.1 Nozzle.....................................................................................................................76
12.2.2 Accessories ............................................................................................................80
12.2.3 Glassware...............................................................................................................82
12.2.4 Spare parts ............................................................................................................. 86
12.2.5 Hoses .....................................................................................................................87
12.2.6 Documents .............................................................................................................89

1 | About this document Büchi Labortechnik AG
8/90 Operation Manual MiniSprayDryer S-300
1 About this document
This operation manual is applicable for all variants of the instrument.
Read this operation manual before operating the instrument and follow the
instructions to ensure safe and trouble-free operation.
Keep this operation manual for later use and pass it on to any subsequent user or
owner.
BÜCHI Labortechnik AG accepts no liability for damage, faults and malfunctions
resulting from not following this operation manual.
If you have any questions after reading this operation manual:
uContact BÜCHI Labortechnik AG Customer Service.
https://www.buchi.com/contact
1.1 Mark-ups and symbols
NOTE
This symbol draws attention to useful and important information.
RThis character draws attention to a requirement that must be met before the
instructions below are carried out.
uThis character indicates an instruction that must be carried out by the user.
ðThis character indicates the result of a correctly carried out instruction.
Mark-up Explanation
Window
Software Windows are marked-up like this.
Tab
Tabs are marked-up like this.
Dialog
Dialogs are marked-up like this.
[Button] Buttons are marked-up like this.
[Field names] Field names are marked-up like this.
[Menu / Menu item] Menus or menu items are marked-up like this.
Status Status is marked-up like this.
Signal Signals are marked-up like this.
1.2 Trademarks
Product names and registered or unregistered trademarks that are used in this
document are used only for identification and remain the property of the owner in
each case.
1.3 Connected devices
In addition to these operating instructions, follow the instructions and specifications
in the documentation for the connected devices.

Büchi Labortechnik AG Safety | 2
Operation Manual MiniSprayDryer S-300 9/90
2 Safety
2.1 Proper use
The instrument is designed for spray drying.
The instrument can be used in laboratories for the following tasks:
Spray drying
2.2 Use other than that intended
The use of the instrument other than described in proper use and specified in
technical data is use other than that intended.
The operator is responsible for damages or hazards that are caused by use other
than that intended.
Specially the following uses are not permitted:
Use of the instrument with non-BUCHI products.
Use of the instrument in closed mode with non-certified instruments.
Use of the instrument in an environment with a potential risk of explosion or
areas which require explosion-safe apparatus.
Use of the instrument without an appropriate leading away exhaust gas from the
working area.
Use of the instrument with gases with unknown chemical composition.
Use of the instrument with organic solvents (> 20 %) without Inert Loop.
Use of the instrument with organic solvents (> 20 %) in open mode.
Use of the instrument with samples containing peroxides.
Use of the instrument with samples that can form peroxides.
Use of the instrument with samples which produce oxygen during the processing.
Use of the instrument with toxic substances without appropriate safety measures.
Use of the instrument with biohazardous materials such as viruses or hazardous
bacteria.
Use of the instrument with samples which can block the feed channel of the
nozzle.
Use of the instrument with substances which might explode or ignite because of
the processing.
Use of the instrument with substances which might explode or ignite because of
the selected parameters.
Use of the instrument with corrosive samples in closed mode.
Use of the instrument with corrosive samples other than the corrosive instrument
version.
Use of the instrument with any other Inert Loop than the S-395 without the O2
box. See Chapter12.2.2 "Accessories", page80
2.3 Staff qualification
Unqualified persons are unable to identify risks and are therefore exposed to greater
dangers.

2 | Safety Büchi Labortechnik AG
10/90 Operation Manual MiniSprayDryer S-300
The instrument may only be operated by suitably qualified laboratory staff.
These operating instructions are aimed at the following target groups:
Users
Users are persons that meet the following criteria:
They have been instructed in the use of the instrument.
They are familiar with the contents of these operating instructions and the
applicable safety regulations and apply them.
They are able on the basis of their training or professional experience to assess
the risks associated with the use of the instrument.
Operator
The operator (generally the laboratory manager) is responsible for the following
aspects:
The instrument must be correctly installed, commissioned, operated and serviced.
Only suitably qualified staff may be assigned the task of performing the
operations described in these operating instructions.
The staff must comply with the local applicable requirements and regulations for
safe and hazard-conscious working practices.
Safety-related incidents that occur while using the instrument should be reported
to the manufacturer ([email protected]).
BUCHI service technicians
Service technicians authorized by BUCHI have attended special training courses and
are authorized by BÜCHI Labortechnik AG to carry out special servicing and repair
measures.
2.4 Personal protective equipment
Depending on the application, hazards due to heat and/or corrosive chemicals may
arise.
uAlways wear appropriate personal protective equipment such as safety goggles,
protective clothing and gloves.
uMake sure that the personal protective equipment meets the requirements of
the safety data sheets for all chemicals used.
2.5 Warning notices in this document
Warning notices warn you of dangers that can occur when handling the instrument.
There are four danger levels, each identifiable by the signal word used.
Signal word Meaning
DANGER Indicates a danger with a high level of risk which could result in
death or serious injury if not prevented.
WARNING Indicates a danger with a medium level of risk which could result in
death or serious injury if not prevented.
CAUTION Indicates a danger with a low level of risk which could result in mi-
nor or medium-severity injury if not prevented.

Büchi Labortechnik AG Safety | 2
Operation Manual MiniSprayDryer S-300 11/90
Signal word Meaning
NOTICE Indicates a danger that could result in damage to property.
2.6 Warning symbols
The following warning symbols are displayed in this operation manual or on the
instrument.
Symbol Meaning
General warning
Device damage
Dangerous electrical voltage
Hot surface
Fig.1: Location of the warning symbols
2.7 Residual risks
The instrument has been developed and manufactured using the latest technological
advances. Nevertheless, risks to persons, property or the environment can arise if
the instrument is used incorrectly.
Appropriate warnings in this manual serve to alert the user to these residual
dangers.

2 | Safety Büchi Labortechnik AG
12/90 Operation Manual MiniSprayDryer S-300
2.7.1 Faults during operation
If an instrument is damaged, sharp edges, moving parts or exposed electrical wires
can cause injuries.
uRegularly check instruments for visible damage.
uIf faults occur, switch off the instrument immediately, unplug the power cord and
inform the operator.
uDo not continue to use instruments that are damaged.
2.7.2 Hot surfaces
The surfaces of the device can become very hot. If touched they can cause skin
burns.
uDo not touch hot surfaces or else wear suitable protective gloves.
2.7.3 Dangerous vapors
The use of the instrument can produce dangerous vapors that are capable of causing
life-threatening toxic effects.
uDo not inhale any vapors produced during processing.
uEnsure that vapors are removed by a suitable fume hood.
uOnly use the device in well ventilated areas.
uIf vapors escape from connections, check the seals concerned and replace them if
necessary.
uDo not process any unknown fluids.
uObserve the safety data sheets for all substances used.
2.7.4 Dangerous particles
The use of the instrument can produce dangerous particles that can cause life-
threatening toxic effects.
uDo not inhale any particles produced during processing.
uEnsure that particles are removed by a suitable fume hood.
uOnly use the instrument in well ventilated areas.
uIf particles escape from connections, check the seals concerned and replace them
if necessary.
uDo not process any unknown fluids.
uObserve the safety data sheets for all substances used.
2.7.5 Glass breakage
Broken glass can cause severe cuts.
Damaged glass components may implode if subjected to a vacuum.
Minor damage to the ground joints impairs the sealing effect and may therefore
diminish performance.
uHandle the flask and other glass components carefully and do not drop them.
uAlways visually inspect glass components for damage every time they are to be
used.
uDo not continue to use glass components that are damaged.
uAlways wear protective gloves when disposing of broken glass.
2.7.6 Malfunction of a connected instrument (option)
A malfunction on a connected instrument can cause poisoning or death.

Büchi Labortechnik AG Safety | 2
Operation Manual MiniSprayDryer S-300 13/90
uMake sure that the connected instrument is prepared and maintained according
to the user documentation.
2.8 Modifications
Unauthorized modifications can effect safety and lead to accidents.
uUse only genuine BUCHI accessories, spare parts and consumables.
uCarry out technical changes only with prior written approval from BUCHI.
uOnly allow changes to be made by BUCHI service technicians.
BUCHI accepts no liability for damage, faults and malfunctions resulting from
unauthorized modifications.

3 | Product description Büchi Labortechnik AG
14/90 Operation Manual MiniSprayDryer S-300
3 Product description
3.1 Description of function
Spray drying is a processing technology to transform a liquid feedstock into a dried
powder through four fundamental steps:
Atomization of the feed into a spray
Spray gas contact
Solvent evaporation
Separation of the dried product from the drying medium
The following spray drying modes are available:
Spray drying mode Solvent composition
Open mode up to 20 % organic solvent
Closed mode with Inert Loop
(When using Ultrasonic Package acces-
sory inert gas adapter is necessary)
between 90 % - 100 % organic solvent
Closed mode with Inert Loop and Dehu-
midifier
(When using Ultrasonic Package acces-
sory inert gas adapter is necessary)
between 20 % - 80 % organic solvent

Büchi Labortechnik AG Product description | 3
Operation Manual MiniSprayDryer S-300 15/90
3.2 Configuration

3 | Product description Büchi Labortechnik AG
16/90 Operation Manual MiniSprayDryer S-300
3.2.1 Front view
5
6
11
10
21
20
19
18
22
12
43
12
14
15
17 16
13
7
8
9
Fig.2: Front view
1 Switch valve
(Advanced and Corrosive only)
2 Peristaltic pump 2 (option)
3 Plug peristaltic pump 2 4 Sample and solvent place area
5 Interface
See Chapter6 "Interface", page29
6 Connections on the side
See Chapter3.2.3 "Connections on
the side", page18
7 Inlet from filter / cyclone
(marked Filter)
8 Filter pressure inlet
(marked IN)
9 Filter pressure outlet
(marked OUT)
10 Aspirator outlet
11 Heater Inlet 12 Tubing protection (option)
13 Outlet Filter 14 Product temperature sensor (option)
15 Product collection vessel 16 Cyclone
17 Connection piece with outlet tem-
perature sensor
18 Separation flask
19 Spray cylinder 20 Cylinder holder and sensor plugs
See Chapter3.2.4 "Cylinder holder
and sensor plugs", page18
21 On/Off master switch 22 Peristaltic pump 1

Büchi Labortechnik AG Product description | 3
Operation Manual MiniSprayDryer S-300 17/90
3.2.2 Rear view
5
6
7
8
13
12
11
10
123
4
9
Fig.3: Rear view
1 Ventilation slots 2 Compressed air for the nozzle
cleaner
3 Spray gas 4 Nozzle
See Chapter3.2.5 "Spray drying noz-
zle (Two fluid nozzle)", page19
5 Handle 6 Spray gas connection
7 Power supply connection 8 Fuses
9 Aspirator ventilation 10 Lower rear door
11 Ventilation slots 12 Upper rear door
13 Ventilation slots

3 | Product description Büchi Labortechnik AG
18/90 Operation Manual MiniSprayDryer S-300
3.2.3 Connections on the side
1245
6
3
Fig.4: Connections
1 USB 2 USB
3 USB 4 LAN
5 RJ32 6 RJ32
3.2.4 Cylinder holder and sensor plugs
2
3
1
Fig.5: Adjustment and sensor plugs
1 Outlet temperature sensor port 2 Handle
3 Product temperature sensor port

Büchi Labortechnik AG Product description | 3
Operation Manual MiniSprayDryer S-300 19/90
3.2.5 Spray drying nozzle (Two fluid nozzle)
4
8
1
2
3
5
6
7
Fig.6: Spray drying nozzle
1 Feeding tube connection
(marked FEED)
2 Cooling in connection
(marked C IN)
3 Nozzle needle 4 Cleaning nozzle gas connection
5 Dispersion gas connection
(marked GAS)
6 Cooling out connection
(marked C OUT)
7 Nozzle tip 8 Nozzle cap
3.3 Type plate
The type plate identifies the instrument. The type plate is located at the rear of the
instrument.

3 | Product description Büchi Labortechnik AG
20/90 Operation Manual MiniSprayDryer S-300
6
7
8
11
9
10
3
2
1
5
4
Fig.7: Type plate
1 Symbol for "electronics recycling" 2 Initial product code
3 Approvals 4 Symbol for "Do not dispose of as
household waste"
5 Year of manufacture 6 Power consumption maximum
7 Frequency 8 Input voltage range
9 Serial number 10 Instrument name
11 Company name and address
3.4 Scope of delivery
NOTE
The scope of delivery depends of the configuration of the purchase order.
Accessories are delivered as per the purchase order, order confirmation, and
delivery note.
3.5 Technical data
3.5.1 MiniSprayDryer S-300
MiniSprayDryer
S-300
MiniSprayDryer
S-300 Advanced
MiniSprayDryer
S-300 Corrosive
Dimensions (W x D x H) 620 mm x 640
mm x 1052 mm
620 mm x 640
mm x 1052 mm
620 mm x 640
mm x 1052 mm
Weight (without glass as-
sembly)
54 kg 54 kg 54 kg
Weight (with glass assem-
bly)
62.5 kg 62.5 kg 62.5 kg
Connection voltage 220 - 240 ± 10 %
VAC
220 - 240 ± 10 %
VAC
220 - 240 ± 10 %
VAC
Power consumption max. 2300 W max. 2300 W max. 2300 W
Fuse 10 AT 10 AT 10 AT
Overvoltage category II II II
Frequency 50 / 60 Hz 50 / 60 Hz 50 / 60 Hz