Buchi Lyovapor L-200 User manual

Lyovapor™ L-200/L-200 Pro
Operation Manual
11593861 | F en

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Product Identification:
Operation Manual (Original) Lyovapor™ L-200/L-200 Pro
11593861
Publication date: 02.2020
BÜCHI Labortechnik AG
Meierseggstrasse 40
Postfach
CH-9230 Flawil 1
E-Mail: [email protected]
BUCHI reserves the right to make changes to the manual as deemed necessary in the light of experi-
ence, especially with respect to structure, illustrations and technical details.
This manual is copyrighted. Information from it may neither be reproduced, distributed, or used for com-
petitive purposes, nor made available to third parties. The manufacture of any component with the aid of
this manual without prior written agreement is also prohibited.

BÜCHI Labortechnik AG Table of contents
Operation Manual Lyovapor™ L-200/L-200 Pro iii
Contents
1 About this document...........................................................................................................7
1.1 Connected devices .............................................................................................................................. 7
1.2 Warning notices in this document........................................................................................................ 7
1.3 Symbols............................................................................................................................................... 7
1.3.1 Warning symbols .....................................................................................................................7
1.3.2 Mandatory directive symbols ...................................................................................................8
1.3.3 Mark-ups and symbols.............................................................................................................8
1.4 Trademarks.......................................................................................................................................... 8
2 Safety....................................................................................................................................9
2.1 Proper use ........................................................................................................................................... 9
2.2 Use other than that intended ............................................................................................................... 9
2.3 Staff qualification ................................................................................................................................. 9
2.4 Location of warning signs on the product .......................................................................................... 10
2.5 Residual risks .................................................................................................................................... 10
2.5.1 Faults during operation ..........................................................................................................10
2.5.2 Damage to the ice condenser................................................................................................ 11
2.5.3 Glass and acrylic breakage.................................................................................................... 11
2.5.4 Low internal pressure............................................................................................................. 11
2.5.5 Cold and hot surfaces............................................................................................................ 11
2.6 Personal protective equipment .......................................................................................................... 11
2.7 Modifications...................................................................................................................................... 11
3 Product description...........................................................................................................12
3.1 Description of function ....................................................................................................................... 12
3.1.1 Freezing phase ......................................................................................................................12
3.1.2 Main drying phase..................................................................................................................12
3.1.3 Secondary-drying phase........................................................................................................13
3.2 Configuration ..................................................................................................................................... 14
3.2.1 Front view ..............................................................................................................................14
3.2.2 Rear view ...............................................................................................................................14
3.2.3 Connections on the rear side................................................................................................. 15
3.2.4 Control panel..........................................................................................................................15
3.2.5 Pro control panel....................................................................................................................16
3.3 Type plate.......................................................................................................................................... 16
3.4 Scope of delivery ............................................................................................................................... 17
3.5 Refrigerant Specification.................................................................................................................... 17
3.6 Technical data ................................................................................................................................... 17
3.6.1 Lyovapor™ L-200 ..................................................................................................................17
3.6.2 Ambient conditions.................................................................................................................18
3.6.3 Materials ................................................................................................................................18
4 Transport and storage ......................................................................................................19
4.1 Transport ........................................................................................................................................... 19
4.2 Storage .............................................................................................................................................. 19
4.3 Lifting the instrument ......................................................................................................................... 19

Table of contents BÜCHI Labortechnik AG
iv Operation Manual Lyovapor™ L-200/L-200 Pro
5 Installation..........................................................................................................................21
5.1 Installation site................................................................................................................................... 21
5.2 Securing against earthquakes ........................................................................................................... 21
5.3 Putting the instrument in operation.................................................................................................... 22
5.3.1 Preparing the instrument........................................................................................................ 22
5.3.2 Establishing electrical connections ........................................................................................22
5.3.3 Fitting the advanced vacuum control unit ..............................................................................23
5.3.4 Manual switch on the main valve........................................................................................... 24
5.3.5 Connecting the inert gas (optional feature)............................................................................25
5.3.6 Assembling pressure sensor PPG010 (optional accessory)..................................................26
5.3.7 Assembling the alternative pressure sensor (optional accessory).........................................26
5.3.8 Fitting the drain valve strainer................................................................................................27
5.3.9 Preparing the condensate drain hose.................................................................................... 27
5.4 Commissioning the vacuum pump..................................................................................................... 28
5.5 Establishing LAN connection............................................................................................................. 29
5.5.1 Requirements for local network settings................................................................................29
5.5.2 Preparing the instrument for app using..................................................................................30
5.5.3 Enabling BUCHI Cloud access ..............................................................................................30
5.6 Insert SD card (Pro control panel only).............................................................................................. 30
6 Operating the control panel..............................................................................................32
6.1 Layout of the control panel ................................................................................................................ 32
6.2 Function bar....................................................................................................................................... 32
6.3 Menu bar............................................................................................................................................ 33
6.3.1 Start menu .............................................................................................................................34
6.3.2 Favourites menu ....................................................................................................................34
6.3.3 Configuration menu................................................................................................................34
6.3.4 Messages menu.....................................................................................................................37
6.4 Status bar .......................................................................................................................................... 37
6.5 Carrying out freeze-drying ................................................................................................................. 39
6.5.1 Preparing the instrument........................................................................................................ 39
6.5.2 Starting freeze-drying............................................................................................................. 39
6.5.3 Editing parameters while the process is running ...................................................................40
6.5.4 Ending freeze-drying..............................................................................................................40
6.5.5 Shutting down the instrument ................................................................................................40
6.5.6 Switching off the instrument...................................................................................................41

BÜCHI Labortechnik AG Table of contents
Operation Manual Lyovapor™ L-200/L-200 Pro v
7 Operating Pro control panel ............................................................................................. 42
7.1 Layout of Pro control panel................................................................................................................ 42
7.2 Function bar....................................................................................................................................... 42
7.3 Other symbols on the control panel................................................................................................... 44
7.4 Menu bar............................................................................................................................................ 44
7.4.1 Start menu .............................................................................................................................44
7.4.2 Favourites menu ....................................................................................................................45
7.4.3 Method menu.........................................................................................................................45
7.4.4 Configuration menu................................................................................................................45
7.4.5 Messages menu.....................................................................................................................48
7.5 Status bar .......................................................................................................................................... 49
7.6 Editing a method................................................................................................................................ 50
7.6.1 Creating a new method..........................................................................................................50
7.6.2 Changing the name of a method............................................................................................51
7.6.3 Setting the sample collapse temperature............................................................................... 51
7.6.4 Setting the gas type ...............................................................................................................52
7.6.5 Setting the shelf loading temperature ....................................................................................52
7.6.6 Setting the steps of a method ................................................................................................52
7.6.7 Setting the phases of a method .............................................................................................54
7.7 Deleting a method.............................................................................................................................. 56
7.8 Setting end point definitions............................................................................................................... 56
7.8.1 Connect the sensors for pressure difference test (optional feature)...................................... 56
7.8.2 Pressure difference test (optional feature).............................................................................56
7.8.3 Temperature difference test...................................................................................................58
7.8.4 Determining offset value ........................................................................................................59
7.9 Performing freeze-drying using a method [Pro control panel] ........................................................... 59
7.9.1 Preparing the instrument........................................................................................................ 59
7.9.2 Selecting a method ................................................................................................................59
7.9.3 Starting freeze-drying............................................................................................................. 60
7.9.4 Ending freeze-drying..............................................................................................................61
7.9.5 Shutting down the instrument ................................................................................................61
7.9.6 Switching off the instrument...................................................................................................61
7.10 Performing freeze-drying manually [Pro control panel]...................................................................... 62
7.10.1 Preparing the instrument........................................................................................................ 62
7.10.2 Starting freeze-drying............................................................................................................. 62
7.10.3 Editing parameters while the process is running ...................................................................63
7.10.4 Ending freeze-drying..............................................................................................................63
7.10.5 Shutting down the instrument ................................................................................................63
7.10.6 Switching off the instrument...................................................................................................64
8 Operating top-mount drying racks ..................................................................................65
8.1 Operating stoppering acrylic drying chamber .................................................................................... 65
8.2 Operating manifold acrylic drying chamber (heatable shelves)......................................................... 68
8.3 Operating manifold acrylic drying chamber (non-heatable shelf) ...................................................... 70
8.4 Operating acrylic drying chamber (heatable shelf) ............................................................................ 72
8.5 Operating acrylic drying chamber (on-heatable shelf)....................................................................... 75
8.6 Operating manifold drying rack.......................................................................................................... 76
8.7 Operating manifold valves ................................................................................................................. 77
9 Cleaning and servicing .....................................................................................................78
9.1 Regular maintenance work................................................................................................................ 78
9.2 Performing a vacuum test.................................................................................................................. 79
9.3 Performing a leak test........................................................................................................................ 80
9.3.1 Performing a leak test with a drying chamber........................................................................80
9.3.2 Performing leak test with a manifold drying rack ...................................................................81

Table of contents BÜCHI Labortechnik AG
vi Operation Manual Lyovapor™ L-200/L-200 Pro
10 Help with faults .................................................................................................................. 83
10.1 Troubleshooting................................................................................................................................. 83
10.2 Faults, possible causes and remedies............................................................................................... 83
10.3 Locating leaking manifold valve......................................................................................................... 84
10.4 Finding a leaking regulating valve or aeration valve.......................................................................... 84
11 Taking out of service and disposal..................................................................................86
11.1 Disposal............................................................................................................................................. 86
11.2 Returning the instrument ................................................................................................................... 86
12 Appendix ............................................................................................................................87
12.1 Spare parts and accessories ............................................................................................................. 87
12.1.1 Accessories............................................................................................................................87
12.1.2 Further accessories ...............................................................................................................88
12.1.3 Spare parts ............................................................................................................................88
12.1.4 Top-mount drying rack accessories.......................................................................................90
12.1.5 Software.................................................................................................................................93

BÜCHI Labortechnik AG About this document | 1
Operation Manual Lyovapor™ L-200/L-200 Pro 7/94
1 About this document
This operation manual is applicable for all variants of the instrument.
Read this operation manual before operating the instrument and follow the instruc-
tions to ensure safe and trouble-free operation.
Keep this operation manual for later use and pass it on to any subsequent user or
owner.
BÜCHI Labortechnik AG accepts no liability for damage, faults and malfunctions re-
sulting from not following this operation manual.
If you have any questions after reading this operation manual:
uContact BÜCHI Labortechnik AG Customer Service.
https://www.buchi.com/contact
1.1 Connected devices
In addition to these operating instructions, you should also follow the instructions and
specifications in the documentation for the connected devices.
1.2 Warning notices in this document
Warning notices warn you of dangers that can occur when handling the device. There
are four danger levels, each identifiable by the signal word used.
Signal word Meaning
DANGER Indicates a danger with a high level of risk which could result in
death or serious injury if not prevented.
WARNING Indicates a danger with a medium level of risk which could result in
death or serious injury if not prevented.
CAUTION Indicates a danger with a low level of risk which could result in mi-
nor or medium-severity injury if not prevented.
NOTICE Indicates a danger that could result in damage to property.
1.3 Symbols
The following symbols may be displayed in this instruction manual or on the device:
1.3.1 Warning symbols
Symbol Meaning
General warning
Breakable items
Device damage

1 | About this document BÜCHI Labortechnik AG
8/94 Operation Manual Lyovapor™ L-200/L-200 Pro
1.3.2 Mandatory directive symbols
Symbol Meaning Symbol Meaning
Wear safety goggles Wear protective clothing
Wear protective gloves Heavy load, do not lift with-
out assistance
1.3.3 Mark-ups and symbols
NOTE
This symbol draws attention to useful and important information.
RThis character draws attention to a requirement that must be met before the in-
structions below are carried out.
uThis character indicates an instruction that must be carried out by the user.
ðThis character indicates the result of a correctly carried out instruction.
Mark-up Explanation
Window Software Windows are marked-up like this.
Tab Tabs are marked-up like this.
Dialog Dialogs are marked-up like this.
[Button] Buttons are marked-up like this.
[Field names] Field names are marked-up like this.
[Menu / Menu item] Menus or menu items are marked-up like this.
Status Status is marked-up like this.
Signal Signals are marked-up like this.
1.4 Trademarks
Product names and registered or unregistered trademarks that are used in this docu-
ment are used only for identification and remain the property of the owner in each
case.

BÜCHI Labortechnik AG Safety | 2
Operation Manual Lyovapor™ L-200/L-200 Pro 9/94
2 Safety
2.1 Proper use
The Lyovapor™ L-200 is used for freeze-drying solid materials in ampoules, vials,
dishes, round-neck or wide-neck flasks and trays is exclusively intended for that pur-
pose. The Lyovapor™ L-200 can be used in laboratories for the following tasks:
Sublimating and re-sublimating water
2.2 Use other than that intended
Use of any other kind than that described in the section Chapter2.1 "Proper use",
page9 and any application that does not comply with the technical specifications
(see Chapter3.6 "Technical data", page17) constitutes use other than that in-
tended.
In particular, the following applications are not permissible:
Use of the instrument in an environment with a potential risk of explosion or areas
which require explosion-safe apparatus.
Use of the instrument for processing substances outside of research and develop-
ment.
Production and processing of substances that can lead to spontaneous reactions,
such as explosives, metal hydrides or solvents that can form peroxides.
Processing with explosive gas mixtures.
Use of acids and alkalis without first checking material compatibility.
Damage or hazards attributable to use of the product other than as intended are en-
tirely at the risk of the operator alone.
2.3 Staff qualification
Unqualified persons are unable to identify risks and are therefore exposed to greater
dangers.
The device may only be operated by suitably qualified laboratory staff.
These operating instructions are aimed at the following target groups:
Users
Users are persons that meet the following criteria:
They have been instructed in the use of the device.
They are familiar with the contents of these operating instructions and the applica-
ble safety regulations and apply them.
They are able on the basis of their training or professional experience to assess
the risks associated with the use of the device.

2 | Safety BÜCHI Labortechnik AG
10/94 Operation Manual Lyovapor™ L-200/L-200 Pro
Operator
The operator (generally the laboratory manager) is responsible for the following as-
pects:
The device must be correctly installed, commissioned, operated and serviced.
Only suitably qualified staff may be assigned the task of performing the operations
described in these operating instructions.
The staff must comply with the local applicable requirements and regulations for
safe and hazard-conscious working practices.
Safety-related incidents that occur while using the device should be reported to the
manufacturer ([email protected]).
BUCHI service technicians
Service technicians authorized by BUCHI have attended special training courses and
are authorized by BÜCHI Labortechnik AG to carry out special servicing and repair
measures.
2.4 Location of warning signs on the product
The following warning symbols are present on the instrument.
Fig.1: Location of warning signs on the product
General warning
2.5 Residual risks
The device has been developed and manufactured using the latest technological ad-
vances. Nevertheless, risks to persons, property or the environment can arise if the
device is used incorrectly.
Appropriate warnings in this manual serve to alert the user to these residual dangers.
2.5.1 Faults during operation
If a device is damaged, sharp edges or exposed electrical wires can cause injuries.
uRegularly check device for visible damage.
uIf faults occur, switch off the device immediately, unplug the power cord and in-
form the operator.
uDo not continue to use devices that are damaged.

BÜCHI Labortechnik AG Safety | 2
Operation Manual Lyovapor™ L-200/L-200 Pro 11/94
2.5.2 Damage to the ice condenser
Damage to the ice condenser leads to coolant leakage and failure of the instrument.
uWait until the ice is completely thawed.
uDo not use mechanical means to remove ice from the ice condenser.
2.5.3 Glass and acrylic breakage
Broken glass and acrylic can cause severe cuts.
Damaged glass and acrylic components may implode if subjected to a vacuum.
Minor damage to the ground joints impairs the sealing effect and may therefore dimin-
ish sublimination capacity.
uHandle the flask and other glass and acrylic components carefully and do not drop
them.
uAlways place the flasks in a suitable holder when they are not mounted on the Ly-
ovapor™.
uAlways visually inspect glass and acrylic components for damage every time they
are to be used.
uDo not continue to use glass and acrylic components that are damaged.
uAlways wear protective gloves when disposing of broken glass and acrylic.
2.5.4 Low internal pressure
Evacuating the system reduces the pressure in the drying chamber. This reduced
pressure can cause glass and acrylic components to implode.
uMake sure that all glass and acrylic components are free of damage.
2.5.5 Cold and hot surfaces
The condenser coil and probes can be extremely cold. Heatable shelf areas can be
extremely hot. If touched, hot and cold surfaces can cause skin burns.
uDo not touch cold or hot surfaces or liquids and/or wear suitable protective gloves.
2.6 Personal protective equipment
Depending on the application, hazards due to heat and/or corrosive chemicals may
arise.
uAlways wear appropriate personal protective equipment such as safety goggles,
protective clothing and gloves.
uMake sure that the personal protective equipment meets the requirements of the
safety data sheets for all chemicals used.
2.7 Modifications
Unauthorized modifications may impair safety and lead to accidents.
uUse only genuine BUCHI accessories, spare parts and consumables.
uTechnical modifications to the device or accessories should only be carried out
with the prior written approval of BÜCHI Labortechnik AG and only by authorized
BUCHI technicians.
BUCHI accepts no liability whatsoever for damage arising as a result of unauthorized
modifications.

3 | Product description BÜCHI Labortechnik AG
12/94 Operation Manual Lyovapor™ L-200/L-200 Pro
3 Product description
3.1 Description of function
The Lyovapor™ is a freeze-dryer in which frozen preparations can be gently dried.
The basis of freeze-drying is sublimation. Sublimation refers to the process whereby a
substance transforms directly from the solid to the gaseous state.
The physical process of sublimation can be explained using the solvent water as an
example.
The water is frozen.
The frozen water is transformed into the gaseous state under vacuum at a pres-
sure below the triple point.
The vacuum prevents the ice melting when heat is applied to the preparation.
Thus, freeze-drying takes place in three phases:
1. Freezing phase: the preparation is frozen at atmospheric pressure.
2. Main drying phase: heat is applied to the frozen preparation under a vacuum.
The frozen water is removed by sublimation.
3. Secondary drying phase (only possible with heatable shelves): the trace lev-
els of water remaining are removed by heating.
The Lyovapor™ consists of an ice condenser and various top-mount drying racks.
The top-mount drying racks can be chosen to suit the availability of the preparation
being dried and the requirements of the end product.
The following top-mount drying racks can be used:
Non-heatable and heatable shelves in rack
Trays in rack
Top-mount rack with manifold valves
3.1.1 Freezing phase
In the freezing phase, the aqueous preparation is transformed to a solid state. Freez-
ing takes place under atmospheric pressure using a separate freezer, a liquid nitro-
gen bath, or a mixture of dry ice and alcohol.
The end of the freezing phase is reached as soon as the water contained in the
preparation has fully crystallized.
3.1.2 Main drying phase
In the main drying phase, the ice crystals are removed from the preparation by subli-
mation. Sublimation in the Lyovapor™ takes place under a vacuum with the addition
of thermal energy.
To create the vaccum, the pressure is lowered to the level required for sublimation.
For water that is: less than 6.11mbar.
As the ice condenser is colder than the preparation being dried, the vapour pressure
in the area of the ice condenser is lower than in the area of the preparation. The wa-
ter vapour escaping from the preparation therefore flows towards the ice condenser.
The water vapour condenses on the coil of the ice condenser.
If a manifold-valve rack is used, heat transfer takes place by convection and radiation
from the surroundings. Control of the thermal energy transferred is then difficult.

BÜCHI Labortechnik AG Product description | 3
Operation Manual Lyovapor™ L-200/L-200 Pro 13/94
If using a drying chamber with heatable shelves, heat transfer takes place by direct
contact. The temperature of the heatable shelves is controllable. Control of the ther-
mal energy transferred is then possible.
Controlling the heat transfer prevents the following critical temperatures for amor-
phous and crystalline materials to be reached:
the glass transition temperature Tg' of the frozen preparation
the collapse temperature Tc.
the eutectic temperature Teu.
Above the glass transition temperature and the collapse temperature, the viscosity of
the frozen preparation increases. The increased viscosity leads to the collapse of the
preparation's matrix structure.
Above the eutectic temperature, the preparation melts.
During the main drying phase, the product temperature must remain below the col-
lapse temperature for amorphous materials in the preparation.
Sublimation of the ice crystals progresses downwards from the surface of the product.
Above the sublimation boundary, the product is dry ("freeze-dried cake"), while further
inside the product is still frozen.
The end of the main drying phase is reached when all ice crystals have been re-
moved from the preparation.
After the main drying phase, the remaining fluid content in the preparation can still be
between 5 to 10%.
3.1.3 Secondary-drying phase
In the secondary-drying phase, the unfrozen water is removed from the preparation
by desorption. The secondary-drying function is performed by the heatable shelves in
the drying chamber of the Lyovapor™.
In the secondary-drying phase, the temperature of the heatable shelves is raised and
held for several hours.
The end of the secondary-drying phase is reached when the residual moisture in the
preparation is between 1% and 5%.

3 | Product description BÜCHI Labortechnik AG
14/94 Operation Manual Lyovapor™ L-200/L-200 Pro
3.2 Configuration
3.2.1 Front view
3
5
2
1
4
Fig.2: Front view Lyovapor™ L-200
1 Connections for heated shelves
(Lyovapor™ L-200 Pro only)
(48 V, max. 2 A)
2 Ice condenser
3 Ventilation slots 4 On/Off master switch
5 User interface
3.2.2 Rear view
3
2
1
Fig.3: Rear viewLyovaporTM L-200
1 Connections on the rear side
(See Chapter3.2.3 "Connections on
the rear side", page15)
2 Drain hose for condensate
3 Ventilation slots

BÜCHI Labortechnik AG Product description | 3
Operation Manual Lyovapor™ L-200/L-200 Pro 15/94
3.2.3 Connections on the rear side
4
3
14
15
2
1
11
9875
6
10
12
13
Fig.4: Connections on rear panel
1 Vacuum pump connection 2 Vacuum connection
3 Type plate 4 Refrigerant details
5 Main valve connection
(24 V, ≤ 0.4 A)
6 Pressure regulating valve connection
(24 V, ≤ 0.4 A)
7 Aeration valve connection
(24 V, ≤ 0.4 A)
8 Spare
(24 V, ≤ 0.4 A)
9 External pressure sensor connection
(24 V, max. 0.125 A)
10 Internal pressure sensor connection
(5 V, max. 0.125 A)
11 LAN port 12 COM port
(24 V, ≤ 0.4 A)
13 Power supply connection 14 Fuse
15 Fuse
3.2.4 Control panel
1
23
Fig.5: Control panel
1 View 2 Function buttons
3 Navigation control

3 | Product description BÜCHI Labortechnik AG
16/94 Operation Manual Lyovapor™ L-200/L-200 Pro
3.2.5 Pro control panel
1
2
Fig.6: Pro control panel
1 Touch-screen display 2 Navigation control
3.3 Type plate
The type plate identifies the instrument. The type plate is located on the rear of the in-
strument.
Buchi Operations India Private Limited
394230 Surat / India
Type xxx
SN xxxxxxxx
Volt xxx-xxx VAC
Freq xx Hz
Power xxxx W
Built 20xx
Designed by BUCHI in Switzerland
Made in India
6
5
4
1
3
2
7
8
910 9
Fig.7: Type plate
1 Company name and address 2 Instrument name
3 Serial number 4 Input voltage range
5 Frequency 6 Power consumption maximum
7 Year of manufacture 8 Product code
9 Approvals 10 Symbol for "Do not dispose of as
household waste"
The following instrument names are possible:
L-200
L-200 Pro

BÜCHI Labortechnik AG Product description | 3
Operation Manual Lyovapor™ L-200/L-200 Pro 17/94
3.4 Scope of delivery
NOTE
The scope of delivery depends of the configuration of the purchase order.
Accessories are delivered as per the purchase order, order confirmation, and deliv-
ery note.
3.5 Refrigerant Specification
The refrigerant details are shown on the back of the instrument.
Type: L-xxx xxHz
Cooling System Refrigerant: Rxxx
Filling: xxx g
Global Warming Potential (GWP): xx tCO2
High Side Design Pressure: xxxx
Low Side Design Pressure: xxxx
5
3
1
2
4
6
Fig.8: Refrigerant details
1 Instrument name 2 Refrigerant details
3 Filling capacity 4 Global warming potential
5 High-pressure system design pres-
sure
6 Low-pressure system design pres-
sure
3.6 Technical data
3.6.1 Lyovapor™ L-200
Specification L-200 for 50Hz L-200 for 60Hz
Dimensions without drying attach-
ments (W x D x H)
460 × 585 × 510 mm 460 × 585 × 510 mm
Weight 75kg 75kg
Minimum clearance on all sides 300mm 300mm
Connection voltage 220-240 VAC 208-230 VAC
Power consumption
(rated)
1200 W 1200 W
Power consumption
(maximum)
1800 W 1800 W
Lug 10 A/250 V 10 A/250 V
Frequency 50 Hz 60 Hz
Overvoltage category II II
Protection rating IP20 IP20
Pollution degree 2 2
Condensing capacity
at 20 °C ambient temperature
≥ 6 kg / 24 h ≥ 6 kg / 24 h
Lowest condenser temperature -55 °C -55 °C
Temperature divergence ± 1.0 °C ± 1.0 °C

3 | Product description BÜCHI Labortechnik AG
18/94 Operation Manual Lyovapor™ L-200/L-200 Pro
Specification L-200 for 50Hz L-200 for 60Hz
Condenser capacity ≤ 6 kg ≤ 6 kg
Condenser surface area 1410 cm21410 cm2
Number of compressors 1 1
Refrigerant R507 CFC-free R507 CFC-free
Refrigerant quantity 485 g 467 g
Drying shelf temperature up to 60 °C up to 60 °C
Inert gas pressure 1.1 - 1.2 bar
(max. 2 bar)
1.1 - 1.2 bar
(max. 2 bar)
Drying shelf temperature tolerance ± 1.0 °C ± 1.0 °C
Cooling capacity compressor 1.97 kW 2.33 kW
Vacuum generation time to 0.1
mbar*
Typically ≤ 10 min Typically ≤ 10 min
Volume-based leakage rate* Typically ≤ 0.001
mbar x L/sec
Typically ≤ 0.001
mbar x L/sec
Minimum system vacuum* Typically ≤ 30 mTorr Typically ≤ 30 mTorr
Optimum control range vacuum* 50 to 500 mTorr 50 to 500 mTorr
* With Pfeiffer Duo 6 vacuum pump / without samples
3.6.2 Ambient conditions
For indoor use only.
Max. altitude above sea level 2000 m
Ambient temperature 15 - 30°C
Maximum relative humidity 80 % for temperatures up to 30°C
Storage temperature max. 45°C
3.6.3 Materials
Component Materials
Lyovapor™ housing Steel 1.4301/304 with powder coating
Vacuum chamber and components Steel 1.4301/304
Main connector PE-UHMW 1000
Drying chamber tube and cover PMMA GS
Seals FKM
Manifold drying rack Steel 1.4301/304
Manifold valves Natural rubber, PP
Cooling medium circuit Copper for freezing applications to EN
12735-1
Vacuum clips Aluminium
Condensate drain tube Silicone
Condensate drain, ventilation and control
valve
Brass with EPDM seal
Main valve Aluminum with FKM seal

BÜCHI Labortechnik AG Transport and storage | 4
Operation Manual Lyovapor™ L-200/L-200 Pro 19/94
4 Transport and storage
4.1 Transport
NOTICE
Risk of breakage due to incorrect transportation
Make sure that the instrument is fully dismantled.
Pack every instrument components properly to prevent breakage. Use the original
packaging whenever possible.
Avoid sharp movements during transit.
uAfter transporting, check the instrument and all glass components for damage.
uDamage that has occurred in transit should be reported to the carrier.
uKeep packaging for future transportation.
4.2 Storage
uMake sure that the ambient conditions are complied with (see Chapter3.6 "Tech-
nical data", page17).
uWherever possible, store the device in its original packaging.
uAfter storage, check the device, all glass components, seals and tubing for dam-
age and replace if necessary.
4.3 Lifting the instrument
WARNING
Danger due to incorrect transportation
The possible consequences are crushing injuries, cuts and breakages.
uThe instrument should be transported by four persons at the same time.
uLift the instrument at the points indicated.

4 | Transport and storage BÜCHI Labortechnik AG
20/94 Operation Manual Lyovapor™ L-200/L-200 Pro
2
1
43
Fig.9: Lifting the instrument
1 Instrument 2 Feet
3 Equipment trolley 4 Castor brakes on trolley
Precondition:
RMake sure that the castor brakes on the equipment trolley are locked on.
uLift the instrument – this requires four persons each lifting at one of the points indi-
cated on the front and rear of the instrument.
uSet the instrument down on the equipment trolley.