CORNING 6840 User manual

Corning® Bottle
Top Dispenser
Instruction Manual
Catalog Numbers:
6840
6841
6842
6843
6844
6845
This manual is available in additional languages at www.corning.com/lifesciences.

Table of Contents
1.0 Introduction.................................................................................................................................... 3
2.0 General Precautions ..................................................................................................................... 3
2.1 General Safety Precautions................................................................................................. 3
2.2 Chemical Resistance............................................................................................................. 4
3.0 Packing............................................................................................................................................. 4
4.0 Corning® Bottle Top Dispenser Design ................................................................................... 5
5.0 Operating Instructions ................................................................................................................ 5
5.1 Before Initial Operation ....................................................................................................... 5
5.2 Attachment of the Telescopic Tube................................................................................... 5
5.3 Volume Adjustment ............................................................................................................. 6
5.4 Air-purging.............................................................................................................................. 6
5.5 Dispensing .............................................................................................................................. 6
5.6 Anti-drip System.................................................................................................................... 6
6.0 Cleaning........................................................................................................................................... 7
6.1 Sterilization............................................................................................................................. 7
7.0 Maintenance ................................................................................................................................. 8
7.1 Disassembling the Corning Bottle Top Dispenser......................................................... 8
7.2 Reassembling the Corning Bottle Top Dispenser .......................................................... 9
8.0 Calibration ....................................................................................................................................10
9.0 Chemical Compatibility.............................................................................................................11
10.0 Troubleshooting .........................................................................................................................13
10.1 Valve Clogging ....................................................................................................................13
11.0 Spare Parts and Accessories .....................................................................................................14
12.0 Limited Warranty ........................................................................................................................15

Instruction Manual | 3
1.0 Introduction
Corning® Bottle Top Dispensers are volumetric instruments designed for convenient
and safe dispensing of liquids with no loss of reagent. Depending on the model,
they can accommodate volumes from 0.25 mL to 100 mL.
Cat. No. Description Volume range (mL) Increment (mL) Systematic Error (mL) Random Error (mL)
6840 Corning Bottle Top Dispenser 0.25 - 2.5 0.05 ±0.012 ≤0.002
6841 Corning Bottle Top Dispenser 0.5 - 5 0.10 ±0.030 ≤0.005
6842 Corning Bottle Top Dispenser 1 - 10 0.20 ±0.060 ≤0.010
6843 Corning Bottle Top Dispenser 2.5 - 25 0.50 ±0.150 ≤0.025
6844 Corning Bottle Top Dispenser 5 - 50 1.00 ±0.300 ≤0.050
6845 Corning Bottle Top Dispenser 10 - 100 2.00 ±0.500 ≤0.100
2.0 General Precautions
2.1 General Safety Precautions
To avoid personal injury from chemicals, wear eye protection and use appropriate safety
equipment and clothing. Please follow all safety instructions, as well as the operating
procedures in this manual.
Highest safety precautions should be used when dispensing corrosive, radioactive,
or hazardous chemicals.
Observe the general safety regulations for handling chemicals (e.g., protective clothing,
protective goggles).
 Alwayscheckthedeviceforleaktightnessandarmpositionoftheplugandsocket
connection before use.
Never use force. Breakage of any part might lead to hazardous exposure for the user,
as well as for other persons.
Clean the device daily.
The temperature of the dispenser and reagent should not exceed 40°C.
The proper and secure function is only guaranteed by using the supplied discharge
tube. Use only the original supplied discharge tubes.
Never use damaged or deformed tubes. If the valve is damaged, the discharge tube
might drop.
The discharge tube should never face the user.
The collection vessel should be placed underneath.
 Checkallscrewttingsfortightnessapproximatelyonehouraftereachdispenser
has been assembled or disassembled. Temperature variations might lead to material
expansions and therefore to leakages.
 Ifyouareunsureaboutdispensingaspecicchemicalsolution,pleasecontactyour
local Corning representative.

4| CORNING BOTTLE TOP DISPENSER
2.2 Chemical Resistance
Use the Corning® Bottle Top Dispenser only with regard to the chemical resistance
of materials and for the purpose for which it is intended. Do not use the Corning Bottle
Top Dispenser for:
PTFE swelling solvents
 Hydrouoricacid
Chemical solutions which react with platinum-iridium alloys
The following components that come directly in contact with reagents are made
of chemical resistant materials:
Spring: platinum-iridium
Valve balls: ceramic
 Piston:PTFE(polytetrauoroethylene)
Cylinder: borosilicate glass
 Tubing:FEP(uorinatedethylenepropylene)
3.0 Packing
Each Corning Bottle Top Dispenser is delivered with the following items:
Description Quantity
Corning Bottle Top Dispenser with discharge tube 1
Telescopic suction tube 1
Calibration tool 1
Thread adaptors, with 4 different diameters
For models 2.5, 5, 10 mL: A25, A28, A40, A45
For models 25, 50, 100 mL: A25, A28, A38, A45/32
1
Instruction manual 1
Certicateofperformance 1

Instruction Manual | 5
4.0 Corning® Bottle Top Dispenser Design
5.0 Operating Instructions
5.1 Before Initial Operation
Check the device for damages.
Make sure the telescopic tube reaches the bottom of the bottle.
Do not use the outer housing (1) for carrying the assembled dispenser.
Carefully attach the discharge tube (4) and protective sleeve (3) to avoid damage.
When screwing the bottle on/off, do not hold the device at its outer housing (1),
hold it at the screw base.
Do not use the device before it has been completely assembled
and a collecting vessel has been placed underneath.
5.2 Attachment of the Telescopic Tube
Thereuxtubeisalreadyattachedtothebiggersocket.
Put the telescopic (suction) tube into the smaller socket
at the bottom part of the instrument.
Check for the proper length of the telescopic tube
(it should reach the bottom of the bottle).
Telescopic
(suction)
tube (14)
Reux
tube
(15)
Outer housing (1)
Quick lock knob* (2)
* 100 mL dispenser
comes with volume
adjustment screw
Protective sleeve (3)
Discharge tube (4)
Thread adaptor (21)

6| CORNING BOTTLE TOP DISPENSER
5.3 Volume Adjustment
Dispenser size up to 50 mL
Push the quick lock knob (2).
Slide it down to the desired volume, and release.
Dispenser size 100 mL
Untighten the volume adjustment screw.
Move the adjustment screw down to the desired volume,
and tighten the screw again.
5.4 Air-purging
Turn the discharge tube to 90°.
Set a small volume.
To remove the air, raise and press the outer
housing 2 to 3 times.
Turn the discharge tube back to the 0° position,
andllitwithliquid.
Fill the cylinder up to the selected volume.
Your dispenser is now ready to use.
5.5 Dispensing
Raise the outer housing until it stops.
Press the outer housing to the lowest point
to dispense.
NOTE: To achieve an exact dispensing volume,
the movements should be smooth and constant.
5.6 Anti-drip System
Turn the discharge tube to 180°. The liquid from
the discharge tube will now dispense back into
the bottle.
In order to seal the dispenser, turn the discharge
tube to 90°.
180°
90°

Instruction Manual | 7
6.0 Cleaning
Before cleaning, follow these steps to remove all liquid without any loss of reagent from
the Corning® Bottle Top Dispenser:
Turn the discharge tube to 180°, and let the remaining reagent from the discharge tube
owbackintothereagentbottle.
Screw off the dispenser from the bottle.
Drain the telescopic tube by slightly tapping inside the reagent bottle.
Turn the discharge tube from 180° to 90°, and remove all of the remaining liquid from
the cylinder back into the reagent bottle.
NOTE: Cleaning is necessary if you want to use the dispenser for another chemical
solution or if not in use for a long period of time.
For cleaning, follow these steps:
Fill the bottle with distilled water or alcohol.
Attach the telescopic tube, and screw the dispenser on to the bottle.
Turn the discharge tube to “Dispense” mode.
Dispense multiple times until the dispenser is cleaned.
If necessary, disassemble the dispenser and clean all components. The dispenser should
be cleaned daily if used with the following chemicals:
Solutions with a tendency to build crystals (e.g., salts)
Inorganic oxidizing solutions (e.g., biuret reagent)
6.1 Sterilization
Afterremovalofthereuxtubeandtelescopictube,thedispensercanbesteam-
sterilized (121°C, 2 bar, 15 minutes) according to EN 285.
NOTE: The telescopic tube is not autoclavable.
Place the dispenser on a cloth, and avoid contact with hot metal surfaces. The discharge
tube has to be attached to the protective sleeve.
In order to prevent loss of adjustment due to heat expansion of the different materials,
the quick lock knob has to be set to a minimum 2/10 of its maximum volume. Before
you use the dispenser, let it reach room temperature (about 2 hours cooling time).
 Afterautoclaving,checkallscrewttingsfortightnessandallpartsfordeformations
or other changes. The dispenser must be checked and recalibrated if necessary.
NOTE: Do not use any deformed or leaking parts. In case of deformation, please contact
your local Corning representative.

8| CORNING BOTTLE TOP DISPENSER
7.0 Maintenance
7.1 Disassembling the Corning® Bottle Top Dispenser
Rinse the dispenser with distilled water or alcohol (Section 3).
 Removethetelescopictube(14)andthereuxtube(15).
Remove the protective sleeve (3) and then discharge tube (4).
 Loosenthexingscrew(7),andpulloutthepiston(8).
Pull off the adaptor ring (10) from outer housing (1).
Press down the quick lock knob (2), and pull it out of the slot.
Remove the outer housing (1).
Loosen the cap nut (11).
Pull the cylinder set out of the valve block (12), keeping in mind that the valve star (17)
and the valve ball (18) might fall out.
Take the valve star (17) and the valve ball (18) out of the valve block (12).
Pull the valve axle (13) out of the valve block (12).
Telescopic tube (14)
Reuxtube(15)
Valve axle (13)
Valve block (12)
Cap nut (11)
Adaptor ring (10)
Cylinder (9)
Cylinder Set
Safety cap (5)
Safety bolt (6)
Fixing screw (7)
Piston (8)
O-rings (20)
Ejection
valve (19)
Suction valve (16)
Valve star (17)
Valve ball (18)

Instruction Manual | 9
7.2 Reassembling the Corning® Bottle Top Dispenser
Push the valve axle (13) into the valve block (12).
Place the valve ball (17) and the valve star (18) into the suction valve (16). Check that
the edges of the valve star (17) point upwards.
Attach the cylinder set to the valve block (12). Check that the notches of the cylinder
set are placed exactly over the spikes of the valve block.
 Tightenthecylinder(9)withthecapnut(11).Checkthatallpartsttightly.
Slide the outer housing (1) on the cylinder (9).
Place the device horizontally, and mount the quick lock knob (2) into the slot
of the outer housing (1).
Clip the adaptor ring (10) to the outer housing (1).
Push the piston (8) into the cylinder (9) until it stops.
 Attachthexingscrew(7)totheouterhousing(1).
Attach the discharge tube (4) to the valve axle (13).
Slide the protective sleeve (3) over the attached discharge tube (4).
 Pushthereuxtube(15)andthetelescopictube(14)intothevalveblock(12).
Screw the assembled device on to the reagent bottle.

10 | CORNING BOTTLE TOP DISPENSER
A B C D
8.0 Calibration
Corning® Bottle Top Dispensers are calibrated according to EN ISO 8655-5 and EN ISO 8655-6.
After each assembly, calibrate the device following the instructions below.
Remove the safety cap (A). The built-in recalibration mechanism will now be visible.
Attach the calibration tool to the safety bolt (B).
NOTE: Alternatively, you can use a standard hex key (8 mm) for adjustment.
Pull out the calibration tool together with the safety bolt. Now attach the calibration
tool with the thicker side to the piston (C).
– Use the calibration tool to correct the adjustment angle by rotating the outer
housing. To recalibrate an undersized volume, rotate the outer housing clockwise.
To recalibrate an oversized volume, rotate the outer housing counter-clockwise.
– Attach the safety bolt to the piston.
– Check the volume. If the measured volume exceeds the tolerance limits, calibrate
the device again.
If the calibration was successful, attach the safety cap (D).

Instruction Manual | 11
9.0 Chemical Compatibility
Chemical Compat. Chemical Compat. Chemical Compat.
Acetaldehyde Butyl methyl ether Dimethyl sulfoxide 
Acetic acid (100%) Butylamine Dimethylaniline 
Acetic acid (96%) Butyric acid Dimethylformamide 
Acetic anhydride Calcium carbonate 1.4 Dioxane –
Acetone Calcium chloride Diphenyl ether 
Acetonitrile Calcium hydroxide Ethanolamine 
Acetophenone –Calcium hypochlorite Ethyl acetate 
Acetylacetone Carbon tetrachloride –Ethyl alcohol 
Acetyl chloride –Chloronaphthalene Ethylbenzene –
Acrylic acid Chloroacetaldehyde
(45%) Ethylene chloride –
Acrylonitrile Chloroacetic acid Fluoroacetic acid 
Adipic acid Chloroacetone Formaldehyde (40%) 
Allyl alcohol Chlorobenzene Formamide 
Aluminum chloride Chlorobutane Formic acid (100%) 
Amino acids Chloroform –Glycerol 
Ammonia (20%) Chlorosulfonic acid Glycol 
Ammonia (20%-30%) Chromic acid (50%) Glycolic acid (50%) 
Ammonium chloride Chromosulfuric acid Heating oil –
Ammoniumuoride Copper sulfate Heptane –
Ammonium sulfate Cresol –Hexane –
n-Amyl acetate Cumene Hexanoic acid 
Amyl alcohol Cyclohexane –Hexanol 
Amyl chloride –Cyclohexanone Hydriodic acid (57%) 
Aniline Cyclopentane –Hydrobromic acid 
Barium chloride Decane Hydrochloric acid
(20%) 
Benzaldehyde 1-Decanol Hydrochloric acid
(20%-37%) 
Benzol Dibenzyl ether Hydrogen peroxide
(35%) –
Benzine –Dichlorobenzene Isooctane –
Benzoyl chloride Dichloromethane –Isoamyl alcohol 
Benzyl alcohol Dichloroacetic acid Isobutanol 
Benzylamine Dichloroethane –Isopropanol 
Benzyl chloride Dichloroethylene –Isopropyl ether 
Boric acid (10%) Diesel oil –Lactic acid 

12 | CORNING BOTTLE TOP DISPENSER
Chemical Compat. Chemical Compat. Chemical Compat.
Bromobenzene Diethanolamine Methoxybenzene 
Bromonaphthalene Diethyl ether –Methyl alcohol 
Butanediol Diethylamine Methyl benzoate 
1-Butanol 1.2 Diethylbenzene Methyl butyl ether 
n-Butyl acetate Diethylene glycol Methyl ethyl ketone 
Methyl formate 
Phosphoric acid (85%)
+ Sulfuric acid (98%),
1:1
Tartaric acid 
Methyl propyl ketone Piperidine Tetrachloroethylene –
Methylene chloride –Potassium chloride Tetrahydrofuran –
Mineral oil Potassium dichromate Tetramethylammonium
hydroxide 
Monochloroacetic acid Potassium hydroxide Toluene –
Nitric acid (30%) Potassium
permanganate Trichloroacetic acid 
Nitric acid (30%-70%) Propionic acid Trichlorobenzene –
Nitrobenzene Propylene glycol Trichloroethane –
Oleic acid Pyridine Trichloroethylene –
Oxalic acid Pyruvic acid Trichlorotriuoro
ethane –
n-Pentane –Salicylaldehyde Triethanolamine 
Peracetic acid Silver acetate Triethylene glycol 
Perchloric acid Silver nitrate Triuoroethane –
Perchloroethylene –Sodium acetate Triuoroaceticacid 
Petroleum –Sodium chloride Turpentine –
Petroleum ether –Sodium dichromate Urea 
Phenol Sodiumuoride Xylene –
Phenylethanol Sodium hydroxide (30%) Zinc chloride (10%) 
Phenylhydrazine Sodium hypochlorite Zinc sulfate (10%) 
Phosphoric acid (85%) Sulfuric acid (98%) 
Disclaimer: The information contained in this table is for general information purposes
only. Corning assumes no responsibility for errors or omissions in this table. In no event
shall Corning be liable for any special, direct, indirect, consequential, or incidental
damages or any damages whatsoever, whether in an action of contract, negligence or
other tort, arising out of or in connection with this table. This table is based on internal
testing; user experience may vary.
Internal tests are conducted with direct and continuous exposure of the Corning® Bottle
Top Dispenser to the tested material.
Chemical Compatibility (continued)

Instruction Manual | 13
10.0 Troubleshooting
Problem Possible Cause Solution
Pistonmoveswithdifculty
or is stuck. Formation of crystals, dirty.
Stop dispensing immediately.
Loosen the piston with circular
motion, but do not disassemble.
Follow all cleaning process
(Section 6).
Filling not possible. Filling valve stuck. Follow cleaning process (Section 6).
Dispensing not possible. Discharge valve stuck. Follow cleaning process (Section 6).
Air bubbles in the instrument.
Reagent with high vapor
pressure has been drawn in
too quickly.
Repeat dispensing, lowering the
speed.
The instrument has not been
primed. Repeat air-purging.
Filling tube is loose or
damaged. Replace the telescopic tube.
Dispensed volume is too low. Dirty valve system. Follow cleaning process (Section 6).
Leaking liquid between
instrument and bottle. Filling tube is too loose. Replace the telescopic tube.
Operating Limits
Vapor pressure: maximum 500 mbar
Viscosity: maximum 500 mm2/s
Temperature: maximum 40°C, minimum 1°C
Density: maximum 2.2 g/cm3
10.1 Valve Clogging
NOTE: To avoid valve clogging, clean the dispenser if not in use for a period of time.
Release clogged valves with a thin object (wire, paper clip, etc.) by pushing the upper side
of the ejection valve (19) and/or the bottom side of the suction valve (16). Make sure that
you rinse the valves residue-free, since clogged valves may lead to leakage of the device.

14 | CORNING BOTTLE TOP DISPENSER
11.0 Spare Parts and Accessories
Contact Corning Customer Service for availability of spare parts. The Corning® Bottle
Dispenser Bottle catalog number and the name of the spare part are required.
Product Volume/Size Cat. No.
Outer housing 2.5 mL 6846
5 mL 6847
25 mL 6848
50 mL 6849
100 mL 6850
Valve head 2.5 - 10 mL 6851
25 - 100 mL 6852
Cylinder set 2.5 mL 6853
5 mL 6854
10 mL 6855
25 mL 6856
50 mL 6857
100 mL 6858
Volume rocker switch 2.5 - 50 mL 6859
100 mL 6860
PTFE plunger 2.5 mL 6861
5 mL 6862
10 mL 6863
25 mL 6864
50 mL 6865
100 mL 6866
Telescopic suction tube 2.5 - 10 mL 6867
25 - 100 mL 6868
Borosilicate glass one-way valve –6869
Borosilicate glass calcium chloride tube –6870
Thread adapters made of Polypropylene A32/A25 6871
A32/A28 6872
A32/A38 6873
A32/A40 6874
A32/A45 6875
A45/A32 6876

Instruction Manual | 15
12.0 Limited Warranty
Corning Incorporated (Corning) warrants that this product will be free from defects
in material and workmanship for a period of three (3) years from date of purchase.
CORNING DISCLAIMS ALL OTHER WARRANTIES WHETHER EXPRESSED OR IMPLIED,
INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A
PARTICULAR PURPOSE. Corning’s sole obligation shall be to repair or replace, at its option,
any product or part thereof that proves defective in material or workmanship within
thewarrantyperiod,providedthepurchasernotiesCorningofanysuchdefect.Corning
is not liable for any incidental or consequential damages, commercial loss, or any other
damages from the use of this product.
This warranty is valid only if the product is used for its intended purpose and within
theguidelinesspeciedinthesuppliedinstructionmanual.Thiswarrantydoesnot
cover damage caused by accident, neglect, misuse, improper service, natural forces, or
other causes not arising from defects in original material or workmanship. This warranty
doesnotcoverpistons,O-rings,seals,valvesandtubing,ordamagetopaintornish.
Claimsfortransitdamageshouldbeledwiththetransportationcarrier.
Intheeventthisproductfailswithinthespeciedperiodoftimebecauseofadefect
in material or workmanship, contact Corning Customer Service at: USA/Canada
1.800.492.1110, outside the U.S. +1.978.442.2200, visit www.corning.com/lifesciences,
orcontactyourlocalsupportofce.
Corning Customer Service will help arrange local service where available or coordinate
a return authorization number and shipping instructions. Products received without
proper authorization will be returned. All items returned for service should be sent
postage prepaid in the original packaging or other suitable carton, padded to avoid
damage. Corning will not be responsible for damage incurred by improper packaging.
Corning may elect for onsite service for larger equipment.
Some states do not allow limitation on the length of implied warranties or the exclusion
orlimitationofincidentalorconsequentialdamages.Thiswarrantygivesyouspecic
legal rights. You may have other rights which vary from state to state.
No individual may accept for, or on behalf of Corning, any other obligation of liability,
or extend the period of this warranty.
For your reference, make a note of the model number, serial number, date of purchase,
and supplier here.
Model No. ________________________________ Date Purchased _________________________________
Serial No. _________________________________ Supplier _______________________________________

© 2020 Corning Incorporated. All rights reserved. 7/20 CLS-AN-567DOC REV2
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