Endress+Hauser analytikjena multi N/C pharma HT User manual

Operating Manual
multi N/C pharma HT
TOC/TNbAnalyzer

Analytik Jena AG
Konrad-Zuse-Str.1
07745 Jena Germany
Phone + 49 3641 / 77 70
Fax + 49 3641 / 77 92 79
Email [email protected]
Analytik Jena AG
Konrad-Zuse-Str. 1
07745 Jena Germany
Phone + 49 3641 / 77-7407 (Hotline)
Email [e-mail]
http://www.analytik-jena.com
multi N/C and multiWin are registered trademarks of Analytik Jena AG in Germany.
Microsoft and Windows are registered trademarks of Microsoft Corp.
The identification with ® or TM is omitted in this manual.
11-0112-001-23
02.17
Analytik Jena AG
© Copyright 2017, Analytik Jena AG
Manufacturer
Service
General information
Copyrights and
Trademarks
Documentation number
Edition
Implementation of the
Technical Documentation

Contents
multi N/C pharma HT Edition 02.17 i
Table of Contents
1Basic Information.......................................1
1.1 User manual notes ........................................1
1.2 Analyzer area of application .......................... 1
1.3 Intended use..................................................2
1.4 Warranty and liability .....................................2
2Technical data............................................4
3Safety instructions ....................................6
3.1 Standards and directives ............................... 6
3.2 Symbols and signal words used ....................7
3.3 Safety markings on the analyzer ...................7
3.4 Technical condition........................................8
3.5 Requirements for the operating personnel ....8
3.6 Safety instructions, transport and installation 9
3.7 Safety instructions - operation ..................... 10
3.7.1 General........................................................10
3.7.2 Safety instructions - Protection against
explosion and fire ........................................ 10
3.7.3 Safety instructions - electrical equipment .... 10
3.7.4 Safety instructions for compressed gas
containers and systems............................... 11
3.7.5 Handling of auxiliary and operating materials11
3.7.6 Safety instructions - service and repair........12
3.8 Behavior during emergencies...................... 13
4Technical description..............................14
4.1 System design............................................. 14
4.1.1 Components for sample preparation ...........15
4.1.2 Hose system................................................ 16
4.1.2.1 Hose diagram ..............................................16
4.1.2.2 Connection method .....................................17
4.1.2.3 Components for flow adjustment .................17
4.1.2.4 Hose pumps ................................................ 18
4.1.3 Combustion system ..................................... 19
4.1.4 Components for measuring gas drying and
cleaning ....................................................... 20
4.1.4.1 Condensation coil ........................................20
4.1.4.2 TIC condensation module............................20
4.1.4.3 Water traps..................................................21
4.1.4.4 Halogen trap................................................ 22
4.1.5 Detectors .....................................................22
4.1.5.1 NDIR detector ............................................. 22
4.1.5.2 Chemiluminescence detector CLD (optional)23
4.1.6 Indicator and control elements, connections23
4.1.7 Accessories................................................. 24
4.1.8 Extension options for the analyzer .............. 25
4.1.8.1 Sampler....................................................... 25
4.1.8.2 Swab test module (optional)........................ 25
4.1.8.3 Chemiluminescence detector CLD (optional)25
4.2 Principle of operation .................................. 26
4.3 Measuring method ...................................... 27
4.3.1 TC analysis ................................................. 27
4.3.2 TOC analysis .............................................. 27
4.3.3 TIC analysis ................................................ 28
4.3.4 NPOC analysis............................................ 28
4.3.5 NPOC analysis according to the
NPOC plus method ..................................... 28
4.3.6 TNb-Analysis ............................................... 29
4.4 Catalysts ..................................................... 29
4.5 Calibration................................................... 29
4.5.1 Calibration strategies .................................. 29
4.5.1.1 Single point calibration ................................ 29
4.5.1.2 Multiple point calibration with constant
concentration .............................................. 29
4.5.1.3 Multiple point calibration with constant
sample volume............................................ 30
4.5.2 Day factor.................................................... 30
4.5.3 Calibration method in multiWin ................... 30
4.5.3.1 TC/NPOC.................................................... 31
4.5.3.2 TIC .............................................................. 31
4.5.3.3 TOC (Diff).................................................... 31
4.5.3.4 NPOC plus .................................................. 32
4.5.3.5 Calibration TNb............................................ 32
4.5.4 Method characteristics ................................ 32
4.5.5 Other calculations ....................................... 33
4.6 System Suitability Test (SST) ..................... 34
4.7 Blank Values ............................................... 35
4.7.1 Blank water values ...................................... 35
4.7.1.1 Blank preparation water value..................... 35
4.7.1.2 Dilution blank value..................................... 35
4.7.1.3 Eluate blank value....................................... 36
4.7.2 Boat blank value ......................................... 37

Contents
ii Edition 02.17 multi N/C pharma HT
5First commissioning................................38
5.1 Site requirements ........................................ 38
5.1.1 Installation conditions.................................. 38
5.1.2 Space requirement...................................... 38
5.1.3 Energy supply ............................................. 39
5.1.4 Gas supply .................................................. 39
5.2 Unpacking and placing the analyzer ........... 39
6Connecting add-on devices ....................40
6.1 Sampler....................................................... 40
6.1.1 AS vario autosampler.................................. 40
6.1.2 AS 21 autosampler...................................... 43
6.1.3 AS 10 autosampler...................................... 46
6.1.4 EPA sampler ............................................... 48
6.2 Chemiluminescence detector (CLD) ........... 53
6.3 Swab test module........................................ 55
6.3.1 Technical data............................................. 55
6.3.2 Structure of the swab test module............... 55
6.3.3 Installing the swab test module ................... 56
6.3.4 Operation of the swab test module.............. 59
6.3.5 Maintenance of the swab test module......... 61
6.3.6 Removal of the swab test module ............... 62
7Operation ..................................................64
7.1 General information for the analysis work ... 64
7.2 Switching on the analyzer ........................... 64
7.3 Carrying out the calibration ......................... 66
7.3.1 Preparing and starting the calibration.......... 66
7.3.2 Displaying calibration results....................... 68
7.3.3 Editing an existing calibration...................... 70
7.3.4 Transferring calibration parameters to a
method ........................................................ 71
7.3.5 Managing calibration data ........................... 73
7.4 Performing measurements.......................... 75
7.4.1 Measurement with manual sample supply .. 75
7.4.2 Measurement with sampler ......................... 75
8Maintenance and care .............................77
8.1 Maintenance intervals ................................. 77
8.2 Adjustment and setup tasks ........................ 79
8.2.1 General notes for adjusting the autosampler79
8.2.2 Adjusting the AS vario autosampler ............ 79
8.2.3 Adjust the NPOC purge flow ....................... 81
8.2.4 Adjusting the EPA sampler ......................... 82
8.3 Replacing the water traps ............................85
8.4 Replacing the halogen trap ..........................86
8.5 Exchanging the catalyst...............................87
8.5.1 Lifetime of the catalyst .................................87
8.5.2 Removing the combustion tube ...................87
8.5.3 Filling the combustion tube ..........................88
8.5.4 Inserting the combustion tube......................90
8.6 Cleaning the TIC condensate vessel ...........92
8.7 Removing and installing the condensation coil94
8.7.1 Removing and cleaning the condensation coil94
8.7.2 Inserting the condensation coil ....................95
8.8 Cleaning and replacing the metering syringe96
8.9 Removing and replacing the pump hose .....97
8.10 Replacing the hose connections ..................99
8.11 Removing and installing the combustion
furnace.......................................................100
8.11.1 Removing the combustion furnace ............100
8.11.2 Installing the combustion furnace ..............102
8.12 Checking the system for tightness .............103
9Fault removal......................................... 104
9.1 General information ...................................104
9.2 Error messages in multiWin.......................105
9.3 Status errors – indications in the window
System state..............................................110
9.4 Equipment faults and analytical problems .112
10 Transport and storage .......................... 115
10.1 Transport ...................................................115
10.1.1 Preparing the analyzer for transport ..........115
10.1.2 Transport notes..........................................117
10.1.3 Preparing the autosampler AS vario for
transport ....................................................117
10.1.4 Moving the analyzer in the laboratory ........118
10.2 Storage ......................................................118
10.3 Recommissioning after transport or storage119
10.3.1 Assembling the analyzer after transport or
storage.......................................................119
10.3.2 Connecting the analyzer ............................120
11 Disposal ................................................. 122
11.1 Waste water...............................................122
11.2 Halogen trap ..............................................122
11.3 Catalyst......................................................122
11.4 Analyzer.....................................................122

Figures
multi N/C pharma HT Edition 02.17 iii
Index of Figures
Fig. 1 Front view (doors open)............................14
Fig. 2 Lateral view left (side wall removed)......... 15
Fig. 3 Syringe pump with 2 port valve.................15
Fig. 4 Hose diagram ...........................................16
Fig. 5 Different FAST connector designs............17
Fig. 6 Fingertight screw connection ....................17
Fig. 7 Needle valve to adjust the NPOC purging
flow (see arrow) ........................................18
Fig. 8 Condensate pump ....................................18
Fig. 9 Phosphoric acid pump .............................. 19
Fig. 10 Combustion furnace (see arrow) ..............19
Fig. 11 Condensation coil .....................................20
Fig. 12 TIC condensation module.........................21
Fig. 13 Water traps ...............................................21
Fig. 14 Halogen trap .............................................22
Fig. 15 LED to indicate readiness for operation....23
Fig. 16 LED strip (right door open) ....................... 23
Fig. 17 Connections on the rear of the device ...... 24
Fig. 18 Swab test module .....................................25
Fig. 19 Principle of operation ................................ 26
Fig. 20 Layout of the AS vario autosampler.......... 41
Fig. 21 Transport lock on autosampler AS vario...41
Fig. 22 Sleeve with 2 cannulas for NPOC
measurements with non-parallel purging .. 42
Fig. 23 Hose in Fingertight connection .................43
Fig. 24 Layout of the sampler AS 21 ....................44
Fig. 25 Connections at the bottom of the
sampler.....................................................44
Fig. 26 Layout of the AS 10 autosampler .............47
Fig. 27 EPA sampler............................................. 49
Fig. 28 Rear of the EPA sampler .......................... 50
Fig. 29 Electrical connections on the rear of the
EPA sampler ............................................ 50
Fig. 30 Transport lock .......................................... 50
Fig. 31 Fitting the stirring arm to the autosampler 51
Fig. 32 Hose in Fingertight connection................. 52
Fig. 33 CLD – display elements, mains
connection and media connections .......... 53
Fig. 34 Structure of the swab test module............ 55
Fig. 35 Sample boat inserted into the swab test
module ..................................................... 61
Fig. 36 Calibration window - Data of new
calibration................................................. 66
Fig. 37 Window Current sample data (with
sampler operation) ................................... 68
Fig. 38 Calibration window - Data of new
calibration................................................. 69
Fig. 39 Disabling individual measured values of
a calibration.............................................. 71
Fig. 40 Window Link to Method ............................ 72
Fig. 41 Window Link with method with three
areas ........................................................ 73
Fig. 42 Window calibration report selection.......... 74
Fig. 43 Adjustment points on the sample tray ...... 80
Fig.44 Angled FAST connector with connected
hose ....................................................... 100
Fig.45 Replacing the Fingertight connection ..... 100
Fig.46 Components behind the front door
secured for transport .............................. 116
Fig.47 Combustion furnace removed and loose
hose ends secured for transport............. 116
Fig. 48 Transport lock on autosampler AS vario 117
Fig.49 Mains connection and gas connections
at the multi N/C pharma HT.................... 120

Basic Information
multi N/C pharma HT Edition 02.17 1
1 Basic Information
1.1 User manual notes
The analyzer multi N/C pharma HT is intended for operation by qualified specialist personnel
observing this user manual.
The user manual informs about the design and operation of the analyzer and provides per-
sonnel familiar with TC/TN analysis the necessary know-how for the safe handling of the
equipment and its components. The user manual further includes notes on the maintenance
and service of the equipment and potential causes and remedies of any faults.
Conventions
Instructions for action which occur in chronological order are numbered and combined into
action units and furnished with the corresponding results.
Lists which are not in chronological order are shown as itemized lists, sub-listings as bullet
points.
Safety notes are indicated by pictographs and signal words. The type and source of the
danger are stated together with notes on preventing the danger. The meaning of the picto-
graphs and signal words used is explained in section "Safety instructions" p. 6.
The elements of the control and analysis software are indicated as follows:
Menu commands, buttons, options etc. are formatted in bold.
Menu commands of a command sequence are separated by slashes ( / ), e.g.
Method / Edit.
Window names are shown in bold italics, e.g. Measurement window.
Buttons are marked with square brackets, e.g. [Save].
1.2 Analyzer area of application
The analyzer multi N/C pharma HT is a device to determine the parameters TC, TOC, NPOC
and TIC in aqueous samples. Detection is by way of thermocatalytic digestion in the pres-
ence of a special catalyst in accordance with the national and international standards. The
analyzer has been designed in particular for pure and ultrapure water analysis and meets the
requirements for water monography by the European Pharmacopeia Commission and the
water monograph of the United States Pharmacopeia Convention (USP).
Complementing the analyzer with a Chemiluminescence detector permits the detection of
TNb(total nitrogen bound).
The analyzer can optionally be upgraded with an integrated module for solids (swab test
module). This permits the carbon detection in solids in the lower concentration range, e.g.
during cleaning verification (swab test).
In line with the device design in respect of measuring range, sample volumes and sample
feeding the pure and ultrapure water analysis is the main area of application of the multi N/C
pharma HT.

Basic Information
2 Edition 02.17 multi N/C pharma HT
Pharmacy, medicine and biotechnology
Water for injection purposes (WFI), aqua purificata water for pharamaceutical purposes must
not exceed a TOC limit of 500 µg/l, therefore the TOC content of this water must be con-
trolled accordingly. The TOC devices used for this purpose must have a lower detection limit
of at least 50 µg/l. With its specification the multi N/C pharma HT exceeds these require-
ments and is thus ideally suited for use in pharmaceutical laboratories, medical facilities etc.
Microelectronics and semiconductor technology
The TOC is an important parameter in the manufacture of semiconductors, because the
water used in their production may only have very low TOC concentrations to guarantee a
high product quality. Due to its sensitive measuring range the multi N/C pharma HT is also
suited for this area of application.
Cleaning validation
The TOC parameter and, more recently, also the TNbparameter have become part of clean-
ing validation. The demands on the measuring range of the analyzer used are also very high
in this case. The multi N/C pharma HT can be used here both for "final rinse" method and for
the swab test.
1.3 Intended use
The analyzer multi N/C pharma HT must only be used for the methods for the detection of
the total carbon and/or the total nitrogen content in aqueous samples as described in this
user manual and for the detection of the total carbon content in small amounts of solid sam-
ples. Any other use is not as intended! Only the operator is liable for any damages that result
from this.
In particular it is prohibited to use the analyzer to analyze flammable liquids or substances
that could farm explosive mixtures. No concentrated acids may be analyzed with the analyz-
er.
The device must only be used with oxygen as a carrier gas.
The operational safety of the analyzer multi N/C pharma HT is only ensured during proper
use according to the information in this user manual. The intended use also includes the
adherence to the installation conditions prescribed by Analytik Jena AG which are available
from the customer service address stated above.
1.4 Warranty and liability
The warranty duration and liability comply with the legal requirements and the provisions in
the general terms and conditions of Analytik Jena AG.
Deviations from the intended use described in this user manual result in limitations of war-
ranty and liability during a damage event. Damage to wearing parts is not included in the
warranty.
Warranty and liability claims are excluded for personal injury and property damage due to
one or several of the following causes:
use of the analyzer multi N/C pharma HT other than intended
improper commissioning, operation and service of the analyzer
modifications of the equipment without prior consultation with Analytik Jena AG

Basic Information
multi N/C pharma HT Edition 02.17 3
unauthorized intervention in the equipment
operation of the device with faulty safety equipment or improperly fitted safety and
protection equipment
inadequate monitoring of the equipment components subject to wear
use of other than original spare parts, wearing parts or consumables
improper repairs
faults due to the non-observance of this user manual

Technical data
4 Edition 02.17 multi N/C pharma HT
2 Technical data
General characteristics
Designation/type analyzer multi N/C pharma HT
Basic device dimensions (W x H x D) 513 x 464 x 550 mm
Mass approx. 28 kg
Procedural data
Digestion principle Thermocatalytic oxidation
Digestion temperature up to 950 °C, depending on the catalyst
Catalyst
−for liquid samples
−for swab test module
−Pt(Al2O3) for pharma HT
−CeO2 , special catalyst for multi N/C
Measuring method TC, TIC, TOC (differential method), NPOC,
TNb(optional)
Industry standards Pharm.Eur. <2.2.44>, USP <643>, JP <2.59>,
FDA 21 CFR Part 11 Compliance, Pharm.Eur.
<2.5.33, 7B>, USP <1047, 7.2>
Carbon detection NDIR (coupled with VITA method)
Nitrogen detection (optional) CLD
sample volumes 50 – 3000 µl
Sample Feed Flow injection
Gas supply Synthetic air (free of HC, free of CO2)
Synthetic/Purified air can be supplied from gas
cylinders or after clean-up of pressurized air by a
TOC gas generator.
Purity specifications to be met: CO2< 1 ppm
Hydrocarbons < 0,5 ppm (as CH4)
Supply pressure: min. 5 bar (72 psi)
Provided flow rate: min. 300 ml/min
Oxygen (minimum 4.5)
Preliminary pressure 4 – 6 bar
Gas consumption:
in total
Analyte gas flow
Purge flow
Measuring gas flow for swab test
module (optional)
approx. 15 l/h, dependent on the measuring mode
approx. 120 ± 3 ml/min
50 – 120 ml/min
400 ± 10 ml/min
Control/analysis (control and analysis
software multiWin)
Real-time graphics, status indication during analy-
sis, graphical display of the measured results,
result print-out
Electrical variables
Connection 230 V AC, optionally 115 V AC, 50/60 Hz
Protection 230 V: T6,3 A H
115 V: T6,3 A H
(Use only original fuses of Analytik Jena AG)
Typical average power consumption 400 VA
PC interface USB 2.0
Environmental conditions

Technical data
multi N/C pharma HT Edition 02.17 5
Temperature during storage 5 – 55 °C
Temperature during operation 10 – 35 °C
Humidity during operation max. 90 % at +30 °C
Humidity during storage (10 – 30) % (use desiccant)
Air pressure 0.7 - 1.06 bar
Minimum equipment for the control and analysis unit
Operating system: Windows 7 Professional or better
Processor: Intel Core I3 or better
Working memory: 4 GB
Free hard disk space: 40 GB
Drive: CD-ROM drive (for software installation)
Monitor resolution: 1024 x 768
Interfaces USB 2.0

Safety instructions
6 Edition 02.17 multi N/C pharma HT
3 Safety instructions
For your own safety and to ensure error-free and safe operation of the analyzer multi
N/C pharma HT, please read this chapter carefully before using the appliance.
Observe all safety notes listed in this user manual and all messages and displayed by the
control and analysis software on the monitor.
3.1 Standards and directives
Safety class and safety type
The analyzer belongs to protection class I. The casing has protection class IP 20.
Device safety
The analyzer conforms to the safety standards
EN 61010-1
EN 61010-2-081
EN 61010-2-010
EN 61010-2-051 (for operation with sampler)
EMC compatibility
The analyzer has been checked for interference emission and resistance.
It meets the requirements for interference emission of
EN 61326-1 (EN 55011 Group 1, Class B)
It meets the requirements of interference resistance of
EN 61326-1 (requirements for use in basic electromagnetic environments)
Environmental compatibility
The analyzer has been tested for environmental compatibility and meets the requirements of
ISO 9022-3
ISO 9022-2
EU directives
The analyzer is built and tested according to standards that meet the requirements of EU
directives 2014/35/EU and 2014/30/EU. The analyzer leaves the factory in a sound condition
as far as technical safety is concerned. To maintain this condition and to ensure safe opera-
tion, the operator must strictly observe the safety and operating instructions contained in this
manual. For accessories which have also been supplied, and system components from other
manufacturers, their operating instructions should be referred to.

Safety instructions
multi N/C pharma HT Edition 02.17 7
Chinese directives
The analyzer contains regulated substances (according to directive SJ / T 11363-2011).
Analytik Jena AG guarantees that these substances will not leak out during the next 25 years
if the analyzer is used in accordance with its intended use and thus do not pose a threat to
the environment or health within this period.
3.2 Symbols and signal words used
The user manual uses the following symbols and signal words to indicate hazards or instruc-
tions. The safety instructions are always placed before an action.
WARNING
Indicates a potentially hazardous situation.
If it is not prevented death or most serious injuries (incapacitation) can result.
WARNING! DANGER OF ELECTRIC SHOCK IF TOUCHED!
CAUTION
Indicates a potentially hazardous situation.
If it is not prevented light or minor injuries and material damage can result.
CAUTION! HOT SURFACE!
Touching the hot surface can cause burns.
IMPORTANT
Indicates application hints and other especially useful information without any resulting
hazardous or damaging situations.
ENVIRONMENTAL PROTECTION
Indicates application hints and information to aid the proper disposal and handling of the
substances and materials used.
3.3 Safety markings on the analyzer
Safety symbols have been attached to the analyzer and accessories whose content must
always be observed.
Damaged or missing safety symbols can cause incorrect actions leading to personal injury or
material damage! The safety symbols must not be removed! Damaged safety symbols must
be replaced without delay!
The following safety symbols have been attached to the analyzer and accessories:

Safety instructions
8 Edition 02.17 multi N/C pharma HT
Fire, naked flame and smok-
ing prohibited!
Warning against dangerous
electrical voltage
Warning against hazardous
substances
Warning against hot surface Warning against corrosive
substances
For China:
The device contains regulated substances (according to
directive SJ / T 11363-2011). Analytik Jena AG guarantees
that these substances will not leak out during the next 25
years if the analyzer is used in accordance with its intended
use and thus do not pose a threat to the environment or
health within this period.
3.4 Technical condition
The analyzer corresponds in its design and construction to the current state of the art tech-
nology. Unauthorized modifications or changes, especially such that affect the safety of the
staff and the environment, are generally not allowed.
The following has to be observed:
Any manipulation of the safety equipment is prohibited! In case of an accident ma-
nipulations of the safety equipment will be interpreted as deliberate!
The operator must only operate the analyzer in a sound and operationally safe con-
dition. The technical condition must always comply with the legal requirements and
regulations.
Prior to every use the analyzer must be checked for damage and sound condition.
Any changes in the analyzer affecting its safety must be reported by the operating
personnel to the operator without delay.
The equipment components must only be connected to supply cables intended and
designed for this purpose.
All safety equipment and interlocks must be well accessible and regularly checked
for proper operation.
3.5 Requirements for the operating personnel
The analyzer multi N/C pharma HT must only be operated by qualified specialist personnel
instructed in the use of the analyzer. The instruction must also include conveying the content
of this user manual and the user manuals of other system components or add-on equipment.

Safety instructions
multi N/C pharma HT Edition 02.17 9
The analyzer may pose dangers if it is not used by trained personnel, improperly or other
than intended.
Therefore, every person tasked with the operation of the analyzer must have read and un-
derstood this user manual and the user manuals of any additional equipment before carrying
out the respective tasks. This also applies if the respective person has already worked with
or been trained on this kind of analyzer.
It is recommended that the operator have the operating personnel confirm the knowledge of
the content of the user manual in writing. The ultimate responsibility for the accident-free
operation of the analyzer rests with the operator or the specialist personnel authorized by
him.
In addition to the safety at work instructions in this user manual the generally applicable
safety and accident prevention regulations of the respective country of operation must be
observed and adhered to. The operator must ascertain the latest version of these regula-
tions.
The user manual must be accessible to the operating and service personnel at any time!
The following has to be observed:
The analyzer must only be commissioned, operated and serviced by trained person-
nel instructed in technical safety.
The operation or servicing of the analyzer by minors or individuals under the influ-
ence of alcohol, drugs or medication is not permitted.
It must be ensured that only authorized personnel works at the analyzer.
The operating personnel must be familiar with the dangers arising from measuring
liquids. The appropriate protective equipment must be used.
Prior to pauses or at the end of the work appropriate skin cleaning and protection
measures must be carried out.
Eating, drinking, smoking or handling open flames in the operating room of the ana-
lyzer is prohibited!
3.6 Safety instructions, transport and installation
The analyzer is always installed by the customer service department of Analytik Jena AG or
its authorized and trained specialist personnel. Independent assembly and installation are
not permitted. Incorrect installation can create serious hazards.
The following has to be observed:
Insufficiently secured components pose a risk of injury! During transport the compo-
nents of the equipment must be secured in accordance with the instructions in the
user manual.
Only transport the analyzer in its original packaging! Ensure that the transport pro-
tections have been fitted and the analyzer is completely empty.
To prevent health damage the following must be observed when moving the analyz-
er in the laboratory (lifting and carrying):
−For reasons of safety 2 persons are required to transport the analyzer and must
position themselves on both sides of the equipment.
−Because the analyzer does not feature any handles, firmly grip the device from
the bottom and make sure prior to simultaneous lifting the device that the sensi-
tive components at the front are protected by the closed doors.

Safety instructions
10 Edition 02.17 multi N/C pharma HT
−The guide values and statutory limits for lifting and carrying loads without auxiliary
equipment must be observed and adhered to.
3.7 Safety instructions - operation
3.7.1 General
The operator of the analyzer must make sure before each commissioning that the condition
of the analyzers including the safety equipment is sound. This applies in particular after each
modification or extension of the analyzer or its repair.
The following has to be observed:
The analyzer must only be operated if all protective equipment (e.g. covers, drip
pans for chemicals and doors) are present, properly installed and fully operational.
The sound condition of the protection and safety equipment must be checked regu-
larly. Any defects must be corrected as soon as they occur.
Protective and safety equipment must never be removed, modified or decommis-
sioned during operation.
Free access to the power switch on the back of the enclosure has to be ensured dur-
ing operation.
The ventilation equipment on the N/C pharma HT and the extension modules must
be in good working order. Covered vents or ventilation slits etc. may cause the de-
vice to break down or may cause damage to it.
The furnace operates with temperatures of up to 950 °C. The hot components (fur-
nace, condensation coil) must not be touched during or directly after the operation of
the analyzer.
Keep all combustible materials away from the analyzer.
3.7.2 Safety instructions - Protection against explosion and fire
The analyzer must not be operated in an explosive environment. Smoking or handling open
flames in the operating room of the analyzer is prohibited!
The operating personnel have to be familiar with the location of the fire-fighting equipment in
the operating room of the analyzer.
3.7.3 Safety instructions - electrical equipment
Work on electrical components of the analyzer may only be carried out by a qualified electri-
cian in accordance with the applicable electrical engineering rules. Life-threatening electrical
voltages may occur in the right-hand side component of the analyzer.
The following has to be observed:
Extension modules or system components must always be connected to or discon-
nected from the analyzer in a deactivated condition.
Before opening the analyzer it must be switched off from the equipment switch and
the mains connector must be disconnected from the mains outlet!

Safety instructions
multi N/C pharma HT Edition 02.17 11
Any work on the right-hand side component of the analyzer may only be carried out
by the customer service of Analytik Jena AG and specially authorized technicians.
The electrical components must be checked regularly by a qualified electrician. Any
defects, such as loose connections, faulty or damaged cables, must be repaired
without delay.
The analyzer must be switched off immediately at the power switch (on the equip-
ment backplate) and the power supply disconnected from the mains if there is any
interference with the electric components.
3.7.4 Safety instructions for compressed gas containers and
systems
The carrier gas (oxygen) is taken from compressed gas containers or local compressed gas
systems. The required purity of the carrier gas must be ensured (see chapter "Technical
data" p. 4)!
Work on compressed gas containers and systems must only be carried out by individuals
with specialist knowledge and experience in compressed gas systems.
The following has to be observed:
For gas cylinder or gas plant operation, the safety instructions and guidelines which
are valid at the operating location must be strictly complied with.
High pressure hoses and pressure reducers may only be used for the assigned gas-
es.
Pipes, hoses, screw connections and pressure reducers for oxygen must be kept
free from grease.
All pipes, hoses and screw connections must be checked regularly for leaks and ex-
ternally visible damage. Leaks and damaged must be repaired without delay.
Prior to inspections, service and repairs the valves must be closed and the analyzer
vented!
After successful repair and service of the components of the compressed air con-
tainers or system the analyzer must be checked for sound operation prior to recom-
missioning!
Independent assembly and installation are not permitted!
3.7.5 Handling of auxiliary and operating materials
The operator is responsible for the selection of substances used in the process as well as for
their safe handling. This is particularly important for radioactive, infectious, poisonous, corro-
sive, combustible, explosive and otherwise dangerous substances.
When handling dangerous substances local safety codes and guidelines must be observed.
The following general notes do not replace the specific local regulations or the regulations in
the EG safety data sheets of the manufacturers for the auxiliary and operating materials.
The following has to be observed:
The relevant regulations and the notes in the EC safety data sheets of the manufac-
turers have to be observed and complied with regards to storage, handing, use and
disposal for all auxiliary and operation materials used during operation or mainte-
nance of the analyzer.

Safety instructions
12 Edition 02.17 multi N/C pharma HT
Auxiliary and operation materials may never be placed in containers or vessels for
food. The approved containers for the relevant material are to be used and these
have to be labeled accordingly. The notes on the labels have to be observed!
Protective goggles and rubber gloves have to be worn when handing reagents. The
notes on the labels have to be observed.
The regulations and notes on the safety data sheets for the handling of orthophos-
phoric acid (H3PO4) or hydrochloric acid (HCl) have to be observed!
The catalyst supplied by the manufacturer (platinum catalyst pharma HT or special
catalyst multi N/C) must be treated with the usual caution when handling chemicals.
Biological samples have to be handled according to local guidelines regarding the
handling of infectious material.
Caution when handing quartz glass and glass parts. Risk of broken glass and there-
fore risk of injury!
Avoid dust formation and inhalation of dust when handing the quartz glass wool dur-
ing filling of the combustion tube.
Auxiliary and operating materials as well as their containers may not be disposed in
domestic waste or enter the sewage system or the soil. The applicable regulations
for disposal of these materials must be meticulously observed.
Ensure good room ventilation in working rooms.
3.7.6 Safety instructions - service and repair
The analyzer is usually serviced by the customer service department of Analytik Jena AG or
its authorized and trained specialist personnel.
Independent servicing can misadjust or damaged the analyzer. Therefore, the operator may
only carry out the tasks listed in the chapter "Service and care".
The following has to be observed:
The exterior of the analyzer may only be cleaned with a damp, not dripping, cloth af-
ter the analyzer has been switched off.
Any service and repair work at the analyzer may usually only be carried out in the
switched-off condition (unless stated otherwise).
Service tasks and the replacement of system components (removal of the combus-
tion tube, catalyst replacement) must only be carried out after a sufficiently long cool-
ing down phase.
Prior to servicing or repair the energy and gas supplies must be disconnected and
the analyzer must be v vented!
Only use original accessories and original replacement parts from Analytik Jena AG.
The notes in the chapter "Service and care" must be observed.
All protective equipment must be reinstalled correctly immediately after completion of
the service and repair work and be checked for operation!

Safety instructions
multi N/C pharma HT Edition 02.17 13
3.8 Behavior during emergencies
The analyzer must be switched off from the power switch (on the equipment backplate) and
the power supply has to be disconnected from the mains in case of dangerous situations or
accidents.
Because a rapid response can save lives during an emergency, the following has to be en-
sured:
The operating staff must be familiar with the location of safety equipment, accident
and danger alarms as well as first aid and rescue equipment as well as their han-
dling.
The operator is responsible for the respective training of the operating staff.
All equipment for first aid (first-aid kit, eyewash bottles, stretcher, etc.) as well as
equipment for firefighting (fire extinguishers) must be within reach and easy to ac-
cess. All equipment has to be in a sound condition and should be checked regularly.

Technical description
14 Edition 02.17 multi N/C pharma HT
4 Technical description
4.1 System design
The analyzer multi N/C pharma HT is a compact laboratory device with permanently installed
main components. The complete measuring design further includes accessory parts and
reagents which must be connected to the analyzer or made ready prior to a measurement.
The control of the analyzer and the analysis of the measurements takes place via the control
and analysis software multiWin installed on an external PC.
All components of the analyzer to be operated or serviced by the user can be reached via 2
doors at the front, the left-hand removable side wall or the top cover.
The analyzer multi N/C pharma HT consists of the following main components:
Components for sample preparation
Hose system
Combustion system
Components for measuring gas drying and cleaning
Detectors
Indicator and control elements, connections
Electronic component
Accessories
1 TIC condensate
container
2 Cooling block
3 Water traps
4 Halogen trap
5 Syringe pump
with 2 port valve
6 LED displays
7 Phosphoric acid
pump
8 Condensate
pump
9 Reagent bottle for
phosphoric acid
10 Drip tray
Fig. 1 Front view (doors open)