Franklin IC-168 User manual

FOLD
User’s Manual
HANDBOOK
OF
ADVERSE
DRUG
INTERACTIONS
Rx
The Medical Letter

DIGITAL BOOK
F
IC-168

Electronic Publishers
For Use with the Franklin
Digital Book System

Electronic Publishers


1
READ THIS LICENSE AGREEMENT BEFORE USING THE
DIGITAL BOOK. YOUR USE OF THE DIGITAL BOOK DEEMS
THAT YOU ACCEPT THE TERMS OF THIS LICENSE. IF YOU
DO NOT AGREE WITH THESE TERMS, YOU MAY RETURN
THIS PACKAGE WITH PURCHASE RECEIPT TO THE DEALER
FROM WHICH YOU PURCHASED THE DIGITAL BOOK AND
YOUR PURCHASE PRICE WILL BE REFUNDED. DIGITAL BOOK
means the software product and documentation found in this
package and FRANKLIN means Franklin Electronic Publishers, Inc.
LIMITED USE LICENSE
All rights in the DIGITAL BOOK remain the property of FRANKLIN.
Through your purchase, FRANKLIN grants you a personal and
nonexclusive license to use the DIGITAL BOOK on a single
FRANKLIN Digital Book System at a time. You may not make any
copies of the DIGITAL BOOK or of the data stored therein, whether
in electronic or print format. Such copying would be in violation of
applicable copyright laws. Further, you may not modify, adapt,
disassemble, decompile, translate, create derivative works of, or in
any way reverse engineer the DIGITAL BOOK. You may not export
or reexport, directly or indirectly, the DIGITAL BOOK without
compliance with appropriate governmental regulations. The
DIGITAL BOOK contains Franklin’s confidential and propriety
information which you agree to take adequate steps to protect from
unauthorized disclosure or use. This license is effective until
terminated. This license terminates immediately without notice from
FRANKLIN if you fail to comply with any provision of this license.
This digital book was developed for use by medical professionals.
No other use of this digital book can substitute for consultation with
yourphysician.
LicenseAgreement

2
Contents
Introduction to the HADI...................................3
Overview of Operation......................................5
Installing the Digital Book ................................7
Viewing a Demonstration .................................9
Selecting Drugs................................................10
Correcting Misspellings ..................................12
Finding Brands, Generics, Groups ................14
Finding Interactions........................................ 16
Between Many Drugs ..................................16
For a Single Drug........................................ 18
Viewing References ........................................ 20
Sending Words to Other Books..................... 22
Digital Book System®.......................................23
Limited Warranty............................................. 25
Product Specifications ................................... 26
Key Guide .........................................................27
Index..................................................................30

3
This handbook offers a quick guide to possible adverse effects
of drug interactions, with brief recommendations for precaution-
ary measures. References are given to original reports that
provide more complete discussions of each interaction.
This book— lists adverse drug interactions, their mechanisms,
and recommendations for clinical management. These listings
are usually based on clinical reports.
Reports of interactions between more than two drugs are
appearing in the medical literature with increasing frequency.
Where these have been documented, they are noted as
comments under interacting pairs of drugs. Interactions listed
for groups of drugs (such as “cephalosporins” or “antidepres-
sants, tricyclic”) may not have been reported for every drug in
the group; known exceptions to the interaction are noted.
It is not possible to determine the frequency of most interac-
tions. When an interaction is documented by one or two case
reports rather than by clinical studies or reports in many
patients, the year of each report is given as some indication of
frequency.
Omissions—New adverse interactions are continually being
reported; the absence of a listing in this digital book does not
necessarily mean that drugs will not interact when given
concurrently. Drugs for which we have no documented
interactions in people are usually not listed; interactions
extrapolated from animal studies or interactions reported
with related drugs, frequently mentioned in other sources,
such as the manufacturer’s package insert, may therefore
not be included here.
Interactions between general anesthetics and drugs likely to be
administered during surgery, such as autonomic drugs and
Introduction to the HADI

4
Introduction to the HADI
local anesthetics, are not included here. Interactions useful in
therapy, such as increased plasma concentration of penicillin
with concurrent use of probenecid, are also not included.
Common additive effects, such as occur with use of two
antihypertensive agents or two central nervous system
depressants, are generally not listed. Effects expected from the
mechanism of a drug’s action, such as that of potassium on
digitalis glycosides or calcium on calcium-entry blockers, and
useful antagonist effects, such as that between a poison and an
antidote, are also not included. Most interactions of drugs with
foods, beverages, or other nutrients are not listed, but foods
interacting with monoamine oxidase inhibitors are included.
Mechanisms of Interaction—Genetic differences can affect
drug metabolism and interactions. Drugs can interact by
changing the metabolism of other drugs, either through
inhibition or induction of any of several hepatic enzyme
activities or through alterations in hepatic blood flow; by altering
the binding of other drugs to plasma proteins or tissue
receptors; by altering the distribution of drugs to active receptor
sites; by delaying or enhancing excretion; or by causing additive
or synergistic effects.
Recommendations—Monitoring is most important when one of
the interacting drugs is stopped or started. Some experienced
clinicians may prefer to monitor the patient’s clinical status
rather than follow serum concentrations of drugs. Concurrent
use of drugs from the same group, e.g., aspirin and other
NSAIDS, should be avoided.

5
Overview of Operation
What this HADI Can Do
The Medical Letter®Handbook of Adverse Drug
Interactions
is a powerful reference. Using this
digital book, you can. . .
• find brand name drugs, generic drugs, drug
groups, and food groups,
• correct drug name misspellings,
• find foods that interact with MAO inhibitors,
• select up to 20 drugs and view a list of their
interactions,
• select a single drug and view a list of the drugs
with which it interacts,
• read descriptions and references about drug
interactions, and
• look up drugs and words in related digital books.
Read this User’s Manual to learn how.
▼

6
How this HADI Works
The Handbook is easy to use. Here are the basics:
Highlight the HADI symbol and press
ENTER
.
• At the main drug list, As you type, the drug
type a drug name. name is highlighted.
Then press
ENTER
.
• Type another drug You see a message to
name. Press
ENTER
. ✻ SHOW INTERACTIONS ✻ .
• Press
ENTER
.You see the interactions,
if any, between the drugs.
• Press
ENTER
.You see a description of
the interaction.
• Press
CLEAR
.You’re ready to find
other interactions.
Overview of Operation
✓About the Screen Illustrations
Some screen illustrations in this User’s Manual
may vary slightly from what you see on screen.
These variations do not mean that this digital
book or your Digital Book System is malfunctioning.
▼

7
Before you can use this digital book, you must install
it. Warning: If you install a digital book
while the
Digital Book System is on, information that you en-
tered in other currently installed digital books may be
erased.
1. Turn the Digital Book System off.
2. Install the digital book into a slot on the
back of the Digital Book System.
Align the tabs on the digital book with the notches
in the slot. Make sure its metal contacts face
down.
3. Press
ON/OFF
.
4. Turn the wheel on the side of the Digital Book
System to adjust the screen contrast.
5. Press CARD .
6. Press or to highlight the HADI icon.
Installing the Digital Book

8
7. Press
ENTER
.
This is the main drug list, where you select drugs
to find interactions.
Installing the Digital Book
✓Resuming Where You Left Off
While using this digital book, you can turn off the
Digital Book System at any time. When you turn
the Digital Book System on again, the screen that
you last viewed appears. Any drugs entered in
your query list are saved, too.
✓Clearing the Main Drug List
You can always return to the main drug list by
pressing
CLEAR
. Note: When you do, the drugs
in your query list are also cleared.
You can return to the previous screen without
clearing your query list by pressing
BACK
.

9
Before you start using this digital book, you may
want to view a brief demonstration of its features and
functionality.
1. Press MENU at the main drug list.
2. Press to highlight
Demo .
3. Press
ENTER
to start the demonstration.
4. Press
CLEAR
to stop the demonstration.
Viewing a Demonstration
✓ Help is Always at Hand
You can view a help message at any screen
(except during the demonstration) by pressing
HELP
. To read the help message, press .
To exit it, press
BACK
.
✓ Auto-shutoff
If you forget to turn this digital book off, don’t
worry. It will automatically shut off in four minutes.