Greiner Bio-One CheckScanner 2.0 User manual

Your Power for Health
www.gbo.com/diagnostics
CheckScanner™ 2.0

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
Revision: BQ-686-01 / March 2017
For in-vitro diagnostic use
by professional laboratory personnel only
CheckScanner™ 2.0
Instructions for Use

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
3
GLOSSARY OF SYMBOLS
en Consult
Instruc-
tions for
Use
Catalog
Number
Manufac-
turer
In Vitro
Diagnostic
Medical
Device
Waste
Disposal
GHS pictograms
with signal words
DANGER or
WARNING
Impor-
tant Note
Warning
Label on
instru-
ment
Warning
label laser
beam
Warning
label elec-
tric shock
en Biological
Risks
Functio-
nal Earth
Contact
!

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
4
TABLE OF CONTENTS
1. TRADEMARKS .............................................................................................................. 6
2. CONTENT OF SALES PACKAGE ................................................................................ 6
3. ENVIRONMENTAL CONDITIONS & SHIPMENT ......................................................... 7
3.1 Environmental Conditions.................................................................................................. 7
3.2 Repacking before Shipment .............................................................................................. 7
4. SAFETY INSTRUCTIONS AND PRECAUTIONS.......................................................... 7
4.1 Operator Qualifi cation ........................................................................................................ 7
4.2 Safety Information ............................................................................................................. 8
4.3 Protection against Laser Power......................................................................................... 8
4.4 Safety Precautions ............................................................................................................. 8
4.5 Warning Messages ............................................................................................................ 9
4.5.1 Electric Shock Precautions....................................................................................................9
4.5.2 Mechanical Safetz Precautions .............................................................................................9
4.6 Caution Messages ............................................................................................................. 9
4.6.1 Lasers ....................................................................................................................................9
4.6.2 Spillage, infectious materials and infl ammable liquids ..........................................................9
4.7 Electromagnetic Compatibility .......................................................................................... 9
5. INTENDED USE........................................................................................................... 10
6. APPROVALS................................................................................................................ 10
7. ABBREVIATIONS......................................................................................................... 10
8. DEFINITIONS............................................................................................................... 11
9. CONVENTIONS ........................................................................................................... 11
10. PREFACE..................................................................................................................... 11
11. SCOPE AND AUDIENCE ............................................................................................ 11
12. INTRODUCTION.......................................................................................................... 12
13. SYSTEM OVERVIEW................................................................................................... 12
14. INSTALLATION............................................................................................................ 12
14.1 Removing Transit Support Screws ................................................................................. 13
14.2 Connections..................................................................................................................... 13

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
5
14.3 Software Installation ....................................................................................................... 14
15. OPERATING................................................................................................................. 15
15.1 LED Color Description .................................................................................................... 15
16. REPACKING BEFORE SHIPMENT............................................................................. 16
16.1 Installing Transit Support Screws ................................................................................... 16
16.2 Repackaging.................................................................................................................... 17
17. SUMMARY................................................................................................................... 19
18. APPENDIX ................................................................................................................... 19
18.1 Technical Data ................................................................................................................. 19
18.2 Maintenance .................................................................................................................... 20
18.3 Waste Disposal ................................................................................................................ 20
18.4 Product Warranty............................................................................................................. 20
19. MANUFACTURER ADDRESS..................................................................................... 21

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
6
1. TRADEMARKS
All trademarks mentioned in these Instructions for Use are the property of their respective trademark
holders. Microsoft®and Windows®are registered trademarks of the Microsoft®Corporation.
These Instructions for Use are written for operators of the CheckScanner™ 2.0 using CheckReport™
Software version 1.1 or higher. Due to software evolution slight changes in the dialog boxes
displayed in this manual may occur. When a modifi cation is made that may have adverse effects on
the system using this manual, an update or amendment will become available.
Every effort has been made to ensure that the information contained in this manual is updated
and accurate as of the date of issue or revision and it is consistent with the product described.
However, no guarantee is given or implied that the document is error-free or accurate with regard to
any specifi cations. The instrument manufacturer reserves the right to make changes to this manual
without notifi cation.
2. CONTENT OF SALES PACKAGE
Equipment Greiner Bio-One Cat.No. Quantity
CheckScannerTM 2.0 862 070 1
power supply 1
line cord 1
Ethernet cable 1
transit support screws and caps 2 of each
CheckScanner™ Verifi cation Kit 862 030 1
Use solely the specifi c external power supply (AC adapter) included in the sales package
of your scanner!
Generally use only accessory parts which are specifi cally provided by Greiner Bio-One
for your instrument type!
All packing material including the transport pallet and transit support mounted at the
instrument are very specifi c. These materials must be kept in case the instrument has
to be shipped!
!

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
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3. ENVIRONMENTAL CONDITIONS AND SHIPMENT
3.1 Environmental Conditions
To ensure trouble-free running of the CheckScanner™ system, it is important to locate the
instrument in an appropriate environment.
Environmental conditions Specifi cation
Temperature Operating: 15 to 30 °C
Storage: 0 to 40 °C
Humidity 20 - 80 %, non-condensing
Sunlight No direct sunlight or other intensive light sources
Altitude Up to 2000 m above mean sea level
Storage: as required for air travel
Dust Preferred dust-free environment
Mains power Wall socket with grounding providing
110/230 V (for external power-supply provided with the instrument)
LAN Connection of PC to LAN (optional)
3.2 Repacking before Shipment
If it is necessary to ship the CheckScanner™ 2.0 special care has to be taken concerning the
packaging. Please refer to chapter 16 for further details.
4. SAFETY INSTRUCTIONS
4.1 Operator Qualifi cation
The CheckScanner™ 2.0 should be operated by or under the supervision of a technician or operator
who is suffi cient qualifi ed to perform laboratory work.
Before operating the CheckScanner™ the operator should:
• Read and understand these Instructions for Use
• Be aware of all relevant laboratory procedures
• Be aware of all relevant safety rules and regulations
Carefully follow the procedures specifi ed in these Instructions for Use for the operation and
maintenance of the system. Maintenance which is not described in these Instructions for Use should
be performed by qualifi ed service engineers only.
DO NOT open the instrument housing.
Electronic equipment can be the source of electrical shocks.
DO NOT attempt to repair any electrical parts.
Service and repair should only be carried out by authorized and qualifi ed personnel of the
manufacturer.

Made in Germany
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Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
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4.2 Safety Information
It is essential that the warnings, cautions and safety requirements contained in this manual are
read and understood by the operator before operating the system. If the equipment is used in
a manner not specifi ed by the manufacturer, the protection provided by the equipment may be
impaired.
Warning symbols have been placed on the instrument to draw your attention to areas of potential
hazards.
Familiarise yourself with the following icons and their meanings:
4.3 Protection against Laser Power
Laser class 1:
Outside label for the classifi cation of the CheckScanner™. Safe under all
conditions of normal use.
Laser class 3B:
Inside label for the classifi cation of the lasers used within the device.
Hazardous if the eye is exposed directly.
4.4 Safety Preauctions
Particular attention must be paid to the following safety precautions. If these safety precautions are
ignored, the operator may suffer injury. Each individual precaution is important.
This label warns that there is a danger of hazardous situations within the vicinity of this
label which may result in serious injury.
This label warns that there is a danger of electric shock when gaining access to parts of
the system marked with this label.
Avoid looking directly into any refl ected laser light potentially leaking from the instrument,
as this may damage your eyesight.
Wear safety glasses while working with open housing.
!
This label warns that there are lasers operating within the vicinity of this label. Do not look
directly into the beam.
Complies with 21CFR1040.10 except Laser Notice No. 50.
CAUTION!
Use of controls, adjustments or performance of procedures other than those specifi ed
herein may result in hazardous radiation exposure.
!

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
9
4.5 Warning Messages
4.5.1 Electric Shock Preauctions
The protection classifi cation of the instrument is IP20.
4.5.2 Mechanical Safety Preauctions
4.6 Caution Messages
4.6.1 Lasers
4.6.2 Spillage, infectious materials and infl ammable liquids
Any liquid spilled on the instrument may result in the malfunctioning of the system. If liquid is spilled
on the instrument, wipe it up immediately.
4.6.3. Biological Risk
4.7 Electromagnetic Compatibility
The CheckScanner™ 2.0 is a class A system with respect to Electromagnetic Compatibility (EMC)
requirements for industrial areas. It fulfi ls the emission limits for class A equipment according to
EN 61326-1. It does not fulfi l the emission limits for class B equipment.
The LAN output insulation fulfi lls the requirement according to IEC60601-1- of 4 kV.
Electronic equipment can be the source of electrical shocks. DO NOT attempt to gain
access to parts of the instrument marked with this label.
DO NOT attempt to repair any electrical parts.
DO NOT open the instrument housing.
Service and repair should only be carried out by authorised and qualifi ed personnel of the
manufacturer.
This is a Class 1 laser product - the operator will not be exposed to laser radiation during
normal operation. When the instrument is undergoing maintenance or service (with panels/
guards removed and interlocks defeated), exposure to Class 3B radiation may occur. Make
sure proper safeguards and related PPE are employed at that time.
As with any mechanical system, certain precautions must be taken when operating the
scanner.
The instrument has a loading lid intended to prevent contact of the operator with any
moving parts.
DO NOT raise the lid when the scanner is in operation.
DO NOT tamper with the safety sensors of the lid.
DO NOT load humid or wetted HTA™Slides. Besides non-reproducible measuring data,
the fast scanning movement of the slide might lead to contamination of optical components
of the scanner, which can only be cleaned by a service technician.
DO NOT use easily infl ammable liquids in the vicinity of the instrument.
Equipment that can be potentially infectious due to the samples or reagents used shall be
prominently marked with symbol 101 of Table 1. At minimum, a biohazard symbol shall
be placed near the sampling area and visible in NORMAL USE.

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
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Electromagnetic Devices: Devices that emit electromagnetic waves may affect measurement data,
or cause the instrument to malfunction. DO NOT operate the following devices in the vicinity of the
instrument when it is in use: mobile or cordless phones, transceivers or other electrical devices that
generate intensive electromagnetic waves.
5. INTENDED USE
The CheckScanner™ 2.0 is a PC-controlled biochip fl uorescence scanner for the daily general
laboratory use in combination with the CheckReport™Software. Hazardous samples must not be
measured. It is designed to scan with high performance ready-to-use microarrays on HTA™Slides
manufactured by Greiner Bio-One. It is important that the operator reads this manual thoroughly
before using the instrument. The scanner must be operated by professionals only.
The manufacturer does not assume any liability for any use of the instrument not described in this
manual, or for any customer modifi cations made to the instrument.
6. APPROVALS
This instrument is in compliance with the following directives of the Council of the European
Community and the according standards:
98/97/EC,89/336/EEC,73/23EEC,2006/95/EC(EN61010-1),2009/95/EC(EN61010-1),2004/108/EC
(EN 61326, EN 61000-3-2, EN 61000-3-3), ISO 13485:2007, ISO 9000, part3ISO/IEC90003,
DIN EN ISO 9001:2000, EN 591, EN 980, EN 13612, ISO 14971, ISO 17050-1, EN 1041,
ISO 15223-1, EN 61010-2-101, ISO/IEC 10007:2003, ISO/IEC 12207:1995, Amd 2:2004, IEC
68025-1.
7. ABBREVIATIONS
Abbreviation Meaning
EN European Standard
DIN Deutsches Institut für Normung = (German Standard)
IEC International Electrotechnical Commission
ISO International Organisation for Standardisation
EMC Electromagnetic Compatibility
LAN Local Area Network
PC Personal Computer (Windows-based)
AC Alternating Current
IP 20 protection class according DIN EN 60529
TIFF Tagged Image File Format
PMT Photo Muliplier
VAC Voltage in Alternating Current
VDC Volts of Direct Current

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
11
8. DEFINITIONS
Defi nition Description
Biochip A biochip is a collection of miniaturised test sites (microarrays) arranged on a solid substrate that per-
mits many tests to be performed at the same time in order to achieve higher output and speed.
HTA™Slide HTA™Slide is a prestructured biochip with 12 wells (HTA™Slide 12), identifi ed by one barcode.
Microarray An arrayed series of microscopic spots of spotted probes.
Test Reaction of sample with spotted probes in one or several wells.
Well Cavity on a prestructured biochip for containing the microarray and sample.
9. CONVENTIONS
The following conventions are used in this document:
10. PREFACE
The CheckScanner™ 2.0 is a fl uorescence biochip reader processing up to four HTA™Slides.
The system is controlled by a PC using CheckReport™Software. Many features of the scanner
are designed to maximize ease of use and thereby minimize the chance of errors. The specifi ed
performance of the instrument can only be warranted if the instrument is serviced by qualifi ed,
trained personnel using the prescribed, original parts.
11. SCOPE AND AUDIENCE
These Instructions for Use are intended for operators of the CheckScanner™ 2.0 describing the
instrument in detail.
It contains no information specifi c to technical service procedures which must be performed by the
manufacturer or its representatives.
WARNING indicates a potentially hazardous situation, which, if not avoided, could
result in death or serious injury.
CAUTION indicates a potentially hazardous situation, which, if not avoided, may result
in minor or moderate injury. It may also be used to alert against unsafe practices.
Symbol for functional earth contact used on the instrument and in this manual.
Keep this manual in the vicinity of the instrument and safe from damage, ensuring that
it is always available for use.

Made in Germany
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Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
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12. INTRODUCTION
The CheckScanner™ 2.0 is a PC-controlled biochip fl uorescence scanner for the general
laboratory use in combination with the CheckReport™Software. It is designed to scan with high
performance ready-to-use microarrays on HTA™Slides manufactured for Greiner Bio-One.
Subsequent scans of the microarray are performed at two different wavelengths. The output of
the instrument are TIFF images which are evaluated using the CheckReport™Software.
The independent scanning of up to four HTA™Slides is automatically carried out in one scan job
according to specifi c scan protocols.
Many features of the CheckScanner™ system have been designed to maximise operator comfort
and thereby minimise the chance of errors.
13. SYSTEM OVERVIEW
The compact CheckScanner™ 2.0 is composed of the bench top instrument, an external power
supply and the controlling computer (Windows PC). Instrument and PC are connected to network
or directly via LAN cable.
Apart from the on/off-switch and the factory reset button the user interaction with the instrument
is limited to loading/unloading the HTA™Slides.
The default LAN settings are:
IP address 192.168.15.245 // subnetmask: 255.255.255.0 // gateway: 192.168.15.245 // port:
6668
A loading lid protects the operator from inadvertent contact with moving parts, and shields the
measuring optics from ambient light during scanning. All further instrument control steps are
processed by means of the CheckReport™Software.
14. INSTALLATION
Although the CheckScanner™ 2.0 will typically be unpacked and installed by your local
distributor, a technically skilled person may install the instrument as well. This is particularly useful
if the system needs to be relocated. This section describes the process required to connect the
instrument to the computer as well as to prepare the software installation.
The CheckScanner™ 2.0 must be placed on a fi rm (laboratory) bench avoiding potential vibration
or shaking due to instrument’s scanning oscillation. After the setup the scanner should not be
moved. Please take the following precautions:
As the sound of the instrument is far below 70dB(A), no extra precautions are needed.
Adequate space should be provided for accessing the system and the accessories:
a) For loading the slides from front during daily use
b) To have access to the mains switch at the right handed rear panel, (as well as to the
plug-in for the 24V-connection of the external AC-adapter at the left handed rear panel)
c) A gap of at least 10 cm behind the instrument is needed for ventilation.
d) The mains plug of the external AC adapter within the power socket (230V) of your lab
must be easily accessible at any time.
Before starting the CheckScanner™ 2.0 installation the transit support screws need to be
removed. Please follow the instructions below.
As the instrument weights over 22 kg, it must be solely lifted (or transported) by two
persons.
Be sure to grip with your fi ngers underneath the solid metal baseplate. The rubber feet
allow enough space between instrument and the benchtop.

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CheckScanner™ 2.0 - Instructions for Use
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14.1 Removing the transit support screws
1Open the CheckScanner™ 2.0 lid.
2Unscrew the two red butterfl y screws in
the direction indicated and remove them.
Keep the red butterfl y screws in
case the instrument needs to be
transported or returned.
3Unpack the two plastic sealing plugs.
4Push the two plastic sealing plugs into
the holes until they are securely fi xed in
position.
14.2 Connections
The following guideline outlines the connections required for the trouble-free operation of the
CheckScanner™ 2.0 system. For the sake of completeness, connections to both the instrument
and the computer are listed.
Instrument Connections
The instrument is connected to the laboratory mains power socket via the specifi c external power
supply (AC adapter) included in the sales package. Use solely this specifi c external power supply!
The mains power must provide grounding. If the mains power does not provide grounding, the
instrument must be grounded via the optional earth, which is located on the right side of the
instrument backside. Switch off the instrument. Connect the 24 V outlet cable of the external power
supply to the corresponding connector at the rear panel of the instrument.
Before starting the CheckScanner™ 2.0 installation the transit support screws need to be
removed. Please follow the instructions below.
!

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Germany 862 070
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CheckScanner™ 2.0 - Instructions for Use
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Connect now the mains power cord of the external power supply to the mains supply voltage
(110/230 V) of your laboratory.
A LAN connection is used to transfer data between the computer and the instrument. Use the included
LAN cable to connect one of the PC’s LAN ports connector at the rear panel of the CheckScanner™ 2.0.
The CheckScanner™ comes with a preconfi gured IPv4 Address, which is 192.168.15.245. To enable
the communication between the computer and the scanner, the network interface of the computer
has to be set into the same subnet (see Figure 1).
Figure 1: Internet Protocol Properties
Computer Connections
A standard computer power cord is used to connect the computer with the mains supply voltage of
the laboratory. The monitor (power supply and data connection) is connected in the same manner as
a standard computer.
14.3 Software Installation
Detailed descriptions of the CheckReport™Software installation IFU and CheckReport operation
IFU are available for download at:
https://www.gbo.com/en_DE/know-how-services/download-center.html

Made in Germany
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Germany 862 070
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CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
15
15. OPERATING
It is recommended to turn on the CheckScanner™ 2.0 at least 20 min before usage. During this time
the CheckScanner™ 2.0 gets equilibrated and hence leads to stable signals.
If applicable, it is recommended to perform a verifi cation using the CheckScanner™ Verifi cation Kit
(Cat.-No. 862 030) before. Thereby, it is secured that the CheckScanner™ 2.0 works fi ne and that
it is equilibrated when scanning the fi rst oCheck®test slide.
Scanning and evaluation of HTA™Slides and test kits of the oCheck®and Inspect™ product line is
done using the CheckReport™Software (cat.no. 862 080 or 862 090).
The installation and usage of the CheckReport™Software is described in the „CheckReport™Software
Installation Guide“ and „CheckReport™Software User Guide“.
Before starting a scan it is necessary to ensure, that the processed oCheck
®
or Inspect™ slide is
entirely dry. Even minimal amounts of liquid can contaminate the scanner with fl uorescence dyes.
To insert slides into the scanner, the lid has to be opened as shown in Figure 2. Always be sure to
hold the slide sideways and not to touch the surface of the slide. Only insert the slide as the slide
carriage has been fully extended. Then, the slide has to be insert up to the stop. After insertion of
the slide, the barcode must be on the upper right hand side of the slot (see also Figure 2).
Figure 2: Insert slide into the CheckScanner™ 2.0.
Before starting the scan, the lid must be closed again.
15.1 LED Color Description
During the scan:
During the default status the LED fl ashes green. It changes to yellow during the scan.
After the scan is completed successfully the status changes back to green.
If an error occurs during the scan the yellow LED fl ashes.
During the fi rmware-download:
During the default status the LED fl ashes green. When fi rmware is downloading it changes to yellow.
When the download is completed successfully the status changes back to green.
If an error occurs during the download the yellow LED fl ashes.
Initialization error:
If an initialization error occurs, the LED fl ashes alternately green and yellow and an error message
appears on the computer screen. In this case please contact the technical support.

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CheckScanner™ 2.0 - Instructions for Use
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16. REPACKAGING BEFORE SHIPMENT
16.1 Installing the Transit Support Screws before Transport
If it is necessary to remove the CheckScanner™ 2.0 from your laboratory, it must be prepared for
transport by installing the transit support screws and repacking has to be performed using the
original package including the transport pallet. Careful packing is essential for a safe transport.
Please follow the transit support screws installation and repackaging instructions below.
If the CheckScanner™ 2.0 has to be transported the transit support screws need to be
reinstalled before repackaging. Please follow the instructions below.
1
Before installing the transit support screws the CheckScanner™ has to be in the parking position.
TURN THE CheckScanner™ ON AND WAIT UNTIL THE AUTOMATIC INITIALISATION OF THE
CheckScanner™ IS FINISHED (Green LED signal). Now the CheckScanner™ 2.0 is in the parking
position and ready to install the transit support screws.
Turn the CheckScanner™ 2.0 off and disconnect it from the AC-adapter.
If the CheckScanner™ 2.0 initialisation can not be carried out completely
and/or error messages occur during initialisation, the parking position
can not be reached. In this case DO NOT INSTALL THE TRANSIT
SUPPORT SCREWS and repack/return the CheckScanner™ 2.0 without
installing the transit support screws.
2
Open the CheckScanner™ 2.0 lid.
Check that there are no slides loaded.
Remove the two indicated plastic sealing
plugs and repack them.
3
Install the two red butterfl y screws by
turning in the direction indicated until they
are securely fi xed in position.
Before repackaging of the CheckScanner™ 2.0, please make sure that the device is free
of any potential hazardous components. Please follow the procedures in your laboratory
for disinfection of electronic devices and confi rm the decontamination by fi lling the GBO
document of compliance available on our homepage:
https://www.gbo.com/en_DE/know-how-services/download-center.html

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Germany 862 070
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16.2 Repackaging
1
Open the CheckScanner™ 2.0 cardboard
box.
Insert at the bottom the lower part of the
foamed packaging material and spread
the protective foil.
2
Make sure that the CheckScanner™
transit support screws are installed and
the CheckScanner™ is disconnected.
Insert the CheckScanner™ and cover it
by the protective foil.
3
Insert on top of the CheckScanner™
the upper part of the foamed packaging
material.
As the instrument weights over 22 kg, it must be solely lifted (or transported) by two
persons. Be sure to grip with your fi ngers underneath the solid metal baseplate. The rubber
feet allow enough space between instrument and the benchtop.
If it is necessary to remove the CheckScanner™ 2.0 from your laboratory, it must be
repacked using the original packaging including the transport pallet. Please ask your local
Greiner Bio-One representative for detailed information. Careful packaging is essential
for a safe transport, please follow the instructions below. Make sure that the transit
support screws have been installed and that the scanner is free of any potential infectious
contamination. If not, it must be disinfected before repackaging.

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CheckScanner™ 2.0 - Instructions for Use
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18
4
Repackage the following CheckScanner™
2.0 accessories in the two small card-
board boxes and insert the boxes on the
sides of the package:
• LAN Cable
• Mains Power Cable
• External Power Supply (AC adapter)
• Transit support accessories
• CheckScanner™ Verifi cation Kit
Enclose a completely fi lled „Packing List“
and a „Document of compliance“. To
receive these forms please contact your
local Greiner Bio-One representative.
5
Close the cardboard box and seal it
with tape. If the cardbox is not perma-
nently mounted on a palett, place the
CheckScanner™ 2.0 on the original
transport pallet.
Fix the cardboard box on the pallet either
by tear-resistant packaging tape or by
clamping devices as displayed.
Now the CheckScanner™ 2.0 is ready for
shipment.

Made in Germany
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Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
19
17. SUMMARY
The CheckScanner™ 2.0 is a PC-controlled biochip fl uorescence scanner for the daily general
laboratory use in combination with the CheckReport™Software.
It is important that the operator reads this manual thoroughly before using the instrument. The
scanner must be operated by professionals only. The service technician (GBO) must install and
initialize the device (installation qualifi cation). After that, a test run must be carried out which ensures
the correct operation. Hazardous samples must not be measured. Since no infectious samples are
measured, no special disinfection is necessary.
The CheckScanner™ 2.0 is designed to scan with high performance ready-to-use microarrays on
HTA™Slides manufactured by Greiner Bio-One. It is important that the operator reads this manual
thoroughly before using the instrument. The scanner must be operated by professionals only. The
manufacturer does not assume any liability for any use of the instrument not described in this manual,
or for any customer modifi cations made to the instrument. Subsequent scans of the microarray are
performed at two different wavelengths. The output of the instrument are TIFF images which are
evaluated using the CheckReport™Software.
The independent scanning of up to four HTA™Slides is automatically carried out in one scan job
according to specifi c scan protocols.
18. APPENDIX
18.1 Technical Data
The CheckScanner™ 2.0 is a PC-controlled biochip fl uorescence scanner for the daily general
laboratory use in combination with the CheckReport™Software.
Item Specifi cation
Sample Size/Capacity Up to 4 HTATMSlides per run
Laser Excitation Wavelengths 532 nm / max. 10 mW and 639 nm / max. 20 mW (solid-state lasers)
Emission Filter Wavelengths 570 nm and 670 nm (standard)
Easy exchange with two positions fi lter drawer or 6 positions fi lter wheel
Laser Safety Class according
EN 60825-1:2014 1
Embedded Laser Class according
EN 60825-1:2014 3B
Focus Motorized focus adjustment
Simultaneous Wavelengths per Scan One
Sample/Substrate Dimension ISO slide standard: max. width 25.4 mm; min. width 24.9 mm (up to 4
simultaneously)
Sample Loading Force-free loading of HTATMSlides
Scanning Field 23 x 76mm
Pixel Resolution 10µm
Scan Speed (per wavelength) a) 20 x 20mm area: approx. 3.5 min
b) 22 x 73mm area: approx. 13 min
Dynamic Range 16-bit dynamic range, linear over 4 decades

Made in Germany
Greiner Bio-One GmbH
Maybachstr. 2
72636 Frickenhausen
Germany 862 070
Your Power for Health
CheckScanner™ 2.0 - Instructions for Use
Revision: BQ-686-01 /March 2017
20
Image File Format TIFF
Dynamic Range settings Quantum effi ciency-independent PMT-gain control
Barcode Identifi cation Barcode reading on slide (using optical scan)
PC Connection LAN interface
Electrical requirements External AC-adapter: autoselecting from 100-230V;
DC-connector at scanner: 24 V; 2.5 A (PTC Resetabel Fuse 250V T3.15 A)
Protection classifi cation IP20
Dimensions (W x H x D) Approx. 395 x 305 x 595 mm
Weight Approx. 22 kg
18.2 Maintenance
The CheckScanner™ 2.0 is a sensitive optical measuring device and should be handled carefully.
For accurate results, it is essential that the instrument is maintained in a dust-free state. The external
CheckScanner™ 2.0 housing must be regularly cleaned with a lint-free cloth. Do not use any
detergents for cleaning.
Moreover, to ensure accurate performance of the CheckScanner™ 2.0, the included Verifi cation Kit
should be regularly used.
Although the CheckScanner™ 2.0 is a robust machine, it is recommended that regular service is
performed by authorized service personnel.
If you are observing any malfunction which is unrelated to the software, please call a qualifi ed
service engineer of the manufacturer or its representative.
18.3 Waste Disposal
Waste disposal has to be performed in accordance with local guidelines.
18.4 Product Warranty
Greiner Bio-One guarantees good workmanship in accordance with generally accepted professional
standards or work of this nature. Greiner Bio-One warrants that the CheckScanner™ 2.0 will conform
to the product specifi cations. Each CheckScanner™ 2.0 shall be warranted for twelve (12) months
after the system is installed at the customer site. The warranty shall be effected by free of charge
repair or replacement of the defective module and/or the instrument by Greiner Bio-One in their
premises in Frickenhausen, Germany.
The above warranty does not cover damages arising from unintended use of the CheckScanner™
2.0, fair wear and tear, improper or negligent treatment, failure to follow the instructions for use,
unsuitable process materials or unauthorized modifi cations of the CheckScanner™ 2.0.
DO NOT open the instrument housing.
Electronic equipment can be the source of electrical shocks.
DO NOT attempt to repair any electrical parts.
Service and repair should only be carried out by authorized and qualifi ed personnel of the manu-
facturer.