Milestone eGROSS pro-x User manual

eGROSS pro-x – eGROSS
Ergonomic Workstation for histopathology
Operator Manual - MM137
MILESTONE
HELPING
PATIENTS

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Thank you for choosing one of our systems and welcome to the ever more crowded club of Milestone laboratory
instrumentation users.
We feel confident that you will be fully satisfied adding this new device to your laboratory.
We recommend to ready carefully this operator manual and to always keep it within reach for convenient and
quick referencing.
For any clarification or request for assistance, please contact our representative in your country:
You can also contact us directly at:
Milestone s.r.l.
Via Fatebenefratelli, 1/5
24010 Sorisole (BG) Italy
Tel. +39.035.412 8264
Fax [phone]
Website www.milestonemed.com
e-mail [e-mail]
Read carefully this manual before using the instrument.
MM137-004 - eGROSS pro-x –eGROSS - Operator Manual
2018-11

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SUMMARY
SUMMARY ........................................................................................................................................................ 4
1. INTRODUCTION........................................................................................................................................ 6
1.1. Symbols used .................................................................................................................................... 6
1.2. Designated uses................................................................................................................................ 7
1.3. Technical specifications..................................................................................................................... 7
1.4. Compatible reagents........................................................................................................................ 12
1.5. Transport and storage conditions.................................................................................................... 13
1.6. Antivirus........................................................................................................................................... 13
1.7. Warning information......................................................................................................................... 13
1.8. Backing up the MacroPATH data (only for eGROSS pro-x)............................................................ 13
1.9. Milestone Remote Connection......................................................................................................... 14
1.10. Labelling........................................................................................................................................... 14
2. eGROSS pro-x/ eGROSS INSTALLATION ............................................................................................. 15
2.1. Space requirements......................................................................................................................... 16
2.2. eGROSS pro-x/eGROSS unpacking and component inspection.................................................... 17
2.3. eGROSS pro-x/eGROSS installation .............................................................................................. 25
2.3.1. Parts to be assembled............................................................................................................. 25
2.3.2. Connection to the plumbing system ........................................................................................ 29
2.3.3. Connection to the fume extraction system .............................................................................. 32
2.3.4. Connection to the fixative loading/unloading system............................................................... 32
2.3.5. Turn ON the eGROSS unit ...................................................................................................... 37
2.4. Installing the camera/PC support (for the eGROSS pro-x only)...................................................... 40
2.4.1. Manual camera settings........................................................................................................... 50
2.4.2. Camera orientation .................................................................................................................. 51
2.4.3. Turn ON the eGROSS pro-x unit............................................................................................. 51
2.5. Description....................................................................................................................................... 53
3. WORKING WITH MacroPATH................................................................................................................. 66
4. MAINTENANCE ....................................................................................................................................... 67
4.1. Safety precautions........................................................................................................................... 67
4.2. Cleaning the eGROSS pro-x unit .................................................................................................... 67
4.2.1. Germicidal efficacy of polyphenol-based disinfectant agents.................................................. 68
4.2.2. General operating procedure................................................................................................... 69
4.2.2.a Keyboard and mouse............................................................................................................... 70
4.2.2.b Foot pedal control.................................................................................................................... 70
4.2.2.c Touch-Pen ............................................................................................................................... 70
4.2.2.d PC Screen and Camera........................................................................................................... 71
4.2.2.e Final general steps .................................................................................................................. 71
4.2.3. Yearly....................................................................................................................................... 71
5. OPTIONAL PARTS .................................................................................................................................. 72
5.1. Ventilated waste paper bin with trolley (CODE 102593) ................................................................. 72
5.2. Filterbox Kit with HEPA filter (CODE 102915)................................................................................. 73
5.3. Filterbox Kit without HEPA (CODE 102920).................................................................................... 75
5.4. Auxiliary Shelf, 380x340mm (CODE 102861)................................................................................. 76
5.4.1. How to assemble a shelf.......................................................................................................... 76
5.5. USB Bar code reader 2D (includes holder) (CODE 102011) .......................................................... 77
5.6. Auxiliary Led lamp (CODE 102740) ................................................................................................ 78
5.6.1. How to install the auxiliary lamp on eGROSS pro-x................................................................ 78
5.7. Stainless Steel Glove Dispenser (CODE 102860) .......................................................................... 79
5.8. Waste Grinder Mod. 66 (CODE 102749)......................................................................................... 79
5.8.1. Specifications for the installation ............................................................................................. 80
5.8.2. How to install the Waste Grinder on eGROSS /eGROSS pro-x.............................................. 80
5.8.3. Warnings.................................................................................................................................. 87
5.8.4. How to properly use the Waste Grinder .................................................................................. 88
5.8.5. Maintenance ............................................................................................................................ 88
5.8.6. Troubleshooting....................................................................................................................... 88
5.9. Polarised lens for Camera (CODE 370608).................................................................................... 90
5.10. Vesa mount for extra monitor (CODE 102945) ............................................................................... 90
5.11. USB Waterproof (sealed) keyboard (CODE 372352)...................................................................... 91
5.12. Mouse wireless laser in silicone (CODE 372363) ........................................................................... 92
6. TROUBLESHOOTING ............................................................................................................................. 93

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6.1. Return for repair to Manufacturer .................................................................................................... 93
7. DISPOSING OF THE UNIT...................................................................................................................... 94

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1. INTRODUCTION
1.1. Symbols used
The instructions marked by this symbol are important and must be read carefully.
An instruction accompanied by this symbol provides a cautionary statement:
WARNING. Failure to follow the instruction may endanger the USER or cause damage
to the instrument.
Be sure to follow the instruction to prevent accidents resulting from electric shock.
Biohazard: be careful when you execute the procedure marked with this symbol: danger
of biohazard contamination.
Biological hazard: pay attention when performing a procedure marked with this symbol:
biological contamination hazard.
Attention, risk of hand crushing.
Attention, toxic substance.
EC Logo: this instrument complies with European Community directives.
IVD medical device according to directive 98/79/EC.
Symbol of the European WEEE directive (2002/96/EC):
electric/electronic material, do not disperse in the environment.
Authorised and qualified technical support personnel only.
Fragile.
Reference number.

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1.2. Designated uses
The eGROSS pro-x/eGROSS is an ergonomic histopathology work station dedicated to the preparation and
cutting of pieces. The table is equipped with a ventilation unit and various optional parts, as defined in this
manual.
The eGROSS pro-x comes equipped with a camera with MacroPATH software.
The MacroPATH has been designed to obtain images of histological samples, as well to ensure their complete,
safe and reliable handling.
The system has been conceived for laboratory use and can therefore withstand the harshest laboratory
conditions (indoor use only).
1.3. Technical specifications
eGROSS pro-x
-REF 102900: Power supply 230V~ 50/60Hz 1400W
-REF 102901: Power supply 115V~ 60Hz 1400W
-Dimensions: WxDxH 185cm (72.8in) x 81cm (31.9in) x 186cm (73.2in). Max. height 216cm (85in)
-Work surface height: adjustable from 90cm (35.4in) to 120cm (47.2in)
-Led illumination of the working area
-Concealed keyboard
-Weight: 265kg (584lb)
Structure:
-Stainless steel work surface
-Vented work surface with washable compartment below
-Blue cutting board for downdraft aspiration (downward flow)
-Magnetic equipment holder bar
The MacroPATH's measurement function is strictly linked to the calibration performed by
the operator, and is not controlled by the unit's software. For this reason, the measurements
of the sample obtained with MacroPATH CAN NOT be taken into account for diagnostic
purposes. These values are purely indicative.
In fact, a ruler must be placed near the sample (see the image below) or else a gauge must be used
to obtain a diagnostic value for the growth of the tumour, the extent of the lesion, etc.
The system must be calibrated in order to perform measurements with MacroPATH (please refer to chapter
3 for the calibration procedure).
Power supply line needs to have a ground connection (Class I device).
Power line protection:
115V version: Miniature circuit breaker curve C, 15A, residual current device: 30mA.
230V version: Miniature circuit breaker curve C, 10A, residual current device: 30mA.

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Touch control terminal:
- CPU: Intel®Core™ i7 Processor 2.6 GHz
- RAM: 8GB DDR-4
- Hard disk: 500GB (SSD)
- Touch-pen: USB cable, tip of 1.5mm diameter.
- Screen: 19" TFT LCD 1280X1024 16.7M Colour
IP 65 front panel
- Fanless
- Wi-Fi 802.11 A/B/G with Bluetooth v4.1 (*)
(*) subject to restrictions of use according to local radio frequency regulations to be checked before enabling
this function.
- Dimensions: LxHxD 470.5 x 415.2 x 75.6mm (18.52” x 16.34” x 2.97”)
- Weight: 7.4kg (16.3lb)
- PC power supply: 18V DC 5.55A MAX
- available I/O (see the picture below)
A. 2x RS-232/422/485 Serial ports
B. 2x Gigabit Ethernet LAN ports (RJ-45)
C. 6x USB 2.0 ports
D. 2x USB 3.0 ports
E. 1x HDMI (max resolution 4096x2304@24Hz)
F. 1x DP Display port (max resolution 4096x2304@60Hz)
G. 2 X built-in 2W speakers
H. Audio Mic-in 3.5mm jack input
I. Line OUT 3.5mm jack
J. Power supply inlet
K. Reading lights
L. Equipotential terminal

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Frontal part of the PC:
1) Switch On button
2) Enable/disable touch-screen
3) Volume
4) Light
5) Switch On reading lights button
At the installation, carefully remove the film present on the screen.
It is suggested to switch off the PC at least once a week.
PC CONNECTIONS

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USB CAMERA W28 marked in yellow
Only in eGROSS pro-x
USB keyboard W37 free
Only in eGROSS pro-x
USB W36 marked in green connected with the USB port present on
the right front panel of eGROSS pro-x.
Only in eGROSS pro-x
USB foot pedal marked in brown
Only in eGROSS pro-x
USB TOUCH PEN free
Only in eGROSS pro-x
Camera image acquisition system:
- Camera resolution: max 20.1 Megapixel
- Video resolution: 1024 x 768 (HD) –15-16 FPS, audio 352Kbps, 22kHz
- Audio rec.: 128 kbps
- Focus: Automatic
- White balance: Automatic
- Zoom: Optical 30x
- Fitted with a set of 3 lenses with different close up levels: +1 - +1.3 - +1.5
- Weight: 2.8 kg (6.1lb) (+250g camera power supply)
- Built-in LED lighting
- Dimensions: 137 x 162 x 211mm (5.39” x 6.37” x 8.30”)
- USB data cable length: 4.5m (4.92yd)
Foot pedal control
- USB foot pedal control with 5 buttons
- IP X5
Software image acquisition system:
- Operating System: Windows 10 Enterprise 64 bit
- MacroPATH SW: MacroPATH including Milestone license already activated
- image capture in JPEG format
- video capture in AVI format
- voice recording in MP3 format
- Microsoft Windows 10 and Microsoft Word are registered Microsoft Corporation Brands
- MacroPATH software: Installed (with license)
The manufacturer reserves the right to change and/or improve specifications without notice
and without incurring in any obligation.

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eGROSS (version without MacroPATH):
-REF 102902: Power supply 230V~ 50/60Hz 1200W
-REF 102903: Power supply 115V~ 60Hz 1200W
-Dimensions: WxDxH 185cm (72.8in) x 81cm (31.9in) x 152cm (59.8in). Max. height 182cm (71.7in)
-Work surface height: adjustable from 90cm-35.4in to 120cm-47.2in
-Led illumination of the working area
-Weight: 255kg (441lb)
Structure:
-Stainless steel work surface.
-Vented work surface with washable compartment below
-Blue cutting board for downdraft aspiration (downward flow)
-Magnetic equipment holder bar
For both versions:
Lighting
Working area lighting: 2000 Lux*
* with environmental conditions of 400 Lux and all the Unit lights switched on
** with Hepta lamp (provided as optional part, as shown into the chapter 5.6)
Distance 50cm: 30000 lux, illuminated area: 15cm
Electrical Connection:
-2.8m power supply cable with Schuko plug
Hydraulics Connection:
-Water input: G 3/8’’
-Wastewater drain: 40mm (1.6in) rigid pipe
Ventilation:
The ventilation is applied in 3 distinct parts that cannot be excluded:
-The area beneath the work/sample preparation surface (downdraft)
-The area on the panel behind the work surface (backdraft)
-The area dedicated to the "waste” bin (optional part - please refer to chapter 5)
The flows of these 3 ventilation areas are expelled on the left side of the unit (front view) through a 3m
(118,11in) long pipe with an internal diameter of 200mm (7.9in).

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Filter (CODE 102915, supplied as an optional part, refer to chapter 5.2)
In the event of connection to the filter, the Ventilation system connected to the unit must compensate for the
550Pa pressure drop of the filter.
- Dimensions: LxDxH 618mmx780mmx1450mm (24.3’’x30.7’’x57’’)
- Infeed and outfeed dimensions Ø: 200mm (7.9in)
- Weight: 72kg (158.7lb)
Fixative loading/unloading system:
- Container transport trolley in stainless steel (dimensions: LxDxH 350 x 500 x 750mm - 13.8x19.7x29.5in,
dimensions container housing base: 470 x 320mm - 18.5x12.6in, max container height 400mm-15.8in),
equipped with a containment tank for any spills (capacity: 0.55 litres), a grille and a retainer for the container
- Fixative dispenser with pedal control
- “Used fixative” container cap equipped with “full container” sensor and fume extraction system (threading
type S55)
- Cap for "new fixative" container (S55 threading). This container is not supplied with the unit.
- The work surface is equipped with a recessed funnel for draining the used fixative in the dedicated container
including the filter
Auxiliary sockets
- For connecting instruments/optional parts (such as printers, scales, etc.)
- 2 type sockets IEC 320 C13 230Watt/1A max total
Environmental conditions:
-Operating temperature: 15°C–30°C (59°F-86°F)
-Relative humidity: 10°C - 80% without condensation
-Altitude: up to 2000m (78.7in)
-Maximum temperature of contact surfaces: lower 40°C (104°F)
1.4. Compatible reagents
Water, ethanol, formaldehyde 10% volume/volume (4% weight/weight), zinc formalin (no chloride), FineFIX,
alcohol-based fixatives, inks.
It is necessary to connect the unit to a fume extraction system.
Output air flow rate: 1200 m³/h ± 100 m³/h.
The system must allow for a flow rate of at least 1300m³/h in case is not present one of the
two filters provided as optional part (refer to chapters 5.2 and 5.3).
Do not use overly acidic reagents (pH <4).
DO NOT USE ANY REAGENTS OTHER THAN THOSE LISTED ABOVE.
For any doubts, please contact us at the following address:
[e-mail].

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1.5. Transport and storage conditions
Temperature: -20°C up to +60°C (-4°F up to 140°F)
Humidity: up to 80% (up to 50% at 40°C (104°F)) non-condensing
1.6. Antivirus
Only for the eGROSS pro-x model.
Milestone suggests to install an antivirus software. Milestone does not install antivirus software so that you
can choose your preferred version, according to your needs. Pay attention when setting the Antivirus so that
data flow on the USB protocols and accesses to the Hard Disk are not limited.
1.7. Warning information
PERSONAL DATA SAFETY
The Device described herein is not intended for managing personal data of natural persons. Personal data of
natural persons shall not be inserted into the Device during the use of the Device. The organization that uses
the Device shall implement appropriate measures to ensure that no personal data of natural persons are
inserted into the Device. All the data referred to a person and inserted into the device shall use, at least, the
“pseudonymization”, in such a manner that the personal data can no longer be attributed to a specific data
subject without the use of additional information, provided that such additional information is kept separately
and is subject to technical and organizational measures to ensure that the personal data are not attributed to
an identified or identifiable natural person.
Equipment shall be connected to main sockets outlets which is accessible and visible by the operator.
All equipment parts and all optional parts shall be supplied only by the manufacturer.
The unit is equipped with replaceable fuses.
If the system is still not properly working, please contact your local representative or the manufacturer (always
provide the serial number of the unit, see label on the left of the unit).
In case of removal of equipment for repair:
1. Shut down the PC.
2. Switch the unit OFF.
3. Disconnect the main plug of unit from the main socket outlets.
4. Disconnect all optional parts, if present (keyboard, barcode reader).
5. Clean and disinfect all parts of the unit according to chapter 4.2.
6. Put all parts of the equipment into the package supplied by the manufacturer (original package).
7. Send device to the manufacturer for repair.
1.8. Backing up the MacroPATH data (only for eGROSS pro-x)
The size of images with the recommended settings is 1.5MB/image (please refer to chapter 3).
Use of the equipment in ways other than those specified may void the warranty provided by
the manufacturer.
Do not open the camera box. Infringement voids the warranty.
Milestone strongly recommends saving all the cases and the relative images on a server or
other kind of support using an automated backup procedure.
Contact your local Network/IT Manager.

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1.9. Milestone Remote Connection
MacroPATH software is provided with Milestone Remote Connection software allowing our Customers support
to manage the unit remotely. To obtain support from Milestone, connect the PC to
Internet, then contact customer support at:
[e-mail] and communicate these data:
- Serial number of the unit,
- version of the remote connection software,
- ID,
- Password.
The connection can only be established if the green icon appears.
1.10.Labelling
eGROSS pro-x:
eGROSS (version without MacroPATH):
For the explanations of the symbols, please refer to chapter 1.1.





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2. eGROSS pro-x/ eGROSS INSTALLATION
This chapter and the following chapters describe all the functions of the eGROSS pro-x and eGROSS units.
The eGROSS instrument has all the same functions as the eGROSS pro-x unit, with the exception of those
relating to the PC and the camera, as shown in the following images.
eGROSS pro-x eGROSS
The Milestone eGROSS pro-x/eGROSS unit is a precision instrument that must be unpacked and installed
with the utmost care.
Make sure that the unit is at level and vibration free and not in contact with flammable material.
Make sure that the unit has not been placed against any lateral surfaces that might limit the intake/discharge
of cooling air.
Make sure the unit is not exposed to direct currents of air on the work surface (e.g. air conditioners, fans,
windows, etc.) that could alter the system of flows.

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2.1. Space requirements
The eGROSS pro-x/eGROSS is delivered in a wooden crate with a total weight of:
•415kg (915lb) for eGROSS pro-x,
•405kg (893lb) for eGROSS
and with the following dimensions:
Width: 206cm (81.1in)
Height: 144cm (56.7in)
Depth: 100cm (39.4in)
Dimensions of the eGROSS pro-x unit:
Width:
185cm
(72.8in)
Height:
186cm (73.2in) min
216cm (85in) max
Depth:
81cm (31.9in)
87cm (34.3in) with trolley
Dimensions of the eGROSS unit:
Width:
185cm
(72.8in)
Height:
152cm (59.8in) min
182cm (71.7in) max
Depth:
81cm (31.9in)
87cm (34.3in) with trolley
Dimensions of space required for positioning the unit, to be added to the dimensions of the unit itself:
35cm (13.8in) left side; 30cm (11.8in) at the back; 5cm (2in) right side.
Dimensions space required for the eGROSS pro-x unit:
Width:
225cm
(88.6in)
Height:
186cm (73.2in) min
216cm (85in) max
Depth:
111cm (43.7in)
117cm (46in) with trolley
Dimensions space required for the eGROSS unit:
Width:
225cm
(88.6in)
Height:
152cm (59.8in) min
182cm (71.7in) max
Depth:
111cm (43.7in)
117cm (46in) with trolley
At this point the eGROSS pro-x/eGROSS unit can be placed in its final position for use.

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2.2. eGROSS pro-x/eGROSS unpacking and component inspection
Installation and preliminary operations are illustrated in this section. Be sure to read the following chapters carefully before using the eGROSS pro-x/eGROSS unit.
Upon opening the crate, check to make sure that all the parts are at present.
eGROSS pro-x –eGROSS includes:
DESCRIPTION
IMAGE
eGROSS
pro-x
eGROSS
1. Cutting board
(Code 102805)
X
X
2. Wastewater discharge
pipe, internal Ø 40mm
(1.57in), with 2 metal straps
5m long
(Code 102480)
X
X
3. Fumes discharge pipe
internal Ø 200mm (7.9in)
with 2 metal straps 3m
(118.1in) long
(Code 102576)
X
X

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DESCRIPTION
IMAGE
eGROSS
pro-x
eGROSS
4. 2 Flexible mixer hoses
3/8”-1/2”
X
X
5. Fixative loading pedal
(Code 102884)
X
X
6. Container transport trolley
complete with tray (Code
102636), drainage grille,
and container retainer
(Code 102723)
X
X
7. 20L “used fixative”
container + one for reserve
(Code102703)
X
X

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DESCRIPTION
IMAGE
eGROSS
pro-x
eGROSS
8. “Fixative drain” funnel
filters
Code 102862
Code 102671
X
X
9. Ink tray (Code 102725)
X
X
10. “Work area” screen
(Code 102819)
X
X
11. Wash basin screen
(Code 102820)
X
X

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DESCRIPTION
IMAGE
eGROSS
pro-x
eGROSS
12. Lateral screens (Code
102761)
X
X
13. “Downdraft” tray (Code
102783) complete with net
(removable, Code 102784)
X
X
14. Wash basin cover (Code
102782)
X
X
15. 2 filters for the “drain”
(wash basin and downdraft
drain) (Code 102558)
X
X