Sartorius BioPAT Pressure User manual

Operating Instructions
Original Operating Instructions
BioPAT®Pressure
0–4 bar
Single-use Pressure Sensor
85037-556-43

Operating Instructions BioPAT® Pressure 3
Contents
Contents
1 About these Instructions............................................................. 5
1.1 Scope ..............................................................................5
1.2 OtherApplicable Documents......................................................5
1.3 TargetGroups......................................................................5
1.4 Symbols Used......................................................................6
1.4.1 Warnings in Operation Descriptions........................................6
1.4.2 Other Symbols Used........................................................6
2 Safety Instructions ....................................................................7
2.1 Intended Use.......................................................................7
2.1.1 Modifications to the Device ................................................7
2.1.2 Repairs and Maintenance on the Device ...................................7
2.2 Qualifications of Personnel ........................................................8
2.3 Significance of these Instructions..................................................8
2.4 Device Functionality ...............................................................8
2.5 Conduct in an Emergency .........................................................8
2.6 Accessories, Consumables, and Spare Parts .......................................9
2.7 Personal Protective Equipment....................................................9
2.8 Process Conditions ................................................................9
2.9 Pressure Sensor Holder ...........................................................10
2.10 Components Under Pressure .....................................................10
2.11 Operating Medium................................................................10
2.12 Single-use Pressure Pipes.........................................................10
3 Device Description...................................................................11
3.1 Device Overview ..................................................................11
3.2 Multi-use Pressure Transmitter....................................................12
3.3 Single-use Pressure Pipe..........................................................13
3.4 Measuring Principle...............................................................14
4 Installation ...........................................................................15
4.1 Scope of Delivery .................................................................15
4.2 Selecting an Installation Site ......................................................15
4.3 Unpacking ........................................................................16
4.4 Acclimatizing......................................................................16
5 Getting Started ......................................................................17
5.1 Inserting into the Pressure Sensor Holder.........................................17
5.2 Connecting to the System ........................................................18
5.2.1 Sartorius Systems..........................................................18
5.2.2 Process Controller for a Different System..................................18
6 Process Preparation..................................................................19
6.1 Checking the Transmitter Membrane.............................................19
6.2 Installing the Single-use Pressure Pipe............................................19
6.3 Performing Zero Point Calibration ...............................................20

4 Operating Instructions BioPAT® Pressure
Contents
7 Operation............................................................................21
7.1 Monitoring the Process ...........................................................21
7.2 Finishing the Process .............................................................21
7.2.1 Preparing the Device ......................................................21
7.2.2 Removing the Single-use Pressure Pipe ...................................21
8 Cleaning and Maintenance .........................................................22
8.1 Cleaning the Device .............................................................22
8.2 Maintenance Schedule .......................................................... 22
9 Faults ...............................................................................23
9.1 Signal Faults......................................................................23
9.2 CheckingtheGaskets............................................................25
9.3 Restarting ........................................................................25
10 Decommissioning ...................................................................26
11 Storage and Shipping ...............................................................27
11.1 Storage............................................................................27
11.2 Returning the Device and Parts...................................................27
12 Disposal.............................................................................28
12.1 Decontaminating the Device.....................................................28
12.2 Disposing of Device and Parts ...................................................28
13 Technical Data ......................................................................29
13.1 Multi-use Pressure Transmitter...................................................29
13.1.1 Dimensions and Weight ..................................................29
13.1.2 Electrical Specifications and Connections................................29
13.1.3 Materials..................................................................30
13.1.4 Approved Cleaning Agents...............................................30
13.2 Single-use Pressure Pipes........................................................30
13.2.1 Dimensions ...............................................................30
13.2.2 Materials...................................................................31
13.2.3 Shelf Life...................................................................31
13.2.4 Chemical Resistance* .....................................................31
13.3 Ambient Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
13.4 Process Conditions ..............................................................32
13.5 Operating Medium...............................................................32
14 Accessories, Consumables, and Spare Parts.........................................33
14.1 Accessories ......................................................................33
14.2 Consumables ....................................................................33
14.2.1 Single-use Pressure Pipes ................................................33
14.3 Spare Parts .......................................................................33
15 Sartorius Service ....................................................................34
16 Conformity Documents .............................................................34

Operating Instructions BioPAT® Pressure 5
About these Instructions
1 About these Instructions
1.1 Scope
These instructions are part of the device. These instructions apply to
thedeviceinthefollowingversions:
Device Type
BioPAT®PressurePressureSensor,consistingofthefollowingcomponents:
BioPAT®Pressure Transmitter, 0-4 bar BPD0005
Single-use components
BioPAT®Pressure Pipe ¼” HB BPD0010
BioPAT®PressurePipe⅜”HB BPD0011
BioPAT®Pressure Pipe ½” HB BPD0012
BioPAT®Pressure Pipe ¾” HB BPD0013
BioPAT®Pressure Pipe ¾” TC BPD0014
BioPAT®Pressure Pipe 1” HB BPD0015
BioPAT®Pressure Pipe 1” TC BPD0016
1.2 OtherApplicable Documents
t Inadditiontotheseinstructions,observethefollowingdocuments:
— ValidationGuide
— Instructions for the device or system to which the device is
connected, e.g., FlexAct®COM
— Instructions for accessories, e.g., benchtop pressure indicator,
pressure sensor holder, tubing holder
— Documentation on customer-specific modifications (if applicable)
1.3 TargetGroups
These instructions are designed for the following target groups. The target
groups must possess the knowledge listed below.
Target Group Knowledge and Qualifications
User The useris familiarwith the operation of the device and
the associated work processes.The user understands
the hazards which may arise when working with the
device and knows how to prevent them.The user has
been trained in the operation of the device.
Operating
engineer |
laboratory
manager
The operating engineer | laboratory manager makes
decisions about the use and configuration of the
device. The operating engineer | laboratory manager
has been trained in the operation of the device.

6 Operating Instructions BioPAT® Pressure
About these Instructions
Target Group Knowledge and Qualifications
Electrician A qualified electrician who has the specialized
training, knowledge, and experience, as well as
familiaritywith applicable standards and regulations,
to evaluate the work assigned to him or her and
identify possible hazards.
Operator The operator of the device is responsible for ensuring
compliancewith workplace health and safety
regulations.The operator must ensure that all persons
who workwith the device have access to the relevant
information and are trained inworking with the device.
1.4 Symbols Used
1.4.1 Warnings in Operation Descriptions
WARNING
Denotes a hazard that may result in death or severe injury if it is not avoided.
CAUTION
Denotes a hazard that may result in moderate or minor injury if it is not
avoided.
NOTICE
Denotes a danger that may result in damage to property if it is not avoided.
1.4.2 Other Symbols Used
t  Requiredaction:Describesactivitiesthatmustbecarriedout.
The actions in the sequence must be carried out in succession.
y Result:Describestheresultoftheactivitiescarriedout.

Operating Instructions BioPAT® Pressure 7
Safety Instructions
2 Safety Instructions
2.1 Intended Use
The BioPAT®Pressure sensor measures the pressure in liquid-flow tubes and
converts it into an electrical signal. The device is intended for use in the
followingapplications:
— Use as a safety system, e.g., for monitoring pressure of liquid-filled
single-use vessels or for installing liquid-flow filter elements to enable
immediate shut-off of the pumps in the event of any blockage.
— Applications in which pressure is a process parameterthat is used for
automated control loops, e.g., tangential flow filtration at constant pressure.
— Monitoring of the pressure in pressure-limiting single-use modules.
The BioPAT®Pressure sensor consists of a multi-use pressure transmitter
and a single-use pressure pipe.The data can be read out by connecting
thetransmittertoaprocesscontrolunitortoadesktopdisplay.
The device is intended exclusively for use in accordance with these
instructions. Any further use beyond this is considered improper.
If the device is used improperly:Thedevice’sprotectivesystemsmaybeim-
paired. This can lead to unforeseeable personal injury or property damage.
Operating Conditions for the Device
Do not use the device in potentially explosive environments. Only use
thedeviceindoors.
The device may only be used with the equipment and under the operating
conditions described in the Technical Data section of these instructions.
2.1.1 Modifications to the Device
Ifthedeviceismodified,e.g.,byattachingextracomponents:Thesafetyof
the device may be impaired or the device compliance may lose its validity.
If you have any queries regarding modifications to the device, contact
Sartorius.
2.1.2 Repairs and Maintenance on the Device
Device repairs and maintenance may only be carried out by persons with
appropriate specialized knowledge of the device. If the device is not
repairedormaintainedbyaspecialist:Thesafetyofthedevicemaybe
impaired or the test marks may lose theirvalidity.
We recommend that any repairwork, even that not covered by the warranty,
be carried out by Sartorius Service or after consulting with Sartorius Service.
Only the maintenance tasks described in these instructions should be
carried out. For maintenance tasks that need to be carried out by Sartorius
Service, contact Sartorius Service.

8 Operating Instructions BioPAT® Pressure
Safety Instructions
2.2 Qualifications of Personnel
If individuals who do not have sufficient knowledge on the safe handling of
thedevicecarryoutworkonthedevice:Thoseindividualsmayinjure
themselves or other people nearby.
t Ensure that all persons working on the device possess the necessary
knowledgeandqualifications(fordescription,seeChapter“1.3
TargetGroups”,page5).
t Ifaparticularqualificationisrequiredfortheactionsdescribed:
Havetheseactivitiescarriedoutbytherequiredtargetgroup.
t If noparticularqualificationisrequiredfortheactionsdescribed:
Havetheseactivitiescarriedoutbythe“user”targetgroup.
2.3 Significance of these Instructions
Failure to follow the instructions in this manual might have serious
consequences, e.g., danger to individuals.
t Read the instructions carefully and in full. The required actions in
theinstructionsbuildoneachother.
t Ensure that the information contained in these instructions is available
to all individuals working on the device.
t Retain the instructions.
t If these instructions are lost, request a replacement or download
thelatestversionfromtheSartoriuswebsite(www.sartorius.com).
2.4 Device Functionality
A damaged device or worn-out parts can cause malfunctions or lead to
hard-to-detect hazards.
t Only operate the device when it is in safe and proper working order.
t Complywith the maintenance intervals (for intervals and maintenance
work,seeChapter“8.2MaintenanceSchedule”,page22).
t Organize the immediate repair of any malfunctions or damage by
Sartorius Service.
2.5 Conduct in an Emergency
If an emergency occurs, e.g., due to the malfunctions of the device or
dangeroussituations:Peoplemaybeinjured.Thedevicemustbe
immediatelytakenoutofoperation:
t Disconnect the device from the supply systems.
t Secure the device to prevent it from restarting.

Operating Instructions BioPAT® Pressure 9
Safety Instructions
2.6 Accessories, Consumables, and Spare Parts
Unsuitable accessories, consumables, and spare parts can adversely affect
functionalityandsafetyandcanhavethefollowingconsequences:
— Risk of injury to persons
— Damage to the device
— Device malfunctions
— Failure of the device
t You should only use approved accessories, consumables, and spare parts
supplied by Sartorius.
t Only use accessories, consumables, and spare parts that are in
technically perfect condition.
2.7 Personal Protective Equipment
Personal protective equipment protects against hazards arising from the
device.Ifpersonalprotectiveequipmentisnotusedorisunsuitable:People
may be injured.
Protective Equipment
Designation Explanation/Examples
Safety gloves Protect against chemicals, heat, and injuries.
Safety glasses Protect against harmful influences, e.g.,
liquids, chemicals, splinters, or particles.
Safety boots Protect against injuries to the feet caused by
mechanical effects and against slipping on wet
surfaces.
t Wear appropriate personal protective equipment.
t If the operating area, or the process in which the device is used, requires
additionalsafetyprecautions:Weartheadditionalappropriatepersonal
protective equipment.
2.8 Process Conditions
The device must be suitable for the measurement range, the type of
measurement, and the specific measurement conditions in the process.
Ifthedeviceisnotsuitablefortheprocess:Thereisariskofinjuryto
personnel working on the device and damage to the device.
t Check whether the device is suitable for the process conditions
(seeChapter“13.4ProcessConditions”,page32).
t For more information on validation and quality assurance, please contact
Sartorius.

10 Operating Instructions BioPAT® Pressure
Safety Instructions
2.9 Pressure Sensor Holder
The device must be attached to the system using a pressure sensor holder.
The pressure sensor holder is used to fix the device securely to the system. If
the device is secured without a pressure sensor holder or with an unsuitable
pressuresensorholder:Thedevicemaybecomelooseduringtheprocess.
t Mount the device on a pressure sensor holder.
t Onlyusesuitablepressuresensorholders(seeChapter“14.1Accessories”,
page 33).
2.10 Components Under Pressure
There is a risk of injury when working on pressurized components, e.g., the
single-use pressure pipe. Leaking operating medium can cause chemical
burns.
t When working on the device, entirelyor partiallydepressurize the system
(for depressurization, see instructions for the connected device or system).
t Only operate the device within the permissible operating parameters
(seeChapter“13.4ProcessConditions”,page32).
t Wear personal protective equipment.
2.11 Operating Medium
The media used in the process (operating media) may be hazardous and
cause personal injury or damage to the device. Using aggressive/corrosive
operating media may carry the risk of chemical burns.
t Observe the applicable safety and occupational health and safety
information concerning the operating media, e.g., handling, storage, and
conduct in emergency situations.
t Wear personal protective equipment.
t Ifrequired:Installadditionalprotectivemeasures,e.g.,splashprotection.
t Only use operating media that is suitable for the device (for suitability,
seeChapter“13.5OperatingMedium”,page32).
t Ifthereismediaresidueinthedevice:Cleanthedevice(see
Chapter“8CleaningandMaintenance”,page22).
2.12 Single-use Pressure Pipes
Only the single-use pressure pipes that are qualified for the multi-use
pressure transmitter may be used with the multi-use pressure transmitter.
Ifapipeotherthanthosespecifiedisused:Theaccuracyofthepressure
measurement cannot be guaranteed. Incorrect measurement results may
lead to serious injuries.
t Useonlyapprovedsingle-usepressurepipes(seeChapter“13.1Multi-
use Pressure Transmitter”, page 29).
t Observe the accuracy test report for the device.

Operating Instructions BioPAT® Pressure 11
Device Description
3 Device Description
3.1 Device Overview
The BioPAT®Pressure sensor consists of a multi-use pressure transmitter
and a single-use pressure pipe.
1
2
Fig.1:BioPAT®Pressuresensor:multi-usetransmitterwithsingle-usepipe½” HB (example)
Pos. Designation
1 Single-use pressure pipe
2 Multi-use pressure transmitter

12 Operating Instructions BioPAT® Pressure
Device Description
3.2 Multi-use Pressure Transmitter
The multi-use pressure transmitter converts the pressure of the operating
medium in the single-use pressure pipe into an electrical signal, which can
be transmitted to a process controller. The transmitter also carries out a
temperature compensation and correction of the signal.
75
64
2
3
1
8
Fig.2:Multi-use pressure transmitter
Pos. Designation Description
1 Protective cap Protects the metal membrane against
mechanical damage or contamination.
2 Transmitter
membrane
Transmits the pressure from the sin-
gle-use pressure pipe.
3 Sensor connection Holds the single-use pressure pipe.
4 Transmitter head
5 Mounting nut Is used to connect the multi-use pres-
sure transmitter to a pressure sensor
holder.
6Manufacturer’sID
label
7 Sleeve Surrounds part of the electronics of the
multi-use pressure transmitter.
8 Signal connection For insertion of the connection cable.
A set of gaskets (O-rings) are inserted in several positions in the mounting
nut and the transmitter head in order to seal off the various parts of the
transmitter.

Operating Instructions BioPAT® Pressure 13
Device Description
3.3 Single-use Pressure Pipe
4
5
2
1
3
Fig.3:Single-use pressure pipe ½” HB, view from front and rear (example)
Pos. Designation Description
1 Mounting bracket Secures the single-use pressure pipe to, or releases it from,
themulti-usepressuretransmitter.
2 Tubing connections Is intended to connect a tube.
3 Upper fixing clip Surrounds the sensor connection.
4 Membrane Transfers the pressure of the operating medium to
thetransmittermembrane.
5 Lower fixing clip Surrounds the sensor connection.

14 Operating Instructions BioPAT® Pressure
Device Description
3.4 Measuring Principle
The BioPAT®Pressure sensor uses the piezoresistive effect for accurate and
quick pressure determination.As soon as the single-use pressure pipe is
installed on the transmitter, the silicone membrane of the single-use pressure
pipe is in contact with the metal membrane of the multi-use transmitter.
During measurement, in the event of pressure fluctuations force is applied to
the membranes, which is detected by a piezoresistive pressure sensor in the
multi-use transmitter. In addition, an integrated thermometer automatically
corrects the influence of the temperature in the output signal.
Pressure Pipe
Silicone membrane
of the pressure pipe
Metal membrane of
the pressure transmitter
Piezoresistive
pressure sensor
Fig.4:Measuring principle of the sensor

Operating Instructions BioPAT® Pressure 15
Installation
4 Installation
4.1 Scope of Delivery
Item Quantity
Multi-use Pressure Transmitter 1
Cablewithopenends,5m 1
Test report 1
Operating Instructions 1
4.2 Selecting an Installation Site
Procedure
t Makesurethatthefollowingconditionsaremetattheinstallationsite:
Condition Requirements
Mounting surface Sufficient installation space is available for
the device and the mounted components
e.g., tubes, pressure sensor holder
(forspacerequiredforthedevice,see
Chapter13,page29;forspacerequired
for the components, see the instructions
forthecomponents)
Ambient conditions Suitabilitytested(seeChapter13.3,page32)
Process conditions Suitabilitytested(seeChapter13.4,page32)
Operating medium Suitabilitytested(seeChapter13.5,page32)

16 Operating Instructions BioPAT® Pressure
Installation
4.3 Unpacking
Procedure
t Unpack the device.
t Install the device at the intended installation site.
t We recommend keeping the original packaging including the protective
cap to return the device securely and appropriately, e.g., for repairs.
4.4 Acclimatizing
Whenacolddeviceisbroughtintoawarmenvironment:Thetemperature
difference can lead to condensation (moisture formation) from humidity in
the device. Moisture in the device can lead to malfunctions.
Procedure
t Allow the device to acclimatize for approx. 2 hours at the installation site.
The device must be disconnected from the power supply during that time.

Operating Instructions BioPAT® Pressure 17
  GettingStarted
5 GettingStarted
5.1 Inserting into the Pressure Sensor Holder
NOTICE
Damage to the connection lines!
Ifthesignalconnectionloosensfromthedevice:Theexposedconnection
cables may be damaged, e.g., by being clamped.
t Carefully position the signal connection on the device and hold in place.
NOTICE
Tools can damage the device!
Ifatoolisusedinthewrongplace:Thedevicemaybedamaged.
t Only apply the open-ended wrench to the mounting nut.
Qualification required: Electrician | Sartorius Service
Tool: Open-endedwrench,42mm
Requirements
— The pressure sensor holder is mounted on the system.
— The device is not connected to a system.
Procedure
t Unscrew the sleeve (2) in the direction of the signal connection (1).
t NOTICE Traction may damage the device! Do not pull on the
connection cable of the looser signal connection.
t Loosen the mounting nut (3) using the open-ended wrench.
t Unscrew the mounting nut (3) from the device.
t Check whether the gaskets have been inserted in the grooves of
themountingnutandtransmitterhead.
t Ifrequired:Pushthegasketsintothegroove.
t Insert the device into the pressure sensor holder.
t Check whether the protective cap is lying in front of the pressure sensor
holder.
t Ifrequired:Pulltheprotectivecapinfrontofthepressuresensor
holder.
t Apply the mounting nut (3) to the device.
t Screw the sleeve (2) onto the device and tighten by hand.
t Tighten the mounting nut using the open-ended wrench.
3
2
1

18 Operating Instructions BioPAT® Pressure
 GettingStarted
5.2 Connecting to the System
5.2.1 Sartorius Systems
If the multi-use pressure transmitter is being connected to a Sartorius
system controller, e.g., FlexAct®COM:Thesuppliedopen-ended
connection cable is not required. The device must be connected to
thecontrolleroftheSartoriussystembySartoriusService.
t Please contact Sartorius Service.
5.2.2 Process Controller for a Different System
Qualification required: Electrician
Requirements
— The multi-use pressure transmitter is sufficiently secured, e.g., using a
sensor holder.
— The system to which the multi-use pressure transmitter is being
connected is switched off.
Procedure
t NOTICE The device can be damaged by incorrect connections! Observe
the correct assignment of the connections on the device and on the
connectioncable(connectionsseeChapter“13.1.2Electrical
Specifications and Connections”, page 29).
t Screw the round plug of the connection cable (1) to the signal
connection (2).
t Connect the contacts of the connection cable to the system controller
(see instructions for the connected system).
t If the device is notgroundedbythesystem:Groundthedevice.
Configuring Process Control on the Device
WARNING
Danger of injury due to incorrect system settings!
Incorrect system settings can impact the accuracy of the pressure
measurement and cause serious injuries.
t Ensure the correct system settings are used.
t Please contact Sartorius Service.
t SeeinstructionsfortheconnectedsystemandChapter“13.1.2Electrical
Specifications and Connections”, page 29.
2
1

Operating Instructions BioPAT® Pressure 19
Process Preparation
6 Process Preparation
6.1 Checking the Transmitter Membrane
Procedure
t WARNING Risk of injury due to damaged transmitter membrane! If
thedeviceisusedwithadamagedtransmittermembrane:Theaccuracy
of the pressure measurement cannot be guaranteed.
t Open the protective cap.
t Check the transmitter membrane for damage, e.g., cracks or dents.
t Ifrequired:Replacethedevice.
6.2 Installing the Single-use Pressure Pipe
Requirements
The system has been entirely or partially depressurized.
Procedure
t WARNING Components under pressure can cause injury! Entirely or
partially depressurize the system (see instructions for the connected
device or system).
t Pull the mounting bracket (1) off the pipe (until it clicks twice).
t NOTICE The transmitter may be damaged if the protective cap is not
removed! Remove the protective cap (2).
t Apply the upper fixing clip (1) to the sensor connection at a slight angle.
y The upper fixing clip (1) reaches fully under the sensor connection.
t Push on the lower fixing clip (2).
y The lower fixing clip (2) surrounds the sensor connection.
t Push the mounting bracket (1) in the direction of the sensor connection
and make sure it fully engages into place.
y The membrane of the single-use pressure pipe and the transmitter
membrane are connected (contact close).
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2
1
2
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20 Operating Instructions BioPAT® Pressure
Process Preparation
6.3 Performing Zero Point Calibration
The contact between the transmitter membrane and the membrane of
thesingle-usepressurepipegeneratesacertainoffsetpressure,whichis
specific for each single-use pressure pipe.
In order to guarantee an accurate measurement of the actual relative
pressureintheprocess:Thezeropointcalibrationcanbeperformedin
thecontrolleroftheconnectedsystemorviaaccessories.
Ifthehydrostaticpressurealsoneedstoberecorded:Performthezero
point calibration when the system is full of air.
Procedure
t Fill the tubes with air/liquid. To do this, refer to the instructions for
theconnecteddeviceorsystem.
t Perform a zero point calibration on the process controller of the
connected device or system (for zero point calibration, see instructions
for the connected system or accessory).
y The device is ready for use.