3D Histech Pannoramic MIDI 1.18.1 User manual

PM1.18.1-UG-Rev1
Pannoramic MIDI
1.18.1
User’s Guide
May 29, 2014
Rev. 1

Pannoramic MIDI 1.18.1 User’s Guide
Contents
Disclaimer....................................................................................................................... 5
Declaration Of Conformity............................................................................................... 7
Character ormats and Symbols....................................................................................... 8
Notes Regarding Operational Safety................................................................................9
Notes on Warranty........................................................................................................ 11
Terms and Abbreviations...............................................................................................12
1 Product Description.................................................................................................... 13
1.1 Product Overview....................................................................................................................13
1.1.1 Intended U e..................................................................................................................................................13
1.1.2 Feature and Benefit .....................................................................................................................................13
1.1.3 Warning and Information Label ....................................................................................................................15
1.1.4 Ba e Unit........................................................................................................................................................16
1.2 Sy tem Overview......................................................................................................................17
1.2.1 Pannoramic MIDI y tem................................................................................................................................17
1.2.2 Hardware Option ..........................................................................................................................................18
1.2.3 Control Software............................................................................................................................................21
2 Installation................................................................................................................. 22
2.1 Control computer port ...........................................................................................................22
2.2 Connector and cable .............................................................................................................23
2.3 Coupling the Lumencor Spectra 6 unit with the canner........................................................24
3 Operating Slides and Trays.......................................................................................... 25
3.1 Preparing Slide and Tray .......................................................................................................25
3.2 Affixing Barcode Sticker to Slide ...........................................................................................26
3.3 In erting and Removing Slide .................................................................................................27
4 Software Description.................................................................................................. 30
4.1 Starting / Exiting Pannoramic MIDI Software Application.......................................................30
4.1.1 Starting the oftware......................................................................................................................................30
4.1.2 Exiting the oftware........................................................................................................................................31
4.2 Option .....................................................................................................................................31
4.2.1 Barcode Setting .............................................................................................................................................31
4.2.2 Image Compen ation.....................................................................................................................................34
4.2.3 Micro cope Setting .......................................................................................................................................36
4.2.4 Event Call Setting ..........................................................................................................................................40
4.3 U ing Brightfield Manual Mode...............................................................................................44
4.3.1 Routine work panel........................................................................................................................................45
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Pannoramic MIDI 1.18.1 User’s Guide
4.3.2 Scan Option window.....................................................................................................................................47
4.3.3 Preview panel.................................................................................................................................................49
4.3.4 Preview area canned by preview camera.....................................................................................................52
4.3.5 Focu panel.....................................................................................................................................................58
4.3.6 Service panel..................................................................................................................................................60
4.3.7 Di play field and toolbar for live image ........................................................................................................61
4.3.8 Start can........................................................................................................................................................63
4.4 U ing Brightfield Automatic Mode..........................................................................................63
4.4.1 Routine work panel........................................................................................................................................63
4.4.2 Barcode panel...............................................................................................................................................65
4.4.3 Preview panel.................................................................................................................................................69
4.4.4 Focu panel.....................................................................................................................................................70
4.4.5 Service panel..................................................................................................................................................71
4.4.6 Start can........................................................................................................................................................72
4.5 U ing Fluore cent Manual Mode.............................................................................................73
4.5.1 Routine work panel........................................................................................................................................73
4.5.2 Scan Option ...................................................................................................................................................78
4.5.3 Preview panel.................................................................................................................................................82
4.5.4 Hardware panel..............................................................................................................................................85
4.5.5 Service panel..................................................................................................................................................88
4.6 U ing Fluore cent Automatic Mode........................................................................................89
4.6.1 Routine work panel........................................................................................................................................89
4.6.2 Barcode panel...............................................................................................................................................94
4.6.3 Preview panel.................................................................................................................................................98
4.6.4 Focu panel.....................................................................................................................................................99
4.6.5 Service panel..................................................................................................................................................99
4.7 Scan To Server........................................................................................................................100
4.8 U ing Profile .........................................................................................................................105
5 Troubleshooting and Maintenance............................................................................107
5.1 Safety Information.................................................................................................................107
5.1.1 Cleaning the device......................................................................................................................................108
5.1.2 Cleaning the tray .........................................................................................................................................108
5.1.3 Preventive maintenance...............................................................................................................................108
5.2 Trouble hooting.....................................................................................................................109
5.2.1 Fluore cent Application (optional).............................................................................................................111
5.3 Maintenance..........................................................................................................................112
5.3.1 Opening the protective cover .....................................................................................................................112
5.3.2 Replacing the halogen lamp.........................................................................................................................114
5.3.3 Replacing Lamp Module (for Fluore cent Option).......................................................................................115
5.3.4 Removing a lide...........................................................................................................................................117
5.3.5 In talling and Removing the Filter Module (Fluore cent Option)................................................................119
5.3.6 Tran porting Pannoramic MIDI....................................................................................................................120
6 Technical Data........................................................................................................... 122
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Pannoramic MIDI 1.18.1 User’s Guide
Index........................................................................................................................... 127
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Pannoramic MIDI 1.18.1 User’s Guide
Disclaimer
Copyright © 2001-2014 3DHISTECH Ltd.
All right re erved.
Intellectual property related to the 3DHISTECH product are a follow :
EP 1,789,831; US 7,663,078; EP 2,024,772; JP 2009-512685; US 12/301,781; EP 1,644,767; JP 2007-
516451; US7,327,515; EP 1,994,398; JP 2008-557835; US 12/281,566; U0700210; US 6,246,785;
HU0900142; HU0700404; PCT/HU2007/000065; EP 08762668.5; US 12/663,537;
PCT/AT2006/000492; JP 2008-542552; EP 06817469; US 12/095,545; PCT/AT2006/000493; EP
06817470.5; US 12/095,596; HU0900741; US 61/264,732; US 11/826,752; P0401870;
PCT/IB2005/050344; US 11/662,976; HU0700409; US 12/042,050; US 77/636,144 and 007502032.
The above mentioned granted patent , granted utility model, regi tered trademark , pending
international and national patent application and the other corre ponding IP are the ole propertie
of the 3DHISTECH Ltd.
3DHISTECH Ltd. is not liable for damage of whatever nature (including, but not limited to, general
or specific damage, indirect damage, consequential damage or incidental damage, including the
results of the analysis of the digitized slides, for example, change of health status related to
erroneous diagnosis from the digitalized slide(s)) that stems from or is associated with use of
Product, digitalized slides, quality of staining, quality of stained slides, quality of used method of
staining. 3DHISTECH Ltd. assumes no responsibility for the functionality and fault-free condition of
your “application programs” (Workflows, VBA macros, Commander scripts).
CAUTION
Thi product ha not been approved or cleared a a medical device by the U.S. Food and Drug
Admini tration.
Do not u e thi device in clo e proximity to ource of trong electromagnetic radiation (e.g.
un hielded intentional RF ource ), a the e may interfere with the proper operation.
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Pannoramic MIDI 1.18.1 User’s Guide
Third-Party Disclaimer (LibTI – TI Library and Utilities)
3DHISTECH Ltd. i not liable for damage of whatever nature (including, but not limited to, general or
pecific damage, indirect damage, con equential damage or incidental damage, including damage
re ulting from lo t profit , interruption of bu ine , lo of bu ine information, pecuniary lo or
imilar damage) that tem from or i a ociated with the incorporated part of thi Product that i
made by Silicon Graphic Inc.
THE SO TWARE IS PROVIDED “AS IS” AND WITHOUT WARRANTY O ANY KIND, EXPRESSED,
IMPLIED OR OTHERWISE, INCLUDING WITHOUT LIMITATION, ANY WARRANTY O
MERCHANTABILITY OR ITNESS OR A PARTICULAR PURPOSE.
IN NO EVENT SHALL SAM LE LER OR SILICON GRAPHICS BE LIABLE OR ANY SPECIAL, INCIDENTAL,
INDIRECT OR CONSEQUENTIAL DAMAGES O ANY KIND, OR OR ANY DAMAGES WHATSOEVER
RESULTING ROM LOSS O USE, DATA OR PRO ITS, WHETHER OR NOT ADVISED O THE POSSIBILITY
O DAMAGE, AND ON ANY THEORY O LIABILITY, ARISING OUT O OR IN CONNECTION WITH THE
USE OR PER ORMANCE O THIS SO TWARE.
urther Information
For the late t information on 3DHISTECH product and ervice , plea e vi it our web ite at the
following URL: http ://www.3dhi tech.com.
Company Addre : 29-33 Konkoly-Thege Miklo treet, Building 6
1121 Budape t – HUNGARY
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Pannoramic MIDI 1.18.1 User’s Guide
Declaration Of Conformity
3DHISTECH Ltd. declare that the product Pannoramic MIDI lide canner i de igned and produced
with con ideration of pecified requirement according to the ISO 13485:2003 and IEC 61326-2-
6:2005 tandard , and conform to the directive and other tandard li ted below:
IEC 61010-1:2001 (ed. 2), “Safety requirement for electrical equipment for mea urement, control,
and laboratory u e – Part 1: General requirement ”
IEC 61010-2-101:2002 (ed. 1), “Safety requirement for electrical equipment for mea urement,
control and laboratory u e – Part 2-101: Particular requirement for in vitro diagno tic (IVD) medical
equipment”
EN 55011:1998, Group 1, Cla A, “Limit and method of mea urement of radio di turbance
characteri tic of indu trial, cientific, and medical (ISM) radio-frequency equipment”
Thi product ha been te ted to the requirement of CAN/CSA-C22.2 No. 61010-1, econd
edition, including Amendment 1, or a later ver ion of the ame tandard incorporating the ame level
of te ting requirement .
Conformity with Directive 98/79/EC i marked by on the Pannoramic MIDI device.
Conformity with Directive IEC 61010-2-101:2002 (ed. 1) i marked by on the product
labeling.
Further information may be obtained from the manufacturer:
3DHISTECH Ltd.
29-33 Konkoly-Thege Miklo treet, Building 6
1121 Budape t – HUNGARY
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Pannoramic MIDI 1.18.1 User’s Guide Character Formats and Symbols
Character ormats and Symbols
Example Word or character that appear on the creen. The e include field name , creen
and window title , pu h-button and menu name , path or option .
Key on the keyboard. For example, function key ( uch a 11) or the Ctrl+M key
combination.
Example Cro -reference within thi document or to other document .
Warning! It might cau e irrever ible damage or harm to the u er of the product or the
product it elf if thi in truction i not followed.
Caution! It might cau e the product to not work properly if thi in truction i not followed
and alert to a potential danger ituation.
Note: Call attention to ome important feature .
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Pannoramic MIDI 1.18.1 User’s Guide Character Formats and Symbols
Notes Regarding Operational Safety
The below ection of thi U er’ Guide contain information and warning of a kind that mu t be
followed by owner/operator per onnel.
Warning and advi ory ymbol which are u ed on the ba e unit of the Pannoramic MIDI and in the
ection 1.1.3 Warning and Information Labels have the following meaning :
CAUTION
Di connect main plug before any kind of intervention into the device!
CAUTION
Cru h hazard!
The Pannoramic MIDI, including any of it original acce ory component , hould not be operated in
any other way than de cribed in ection 1.1.1 Intended Use.
Any of the following note hould be trictly ob erved:
Caution!
In the event of any non-conforming type of u e, including non-conforming u e
of a emblie or ingle part , no liability will be a umed by the Manufacturer.
Thi hall al o apply to ervice or repair work of any kind, which i performed by
other than authorized ervice per onnel. All claim for warranty and warranty
ervice will be null and void in any uch ca e.
Warning!
In ert the power cord plug only into a grounding outlet. The protective action
mu t not be rendered ineffective by exten ion cable without protective
conductor. The Pannoramic MIDI ha a built-in protection which mu t not be
rendered ineffective by exten ion cable without protective (earth-ground)
conductor.
Warning! The operation of the in trument in explo ion-ri k environment i not allowed.
Warning!
If protective device are found to be ineffective, the Pannoramic MIDI mu t be
hut down and precaution mu t be taken to prevent unintended u age. For
nece ary repair work or work to re tore proper operating condition, you
hould contact the 3DHISTECH Cu tomer Service.
Note:
Electric power to the Pannoramic MIDI i upplied via an external main power
upply unit. It allow for operation at line voltage in the range of 100 V to 240
V ±10%, 50/60 Hz, without any extra facilitie required for voltage
tran formation.
Warning! Check that your local line voltage i compatible with Pannoramic MIDI
pecification before you turn power on.
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Pannoramic MIDI 1.18.1 User’s Guide Character Formats and Symbols
Disconnect plug! Remember to unplug the power cord before you open the Pannoramic MIDI
ba e unit or replace a fu e!
Warning! Only connect external device that are afety extra low voltage rated to the
in trument to avoid the ri k of electrical hock.
Warning!
The Pannoramic MIDI doe not include any pecial facilitie to protect from
ample with an etching, potentially infectiou , toxic, radioactive or other
health-damaging effect. You are under obligation to comply with all currently
binding legi lation, notably, national accident prevention rule when handling
ample of thi kind.
Caution!
Dirt or du t may adver ely impact the operating capability of the Pannoramic
MIDI. For thi rea on, mea ure mu t be taken to eliminate uch influence to a
maximum po ible degree. During period of non-u e, the Pannoramic MIDI
mu t be protected with a du t cover. Check that power i turned off before you
put the cover on.
Caution! Avoid touching the lamp bulb. Di connect power and allow the bulb to cool
down by waiting for about 15 minute before replacing it.
Crush hazard!
There i cru h hazard in the movement area of the lide in ert during operation.
Plea e note that the digitizing proce ha to be interrupted and the in ert
moved via oftware to the output po ition before removing the in ert.
Warning! A defective Pannoramic MIDI i not cla ified a dome tic wa te. It mu t be
properly di po ed in accordance with currently valid legal requirement .
Warning!
The Pannoramic MIDI may not be operated by other than properly in tructed
per on . Operating per onnel mu t be fully aware of the potential danger
which a particular field of application involve . The Pannoramic MIDI i a
preci ion in trument which may uffer a ignificant reduction in operational
function or even phy ical de truction following intervention performed in any
nonconforming manner.
Warning! If an HXP 120 fluore cent illumination unit i u ed, the corre ponding warning
included in the manufacturer’ operating manual have to be ob erved.
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Pannoramic MIDI 1.18.1 User’s Guide Character Formats and Symbols
Notes on Warranty
3DHISTECH Ltd. – a the Product Manufacturer – warrant the Pannoramic MIDI to be free from fault
in material and workman hip at the moment of in tallation. Defect mu t be notified immediately on
identification and maximum effort mu t be undertaken in order to minimize damage. On receiving
notice of a fault, the Product Manufacturer will be under obligation to remove the fault, at hi own
option, either by providing adequate repair ervice or by delivering a faultle product for
replacement. No warranty will be accepted in ca e of natural wear (notably, wear and tear) or
improper product handling.
The Product Manufacturer will refu e any liability in the event of damage re ulting from faulty
operation, negligence or unauthorized intervention into the product, notably, from the replacement
of product part or the u age of acce ory part from other manufacturer . Any uch ca e will void
the u er’ claim for warranty.
Except for action which are explicitly de cribed in thi U er’ Guide, you are prohibited from
performing any kind of maintenance or repair work at the Pannoramic MIDI. Only authorized
3DHISTECH Service per onnel or pecifically authorized repre entative are allowed to handle repair
work. In ca e of malfunction contact 3DHISTECH Service Support fir t.
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Pannoramic MIDI 1.18.1 User’s Guide Character Formats and Symbols
Terms and Abbreviations
CSV Comma Separated Value
OV Field of View
NA Numerical Aperture
Virtual Slide / Slide A digital image of a thin gla plate on which pecimen are mounted for
micro copic tudy:
a dynamic, interactive image that you can manage, ave, magnify, zoom, name,
evaluate, annotate, mark, comment, end to a colleague electronically for co-
operation or advice, and o on.
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
1 Product Description
1.1 Product Overview
1.1.1 Intended Use
The Pannoramic MIDI i de igned to u e tran mitted light and reflected light fluore cence to digitize
biological ample and pecimen (hi tological ection , typically). The target u er of the product can
work for example, in education, re earch, indu try or medical ector .
Warning!
After each canning make ure to in pect the digital lide for over-
expo ed area . In ca e the lide i canned ba ed on improperly et
parameter , it can highly affect the diagno tic re ult becau e of
information lo .
Warning!
Any modification to a hardware or oftware component of the PC will
highly affect the functionality of the canner program.
1.1.2 eatures and Benefits
The Pannoramic MIDI offer world cla brightfield and fluore cent whole lide canning on up to 9
channel . An out tanding 0.12 µm/pixel (in Brightfield) and 0.16 µm/pixel (in Fluore cent) re olution
i achieved with the 40×/0.95 NA (equivalent to 80× magnification) Carl Zei Plan-Apochromat
objective.
Key feature of the Pannoramic MIDI canner:
•Up to 9 freely electable color filter for fluore cence
•High-end fluore cent illumination device – Lumencor SPECTRA 6 Light Engine
•Multiband filter upport
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
•FL canning with a low noi e, 16-bit cientific CMOS pco.edge 4.2 camera
•New oftware-aimed flat-field correction compen ation method to create homogenou
lide image
•12 lide automatic loading and canning
•Improved permanent autofocu
•Compact and robu t device
•Good quality and table manufacturing
•3MP camera for barcode reading and preview image
•Image harpening (for both Fluore cence and Brightfield) feature to improve the vi ual
appearance of digital lide
•Focu algorithm find the focu which i mo t appealing to the human eye
Pannoramic MIDI i an optimal choice for cu tomer who want to can in brightfield and in
fluore cent mode where the quantity of canned lide will be regularly over 10 lide per day. It ha
the be t price/performance ratio with a reliable loading/ canning mechani m.
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
1.1.3 Warning and Information Labels
The following figure contain the label u ed on the Pannoramic MIDI main unit, the external main
power upply unit, and the HXP 120 illumination unit.
Figure 1 – Warning and information labels
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
1.1.4 Base Unit
The following figure how the main part of the ba e unit.
Figure 2 – Main parts of base unit
1. Protective cover
2. Slide tray
3. Manual camera changer
4. AxioCam MRm Rev3 camera
5. CIS VCC-FC60FR19CL can camera
•lourescent option – A
6. HXP 120 fiber-coupled illumination unit (can be u ed with AxioCam MRm Rev3 and Stingray
camera only)
7. HXP 120 illumination adapter and cable (u e with AxioCam MRm Rev3 and Stingray camera
only)
•lourescent option – B
6. Lumencor SPECTRA 6 Light Engine fiber-coupled illumination unit (can be u ed with pco.edge 4.2
camera only)
7. Lumencor illumination adapter and cable
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
1.2 System Overview
The tandard cope of delivery of the product include the following hardware and oftware
component .
1.2.1 Pannoramic MIDI system
The following figure how the main part of the Pannoramic MIDI y tem.
Figure 3 – Pannoramic MIDI system overview
1. Lumencor SPECTRA 6 Light Engine illumination unit (option)
2. HXP 120 fiber-coupled illumination unit (option)
3. 24 V power upply
4. Pannoramic MIDI ba e unit
5. Monitor
6. Mou e
7. Control computer
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
8. Keyboard
9. Slide tray
1.2.2 Hardware Options
Note:
The configuration of the control computer and monitor can vary
depending on the product order.
Cameras
AxioCam MRm Rev 3
1 CCD cientific, cooled, monochrome camera for
high quality, en itive fluore cent application .
CIS VCC- C60 R19CL
CMOS camera for high-quality brightfield
application allowing fa t canning.
pco.edge 4.2
Equipped with a high-quality CMOS image en or
for fluore cent application allowing fa t canning
and an out tanding low read out noi e. High
quantum efficiency, cooled with Peltier element.
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
Stingray 146C IR Medical camera
1 CCD camera for normal brightfield application
and entry level fluore cent application .
Camera adapters
0.63× adapter 1× adapter 1.6× adapter
Warning!
The in tallation of the camera in Pannoramic MIDI mu t be carried out
by trained profe ional !
In any other ca e the warranty will be automatically voided. The
upplier or di tributor i not liable for any damage cau ed by an
in tallation carried out by an unauthorized per on.
Base Unit options
•Pannoramic MIDI Ba ic Scan Option / Fa t Option – ba e unit equipped with Stingray or CIS
camera for Brightfield canning (no fluore cent acce orie included)
•Pannoramic MIDI Ba ic Fluore cence Option – ba e unit completely equipped with AxioCam
camera and HXP 120 illumination unit, trigger cable and filter for fluore cence canning
•Pannoramic MIDI Advanced Fluore cence Option – ba e unit completely equipped with
pco.edge 4.2 camera and Lumencor fluore cence illumination unit, trigger cable and filter
for fluore cence canning
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Pannoramic MIDI 1.18.1 User’s Guide 1 Product Description
•Pannoramic MIDI Ba ic Mixed Option – ba e unit completely equipped with Stingray or CIS
VCC-FC60FR19CL camera for Brightfield canning; with AxioCam camera and HXP 120
illumination unit, trigger cable and filter for fluore cence canning
•Pannoramic MIDI Advanced Mixed Option – ba e unit completely equipped with CIS VCC-
FC60FR19CL camera for Brightfield canning, and with pco.edge 4.2 camera and Lumencor
fluore cence illumination unit, trigger cable and filter for fluore cence canning
NOTE: If Lumencor light ource i ordered, the cu tom light ource and filter module can
be variable. For more information, contact 3DHISTECH cu tomer ervice.
Objectives
•Carl Zei Plan-Apochromat 20×/NA 0.8
•Carl Zei Plan-Apochromat 40× Corr/NA 0.95
Warning!
Do not change correction collar etting on 40×/NA objective, if you need it to be
et, contact cu tomer ervice.
luorescent Option for Pannoramic MIDI
luorescent illumination unit Description
HXP 120 Fluore cent illumination unit
(can be u ed with AxioCam MRm Rev3
and Stingray camera only)
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