AB Sciex 4000 Series Technical manual

AB SCIEX 4000 Series of Instruments
Site Planning Guide
June 2014RUO-IDV-01-0563-A | D5040008 A

This document is provided to customers who have purchased AB Sciex equipment to use in the operation of such AB Sciex
equipment. This document is copyright protected and any reproduction of this document or any part of this document is
strictly prohibited, except as AB Sciex may authorize in writing.
Software that may be described in this document is furnished under a license agreement. It is against the law to copy, modify,
or distribute the software on any medium, except as specifically allowed in the license agreement. Furthermore, the license
agreement may prohibit the software from being disassembled, reverse engineered, or decompiled for any purpose. Warranties
are as stated therein.
Portions of this document may make reference to other manufacturers and/or their products, which may contain parts whose
names are registered as trademarks and/or function as trademarks of their respective owners. Any such use is intended only
to designate those manufacturers' products as supplied by AB Sciex for incorporation into its equipment and does not imply
any right and/or license to use or permit others to use such manufacturers' and/or their product names as trademarks.
AB Sciex warranties are limited to those express warranties provided at the time of sale or license of its products and are
AB Sciex’s sole and exclusive representations, warranties, and obligations. AB Sciex makes no other warranty of any kind
whatsoever, expressed or implied, including without limitation, warranties of merchantability or fitness for a particular
purpose, whether arising from a statute or otherwise in law or from a course of dealing or usage of trade, all of which are
expressly disclaimed, and assumes no responsibility or contingent liability, including indirect or consequential damages, for
any use by the purchaser or for any adverse circumstances arising therefrom.
For research use only. Not for use in diagnostic procedures.
The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners.
AB SCIEX™is being used under license.
©2014 AB Sciex Pte. Ltd.
Printed in Canada.
AB Sciex Pte. Ltd.
Blk 33, #04-06
Marsiling Ind Estate Road 3
Woodlands Central Indus. Estate.
SINGAPORE 739256
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Chapter 1 Customer and FSE Responsibilities...........................................................................................5
Customer Site Planner Responsibilities..............................................................................................................................5
FSE Responsibilities............................................................................................................................................................6
During Installation.......................................................................................................................................................6
Operator Familiarization..............................................................................................................................................6
Technical Support..............................................................................................................................................................7
Chapter 2 Site Planning Checklist..............................................................................................................8
Customer Information........................................................................................................................................................8
Requirements.....................................................................................................................................................................8
Site Layout Requirements............................................................................................................................................8
Electrical Requirements................................................................................................................................................9
Gas Supply Requirements..........................................................................................................................................10
Ventilation and Waste-Collection Requirements........................................................................................................11
Computer and Network Requirements.......................................................................................................................11
Environmental Requirements.....................................................................................................................................12
Mass Spectrometer Bench Requirements...................................................................................................................13
Customer Supplied Solutions and Equipment............................................................................................................13
Additional Site Planning............................................................................................................................................13
Product Familiarization..............................................................................................................................................13
Comments........................................................................................................................................................................14
Exceptions........................................................................................................................................................................14
Signoff.............................................................................................................................................................................14
Appendix A Site Requirements................................................................................................................15
Site Layout Requirements................................................................................................................................................15
Laboratory Layout and Site Clearances......................................................................................................................15
Weights and Dimensions...........................................................................................................................................16
Electrical Requirements....................................................................................................................................................17
Mains Supply Connections.........................................................................................................................................18
Mains Supply Fluctuations.........................................................................................................................................20
Protective Earth Conductor........................................................................................................................................20
Uninterruptible Power Supply or Power Conditioner..................................................................................................20
System Electrical Specifications..................................................................................................................................21
Gas Supply Requirements................................................................................................................................................23
Optional Gas Generators...........................................................................................................................................24
Ventilation and Waste Collection Requirements..............................................................................................................25
Computer and Network Requirements.............................................................................................................................27
Acquisition Computer................................................................................................................................................27
Printer Requirements.................................................................................................................................................27
LAN Connection (Optional)........................................................................................................................................27
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Contents

Environmental Requirements...........................................................................................................................................28
BioSafety Requirements.............................................................................................................................................28
Sound Pressure Level.................................................................................................................................................29
Vibration....................................................................................................................................................................29
Customer Supplied Solutions and Equipment..................................................................................................................30
Appendix B Health and Safety Precautions............................................................................................31
Chemical Precautions.......................................................................................................................................................31
Appendix C Equipment Safety Categories..............................................................................................32
Revision History........................................................................................................................................33
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Contents

This guide is for the site planner, the individual responsible for preparing the facility for the installation of the
AB SCIEX 4000 series systems.
For safety and regulatory information, refer to the Safety Practices Guide, available at www.absciex.com.
Note: If the site preparation tasks are not complete when the AB SCIEX Field Service Employee (FSE) arrives,
then the scheduled installation will be postponed.
Customer Site Planner Responsibilities
Complete the Site Planning Checklist on page 8, in consultation with facilities services personnel (gas,
electrical, ventilation, and IT), and return it to the FSE before the completion date. Refer to Signoff on page
14.
Note: The FSE will follow up if the checklist is not received prior to the scheduled installation date.
•Verify that adequate space and the required shipping facilities are available. Refer to Site Layout
Requirements on page 15.
•Provide all required electrical receptacles. Refer to Electrical Requirements on page 17.
•Provide all required regulators, shut off valves, and gases. Refer to Gas Supply Requirements on page
23.
•Provide and install all required vents and ventilation devices. Refer to Ventilation and Waste Collection
Requirements on page 25.
•Provide a printer and (optional) active, tested LAN connection. Refer to Computer and Network
Requirements on page 27.
•Verify that the requirements for the operating environment are met. Refer to Environmental Requirements
on page 28.
•Provide all required solutions and laboratory equipment, including all fittings, and sample tubing for the liquid
chromatography (LC) equipment, unless purchased from AB SCIEX. Refer to Customer Supplied Solutions
and Equipment on page 30.
CAUTION: Potential System Damage: Do not unpack the mass spectrometer crate or
computer boxes. The FSE will unpack and move the mass spectrometer at the time of
the installation.
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Customer and FSE Responsibilities

•When the shipment arrives, inspect the packaging for damage and contact AB SCIEX Customer Service or the
local FSE to schedule the installation.
•If available (or applicable), identify a qualified maintenance person (QMP) who is suitably aware of the electrical
and chemical risks associated with servicing laboratory equipment. The FSE will review the Qualified
Maintenance Person Guide with this person during the installation.
FSE Responsibilities
•Review the checklist and discuss outstanding issues with the site planner.
•Supply all fittings, plugs, and cables required to connect the mass spectrometer to the electrical receptacles
and regulators. Electrical receptacles must be within the maximum distances described in this document.
•Assemble and set up any optional AB SCIEX benches ordered with the mass spectrometer.
•Unpack and set up the mass spectrometer and acquisition computer.
•Unpack and set up optional LC equipment sold and supported by AB SCIEX. Integrate other supported LC
equipment.
•Unpack and set up optional gas generator equipment sold by AB SCIEX.
•Test and qualify the system to the specifications in the Installation Guide.
During Installation
The FSE unpacks the system (with assistance from people at your site), sets up the system, and then confirms its
operation. When the system reaches proper vacuum, the FSE conducts system performance tests.
Note: It takes several days for the FSE to set up the system and confirm operation.
Operator Familiarization
During installation, the FSE provides a system and software overview, reviews data, and provides some basic
operator familiarization. Training for auxiliary equipment supplied by other manufacturers is not provided by the
FSE.
Note: Online training is available at www.absciex.com/training.
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Customer and FSE Responsibilities

Technical Support
AB SCIEX and its representatives maintain a staff of fully-trained service and technical specialists located throughout
the world. They can answer questions about the system or any technical issues that might arise. For more
information, visit the Web site at www.absciex.com.
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Customer and FSE Responsibilities

Customer Information
Organization
Address
Zip/Postal code
Telephone
FaxSite planner contact
name
E-mail address
Requirements
Site Layout Requirements
Refer to Site Layout Requirements on page 15.
CompleteRequirement
The measured building clearances can accommodate the equipment and crate dimensions.
If the requirements cannot be met, then contact the FSE.
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2
Site Planning Checklist

Electrical Requirements
Refer to Electrical Requirements on page 17.
N/ACompleteRequirement
Installation of electrical supplies and fixtures complies with local regulations and safety
standards.
One branch circuit is provided for the mass spectrometer. The mains supply outlet is less
than 1.6 m (63 inches) from the mass spectrometer. One outlet is required. The outlet is
accessible so that the mass spectrometer can be disconnected in an emergency.
One branch circuit is provided for the roughing pump. The mains supply outlet for the
roughing pump is less than 1.6 m (63 inches) from the roughing pump. One outlet is required.
(Optional) One branch circuit with one or more outlets is provided for a gas generator, if
required. Contact the manufacturer of the gas generator for more information.
One branch circuit is provided for the acquisition computer, monitor, and options such as
the mass spectrometer bench. At least two outlets are required, for the acquisition computer
and monitor.
For LC equipment and other options, contact the manufacturer for more information.
The AC mains supply voltage source does not fluctuate more than ±5% from the nominal
voltage.
Note: Peripheral devices might have different mains supply fluctuation limits. Confirm
the mains supply fluctuation limit with the vendor of each peripheral device that will be
used with the mass spectrometer.
If the voltage is not in the recommended range, a Line Adjustment Transformer (PN WC04179)
is available.
The mains supply includes a correctly installed protective earth conductor.
(Optional) A customer-supplied UPS or power conditioner is provided for the system. The
UPS or power conditioner must deliver 207 VAC to 242 VAC, 50 Hz or 60 Hz, 3200 VA
(minimum). Refer to Uninterruptible Power Supply or Power Conditioner on
page 20.
A qualified electrician has determined the appropriate AC mains supply configuration based
on the system electrical specifications found in System Electrical Specifications on
page 21.
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Site Planning Checklist

Electrical Requirements (North America)
Refer to Electrical Requirements on page 17.
N/ACompleteRequirement
Branch circuits for the mass spectrometer and roughing pump are 15 A, 207 VAC to 240
VAC (220 VAC typical), 50 Hz or 60 Hz. Receptacles for these branch circuits are equipped
with CSA/NEMA 6-15R straight-blade receptacles.
The branch circuit for the computer, monitor, and options is 15 A 100 VAC to 240 VAC (120
VAC typical), 50 Hz or 60 Hz.
For requirements for LC equipment, contact the manufacturer.
Gas Supply Requirements
Refer to Gas Supply Requirements on page 23.
N/ACompleteRequirement
Installation of gas supplies and connections complies with local regulations and safety
standards.
Gas 1/Gas 2 is available:
•Zero-grade air or an AB SCIEX-recommended gas generator
•Delivery pressure of 100 psi (6.89 bar) to 105 (7.25 bar) psi with flows up to 22 L/min
Curtain GasTM supply and CAD gas supply is available:
•UHP nitrogen (99.999%) or an AB SCIEX-recommended gas generator
•Delivery pressure of 55 psi (3.79 bar) to 60 psi (4.14 bar) with flows up to 5 L/min for
API 4000TM systems or 6 L/min for 4000 QTRAP®systems
Source exhaust gas is available:
•Clean, dry, and oil-free air or UHP nitrogen (99.999%) or an AB SCIEX-recommended
gas generator
•Delivery pressure of 55 psi (3.79 bar) to 60 psi (4.14 bar) with flows up to 6 L/min
(Optional) If an AB SCIEX-recommended gas generator or mass spectrometer bench is used,
then a supply of compressed oil-free air is provided, with a delivery pressure of 120 psi (8.3
bar).
(Optional) If a gas generator without a compressor is used, then a supply of compressed
oil-free air is provided. Contact the manufacturer for more information.
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Site Planning Checklist

Ventilation and Waste-Collection Requirements
Refer to Ventilation and Waste Collection Requirements on page 25.
CompleteRequirement
Installation of plumbing and ventilation fixtures complies with local biohazard regulations and
safety standards.
Ventilation of the laboratory environment in which the mass spectrometer will be used complies
with local regulations and the air exchange rate is appropriate for the work performed.
A negative flow vent is provided with a total flow rate capacity of 283 L/min (10 cfm), as measured
at the inlet to the laboratory ventilation system.
A smooth fitting is provided for the roughing pump, with an outside diameter (o.d.) of 3.2 cm
(1.25 inches). The vent is within 1.5 m (60 inches) of the exhaust port on the roughing pump and
at least 1 m (40 inches) above the floor.
A fitting is provided for the source exhaust drain bottle with an o.d. of 1.3 cm (0.5 inch). The vent
is within 1.5 m (60 inches) of the source exhaust drain bottle.
Computer and Network Requirements
Refer to Computer and Network Requirements on page 27.
N/ACompleteRequirement
A table is provided for the data acquisition workstation, located within 3 m (120 inches) of
the mass spectrometer.
A computer name and password are available.
(Optional) A network or IT specialist is available to install the security software while the
FSE is present.
A network printer or a dedicated printer and necessary print drivers are available.
(Optional) An active, tested LAN connection is available.
(Optional) The computer name and password supplied are a network computer name and
domain password.
(Optional) A network or IT specialist is available to connect the computer to the company
LAN while the FSE is present.
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Site Planning Checklist

Environmental Requirements
Refer to Environmental Requirements on page 28.
N/ACompleteRequirement
An ambient temperature of 15°C to 30°C (59°F to 86°F) is maintained.
Over time, the temperature remains within a range of 4°C (7.2°F), with the rate of the
change in temperature not exceeding 2°C (3.6°F) per hour. Ambient temperature fluctuations
exceeding the limits might result in mass shifts in spectra.
Note: Peripheral devices might have different operating environment requirements.
Confirm the operating environment requirements with the vendor of each peripheral device
that will be used with the system.
Relative humidity is 35% to 50%, non-condensing.
Air conditioning provides a minimum of 8700 Btu/hr (mass spectrometer and roughing pump
only).
BioSafety Requirements
Refer to BioSafety Requirements on page 28.
CompleteRequirement
The site is not designated as BioSafety Level 3 (BSL-3) or BioSafety Level 4 (BSL-4).
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Site Planning Checklist

Mass Spectrometer Bench Requirements
Refer to Site Layout Requirements on page 15.
CompleteRequirement
A moveable or fixed bench meeting physical requirements (dimensions and mass) of the system
as listed in Laboratory Layout and Site Clearances on page 15 is provided for the mass
spectrometer with 1 m (40 inches) of clearance on all sides for service access.
Note: If the bench is moveable, then make sure that it is fixed during normal use.
Customer Supplied Solutions and Equipment
Refer to Customer Supplied Solutions and Equipment on page 30.
CompleteRequirement
All required solutions and bottles are available.
Additional Site Planning
N/ACompleteRequirement
Site planning for optional peripheral devices and software is completed, as required.
Product Familiarization
N/ACompleteRequirement
Go to the AB SCIEX Learning Portal at www.training.absciex.com and click the link to request
an account. When you receive your account information, complete the online learning
modules.
Obtain and review system documentation. Go to www.absciex.com/userguides.
(Optional) A qualified maintenance person (QMP) who is suitably aware of the electrical
and chemical risks associated with servicing laboratory equipment is available for review
of the service procedures with the FSE.
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Site Planning Checklist

Comments
Exceptions
Signoff
Completion date
(yyyy-mm-dd)
Site planner contact name
I acknowledge that all installation requirements, as specified in this document, have been met.
Return date
(yyyy-mm-dd)
FSE name
FSE e-mail
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Site Planning Checklist

Site Layout Requirements
Return to checklist.
Laboratory Layout and Site Clearances
Make sure that the site meets the required building clearances for installation and service access. Refer to Figure
A-1.
Figure A-1 Laboratory Layout
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A
Site Requirements

DescriptionItem
Distance to wall, minimum 1.9 m (76 inches)1
Distance to wall, minimum 1 m (40 inches)2
Mass spectrometer, front (50 cm × 130 cm)3
Distance to roughing pump, 1.8 m (72 inches), allow for slack4
Distance to computer (up to approximately 3 m), allow for slack5
LC system6
Acquisition computer7
Roughing pump8
Weights and Dimensions
Return to checklist.
Consult Table A-1 to Table A-4 for weights and dimensions and make sure that you can move the system to
the installation site. Make sure that the installation site can accommodate the equipment dimensions, weight,
and associated clearance.
Table A-1 Mass Spectrometer
WeightLengthWidthHeightEquipment
136 kg (300 lbs)130 cm (53 inches)50 cm (20 inches)52.5 cm
(21.5 inches)
Mass spectrometer
218 kg (480 lbs)161 cm (63 inches)72 cm (28 inches)104 cm
(41 inches)
Shipping crate (including
mass spectrometer)
Table A-2 Roughing Pump
WeightLengthWidthHeightEquipment
33 kg (73 lbs)42 cm (16.5 inches)30 cm (11.8 inches)23 cm (9 inches)Roughing pump (wet
pump)
48 kg (106 lbs)48 cm (18.9 inches)33 cm (13 inches)40 cm
(15.7 inches)
Roughing pump (dry
pump)
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Site Requirements

Table A-3 Acquisition Computer
WeightLengthWidthHeightEquipment
7.6 kg (16.8 lbs)6.8 cm (3 inches)57.4 cm (22.5 inches)38.6 cm
(15 inches)
Dell OptiPlex 9010
5.1 kg (11.25 lbs)18.2 cm (7.25 inches)37.2 cm (15 inches)46.36 cm
(18.5 inches)
Monitor
The acquisition computer and monitor are included in the Accessories box.Shipping weight
Table A-4 Other
WeightLengthWidthHeightEquipment
87 kg (192 lbs)75 cm (30 inches)150 cm (59 inches)80 cm
(32 inches)
Bench (optional)
15 kg (33 lbs)28 cm (11 inches)20 cm (8 inches)20 cm (8 inches)Line Adjustment
Transformer (optional)
Refer to the documentation for the gas generator system.Gas generator (optional)
Electrical Requirements
Return to checklist.
WARNING! Electrical Shock Hazard: Use only qualified personnel for the installation
of all electrical supplies and fixtures, and make sure that all installations adhere to
local regulations and safety standards.
The total combined system (mass spectrometer and roughing pump) power consumption is 3200 VA (50 Hz or 60
Hz) at 230 VAC.
A Line Adjustment Transformer (PN WC04179) is required if the voltage is not in the recommended range (207
VAC to 242 VAC), but it is not less than 188 VAC or greater than 250 VAC.
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Site Requirements

Mains Supply Connections
Return to checklist.
WARNING! Electrical Shock Hazard: Make sure that the mass spectrometer can be
disconnected from the AC mains supply outlet in an emergency. Do not block the
AC mains supply outlet.
Provide a minimum of three branch circuits. Refer to Figure A-2.
•One branch circuit for the mass spectrometer.
•One branch circuit for the roughing pump.
•(Optional) One branch circuit with one or more outlets for the optional standalone gas generator. Contact the
manufacturer of the gas generator for more information.
•One branch circuit for the acquisition computer, monitor,and printer.
For electrical requirements for AB SCIEX-supplied components, refer to System Electrical Specifications on
page 21. For other components, contact the manufacturer.
Note: Use receptacles that comply with local standards. Receptacles shown in Figure A-2 are representations
only.
Figure A-2 Branch Circuit Configuration
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Site Requirements

DescriptionItem
Branch circuit for the mass spectrometer. One outlet is required. It must be within 1.6 m
(63 inches) of the mass spectrometer.
1
Branch circuit for the roughing pump. One outlet is required. It must be within 1.6 m (63 inches)
of the roughing pump. The optional mass spectrometer bench can be connected to this branch
circuit.
2
(Optional) One branch circuit with one or more outlets for the optional gas generator. Contact
the manufacturer of the gas generator for more information. The optional mass spectrometer
bench can be connected to this branch circuit.
3
Additional branch circuit for the acquisition computer, monitor, and options, such as the optional
mass spectrometer bench.
4
Note: The optional mass spectrometer bench can be connected to branch circuits 2, 3, or
4.
International Requirements
Return to checklist.
•For installations outside of North America, use locally approved standard connections and cables.
North American Requirements
Return to checklist.
•Branch circuits for the mass spectrometer and roughing pump (branch circuits 1 and 2 in Figure A-2 on
page 18) must be 15 A 207 VAC to 242 VAC (typical 220 VAC), 50 Hz or 60 Hz. Receptacles are equipped
with CSA/NEMA 6-15R straight-blade receptacles. Refer to Figure A-3 on page 20.
•One branch circuit with one or more outlets might be required for the optional gas generator (branch circuit
3 in Figure A-2 on page 18). Refer to the manufacturer’s documentation for the branch circuits and
receptacles required if a gas generator is used.
•The branch circuit for the acquisition computer and monitor (branch circuit 4 in Figure A-2 on page 18)
can be 15 A 120 VAC.
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Site Requirements

Figure A-3 Duplex Receptacle and Plug
Mains Supply Fluctuations
Return to checklist.
In areas where the mains supply is subject to voltage fluctuations exceeding 5% of the nominal value (200 VAC
to 240 VAC), a power conditioner is required. High or low voltages can adversely affect the electronic components
of the mass spectrometer. Refer to Uninterruptible Power Supply or Power Conditioner on page
20.
Note: Peripheral devices might have different mains supply fluctuation limits. Confirm the mains supply fluctuation
limit with the vendor of each peripheral device that will be used with the mass spectrometer.
Protective Earth Conductor
Return to checklist.
WARNING! Electrical Shock Hazard: Do not intentionally interrupt the protective
earth conductor. Any interruption of the protective earth conductor is likely to make
the installation dangerous.
The mains supply must include a correctly installed protective earth conductor that must be installed or checked
by a qualified electrician before connecting the mass spectrometer.
Uninterruptible Power Supply or Power Conditioner
Return to checklist.
Use a pure sine-wave uninterruptible power supply (UPS) or power conditioner to maintain the system supply
(mass spectrometer, computer, monitor, and roughing pump) during power outages.
If the system is powered by a UPS or power conditioner, then it must meet the following specifications.
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Site Requirements