Andrew Alliance Waters Andrew+ User manual

Andrew+
User Manual

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©2011-2021 All Rights Reserved. Andrew Alliance - A Waters Company.

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Instruction icons........................................................................................................................................................................... 4
Trademarks .................................................................................................................................................................................. 4
Abbreviations used ...................................................................................................................................................................... 5
Glossary........................................................................................................................................................................................ 5
Delivery package .......................................................................................................................................................................... 6
Introduction........................................................................................................................................................................ 6
1.1. Unit description ....................................................................................................................................................... 6
1.2. Safety precautions and warnings............................................................................................................................ 7
1.3. Symbols.................................................................................................................................................................... 9
Overview of the hardware ................................................................................................................................................. 9
Technical specifications.................................................................................................................................................... 10
Working area of Andrew+ ................................................................................................................................................ 11
Unpacking Andrew+ ......................................................................................................................................................... 12
5.1. Andrew+ is delivered fully assembled and requires no tools for the following steps. ....................................... 12
Connect Andrew+ to OneLab........................................................................................................................................... 13
Andrew+ tools .................................................................................................................................................................. 14
7.1. Single-channel and multi-channel electronic pipettes......................................................................................... 14
7.1.A. How to equip an Andrew Alliance pipette with a pipette adaptor ....................................................................... 15
7.1.B. How to install Andrew Alliance pipettes on the Andrew+ stand .......................................................................... 18
7.2. Labware gripper .................................................................................................................................................... 19
7.3. Liquid level detector .............................................................................................................................................. 19
Dominos ........................................................................................................................................................................... 20
8.1. Waste ..................................................................................................................................................................... 20
How to install the Waste Domino .................................................................................................................................... 21
8.2. Tip box Domino ..................................................................................................................................................... 21
8.2.A. Tip box Domino based on TIS technology............................................................................................................. 21
8.2.B. Tip rack holder Domino for 5mL and 10mL tips ................................................................................................... 21
8.2.C. Installation of the tip rack ...................................................................................................................................... 22
External tool docking station ........................................................................................................................................... 22
Liquid handling operations........................................................................................................................................ 23
10.1. Volumes in consumables ...................................................................................................................................... 23
How to use Andrew+.................................................................................................................................................. 23
Maintenance............................................................................................................................................................... 26
12.1. General information.............................................................................................................................................. 26
12.1.A. Recommended maintenance if Andrew+ is moved............................................................................................ 26
12.2. Compatible solvents with Andrew+ ...................................................................................................................... 27
Unit end of life............................................................................................................................................................ 27
Certification ................................................................................................................................................................ 27
Contacts...................................................................................................................................................................... 28
15.1. How to contact Andrew Alliance support team.................................................................................................... 28
15.2. Andrew Alliance contacts/locations ...................................................................................................................... 28

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About this manual
This user manual is specially designed to detail the device’s functions and features.
•Please read this manual before using the device to ensure proper use and safety
•Please view this manual as part of the product and keep it somewhere easily
accessible
•Ensure adequate material resistance when using chemical substances
•Descriptions are based on the default setting of the device
•Images and screenshots may differ in appearance from the actual product
•Content may differ from the final product, or from software provided by service
providers or carriers, and is subject to change without prior notice
•Andrew Alliance is not liable for performance issues or incompatibilities caused
by misuse of this device
Instruction icons
DANGER
Situation that
could cause
injury to yourself
and others
DANGER
Radiation with
potential for risk
to health or
death as a
consequence
DANGER
Biohazard with
potential for risk
to health or
death as a
consequence
CAUTION
Situation that
could cause
damage to your
device or other
equipment
NOTE
Notes, usage
tips, or
additional
information
Trademarks
•Andrew Alliance and Andrew Alliance logo are registered trademarks of Andrew
Alliance S.A.
•2011, Andrew Alliance S.A., All rights reserved. Duplication or distribution without
written permission is prohibited. Andrew Alliance S.A. reserves the right to revise
this manual. Issue August 2018.
•Registered trademarks are not marked in all cases with ™ or ® in this manual
Andrew Alliance S.A.
Chemin Grenet 21
1214 Vernier (Genève)
Switzerland

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Abbreviations used
MCP
Microplate
LH
Liquid handling
DWP
Deepwell plate
BSL
Biosafety level
PIPETTE ADAPTOR
Magnetic interface device adaptor
AA PIPETTE
Andrew Alliance electronic pipette
OLM
Optical localization module
LLD
Liquid level detector
TIS
Tip insertion system
ROW
Rest of the world
Glossary
Tool
Device which can be automatically handled by Andrew+ robot. Some
tools may require an adaptor (e.g. PIPETTE ADAPTOR) as interface to
allow the manipulation
Tool stand
Part of Andrew+ Robot designed to host up to 4 tools. The tool stand is
the right arm of Andrew+ and allows both charging and wireless
communication with the tools
Docking
stations
Optional component used by Andrew+ to host additional tools for
experiments which require more than 4 tools or tools which cannot be
installed on the Andrew+’s tool stand
Pipette+
Smart pipette stand+ with cloud connectivity capable of wirelessly
control ling Andrew Alliance electronic pipettes

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Delivery package
QUANTITY
PART NUMBER
DESCRIPTION
1
718.8000
Andrew+ robot
1
718.5131
Power supply
1
718.5871
Ethernet cable
1
218.1301
Waste Domino
Introduction
This paragraph describes the small number of steps that should be followed in order to
have your Andrew+ unit operational in less than 5 minutes.
1.1. Unit description
Andrew+ is a laboratory benchtop robot able to execute experiments according to
protocols described by a user through its software: OneLab™.
Andrew+ is capable of handling a variety of laboratory tools which are automatically
used by the system. Examples of such tools are:
•Andrew Alliance electronic pipettes
•Labware gripper
•Liquid level detector
Laboratory conventional consumables required to execute experiments are arranged
into in a magnetic-based modular system called Dominos. Using its camera, Andrew+
can localize and identify the consumables present in its working area. It stands on a
base which has a dual functionality, namely, avoiding involuntary movement of the
robot arm, and hosting the Optical Location Module (OLM) with which it can measure
the length of the pipettes and tips. The right arm of Andrew+, referred to as the ‘tool
stand’ can hold up to a maximum of 4 tools. Their manipulation does not require any
user intervention. Your consumables should be placed in appropriate Dominos, located
within the Andrew+ workspace, so that Andrew+ can identify them. Depending on your
protocol, you can have 2 Dominos for a small experiment and up to 11 Dominos,
compatible with multi-channel pipettes, for a more complex one. Andrew+ is made for
research and development, industrial laboratories and routine work, with applications
limited but not restricted to life sciences, biotechnology, chemistry, clinical research and
diagnostic.

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1.2. Safety precautions and warnings
For safe and correct use of Andrew+, it is recommended that both operating and service
personnel follow the instructions contained in this guide when installing, using, cleaning,
and maintaining this instrument. If the instructions described in this manual are not
carefully followed, Andrew+ cannot function correctly and the warranty will be null and
void.
DANGER:
Potential injuries
The potential exists for bodily harm if you interfere with the work area of the
instrument while it is running.
•DO NOT put any part of your body into the working area of Andrew+ when it is
moving.
•DO NOT put hands or fingers into this area when Andrew+ is gripping or releasing
a tool.
•DO NOT put hands or fingers inside the vertical movement compartment of
Andrew+.
Consumables can be moved only when Andrew+ is switched off or when its arm is
folded back into the idle position. The hand should be close to the shoulder.
•The laboratory tools compatible with Andrew+ can be removed or placed on the
tool stand only when Andrew+ is in the idle position.
•DO NOT stay close to the arm when it is opening.
•DO NOT place anything inside the Optical Location Module aperture.
•DO NOT try to manually open the aperture of the Optical Location Module.
•DO NOT place your fingers in front of the light or in front of the camera located on
the underside of the hand of Andrew+.

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Use of biohazardous
and radioactive substances
If Andrew+ is potentially biohazardous due to the use of biohazardous substances, it
should be prominently marked with the following symbol:
At a minimum, a biohazard symbol should be placed near the sampling area and visible
during NORMAL USE.
Any part of the equipment that contains biohazardous waste material which can be
removed from the equipment during NORMAL USE, or a biohazardous drain connection,
should be marked with an appropriate biohazard symbol.
Be aware that Andrew Alliance S.A.:
Will only accept an Andrew+ for repair or return (from loan) r if the instrument has
both been removed from and fully decontaminated from Biological substances,
and that the appropriate Decontamination Form has been correctly completed
and sent to Andrew Alliance Service & Support at [e-mail]
Entry into your Biosafety level (BSL) 4 by Andrew Alliance personnel, or its
representatives, is not permitted under any circumstances.
Entry into your BSL 3 is permitted and Services provided, with appropriate
confidentiality, when you can justify that removal of the Product from your
location is not feasible. In this instance, you must provide evidence of
decontamination, when asked, for Products that require Service. You must
provide a list of recommended inoculations available against the bio-hazardous
materials used, providing information about hazards in the location, instructions
for safe entry into the location, instructions in the event of a fire, exposure or spill
and other potential emergencies, ensuring the provision of appropriate safety
equipment that is in appropriate working order, and with full guidance for use.
Waivers are not signed before entry or visit to any bio-hazardous area at your location.
Andrew Alliance retains the right to refuse Services until the above requirements are met
to the complete satisfaction of company employees who have been trained to expect
appropriate safety standards.

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1.3. Symbols
Advice to be aware and to be careful about!
These symbols point out a potential danger for users and/or damage to Andrew+ if
they are not followed. When this symbol is visible, it is mandatory to carefully read
the User Manual before taking any action or using the system.
Overview of the hardware

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Technical specifications
TECHNICAL SPECIFICATION
DEFINITION
Warranty
1 year
Power requirement
Voltage range 90~264 VAC, AC current 1.85A/115VAC,
1.0A/230VAC, Frequency 47~63Hz, inrush current (max)
120A/230VAC
Electrical configuration
Andrew+ should be connected exclusively with the power
supply GSM160B24-R7B and electrical cable supplied with the
instrument
Interfaces
•Wi-fi (2.4 GHz / 5 GHz)
•Ethernet connection (1Gigabit)
Operating temperature
4°C-37°C
Imaging system
Hand:
•High resolution camera equipped with white LED light
OLM:
•High resolution camera equipped with low power white
LED and class II red laser (wavelength = 650 nm)
Operating humidity
Maximum relative humidity 80% for temperatures up to 37°
C.
Altitude
Up to 2000 m above mean sea level
Safe operating conditions for
the system
•Fluctuation of the supply voltage up to 10% of the rated
voltage
•Transient overvoltage
Degree of protection
IP 20
Required personal
computer characteristics
Tablet or computer equipped with Internet browser and
network capability.
Dimensions
Dimension with both arms folded:
53.5 cm (H) x 43 cm (W) x 45.5 cm (L)
Weight
16 kg (only the robot)
Audio
Integrated audio system (nominal power = 1.5 W)
Additional external power
interfaces
•Connection with docking station (1A @ 24 V)
•4 tool slots embedded in the tool stand (500mA @ 7.5 V)
Working space
Domino self-assembling configuration dynamically set-up on
a conventional bench space, allowing operations on an
arbitrary set of Dominos from 1 up to 11 elements
compatible with multi-channel pipettes - according to
available space and experiment requirements.