Argonaut Technologies QUEST GASEOUS REACTION AND CONCENTRATION... User manual

Artisan Technology Group is your source for quality
new and certied-used/pre-owned equipment
• FAST SHIPPING AND
DELIVERY
• TENS OF THOUSANDS OF
IN-STOCK ITEMS
• EQUIPMENT DEMOS
• HUNDREDS OF
MANUFACTURERS
SUPPORTED
• LEASING/MONTHLY
RENTALS
• ITAR CERTIFIED
SECURE ASSET SOLUTIONS
SERVICE CENTER REPAIRS
Experienced engineers and technicians on staff
at our full-service, in-house repair center
WE BUY USED EQUIPMENT
Sell your excess, underutilized, and idle used equipment
We also offer credit for buy-backs and trade-ins
www.artisantg.com/WeBuyEquipment
REMOTE INSPECTION
Remotely inspect equipment before purchasing with
our interactive website at www.instraview.com
LOOKING FOR MORE INFORMATION?
Visit us on the web at www.artisantg.com for more
information on price quotations, drivers, technical
specications, manuals, and documentation
Contact us: (888) 88-SOURCE | [e-mail] | www.artisantg.com
SM
View
Instra

QUEST GASEOUS
REACTION AND
CONCENTRATION
MANIFOLD
PN 103952
Rev 1.0
28 October 1999
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Quest" Gaseous Reaction & Concentration Manifold - User Manual
Part Number 103952
Revision 1.0 28 October 1999
Copyright
0 1999 by Argonaut Technologies
All rights reserved.
Argonaut Technologies
887 Industrial Rd., Suite
G
San Carlos, CA 94070
Printed in the United States.
The information in this document has been carefully checked and is
believed to be entirely reliable. However, no responsibility is assumed for
inaccuracies. Statements in this document are not intended to create any
warranty, expressed or implied. Argonaut reserves the right to make
changes in any products herein to improve reliability, function, or design.
Argonaut does not assume any liability arising out of the application or use
of any product described herein; neither does it convey any license under
its patent rights nor the rights of others. Inclusion in this document does not
imply that any particular feature is standard on the instrument. The
information in this document is subject to change at any time.
Quest and writare registered trademarks of Argonaut Technologies, Inc.
Teflon is a registered trademark of DuPont. Tygon is a registered trademark
of Norton Performance Plastics. Other product names in this document are
registered trademarks or trademarks of their respective holders.
GRCM - User .Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Limited Warranty
All individual instrument parts, consumables and the like are subject to the
provisions of the Seller Limited Ninety (90) Days Warranty as outlined
below. Resin consumable products or the like are only warranted to
conform to the quantity and content stated on the label at the time of
delivery. All instrument system products are provided subject to the
provisions of the SELLER Limited One
(1) Year Warranty, a copy of which
is available to Buyer and which is incorporated herein in its entirety by this
reference.
SELLER'S LIMITED NINETY (90) DAYS WARRANTY IS
EXCLUSIVE AND IN LIEU OFALL OTHER WARRANTIES, AND
SELLER MAKES NO OTHER WARRANTIES, EXPRESS OR
IMPLIED, EITHER IN FACT OR BY OPERATION OFLAW,
STATUTORY OR OTHERWISE, AND SELLER EXPRESSLY
EXCLUDES AND DISCLAIMS ANY WARRANTY OF
MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.
Limitation of Liability
Buyer agrees that SELLER'S liability to Buyer in any way connected with
the sale and/or license of products or services to Buyer, regardless of the
form of action, shall in no event exceed the price paid by Buyer for such
products or services. Under no circumstances will SELLER be liable for
any damages resulting from SELLER'S failure to meet any delivery
schedule, even if SELLER has been advised of the possibility of such
damages. IN NO EVENT WILL SELLER BE LIABLE FOR COSTS OF
PROCUREMENT OFSUBSTITUTEPRODUCTS OR SERVICES, LOST
PROFITS, OR ANY SPECIAL INDIRECT, CONSEQUENTIAL OR
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

INCIDENTAL DAMAGES, HOWEVER CAUSED AND ON ANY
THEORY OFLIABILITY, ARISING IN ANY WAY OUT OFTHE SALE
AND/OR LICENSE OFPRODUCTS OR SERVICES TO BUYER. THIS
LIMITATION SHALLAPPLY EVEN IF SELLER HAS BEEN ADVISED
OFTHE POSSIBILITY OFSUCH DAMAGES AND
NOTWITHSTANDING ANY FAILURE OF ESSENTIAL PURPOSE OF
ANY LIMITED REMEDY.
Exclusions
This limited warranty covers normal use. Exclusions from this limited
warranty may
include:
Servicing or modification by anyone other than a qualified Argonaut
Technologies Service Representative;
Non-conformance to recommended instrument operating procedures as
noted throughout this manual;
Failure to perform routine preventative maintenance;
Any natural disaster, including earthquake, lightning, tornado, flood, or
fire; electrical surges or the use of improper power sources.
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Warranty
Argonaut Warranty Agreement
Limited Warranty
Limitation of Liability
Exclusions
Contents
Introduction
Overview
Interference Information
Year
2000 Software and Firmware Compliance
Safety
User Attention Words
Warning Labels
System Safety
Safety Equipment
Operating Environment
RV Sealing Capabilities
Material Safety Data Sheets (MSDS)
GRCM Installation
List Of Parts
Components and Parts Supplied by Argonaut
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Parts Supplied by User
Overview
Installation Steps
Control Box
Gas Delivery Manifold
Solvent Trap Manifold
Expansion Kit
Gas Delivery Manifold
Solvent Trap Manifold
4 Usingthe GRCM
Hydrogenation
Concentration By Evaporation
Cleaning the GRCM
Gas Delivery Manifold
Using the Quest
210
Using the Quest ASW
Female Luers on the Quest Lower Manifold
A Service
Contact Information
B List Of Components
Basic GRCM
Expansion Kit
Index
GRCM - User Munuul
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

OVERVIEW
11##1l1#1111#1111111#ll#1~#III#I#IIII##111811#1~~#1#
The QuestTMGaseous Reaction and Concentration Manifold (GRCM) is
designed for use on the Quest 210 SLN organic synthesizer, and on the
standard Quest 210 with the Lower Manifold Luer Upgrade.
The GRCM enables gaseous reactions (e.g., hydrogenation, carbonylation,
etc.) and sparging to be to be carried out. It also enables products to be
concentrated and evaporated directly, simplifying solvent exchanges and
the transition from synthesis to purification.
The GRCM consists of the following components:
Control Box. The control box has two gas inputs,athree positionvalve, a
pressuregauge, and two gas outlets eachwith a needlevalve to regulategas
flow. The gas suppliesfor concentrationand gaseous reactions connect to the
controlbox. The User selects either gas input
1, gas input 2, or closed usingthe
three-way valve. One gas outlet connectsto the gas deliverymanifoldvia 118"
Teflon tubing, and the other isfor usewith an additional gas delivery manifold.
Gas Delivery Manifold. The gas delivery manifoldattachesto the Quest 210
lower manifold luers and delivers gas
to the reactionvessels. The delivery
manifoldhas a gas input, a manifoldtodistributegas to 10reactionvessels, and
10gas outletswithfemale luerswhich matewiththe malehersof the Quest 210
lowermanifold. Each gas outlet has a check-valveto preventits reactionvessel
from draining while allowinggas delivery.
Solvent Trap Manifold. The solvent trap manifoldattaches to the Quest210
uppermanifoldandvents the reactionvessels duringconcentration. The solvent
trap manifoldhas a portfor each reactionvessel, a manifoldto collect theexiting
gas, and an outletwhich connectsto a solventtrap.
The GRCM can be used to concentrate or add a gaseous reagent to a single
bank of ten Quest reaction vessels (10 RVs) and has a maximum operating
pressure of
10 psig (1.69 barr).
An Expansion Kit is available which provides additional delivery and
solvent trap manifolds to expand the number of parallel concentrations and
gaseous reactions to twenty (20 RVs).
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

INTERFERENCE INFORMATION
11111I11111111111111IIII11II1aI1IIIIIII$ImI1IIl111I,
This equipment does not generate or use radio frequency energy.
YEAR 2000 SOFTWARE AND FIRMWARE
COMPLIANCE
11l1Il1I1If1I11II1II1IlII1IIIII1IIIIIIII1II1IIII111I
The Gaseous Reaction and Concentration Manifold has no related software
or firmware.
For a detailed Year 2000 Compliance Report, please contact
the Argonaut Technologies office listed in Appendix A,
"Service."Appendix A:
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

T
his chapter discusses safety issues related to the operation and use
of the Quest Gaseous Reaction and Concentration Manifold
(GRCM)when used in conjunction with a Quest 210
SLN or a
Quest 210 with the Lower Manifold Luer Upgrade. Please read it carefully
before attempting to operate the system.
/F\ Warning!
-
This chapter only discusses safety issues relatedto the
Quest Gaseous Reactionand Concentration Manifold
(GRCM). Users of the GRCM must befamiliar with the
safety issues relatedto the Quest synthesizer equipment
on which it is used.
USER ATTENTION WORDS
1111I11111ln1o11111IIIIIIIIIIIIIIlIItItl1l111l1l111
"User attention words" appear in the text of this manual. Careful attention
to these entries while consulting the user manual will help ensure the safety
of the user and the instrument. Each word implies a particular level of
observation or action described as follows:
Note: This word is used to call attention to information.
A Caution
Thisword informsthe userthatdamagetothe instrument could
occur
if the user does not comply with the information.
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

SAFETY
Warning Labels
A Warning!
This word informsthe users that physical injury or death
could occur to themselves or others if the required
precautions are not taken.
Warning labels are applied to the equipment in specific areas where the
user must observe safety precautions. Following is a list of these labels and
their meanings:
Label
Thissymbolindicatesahot surface.
Use cautionwhen working on or
near locations with this symbol.
Earth ground.
Picture
Caution!
Hot Surface
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

SAFETY '
System Safety .
SYSTEM SAFETY
IIIIIIItIII1IIIBI1I1IIIIEIIIIIIIIIIIIIIIIIlBIIIIIIIl
During operation of the GRCM, hazardous chemicals are stored and
manipulated, heavy objects shake and move, and high voltage electricity is
present. Caution must be exercised by trained personnel at all times.
A Warning!
Failureto usethe GRCM with adequate ventilation may
result in instrument damage and personal injury.
/f\ Caution
Do not heat ReactionVessels above the boiling point of their
contents,and do not coolthe ReactionVessels to the freezing
point
of their contents. Instrumentoperationwill be adversely
affected. Quest software and hardware does not control
temperature based uponthe boiling point andfreezing point of
the contents of reactionvessels.
A Caution
The GRCM is designedto work only with non-corrosive gases
(e.g., hydrogen,etc.). Usingcorrosive gases with the GRCM
will result in instrument damage and personal injury and is not
covered underwarranty.
SAFETY EQUIPMENT
II#I1B1IB1IBIIBIIB1IBIII#IIBlwIIIIIIIIIIIB~IIBlIllIl
The GRCM has been designed to handle chemicals that may be deemed
hazardous, but should only be operated by personnel trained to safely
handle such chemicals. Protective hand and eye equipment should be worn
during instrument operation.
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

We recommend that the following safety equipment be readily available
during instrument operation: fire extinguisher, eye wash station, safety
shower, eye and hand protection, adequate ventilation, and protection from
sources of radiation (e.g. lasers, radioisotopes, contaminated equipment,
radioactive waste).
A Warning!
If the equipment is used in a manner not specified by the
manufacturer,the protection provided
by the equipment
may be impaired.Wear adequateeyeand hand protection
during instrumentoperation.
OPERATING ENVIRONMENT
11111111111111111111111II11I~1I111111111111111111111
The Questm Gaseous Reaction and Concentration Manifold has been
tested and validated in the following operating environments. Argonaut
does not recommend operation of the Questm Gaseous Reaction and
Concentration Manifold in environmental conditions outside these ranges.
I Laboratory Humidity
I <= 70% RH
Operational Requirement
Laboratory Temperature
I Gas Reaction Pressure
I <= 10 psig (1.69 ban)
Specification
18 "C to 30 "C
I Gas Input Pressure / <= 30 psig (3.08 ban)
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

SAFETY '
RV Sealing Capabilities .
RV SEALING CAPABILITIES
111111111111111111111111111~1~11#1111~11111111111111
The GRCM has been tested and validated in the following operational
conditions. Argonaut does not recommend operation of the GRCM in
environmental conditions outside these ranges.
Operational Requirement Specification
Reaction Vessel sealing, with Gas
10 psig (1.69 barr)
Delivery Manifold installed.
MATERIAL SAFETY DATA SHEETS (MSDS)
1111111111111111111111l111111111111111111111111l1111
The MSDS associated with each chemical used with this equipment must
be kept at your facility for easy reference by employees. Adherence to the
safety precautions listed in the MSDS for each of these chemicals is
mandatory for the safe operation of this equipment and for the safety of the
people operating it.
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

GRCM INSTALLATION
T
his chapter describes the Quest Gaseous Reaction and Concentra-
tion Manifold (GRCM) and how it is installed
by the user. Installa-
tion of the Expansion Kit (available separately) is described at the
end of this chapter.
COMPONENTS AND PARTS SUPPLIED BY ARGONAUT
The GRCM consists of the following components:
Control Box - Controls which of the two gas inputs is used and
regulates the gas flow rate from the selected input to the Quest Reaction
Vessels (RVs). A pressure gauge allows the user to monitor the gas
pressure delivered to the gas delivery manifold. (Part number 300678)
Gas Delivery Manifold - This manifold attaches to the reaction vessel
drain hers to allow the delivery of gas to a bank of reaction vessels.
(Part number 300676)
Solvent Trap Manifold - This manifold is inserted into the luer fittings
of the Quest upper manifold to trap gases during solvent evaporation or
concentration. (Part number 300677)
Also included are one of each of the following tubing and fittings required
to attach the GRCM to the reaction gas regulator and the Quest inert gas
supply:
Gas Delivery Manifold Line (part number 300794)
Inert Gas Inlet Line (partnumber 300795)
- Reagent Gas Inlet Line (part number 300796)
GRCM - User Manual
Inert Gas Extension Line (part number 300797)
118 inch "T" (part number 104027)
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Two plugs: for the "T" when the gas manifold is not in use, and for the Gas
Out B port when the Expansion Kit is not in use (part number 100083)
114 inch ID tubing for solvent trapping, 3 feet (part number 103954)
Barbed fitting adapter (114 - 318 inch) for solvent trap (part number 103669)
I
I
Figure 1: GRCM - Three Main Components
PARTSSUPPLIED BY USER
The user must provide the following items:
An external gas tank for gaseous reagents, with a 0-30 psig
(1.01-3.08 barr) regulator to control the input pressure.
Nitrogen gas for sparging. A house-supply is preferred.
A solvent recovery condensor. Suggested parts forthe solvent condensor
(available from ChemGlass):
- 2-Neck 24140 round-bottom flask (CG-1520-04)
- Dewar type condenser (CG-1290-A-26)
- Innerjoint 24/40 Adapter (CG-1014-01)
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

GRCM INSTALLATION '
Overview
,A Caution
Donotusecorrosivegases, e.g., hydrogenchloride, ammonia,
or ozonewith the GRCM. Using corrosive gases will damage
the GRCMandvoid the warranty.
OVERVIEW
11111111l11111l1111IIIIlIIII1IIIIIIIIIIslllItlllllll
The Control Box fits neatly on the top of the Quest controller. It must
be placed within four feet of the external reagent gas tank, and within four
feet of the Quest
210 Reactor.
The control box has two gas inputs:
Input 1 is the inert gas input which connects to the Quest controller
using the supplied "T" and Teflonmtubing.
Input 2 is the reagent gas input which connects to a user-provided
regulator. We recommend using a regulator designed for low pressure,
allowing no more than
30 psig (3.08 barr) for reagent gases.
The Gas Delivery Manifold is installed onto the lower manifold
hers of the Quest reactor and receives gas from the GRCM Control box.
The Solvent Trap Manifold is installed onto the upper manifold of
the Quest reactor. It combines the gas used for product concentration from
each reaction vessel and diverts it to the Solvent Trap Manifold outlet for
trapping and reclaiming.
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

INSTALLATION STEPS
11111111111l11111111IIIIIIIIIIDIIDII1III#atl1ll1l111
Control Box
7 GRCM Control Box
I Quest 210 I
Installation
Outlets
UmbilicalLine 3
Inert Gas ExtensionLine
Part Number300796
Figure 2: GRCM Control Box Installation
1. On the front of the Quest controller, locatethe ports for the five 118 inch
Teflon linesfrom the Reactor Umbilical.
2. Removethe line from port #3 by unscrewingthe 118 inch PEEK fitting.
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

GRCM INSTALLATION '
Installation Steps ,
3. Attachthe endof that linetoside B of the "T" (Part number101955)and
make itfinger-tight.
4. lnsertoneendof the lnertGas Extension Line(Part number 300797)into
side
A of the "T" and makefinger-tight. lnsert the other end of the lineinto
port #3 of the Questcontroller and makefinger-tight.
5. Attachoneendof the lnertGas InletLine(Part number300795)toside C of
the
"T". Connectthe other endto input1of the GRCM Control box. See
Figure3 below.
6. lnsert the 118 inch PEEK fitting of the reagentgas inlet line(Part number
300796)to input
#2 of the Control box and makefinger-tight. Connectthe
compressionfitting onthe other end of this Teflon tubingtothe outlet of
the reagentgas regulator.Do notsetthe regulatorabove30 psig(3.08 barr).
See Figure3 below.
Figure
3: Control Box showing Gas Connections 1 and 2
GRCM - User Manual
Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com