Avacen HOME XL User manual

User Guide
Models AVACEN HOME XL,
AVACEN R3 HOME XL
Caution: Please read the entire user guide with care prior to using the device.
AVACEN is a Registered Trademark of AVACEN Medical, Inc.
Protected by one or more of the following U.S. patents: 8,679,170; 9,066,781; 9,192,509;
9,687,385; 10,537,464; and international equivalents. Other patents pending.
AVACEN Medical
2365 Camino Vida Roble, Suite C
Carlsbad, CA 92011
(888) 4-AVACEN (888-428-2236)
www.AVACEN.com
QUICK START GUIDE IS ON BACK COVER

Touchscreen/
Color Graphics Display (CGD)
Inflatable Cuff
Metal
Heat Pad
Pressure Holes
Power Supply Connector
Hand Positioning Tips: KEEP WRIST STRAIGHT AND IN THE CENTER OF THE CUFF!
POSITION WRIST
IN MIDDLE OF CUFF
PARALLEL
WITH CHAMBER
CORRECT
CORRECT
INCORRECT
INCORRECT
Sanitary Mitt
Metal
Heat Pad
Inflatable Cuff
POSITION WRIST
IN MIDDLE OF CUFF
PARALLEL
WITH CHAMBER
AVACEN HOME XL Device
Diagram

Table of Contents
1. DESCRIPTION....................................................................................................................... 1
2. UNPACKING THE UNIT ........................................................................................................ 1
3. NORMAL USE ...................................................................................................................... 1
4. INDICATIONS FOR USE ........................................................................................................ 1
5. CONTRAINDICATIONS ......................................................................................................... 2
6. WARNINGS & PRECAUTIONS .............................................................................................. 2
7. IMPORTANT SAFETY INFORMATION................................................................................... 3
8. CONTACT INFORMATION.................................................................................................... 4
9. EXPLANATION OF SYMBOLS................................................................................................ 4
10. OPERATING INSTRUCTIONS (NORMAL MODE OPERATION) .............................................. 5
11. CUFF SEALING ..................................................................................................................... 6
12. HAND PRESSURE INDICATOR (HPI) ..................................................................................... 6
13. PAUSING A THERAPY SESSION............................................................................................ 7
14. ADJUSTING THE THERAPY TIME.......................................................................................... 7
15. ADJUSTING THE THERAPY TEMPERATURE.......................................................................... 7
16. END OF THERAPY ................................................................................................................ 7
17. STANDBY MODE OPERATION.............................................................................................. 7
18.GAME MODE OPERATION................................................................................................... 8
19. TROUBLESHOOTING AND FAQS.......................................................................................... 9
A. How long should treatment last? ........................................................................................ 9
B. How important is the placement of my hand?.................................................................... 9
C. Is it necessary to wear the AVACEN Mitt?........................................................................... 9
D. Do I need a new a Mitt every time I have a treatment? ..................................................... 9
E. Do I need to purchase the Mitts from AVACEN?................................................................. 9
F. The AVACEN unit displays 'Did Not Seal' or 'Lost Vacuum Seal' message......................... 10
G. "Rest Palm On Heatpad" message..................................................................................... 10
H. "Calibration Failed" message............................................................................................. 11
I. "System Error" Message .................................................................................................... 11
J. There is noise while the AVACEN device is running .......................................................... 11
K. The inflatable cuff is too tight............................................................................................ 12
L. I keep getting a "Press Down" or "Lift Up" message ......................................................... 12
M. The AVACEN Heatpad is too hot (or too cold)................................................................... 12
N. The Heatpad seems "loose"............................................................................................... 12
O. The Display does not illuminate after plugging in power cord.......................................... 13
P. Checking the Inflatable Cuff for leaks................................................................................ 13
Q. Excessive swelling of the hand........................................................................................... 13

R. Red or purple spots on the hand ........................................................................................13
S. Hand itches or tingles .........................................................................................................13
T. My hand is reddish-colored like it has been in hot water..................................................13
U. Sweating when using the AVACEN .....................................................................................13
V. Discomfort in wrist or forearm during use.........................................................................13
20. SETTINGS...........................................................................................................................14
A. Language Selection .............................................................................................................14
B. Game Mode On/Off............................................................................................................14
C. Change Defaults..................................................................................................................14
D. Usage Statistics ...................................................................................................................15
E. Hardware Tests...................................................................................................................15
F. Last Failure..........................................................................................................................15
G. Factory Restore...................................................................................................................15
21. CLEANING...........................................................................................................................15
22. PERIODIC MAINTENANCE ..................................................................................................16
Replacing the Inflatable Cuff .....................................................................................................16

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 1
1. DESCRIPTION
Product model names - The AVACEN HOME XL family consists of two models: the AVACEN HOME
XL, which is sold in the USA, and the AVACEN R3 HOME XL, which is sold outside the USA. This
User Guide applies to both models. In the User Guide when the term "the AVACEN", "the
AVACEN device", or "the AVACEN system" is mentioned, the information applies to both models.
When the term "AVACEN HOME XL" is mentioned, the information applies only to the AVACEN
HOME XL. When the term "AVACEN R3 HOME XL " is used, the information applies only to the
model AVACEN R3 HOME XL.
The AVACEN HOME XL is a Dry Heat Therapy FDA Class II Medical Device. The AVACEN R3 HOME
XL is a dry heat therapy device for household use. Both models consist of a control panel, metal
heat pad, and a Vacuum Chamber with an Inflatable Cuff. The vacuum pump and heat source are
in the base of the unit. For proper function and to maintain sanitary conditions, the AVACEN
device MUST be used with the supplied hand mitts. Extra hand mitts can be purchased by
contacting AVACEN at [email protected].
2. UNPACKING THE UNIT
The shipping box contains the AVACEN device, power cord, power supply, mitts, and this user
guide. Lift the top shipping foam piece out of the box. Then lift the AVACEN out of the box with
two hands. Keep the shipping box and foam in case the AVACEN needs to be returned. Be sure to
read the What to Expect flyer before the first use.
3. NORMAL USE
The AVACEN is designed to provide dry heat therapy. Treatment time and/or number of uses per
day can be increased based on professional recommendations or absence of response to
treatment. Proposed use is 20 minutes first thing in the morning using the LEFT hand (hint: "Left
is for day Light") and 20 minutes before bed using the RIGHT hand (hint: "Right is for Night"),
healthy hand condition permitting.
Any level of major discomfort (after lowering Heat setting first) is not normal. If this happens,
stop using the AVACEN right away and report the problem to AVACEN Medical Customer
Service at (888) 4-AVACEN (888-428-2236) or send an email to [email protected].
4. INDICATIONS FOR USE
United States - The AVACEN HOME XL is a heat therapy system indicated for: the temporary relief
of minor muscle pain, stiffness, and the temporary relief of joint pain associated with arthritis,
muscle spasms, minor strains and sprains. The device is also used for muscular relaxation, and
the temporary increase of local circulation where applied.
Outside the United States - The AVACEN R3 HOME XL is a heat therapy system indicated for: the
temporary relief of minor muscle pain, stiffness, and the temporary relief of joint pain associated
with muscle spasms, minor strains and sprains. The device is also used for muscular relaxation, as
well as the temporary increase of systemic microcirculation associated with increased healing,
general wellness and longevity.

2AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
5. CONTRAINDICATIONS
Although there have been no issues reported, it is suggested that you contact a doctor before
using the AVACEN if you are under 18 years of age, are pregnant, or have a temperature higher
than 99.5°F (37.5°C). Do not use the AVACEN on a hand that has open sores or wounds.
6. WARNINGS & PRECAUTIONS
WARNINGS are used to signal potential hazards which could lead to death or serious injury.
PRECAUTIONS are used to warn the reader of potential hazardous situations. If not avoided,
these hazards may result in minor or moderate injury to the user or patient or damage to the
device or other property.
Warnings
•This device IS NOT meant to provide ample heating where the internal body core
temperature is falling uncontrollably or is lower than 95F (35C). In these cases, GET
MEDICAL ATTENTION FAST!
•Making changes to this device is not allowed.
•Do not use the AVACEN with other devices or accessories except as described in this User
Guide.
•Choking hazard - contains small parts. Keep out of reach of children.
•Strangulation hazard - contains a long power cord that may cause strangulation if used
improperly. Keep out of reach of small children.
Precautions
•The following cautions are guidelines only and are not meant to replace a health care
professional’s advice. If any harmful effect occurs while using the product, stop use and
contact your health care professional.
•Use with care. May cause serious burns. Do not use on sensitive skin areas or in the
presence of poor circulation.
•The unattended use of the AVACEN by children or incapacitated persons may be
dangerous.
•Do not use with liniment, salve, essential oils or ointments - may cause skin irritation.
•To prevent damage to the mitt and inflatable cuff, remove all jewelry (rings, bracelets,
watches) from the hand that will be used for therapy.
•Do not use the AVACEN on a hand that has open sores or wounds. Any level of major
discomfort (after lowering temperature first) is not normal.
•Metal implants - pay attention for signs of any uncomfortable heat buildup in the
treatment area. If this occurs, stop using the device.
•Stop using the AVACEN right away and report any major discomfort problems to AVACEN
Medical customer support at (888) 4-AVACEN (888-428-2236) or email AVACEN Medical
at [email protected].
•To remove your hand from the Vacuum Chamber at any time, unplug the unit. The air will
drain from the cuff as you slowly pull your hand out of the device.
•Although there have been no issues reported, consult your healthcare professional before
using the AVACEN if you have any of the following:.
•Malignancy (A term for diseases in which abnormal cells divide without control and
can invade nearby tissues) .
•Pregnancy.
•Chronically hot or swollen joint in the hand, fingers, or wrist..
•Circulatory diseases.
•Recent acute joint injury in the hand, fingers, or wrist..

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 3
7. IMPORTANT SAFETY INFORMATION
•Read the entire AVACEN device User Guide before using this device.
•For continued protection against risk of fire and shock, use the hand unit only with the
provided power supply, AVACEN part number 50-100000.
•Do not store the AVACEN device in direct sunlight. The AVACEN should be stored in a clean,
well-ventilated area at room temperature. Keep out of reach of small children and pets.
Optional carrying bags should be left open to allow for ventilation.
•Do not use outdoors in the rain, snow, or under water. While the device is protected against
vertically dripping water, it is not water resistant, and should not be used in wet areas.
•Pressing too hard on the heat pad can cause the AVACEN to be ineffective.
•The Power Supply Connector is the main power disconnect device for the AVACEN device. If a
malfunction is suspected, unplug the power supply or remove the power input from the unit.
•This device complies with Part 18 of the FCC Rules, as well as international electromagnetic
compatibility requirements. Use is subject to these two conditions:.
1) This device may not cause harmful interference, and 2) This device must accept any
interference received, including interference that may cause undesired operation.
These limits are designed to provide reasonable protection against harmful interference in a
residential installation. However, there is no guarantee that interference will not occur in a
particular installation. If this equipment causes problems with radio or TV reception, which
can be checked by turning the equipment off and on, you are encouraged to try to correct the
interference by one or more of the following measures:.
• Reorient the receiving antenna
• Relocate the system with respect to the receiver
• Move the system away from the receiver, and/or
• Plug the system into a different outlet so that the system and the receiver are on different
branch circuits.
Environmental Conditions
Temperature
Operating
50F (10°C) to 104F
(40°C)
Storage
32F (0°C) to 140F (60°C)
Relative
Humidity
Operating
30% to 75% rH
Storage
10% to 95% rH
Atmospheric
Pressure
Operating
700hPa to 1060hPa
Storage
500hPa to 1060hPa
AC Input Voltage
HOME XL - 240V~, 50-
60Hz
Expected service life of equipment
and accessories
5 years

4AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
8. CONTACT INFORMATION
Manufacturer:
AVACEN Medical
2365 Camino Vida Roble, Suite C
Carlsbad, CA 92011
Phone: (888) 4-AVACEN (888-428-2236)
Web: AVACEN.com
Email: [email protected]
9. EXPLANATION OF SYMBOLS
Symbol
Description
Home Icon
Mute and Unmute Icons for sound
Start/Advance/Resume and Pause Icons
Settings Icon
OK/Accept/Confirm Icon
Up / Down Adjust
Low/Medium/High Temperature Settings
Remove all jewelry and watch before inserting hand in the device.
Do not allow your shirt sleeve to enter into the Inflatable Cuff.
Caution: Refer to Instructions
Read Instruction Manual
Atmospheric Pressure Range
Temperature Range
Humidity Range
IP21
Protection rating for ingress of solid objects and water - protected
against solid objects larger than 12.5 mm and vertically dripping
water
Type BF Applied Part (model AVACEN HOME XL only)
Do Not Dispose in Trash
Identification of Manufacturer
Complies with 47 CFR Part 18 for Industrial, Scientific, and Medical
Equipment

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 5
10. OPERATING INSTRUCTIONS (NORMAL MODE OPERATION)
Connect the Power Supply Connector into the power supply jack. The
power supply jack is located on the right side panel towards the lower
back corner. Plug the AC power cord end from the power supply cord
into the correct power source (wall plug) - HOME XL-240V~, 50-60Hz.
International use: Care should be taken to ensure that you have the
correct cord and wall plug for the country in which the AVACEN R3
HOME XL is to be used. Contact AVACEN if the wall plug on the cord does not fit.
If the device has been stored in a hot or cold area, allow it to reach normal room temperature for
1 hour before turning it on.
Turn on the AVACEN device by inserting power plug. The display will show a welcome message.
Advancing beyond this welcome screen, you will see the Language selection. Please select the
desired language. After the language is selected, there will be disclaimer screens (only on first
power up). Please acknowledge that you meet the criteria by pressing “Yes” for these disclaimers.
Once completed, you will arrive at the “Please Wait, Warming up”screen. This message will
remain until the hand pad has reached 98.6° F.
When the hand pad reaches the predetermined standby
temperature, the home screen will be displayed. For best
results, the default temperature is “High,” and the default
therapy time is 20 minutes. These values may be adjusted by
pressing the up and down arrows for the subsequent settings.
Once you have selected your desired settings for therapy and advance to the next screen, you
will see a message to remove all jewelry. This is to prevent damage to the Mitt and cuff
membrane. Please remove all jewelry (rings, bracelets, watches) from the hand and wrist that
will be used for therapy. If you are wearing a shirt or jacket
with long sleeves, pull the sleeve up your arm so that the
inflatable cuff contacts bare skin on your arm. The inflatable
cuff WILL NOT seal against a watch or shirt sleeve.
The next screen will prompt you to place the AVACEN mitt on the hand you
plan to use for therapy. Place therapy hand in the Mitt. All 4 fingers should
be placed in the body of the mitt and the thumb should be placed in the right
or left thumb cavity of the mitt. Important - Leave 1 cm (1/2 inch) in top of
mitt free when placing hand inside, and ensure that the pressure holes are
facing up.
When ready, press the “Next” icon.

6AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
The final preparation screen will prompt you to SLOWLY insert your hand (with Mitt applied) into
the Inflatable Cuff. The raised, egg-shaped portion of the heat pad should be cupped in the
center of the palm. To be most effective, keep all four fingers resting on the fingertip end of the
Metal heat pad. Please take care not to puncture or rip the flexible cuff, which is critical to the
operation of the device. When ready, press the “Next” icon, and therapy will begin!
It is very important that the AVACEN is placed on a level surface and your hand is NOT inside the
Vacuum Chamber when you power the device on. If your hand is inside the vacuum chamber
(resting on the heat pad) when the device is powered on, the onboard computer will not
measure your hand pressure correctly. If you power the device off (by mistake or on purpose),
remove your hand from the Vacuum Chamber before powering the device back on again.
11. CUFF SEALING
The "Pressurizing/Calibrating" message is displayed while
the vacuum motor runs. The bar along the bottom shows
the vacuum level; when the bar has fully changed color,
the full vacuum has been achieved.
IMPORTANT NOTE: The seal on the cuff may have become dislodged during shipping and
unpacking. If the seal is not properly in place, the Vacuum Chamber will not seal. Refer to the
"Troubleshooting" section of this User Guide for simple ways to correct this issue.
12. HAND PRESSURE INDICATOR (HPI)
When the unit seals properly, the top of the display will show the
remaining therapy time.
Too much hand pressure on the hand pad will set off an alarm
(beep) and display "Lift Up."
Too little hand pressure on the hand pad will set off an alarm
(beep) and display "Press Down."
Min Max
Sanitary
Mitt
should
extend
beyond
Inflatable
Cuff
Metal Heat pad Diagram
Rear Base
(fingertip end)
Front Base
(wrist end)
Position
Heel of Palm
on Front Base

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 7
13. PAUSING A THERAPY SESSION
PAUSE: If the (pause) icon on the display is pressed
during treatment, the timer and Vacuum motor are
paused. The cuff will depressurize and the treatment hand
may be slowly removed.
Pressing the (resume) icon will cause the timer and
Vacuum Chamber sealing process to resume.
14. ADJUSTING THE THERAPY TIME
Pressing the ▲ and ▼icons near the (clock) icon on
the display while running a therapy session will cause the
therapy timer to increase or decrease in value.
15. ADJUSTING THE THERAPY TEMPERATURE
Pressing the ▲or ▼buttons near the (temperature) icon on the display during therapy will
switch the Temperature setting from High to Medium to Low, and back to High again.
16. END OF THERAPY
When the treatment time runs down to zero, the device will
finalize the session. The cuff will begin to deflate and the
"Remove Hand Slowly" message is displayed. Remove your
hand from the Vacuum Chamber. Remove the Mitt and
discard or retain for your own use at a later time. Therapy is
now complete. The device will return to the Welcome
screen for the next session.
If there is a problem during operation, the device will display an error message. Please refer to
the “Troubleshooting” section of this user guide for instruction.
17. STANDBY MODE OPERATION
The AVACEN device will enter a standby mode after 5 minutes of inactivity. The display will turn
off, and the hand pad temperature will stay at 98.6°F. To wake the device, simply press anywhere
on the display. It will resume operation from the Welcome screen. The rest of the device
functions are the same as described in the "Normal Mode Operation" section of this manual.

8AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
18. GAME MODE OPERATION
To enter Game Mode, go to the settings page
and press on “Game Mode.” This will toggle the
selection between “On” and “Off.” Leave the
setting at “On” to enable game mode. This setting
will reset after the game session has completed.
Game Mode is used to encourage the user to
maintain the proper amount of pressure on the heat pad. The Hand Pressure Indicator (HPI)
position in the center of the screen is used as the gauge for the game. The goal is to score the
most points by keeping the HPI a solid color. If the hand is resting too lightly or heavily on the
hand pad, a different color of the bar will start to appear from the center of the bar in the
direction of non-compliance (up means too light, down means too heavy).
Balanced Hand Force Slightly Light Hand Force Slightly Heavy Hand Force
Points will be tallied during the game, positioned below the HPI. The number of points earned is
based on how well the user keeps the HPI a solid color. Points are scored as long as the "Lift Up"
message or the "Press down" messages are not displayed. If these messages are displayed, the
user will hear an audio beep, and 5,000 points will be subtracted from the total score every
second.
The highest number of points awarded is 150,000 points per minute. Therefore, the user could
accumulate as many as 3,000,000 points in a 20-minute therapy session (more or fewer points
depending on the length of the session). A score of half the highest possible score (e.g. 1,500,000
for a 20-minute session) would indicate that the user did a very good job of keeping their hand
properly seated on the heat pad. The final score can also be used as a gauge of proper hand
position during unattended patient therapy sessions. The unit must be used for a minimum of 10
minutes in order to qualify for a high score.
If a new high score was earned, this will be stored and viewable in the settings tab under “Usage
Statistics.”

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 9
19.TROUBLESHOOTING AND FAQS
If you are having problems using the AVACEN device, review this section to see if a solution is
described. If you are still having trouble, call AVACEN Medical at (888) 4-AVACEN
(888-428-2236) and select "Customer Service" or email su[email protected]. When you call,
have your AVACEN ready and make note of the device serial number (marked on the bottom of
the device).
A. How long should treatment last?
The AVACEN device is designed to comfortably and noninvasively provide dry heat therapy for a
period between 10 and 60 minutes. For many conditions, 20 minutes twice daily is sufficient.
Treatment time and/or use frequency can be increased to accommodate professional
recommendations or absence of response to treatment. The best times for treatment are in the
early morning and prior to bed. Suggested use should be: 20 minutes first thing in the morning
using the LEFT hand (reminder hint: "Left is for day Light") and 20 minutes before bed using the
RIGHT hand (reminder hint: "Right is for Night"). Switching hands assumes both hands are equally
healthy. If not, use the healthy hand only.
Any level of major discomfort (after adjusting temperature) is not normal. Stop using the
AVACEN right away and report the problem to AVACEN at (888) 4-AVACEN (888-428-2236) and
select "Customer Service" or email [email protected].
B. How important is the placement of my hand?
It is critical to make sure that the palm is completely inside the vacuum chamber and resting on
the metal heat pad. The raised, egg-shaped portion of the heat pad should be cupped in the
center of the palm.
C. Is it necessary to wear the AVACEN Mitt?
The AVACEN device design requires a special mitt. Without this mitt, the AVACEN may not seal
properly. Using the mitt also provides a sanitary environment for multiple family members or
clinic users. In addition, the mitt keeps dirt and hand oils off of the critical metal heat pad and
from inside the vacuum chamber. This prolongs the efficiency and extends the useful life of the
AVACEN.
D. Do I need a new a Mitt every time I have a treatment?
No. As long as the mitt appears to be in good repair and clean, the same person may use it for
months.
E. Do I need to purchase the Mitts from AVACEN?
The AVACEN was developed and tested for FDA Clearance using a very specific mitt material and
design. We have priced the mitts to be very affordable and therefore recommend that mitts be
purchased by contacting AVACEN at [email protected].

10 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
F. The AVACEN unit displays 'Did Not Seal' or 'Lost Vacuum Seal' message
If the AVACEN is not able to reach the proper vacuum level
after 60 seconds, the "Unit Did Not Seal Properly" message is
displayed. User has the opportunity to try again, or contact
AVACEN if the issue persists.
If vacuum is lost during a therapy session the "Unit Has Lost
Vacuum Seal" message is displayed and the user has the
opportunity to try again, or contact AVACEN if the issue
persists. This can occur if:
(i) The Inflatable Cuff is not properly sealed at the wrist.
- See Item P: "Checking the Inflatable Cuff for leaks"
(ii) A mitt is not being used.
- Put on a mitt.
(iii) The end of the mitt does not extend beyond the sealed cuff.
- Pull the mitt on your hand and make sure the end of the mitt is outside the cuff.
(iv) The user's hand is not properly positioned.
- It is critical to make sure that the heel of the palm (where the palm connects to the wrist) is
completely inside the vacuum chamber and touching the palm end of the metal heat pad (closest
to opening).
(v) The Inflatable Cuff is not properly positioned.
- See section 22: " PERIODIC MAINTENANCE" for taking the Inflatable Cuff on and off.
If your skin is very dry, put a small amount of hand lotion on your wrist and rub it in to improve
sealing after your hand is placed into the mitt. If you are still having trouble, call AVACEN Medical
at (888) 4-AVACEN (888-428-2236) and select "Customer Service" or email
[email protected].
G. "Rest Palm On heat pad" message
To make sure the device calculates the proper pressure of your hand against the metal heat pad,
it is important during the initial sealing and calibration process that you apply slight pressure with
your palm against the heat pad. Without this base pressure, the onboard computer will not be
able to properly measure the pressure of the palm against the heat pad and "Rest Palm On heat
pad" message will continue to appear for 45 seconds and the AVACEN will power down.
It is very important that the AVACEN is placed on a level surface and your hand is NOT inside the
Vacuum Chamber when you turn the unit on. If your hand is inside the vacuum chamber (resting
on the heat pad) when the unit is turned on, the onboard computer will not measure your hand
pressure correctly. If you turn the unit off (by mistake or on purpose), remove your hand from
the Vacuum Chamber before turning the unit back on again.

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 11
H. "Calibration Failed" message
It is very important that the AVACEN is placed on a level surface
and your hand is NOT inside the Vacuum Chamber when you
turn the device on. If your hand is inside the vacuum chamber
(resting on the heat pad) when the device is turned on, the
onboard computer will not measure your hand pressure
correctly. If you remove power (by mistake or on purpose),
remove your hand from the Vacuum Chamber before plugging the device back in.
To make sure that the device computes the proper weight of your hand against the Metal heat
pad, it is important during the initial sealing and calibration process to apply slight pressure with
your palm against the heat pad. Without this base pressure, the onboard computer will not be
able to properly manage the pressure of the palm against the heat pad. At that point the
"Calibration Failed" message will appear and the user will have the opportunity to try again or
contact AVACEN if the issue persists. If trying again, remove hand from the Vacuum Chamber,
and relaunch the session.
After the weight of the hand is measured during the calibration phase, the onboard computer
monitors if there is too much or too little palm pressure against the heat pad. A warning will
appear on the display if too little or too much hand pressure has been applied. After a number of
uses, it will become much easier to judge the proper pressure of your palm against the heat pad.
If you are still having trouble, call AVACEN at (888) 4-AVACEN (888-428-2236) and select
"Customer Service" or email [email protected].
I. "System Error" Message
The device is always checking and adjusting the temperature
of the heat pad. If for some reason it cannot measure the
heat pad temperature, a warning message will be displayed.
This can happen for a couple reasons:
(i) The device is very cold.
-Turn off the device and allow it to warm to room
temperature before turning on.
(ii) The device has been stored somewhere very hot.
-This may have damaged the device. Unplug the unit, then plug back in and try again. If the
message is displayed a second time, call AVACEN at (888) 4-AVACEN (888-428-2236) and select
"Customer Service" or email [email protected].
J. There is noise while the AVACEN device is running
There is an air pump inside the AVACEN that runs during therapy. Some motor noise is normal,
and the noise will vary as the AVACEN adjusts the air pressure of the inflatable cuff and inside the
vacuum chamber. This improves the comfort of the inflatable cuff.

12 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
K. The inflatable cuff is too tight
The inflatable wrist bladder is designed to work on almost any size wrist and therefore it may feel
tighter to some people than others. The first inflation exerts the most pressure to assure a proper
seal every time. This highest pressure will only last for less than a minute. After that the pressure
will relax to a more comfortable level. If the pressure does not relax there may be a vacuum leak.
Refer to Item F: "The AVACEN unit displays 'Did Not Seal' or 'Lost Vacuum Seal' message" for
solutions.
L. I keep getting a "Press Down" or "Lift Up" message
It is very important that the AVACEN is placed on a level surface and your hand is NOT inside the
Vacuum Chamber when you turn the device on. If your hand is inside the vacuum chamber
(resting on the heat pad) when the device is turned on, the onboard computer will not measure
your hand pressure correctly. If you turn the device off (by mistake or on purpose), remove your
hand from the Vacuum Chamber before turning the device back on again.
To make sure that the device calculates the proper pressure of your hand against the heat pad, it
is important that during the initial sealing and calibration process that you apply slight pressure
with your palm against the heat pad. Without this base pressure, the onboard computer will not
be able to properly manage the pressure of the palm against the heat pad and "Push Hand Down
Slightly" or "Lift Hand Slightly" message will continue to appear along with a beeping sound.
During treatment there is a chance the heel of your palm will be pushing too hard against the
palm end of the Metal heat pad (end nearest the wrist opening). This condition is not wanted and
will cause the "Lift Hand Slightly" message to appear along with a beeping sound. At this point
just retract your hand into the cuff to its original position and the alerts will stop. To make it
easier to shift your hand, briefly press in the pressure release button on the bottom of the cuff to
deflate the cuff slightly.
One of the top features of the device is to monitor and display too much or too little pressure of
the hand on the Metal heat pad. Correct hand pressure on the heat pad increases heat transfer.
After the weight of the hand is calculated during the calibration phase, the onboard computer is
responsible for monitoring the palm pressure. If there is too much or too little palm pressure
against the heat pad, it will be displayed on the Hand Pressure Indicator (HPI). After a number of
uses, it will become much easier to judge the proper pressure of your palm against the heat pad.
If you are still having trouble, call AVACEN at (888) 4-AVACEN (888-428-2236) and select
"Customer Service" or email [email protected].
M.The AVACEN heat pad is too hot (or too cold)
For the most benefit "High" is recommended. Select "Med" or "Low" only in the case of major
discomfort. The heat pad will feel hot during use. If a lower temperature is used, return to the
"High" mode after several uses to determine if the discomfort has been reduced. If the heat does
not recede to a more comfortable level RIGHT AWAY, stop using the device and call AVACEN
Medical at (888) 4-AVACEN (888-428-2236) and select "Customer Service" or email
[email protected]. After using the device for some time, your hand may get used to the
heat pad temperature, so that it does not "feel" as hot as it used to. This is normal and does not
mean there is a problem with the device.
N. The heat pad seems "loose"
For proper measurement of hand weight on the heat pad, the heat pad must be free to move up
and down and side-to-side slightly. This is normal and does not mean there is a problem.

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 13
O. The Display does not illuminate after plugging in power cord
Make sure that the power cord is plugged into the unit securely and the light on the Power
Supply (black box between the device plug and wall plug) is on. If the light on the Power Supply is
not on, check the ends of the power cord to make sure it is plugged into both the Power Supply
and the wall plug. If the power Supply light is still not on, make sure that the wall plug is working
properly. Do this by plugging in another device or lamp that you know works into the wall plug. If
you are still having trouble, call AVACEN Medical at (888) 4-AVACEN (888-428-2236) and select
"Customer Service" or email [email protected].
P. Checking the Inflatable Cuff for leaks
Running a “Self Seal Test” can check the quality of the cuff and seal it achieves. This test can be
found in SETTINGS. Refer to section 20 "SETTINGS" in this Guide for details on starting the test.
Q. Excessive swelling of the hand
The AVACEN device is designed to comfortably and noninvasively provide dry heat therapy. Any
level of major discomfort is not normal. Right away stop using the AVACEN and report the
problem to AVACEN Medical at (888) 4-AVACEN (888-428-2236) and select Customer Service.
R. Red or purple spots on the hand
Red or purple spots on the hand (usually the backside) after the first couple of AVACEN device
uses can be caused by a minor hemorrhage (petechia). These spots are harmless and will likely
vanish within a few days. Should they not disappear or if they are accompanied by any level of
major discomfort, this is not normal. Right away stop using the AVACEN and report the
problem to AVACEN Medical at (888) 4-AVACEN (888-428-2236) and select Customer Service.
S. Hand itches or tingles
It is common and normal for the hand to slightly itch or tingle during a treatment session as
circulation in the hand increases. If this at any time becomes uncomfortable or painful,
immediately stop the treatment session and call AVACEN Medical at (888) 4‐AVACEN (888‐428‐
2236) and select Customer Service.
T. My hand is reddish-colored like it has been in hot water
This state is normal and you will likely see this on every treatment. It is due to the increased
microcirculation (blood in the capillaries).
U. Sweating when using the AVACEN
The AVACEN device is designed to comfortably and noninvasively provide heat therapy. Mild
sweating is not typical but seldom may occur and is not a serious indication. Any level of major
discomfort pain is not normal. Right away stop using the AVACEN and report the problem to
AVACEN Medical at (888) 4-AVACEN (888-428-2236).
V. Discomfort in wrist or forearm during use
Raise or lower forearm or try a support cushion under the arm.

14 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
20. SETTINGS
There are some settings that can be made on the
AVACEN unit that will be stored. Even if power is
removed, the settings are kept. The following
Settings can be made on the AVACEN:
•Language Selection
•Game Mode On/Off
•Change Default Therapy settings
(Time/Temperature)
•Usage Statistics
In addition, there are some settings that can be used to help diagnose problems with the device:
•Hardware Tests
•Last Failures
•Factory Restore
All of these features are accessed in the “Settings”menu. To access “Settings”, press the icon
from the Home screen.
Moving through the different Settings is done using the touchscreen:
Touch an item to select.
Press to go to previous menu.
Press to return to the Home screen.
A. Language Selection
Messages can be displayed in multiple languages on
some device versions. From the Settings Menu, press
“Language” - the current selection is underlined. Choose
the desired language, and it will become underlined.
Press “Go Back” to return to settings menu.
B. Game Mode On/Off
From the Settings Menu, tap the “Game Mode: On/Off” line to toggle between game mode
enabled and disabled. The underline shows which mode the device is in.
C. Change Defaults
The default setting for therapy time is 20 minutes. At any
time before the start of a therapy session, the therapy
time may be changed from 20 minutes to 10, 15, 20, 25,
30, 35, 40, 45, 50, 55, or 60 minutes. If you find that you
are usually selecting a time other than 20 minutes for
therapy, the default therapy time can be changed. From
the Settings menu, press “Change Defaults.”Press ▲or
▼ one or more times to choose a default therapy time
setting. Press ✔to store the setting. Now, whenever the device is turned on, the new default
therapy time will be selected. This setting will be erased with a Factory Restore.
The default setting for therapy temperature is HIGH. This is the preferred setting for maximum
benefit. At any time during therapy, the temperature setting can be changed by pressing the ▲

20220913 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 15
or ▼ buttons. If you find that you are usually selecting the MEDIUM or LOW temperature setting,
the default setting can be changed from HIGH to MEDIUM or LOW. From the Settings menu,
select “Change Defaults,”then press ▲or ▼ to choose a default therapy temperature setting.
Press ✔to store the setting. Now, whenever the device is turned on, the new default therapy
temperature will be selected. This setting will be erased with a Factory Restore.
To exit without changing default temperature or time, press the icon.
D. Usage Statistics
For information on number of sessions and total therapy time
of the device, go the “Settings” menu and select “Usage
Statistics.” From there you can view this information. Content
will NOT be lost after a Factory Restore. Press icon to
return to “Settings” menu.
E. Hardware Tests
If you are talking to AVACEN Customer Support, they may ask you to go to this menu for a variety
of troubleshooting tests.
i. Self-Sealing Test
ii. Temperature Calibration (locked)
iii. Force Sensor Calibration (locked)
iv. Force Measurement Test
v. Vacuum Level Average
F. Last Failure
This menu stores information about errors when the device was last used. If you are talking to
AVACEN Customer Support, they may ask you to go to this menu. From the "Settings" menu,
select “Last Failure” to show the last error that was recorded.
G. Factory Restore
This menu will restore the unit to the same configuration as when it left the factory –default
temperature and time will revert to HIGH and 20 minutes, and game scores will be deleted.
Language will need to be reselected, and Disclaimers will again need to be verified after a Factory
Restore. Usage statistics for total hours of operation and number of therapy sessions will be
retained.
21. CLEANING
The outside surfaces of the AVACEN device can be wiped down with a damp cloth or a
disinfectant hand wipe. Do not use any harsh cleaners or gel sanitizers as damage to the
enclosure may result.
Cleaning the inside of the Vacuum Chamber is not needed between uses as long as clean Mitts
are used. If it is needed to disinfect the Vacuum Chamber, ensure the cuff is fully deflated and
use a disinfectant hand wipe on the inside surfaces.

16 AVACEN HOME XL, AVACEN R3 HOME XL User Guide 20220913
22. PERIODIC MAINTENANCE
If the Inflatable Cuff is too worn out or gets torn, it must be replaced. A "Refresh Kit" (an
Inflatable Cuff assembly) is available. The Refresh Kit can be purchased by contacting AVACEN at
[email protected].
To check the Inflatable Cuff for leaks, see Item P in section 19 "TROUBLESHOOTING AND FAQS."
Replacing the Inflatable Cuff
If you need to replace the inflatable cuff, begin by removing the cuff
cover and setting aside for reassembly.
Next, lift up four tabs of the lock ring, circled in the images below –two on top, two on bottom. A
tool has been provided to access some of the more difficult snaps. A video instruction may also
be found on the AVACEN website. Note that the cuff gasket has silicone grease on the exterior.
Gently remove the lock ring and set aside for reassembly.
Note the location of the cuff gasket and its proximity to the tab/snaps on the
device (approximately 5mm).
Remove old cuff.
With the new cuff, ensure that the flexible portion is nested inside the
rigid plastic portion.
Orient the cuff with the gasket facing the product.
Lower Left
Upper two
Lower Right
x
Cuff Gasket