Bruker SampleXpress User manual

Version
Bruker BioSpin
think forward
NMR Spectroscopy
SampleXpress
001
Sample Changer
User Manual

Copyright © by Bruker BioSpin GmbH
All rights reserved. No part of this publication may be
reproduced, stored in a retrieval system, or transmitted, in any
form, or by any means without the prior consent of the publisher.
Product names used are trademarks or registered trademarks of
their respective holders.
This manual was written by
Volker Reiss, Gilbert Cyppel, Stanley J. Niles
© July 15, 2010: Bruker Biospin GmbH
Rheinstetten, Germany
P/N: Z31900
DWG-Nr.: Z4D11037
For further technical assistance on the SampleXpress unit,
please do not hesitate to contact your nearest BRUKER dealer
or contact us directly at:
BRUKER BioSpin GMBH
am Silberstreifen
D-76287 Rheinstetten
Germany
Phone: + 49 721 5161 0
FAX: + 49 721 5171 01
E-mail: [e-mail]
Internet: www.bruker.com

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Table of Contents
Contents
1 About ..............................................................................................................7
1.1 This Manual.............................................................................................................. 7
1.2 Policy Statement ...................................................................................................... 7
1.3 Symbols and Conventions........................................................................................ 7
2 Introduction....................................................................................................9
2.1 Concept .................................................................................................................... 9
2.2 Limitation of Liability ............................................................................................... 10
2.3 Copyright ................................................................................................................ 10
2.4 Warranty Terms...................................................................................................... 10
2.5 Customer Service................................................................................................... 10
2.6 EC Declaration of Conformity................................................................................. 11
2.7 EG-Konformitätserklärung...................................................................................... 12
3 Safety............................................................................................................13
3.1 Intended Use .......................................................................................................... 13
3.2 Owner‘s Responsibility ........................................................................................... 13
3.3 Personnel Requirements........................................................................................ 15
3.3.1 Qualifications.......................................................................................................... 15
3.3.2 Unauthorized Persons............................................................................................ 16
3.3.3 Instruction............................................................................................................... 16
3.4 Personal Protective Equipment .............................................................................. 16
3.5 Basic Dangers ........................................................................................................ 17
3.5.1 Position of the Safety Devices................................................................................ 17
3.5.2 Description of the Installed Safety Devices ............................................................ 17
3.5.3 General Workplace Dangers .................................................................................. 18
3.5.4 Dangers from Electric Power.................................................................................. 19
3.5.5 Mechanical Dangers............................................................................................... 21
3.5.6 Dangers from Gases Under Pressure .................................................................... 22
3.5.7 Dangers from Radiation ......................................................................................... 23
3.5.8 Dangers Due to High or Low Temperatures........................................................... 24
3.5.9 Danger from Chemical Substances........................................................................ 25
3.6 Environmental Protection ....................................................................................... 27
3.7 Signage .................................................................................................................. 28
3.8 Spare Parts ............................................................................................................ 30
3.9 Location of Safety Label......................................................................................... 30
4 Technical Data .............................................................................................31
4.1 General Information................................................................................................ 31
4.2 Connection Values ................................................................................................. 31
4.3 Operating Conditions.............................................................................................. 32
4.4 Rating Plate............................................................................................................ 33

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4.5 Sample Usage ........................................................................................................ 34
5 Design and Function ...................................................................................35
5.1 Overview................................................................................................................. 35
5.2 Brief Description ..................................................................................................... 36
5.3 Unit Description ...................................................................................................... 37
5.3.1 Base Unit ................................................................................................................ 37
5.3.2 Cassette ................................................................................................................. 42
5.3.3 Control Panel.......................................................................................................... 43
5.4 Connections............................................................................................................ 44
5.5 Indicator Lamp........................................................................................................ 46
5.6 Work and Danger Zones ........................................................................................ 47
5.7 Accessories ............................................................................................................ 49
6 Transport, Packaging and Storage ............................................................51
6.1 Symbols on the Packaging ..................................................................................... 51
6.2 Inspection at Delivery ............................................................................................. 53
6.3 Packaging............................................................................................................... 54
6.4 Storage ................................................................................................................... 54
7 Installation and Initial Commissioning......................................................55
8 Operation Overview.....................................................................................57
8.1 Safety ..................................................................................................................... 57
8.1.1 Emergency Shutdown ............................................................................................ 57
8.2 General Operating Guidelines ................................................................................ 58
8.2.1 Switching On the Device ........................................................................................ 59
8.2.2 Switching Off the Device ........................................................................................ 59
8.2.3 Sample Adjustment and Maximum Sample Height ................................................ 60
9 Operation......................................................................................................61
9.1 Operation Modes .................................................................................................... 61
9.2 Main Display ........................................................................................................... 62
9.2.1 Main Menu Touch Screen Buttons in Single Access Mode.................................... 65
9.3 Starting the Application Software ........................................................................... 66
9.3.1 Program Start ......................................................................................................... 66
9.4 Displaying Position Information .............................................................................. 67
9.5 Add or Remove Samples in Single Access Mode .................................................. 68
9.5.1 Adding Samples ..................................................................................................... 69
9.5.1.1 Adding Samples - Go to Free Position ................................................................... 71
9.5.1.2 Adding/Replacing Samples in Sequence ............................................................... 73
9.5.2 Removing Samples ................................................................................................ 74

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9.5.2.1 Removing All the Samples ..................................................................................... 75
9.5.2.2 Remove Measured Samples from the Cassette..................................................... 77
9.5.2.3 Removing Samples in Sequence ........................................................................... 79
9.5.3 Security Eject ......................................................................................................... 79
9.6 Removing and Inserting the Cassette .................................................................... 80
9.6.1 Removing the Cassette .......................................................................................... 80
9.6.2 Inserting the Cassette ............................................................................................ 82
9.7 The Settings Window ............................................................................................. 82
9.7.1 Touch Screen Calibration....................................................................................... 82
9.7.2 Date and Time Setting............................................................................................ 84
9.7.3 About the Device .................................................................................................... 85
9.8 Working in Random Access Mode ......................................................................... 87
9.9 Working in Manual Mode........................................................................................ 88
10 Maintenance.................................................................................................89
10.1 Safety ..................................................................................................................... 89
10.2 Replacement Parts................................................................................................. 91
10.3 Preventative Maintenance...................................................................................... 91
10.4 Lift Adjustment........................................................................................................ 92
10.5 Magnet Service ...................................................................................................... 93
10.5.1 Refilling................................................................................................................... 93
10.5.2 After a Quench ....................................................................................................... 93
10.6 Maintenance Schedule........................................................................................... 93
10.7 Software ................................................................................................................. 94
10.7.1 Service File............................................................................................................. 94
10.7.2 Firmware Upgrade.................................................................................................. 96
10.7.3 Device Report File.................................................................................................. 99
10.8 Cleaning ............................................................................................................... 101
10.8.1 Before Cleaning.................................................................................................... 101
10.8.2 Cleaning the Outside of the SampleXpress Chassis and Units ........................... 102
10.8.3 Cleaning the Outer Shell of the Device ................................................................ 102
10.8.4 Cleaning the Magazine Light Barrier .................................................................... 102
10.8.5 Cleaning the Cassette .......................................................................................... 103
10.8.6 Other Cleaning Operations................................................................................... 103
11 Troubleshooting ........................................................................................105
11.1 Safety ................................................................................................................... 105
11.2 Fault Indicators..................................................................................................... 108
11.2.1 Touch Panel ......................................................................................................... 108
11.2.2 Indicator Lamp...................................................................................................... 109
11.3 Start-up Following Fault Rectification................................................................... 110
12 Error Codes................................................................................................111

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12.1 List of Error Codes................................................................................................ 111
13 Dismantling and Disposal.........................................................................117
13.1 Safety ................................................................................................................... 117
13.2 Dismantling........................................................................................................... 118
13.3 Disposal................................................................................................................ 118
14 Contact .......................................................................................................121
Appendix A .........................................................................................................123
A.1 Safety Notices ...................................................................................................... 123
A.2 Avertissements De Sécurité ................................................................................. 133
A.3 Sicherheitshinweise.............................................................................................. 145
Appendix B .........................................................................................................157
B.1 Repair Declaration................................................................................................ 157
Appendix C .........................................................................................................159
C.1 Warning Signs ...................................................................................................... 159
C.2 Figures.................................................................................................................. 161
C.3 Tables................................................................................................................... 165
C.4 Glossary ............................................................................................................... 167
C.5 Index..................................................................................................................... 169

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1 About
1.1 This Manual
This manual enables safe and efficient handling of the device.
This manual is an integral part of the device, and must be kept in close proximity to the
device where it is permanently accessible to personnel.
Before starting any work, the personnel must have read the manual thoroughly and
understood its contents. Compliance with all specified safety instructions and operating
instructions is vital to ensure safe operation.
In addition, local accident prevention regulations and general safety instructions must be
observed for the operational area of the device.
Illustrations in this manual are intended to facilitate basic understanding, and may differ
from the actual design.
This SampleXpress user manual must be kept with the device. In addition to the Sam-
pleXpress user manual, instructions concerning labor protection laws, operator regula-
tions tools and supplies must be available and adhered to.
1.2 Policy Statement
It is the policy of Bruker to improve products as new techniques and components
become available. Bruker reserves the right to change specifications at any time.
Every effort has been made to avoid errors in text and figure presentation in this publica-
tion. In order to produce useful and appropriate documentation, we welcome your com-
ments on this publication. Support engineers are advised to regularly check with Bruker
for updated information.
Bruker is committed to providing customers with inventive, high quality products and ser-
vices that are environmentally sound.
1.3 Symbols and Conventions
Safety instructions in this manual are marked with symbols. The safety instructions are
introduced using indicative words which express the extent of the hazard.
In order to avoid accidents, personal injury or damage to property, always observe safety
instructions and proceed with care.
DANGER
This combination of symbol and signal word indicates an immediately hazardous sit-
uation which could result in death or serious injury unless avoided.

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About
iThis symbol highlights useful tips and recommendations as well as information designed
to ensure efficient and smooth operation.
Special Safety Instructions
The following symbols are used in the safety instructions to draw attention to specific
danger:
WARNING
This combination of symbol and signal word indicates a potentially hazardous situa-
tion which could result in death or serious injury unless avoided.
CAUTION
This combination of symbol and signal word indicates a possibly hazardous situation
which could result in minor or slight injury unless avoided.
NOTICE
This combination of symbol and signal word indicates a possibly hazardous situation
which could result in damage to property or the environment unless avoided.
DANGER
This combination of symbol and signal word indicates dangers posed by electric
power. If the safety instructions are not observed, there is a danger of serious or fatal
injuries.

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2 Introduction
The new Bruker sample changer SampleXpress allows automatic measurement of NMR
samples with Bruker NMR spectrometers. It is the successor of the B-ACS sample
changer system. Its compact, exceptionally integrated design, drastically reduces sam-
ple transfer distances, delivering exchange times of just a few seconds, making Sam-
pleXpress ideal for optimizing throughput in standard NMR service laboratories running
30-200 samples per day. In addition, efficiency is maximized thanks to exchangeable,
easy-fill, cassette modules that can be loaded off-system and in parallel with current
experiments.
2.1 Concept
SampleXpress is controlled by TopSpin or ICON-NMR, Bruker’s graphical user interface
for fully-automated acquisition and processing.
The system is also equipped with integrated barcode reader registration, which is under
control of SampleTrack, Bruker‘s information and data management software.
Refer to "Design and Function" on page 35 for a complete description of the design and
function of SampleXpress.
Figure 2.1 SampleXpress

10 Z31900_00_01
Introduction
2.2 Limitation of Liability
All specifications and instructions in this manual have been compiled taking account of
applicable standards and regulations, the current state of technology and the experience
and insights we have gained over the years.
The manufacturer accepts no liability for damage due to:
• Failure to observe this manual.
• Improper use.
• Deployment of untrained personnel.
• Unauthorized modifications.
• Technical modifications.
• Use of unauthorized spare parts.
The actual scope of supply may differ from the explanations and depictions in this man-
ual in the case of special designs, take-up of additional ordering options, or as a result of
the latest technical modifications.
The undertakings agreed in the supply contract, as well as the manufacturer's Terms
and Conditions and Terms of Delivery, and the legal regulations applicable at the time of
the conclusion of the contract shall apply.
2.3 Copyright
This manual is protected by copyright and intended solely for internal use.
This manual must not be made available to third parties, duplicated in any manner or
form – whether in whole or in part – and the content must not be used and/or communi-
cated, except for internal purposes, without the written consent of the manufacturer.
Violation of the copyright will result in legal action for damages. We reserve the right to
assert further claims.
2.4 Warranty Terms
The warranty terms are included in the manufacturer's Terms and Conditions.
2.5 Customer Service
Our customer service division is available to provide technical information. See "Con-
tact" on page 121 for contact details.
In addition, our employees are always interested in acquiring new information and expe-
rience gained from practical application; such information and experience may help
improve our products.

11
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Introduction
2.6 EC Declaration of Conformity

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Introduction
2.7 EG-Konformitätserklärung

13
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3 Safety
This section provides an overview of all the main safety aspects involved in ensuring
optimal personnel protection and safe and smooth operation.
Non-compliance with the action guidelines and safety instructions contained in this man-
ual may result in serious hazards.
iThe combined safety notices for this manual in English can be found in "Safety Notices"
on page 123.
The combined safety notices for this manual in French can be found in "Avertissements
De Sécurité" on page 133.
The combined safety notices for this manual in German can be found in "Sicherheitshin-
weise" on page 145.
3.1 Intended Use
The device has been designed and constructed solely for the intended use described
here.
The SampleXpress must only be used for keeping NMR samples in a cassette module,
inserting them into the NMR spectroscopy magnet and ejecting them after measurement
back into the magazine.
Intended use also includes compliance with all specifications within this manual.
Any use which exceeds or differs from the intended use shall be considered improper
use.
No claims of any kind for damage will be entertained if such claims result from improper
use.
3.2 Owner‘s Responsibility
Owner
The term 'owner' refers to the person who himself operates the device for trade or com-
mercial purposes, or who surrenders the device to a third party for use/application, and
who bears the legal product liability for protecting the user, the personnel or third parties
during the operation.

14 Z31900_00_01
Safety
Owner‘s Obligations
The device is used in the industrial sector, universities and research laboratories. The
owner of the device must therefore comply with statutory occupational safety require-
ments.
In addition to the safety instructions in this manual, the safety, accident prevention and
environmental protection regulations governing the operating area of the device must be
observed.
In this regard, the following requirements should be particularly observed:
• The owner must obtain information about the applicable occupational safety regula-
tions, and - in the context of a risk assessment - must determine any additional dan-
gers resulting from the specific working conditions at the usage location of the
device. The owner must then implement this information in a set of operating
instructions governing operation of the device.
• During the complete operating time of the device, the owner must assess whether
the operating instructions issued comply with the current status of regulations, and
must update the operating instructions if necessary.
• The owner must clearly lay down and specify responsibilities with respect to installa-
tion, operation, troubleshooting, maintenance and cleaning.
• The owner must ensure that all personnel dealing with the device have read and
understood this manual. In addition, the owner must provide personnel with training
and hazards information at regular intervals.
• The owner must provide the personnel with the necessary protective equipment.
• The owner must warrant that the SampleXpress is operated by trained and autho-
rised personnel as well as all other work, such as transportation, mounting, start-up,
the installation, maintenance, cleaning, service, repair and shutdown, that is carried
out on the device.
• All personnel who work with, or in the close proximity of the SampleXpress device,
need to be informed of all safety issues and emergency procedures as outlined in
this user manual.
• The owner must document the information about all safety issues and emergency
procedures in a laboratory SOP (Standard Operating Procedure). Routine briefings
and briefings for new personnel must take place.
• The owner must ensure that new personnel are supervised by experienced person-
nel. It is highly recommended to implement a company training program for new
personnel on all aspects of product safety and operation.
• The owner must ensure that personnel are regularly informed of the potential haz-
ards within the laboratory. This is all personnel that work in the area, but in particular
laboratory personnel and external personnel such as cleaning and service person-
nel.
• The owner is responsible for taking measures to avoid inherent risks in the handling
of dangerous substances, preventing industrial disease, and providing medical first
aid in emergencies.
• The owner is responsible for providing facilities according to the local regulations for
the prevention of industrial accidents and generally accepted safety regulations
according to the rules of occupational medicine.

15
Z31900_00_01
Safety
• All substances needed for operating and cleaning the device samples, solvents,
cleaning agents, gases, etc. have to be handled with care and disposed of appropri-
ately. All hints and warnings on storage containers must be read and adhered to.
• The owner must ensure that the work area is sufficiently illuminated to avoid reading
errors and faulty operation.
• The owner must ensure that the laboratory is equipped with an oxygen warning
device, in case the device is operated with nitrogen.
Furthermore, the owner is responsible for ensuring that the device is always in a techni-
cally faultless condition. Therefore, the following applies:
• The owner must ensure that the maintenance intervals described in this manual are
observed.
• The owner must ensure that all safety devices are regularly checked to ensure full
functionality and completeness.
3.3 Personnel Requirements
3.3.1 Qualifications
iNote: Only trained Bruker personnel are allowed to mount, retrofit, repair, adjust and dis-
mantle the unit!
This manual specifies the personnel qualifications required for the different areas of
work, listed below:
Laboratory Personnel
Laboratory personnel are health care professionals, technicians, and assistants staffing
a research or health care facility where specimens are grown, tested, or evaluated and
the results of such measures are recorded. Laboratory personnel are able to carry out
assigned work and to recognize and prevent possible dangers self-reliant due to their
professional training, knowledge and experience as well as profound knowledge of
applicable regulations.
The workforce must only consist of persons who can be expected to carry out their work
reliably. Persons with impaired reactions due to, for example, the consumption of drugs,
alcohol, or medication are prohibited from carrying out work on the device.
When selecting personnel, the age-related and occupation-related regulations governing
the usage location must be observed.

16 Z31900_00_01
Safety
3.3.2 Unauthorized Persons
3.3.3 Instruction
Personnel must receive regular instruction from the owner. The instruction must be doc-
umented to facilitate improved verification.
3.4 Personal Protective Equipment
Personal protective equipment is used to protect the personnel from dangers which
could affect their safety or health while working.
Personnel must wear personal protective equipment while carrying out the different
operations at and with the device.
This equipment will be defined by the head of the laboratory. Always comply with the
instructions governing personal protective equipment posted in the work area.
WARNING
Risk to life for unauthorized personnel due to hazards in the danger and
working zone!
Unauthorized personnel who do not meet the requirements described in this manual
will not be familiar with the dangers in the working zone. Therefore, unauthorized per-
sons face the risk of serious injury or death.
fUnauthorized persons must be kept away from the danger and working zone.
fIf in doubt, address the persons in question and ask them to leave the danger and
working zone.
fCease work while unauthorized persons are in the danger and working zone.
Date Name Type of
Instruction
Instruction
Provided By
Signature

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Safety
3.5 Basic Dangers
The following section specifies residual risks which may result from using the device and
have been established by means of a risk assessment.
In order to minimize health hazards and avoid dangerous situations, follow the safety
instructions specified here as well as in the following chapters of this manual.
3.5.1 Position of the Safety Devices
EMERGENCY STOP Button
The position of the EMERGENCY STOP button is indicated in the illustration by an
arrow.
Figure 3.1 Position of the Emergency Stop
3.5.2 Description of the Installed Safety Devices
EMERGENCY STOP Button
Pressing the EMERGENCY STOP button triggers an emergency stop. After the emer-
gency stop button has been pressed, it must be unlocked by rotating it in order to enable
a restart.
Figure 3.2 Emergency Stop Button

18 Z31900_00_01
Safety
3.5.3 General Workplace Dangers
Dirt and Scattered Objects
Working in Heights
Software Error
CAUTION
Danger of injury from tripping over dirt and scattered objects!
Dirt and scattered objects may cause people to slip or trip. A fall may result in inju-
ries.
fAlways keep the work area clean.
fRemove objects which are no longer required from the work area and particularly
from the floor.
fIndicate unavoidable hazards using marking tape.
CAUTION
Accident hazard from falling from ladder!
It is possible to fall from a ladder when it is used to reach the SampleXpress on some
magnets.
fDo not use a ladder.
fUse an approved platform to reach the device on the magnet.
fWear non-slip shoes.
NOTICE
Material damage due to a software error!
Samples or SampleXpress may be damaged due to a software error causing mal-
function of the control system. Users may also be shocked by abrupt malfunction or
unexpected system start.
fDummy samples must be used during installation and service.
fPersonnel should be alerted to unexpected malfunctions.

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Safety
Impacting Magnet
Genuine Samples
3.5.4 Dangers from Electric Power
Stored Charges
NOTICE
Material damage hazard due to impacting the magnet!
Impacting the magnet may result in a quench.
fMount the SampleXpress carefully on the magnet.
fAvoid banging the magnet during installation and operation, e.g. when replacing
the sample cassette.
NOTICE
Material damage due to the use of genuine samples during installation
and maintenance!
Using genuine samples during installation and maintenance may result in material
damage.
fUse only dummy samples during installation and maintenance.
DANGER
Danger to life from stored charges!
Electric charges may be stored in electrical components even after the system has
been switched off and disconnected from the power supply. Contact with these com-
ponents may result in serious or fatal injury.
fBefore working on the specified components, ensure that they have been com-
pletely disconnected from the power supply. Allow 10 minutes to elapse in order to
ensure that the internal capacitors have been fully discharged.

20 Z31900_00_01
Safety
Electric Current
Residual Electrostatic Potentials
Electrostatic Discharge
iElectrostatic discharge from friction may occur, resulting in an electric spark and loud
bang. Use ESD flooring and wear ESD shoes.
WARNING
Electrical hazard from electrical shock!
A life threatening shock may result when the housing is open during operation.
fDisconnect the device from the electrical power supply before opening the device.
Use a voltmeter to verify that the device is not under power!
fBe sure that the power supply cannot be reconnected without notice.
fThe housing must be closed during operation.
WARNING
Danger to life from residual electrostatic potentials!
Friction between material being conveyed may result in significant development of
electrostatic potential. Contact with parts immediately following the conveying opera-
tion may therefore be life-threatening.
fTherefore, potential equalisation must be ensured before making contact with
parts, unless such equalisation is provided by the customer.