Izon EXOID User manual

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USER MANUAL
EXOID

Izon Science Limited provides this document to its customers with a product purchase to use in the
product operation. This document is copyright protected and any reproduction of the whole or any part
of this document is strictly prohibited, except with the written authorisation of Izon Science Limited.
The contents of this document are subject to change without notice. All technical information in this
document is for reference purposes only. System configurations and specifications in this document
supersede all previous information received by the purchaser.
Izon Science Limited makes no representations that this document is complete, accurate or error-
free and assumes no responsibility and will not be liable for any errors, omissions, damage or loss
that might result from any use of this document, even if the information in the document is followed
properly.
Izon products are designed and manufactured under a quality system certified to ISO 13485:2016.
This document is not part of any sales contract between Izon Science Limited and a purchaser.
This document shall in no way govern or modify any Terms and Conditions of Sale, which Terms and
Conditions of Sale shall govern all conflicting information between the two documents.
FCC Declaration of Conformance
This device complies with part 15 of the FCC Rules. Operation is subject to the following two conditions:
(1) This device may not cause harmful interference
(2) This device must not accept any interference received, including interference that may cause
undesired operation. Changes or modification not expressly approved by the party responsible for
compliance could void the user’s authority to operate the equipment.
Izon Science Limited Telephone: [phone]
PO Box 9292 Email: [email protected]
Addington Website: www.izon.com
Christchurch 8024
New Zealand
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TABLE OF CONTENTS
1 Definitions and Writing Conventions .......................................................................................................... 4
2 Safety and Hazards......................................................................................................................................... 6
2.1 Safe Use Requirements and Specifications ................................................................................................... 6
2.2 Hazards........................................................................................................................................................................6
2.3 Intended Use ...............................................................................................................................................................7
3 Assembly and Setup Instructions ................................................................................................................ 8
3.1 System Components ...............................................................................................................................................8
3.2 Assembling and Installing the Exoid ..................................................................................................................9
3.3 Instrument Power and General Operation ...................................................................................................... 9
3.4 General Operating Procedures............................................................................................................................9
3.5 Computer Setup...................................................................................................................................................... 10
4 Operations Instructions.................................................................................................................................12
4.1 Required Materials................................................................................................................................................. 12
4.2 Exoid Lighting........................................................................................................................................................... 13
4.3 Fluid Cell .................................................................................................................................................................... 14
4.4 Exoid Control Suite Software ............................................................................................................................. 15
5 Troubleshooting.............................................................................................................................................. 18
6 Further Support .............................................................................................................................................20
Exoid User Manual 3

DEFINITIONS AND WRITING CONVENTIONS
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This symbol indicates general advice on how to improve procedures or
recommends measures to take in specific situations.
This symbol indicates where special care should be taken.
Direct Current (DC)
Voltage polarity of the jack
Make sure to follow the precautionary statements presented in this guide. Safety and other special
notifications will appear in boxes and include the symbols detailed in Table 1.
Table 1: Safety and Hazard Symbols
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Table 2: Terminology used in this manual
TERM DEFINITION
Automatic Pressure
System (APS)
A component of the Exoid which controls pressure to a limit of ±2500
Pascals (Pa).
Delta The stretcher unit consisting of a set of jaws with teeth that the
nanopore fits on to.
Exoid Control Suite (ECS) The software used to operate the Exoid.
Exoid lighting Lighting halo located around the top of the Exoid.
Izon Data Suite (IDS) The software used to process data produced by the Exoid.
Load position The stretcher unit position that enables a nanopore to be fitted onto
the teeth.
Nanopore Flexible polyurethane membrane with a nanoscale size hole in the
centre.
RMS noise Root mean square: a real-time measure of the background electrical
noise of the system.
Shielding lid Hinged cap on the top face of the Exoid which opens to reveal the fluid
cell and nanopore working area. Closing this will reduce noise from
external sources such as large machinery and fluorescent lighting.
Voltage Clamp Amplifier
(VCA)
A component of the Exoid which controls the voltage applied to the
system in order to manipulate current.
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2.2 Hazards
The Exoid is a laboratory product, however if any biohazardous samples are present then adhere
to current Good Laboratory Practices (cGLPs) and comply with any local guidelines specific to your
laboratory and location.
Fire or Electrical Hazard
The Exoid poses no uncommon electrical or fire hazard to operators if installed and operated properly
without physical modification and connected to a power source of correct specification.
SAFETY AND HAZARDS
2.1 Safe Use Requirements and Specifications
Make sure to adhere to the safe use requirements as specified in Table 3. If the equipment is
used in a manner not specified, protection provided by the equipment may be impaired.
Table 3: Safe use requirements and specification of the Exoid
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SAFE USE REQUIREMENT SPECIFICATION
Operating Temperature Indoor Use
Ambient temperature of 5-40 ˚C is safe for the
instrument, however operation at 5-25 ˚C is
recommended.
Altitude Up to 2000 meters above sea level
Relative Humidity 20-80% relative humidity
Power Consumption 80 W
Pollution Degree Rating 2
Ingress Protection Rating IP30 / Type 1 - UL50E
Power Supply Unit
(TRH100A240-21E11 +
CCCVI)
Input AC
100-240 V
1.5 A
47-63 Hz
Output DC
24 V nom
4.17 A max current
100.08 W max power
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Chemical Hazards
The Exoid system contains no potentially hazardous chemical materials.
Mechanical Hazards
The Exoid stretcher unit contains automatically moving parts. Keep fingers and loose clothing clear
while automatic processes are in operation.
Transport
To protect the Exoid during transport or storage, decontamination procedures must first be performed.
To protect the instrument from damage, always use the packaging materials supplied when
transporting the Exoid. Use appropriate heavy lifting techniques to avoid injury. If appropriate packing
materials cannot be obtained then contact your local Izon Science office.
Disposal
The Exoid system contains electrical materials; it should be disposed of as unsorted waste and must
be collected separately, according to the European Union Directive: Waste Electrical and Electronic
Equipment. The user is fully responsible for ensuring that the obsolete Equipment and/or Consumables
are recycled or disposed of in accordance with this and/or any other relevant laws and regulations in
the countries where the instrument is being recycled or disposed of. Contact your local Izon Science
representative for more information.
2.3 Intended Use
The Exoid is used to measure size, concentration and zeta potential of nanoparticles. The instrument
is intended for use in research laboratories by professional personnel. The Exoid is not intended for
diagnostic purposes and should not be used to make treatment decisions.
For verification of the entire system, it is recommended that cGLPs are followed to ensure reliable
analyses.
Exoid User Manual 7

ASSEMBLY AND SETUP INSTRUCTIONS
3.1 System Components
The following components are provided in the box:
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1Exoid Instrument 5Lower Fluid Cell
2Shielding Cap 624 V Power Supply
3Upper Fluid Cell 7Power Lead
410 MΩ Reference Cell 8USB-A to USB-C Cable
Figure 1: The Exoid and components with an Exoid.
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3.2 Assembling and Installing the Exoid
1. Unpack the Exoid and box contents.
We recommend that you save the box and packaging materials in case the instrument needs to be
returned for servicing.
If you decide to dispose of the packaging, first check that all components are present so as not to
inadvertently throw anything away.
2. Place the Exoid onto a stable and level laboratory bench.
3. Ensure that the buttons near the top of the Exoid are facing the user.
4. Connect the power lead to the 24 V power supply.
5. Ensure the Exoid is switched off, and if the power socket at the wall has a switch, ensure the switch
is turned off. Plug the power lead into a wall socket and connect the cable from the 24 V power
supply to the rear of the instrument.
6. Connect the USB cable to the instrument and the computer.
7. Turn the instrument on first using the power switch at the wall socket (if applicable) and then the
Exoid power switch.
3.3 Instrument Power and General Operation
Make sure the power supply box is positioned away from fluids.
To prevent heat buildup do not cover the power supply box.
Position the unit so it can be quickly and easily disconnected from the mains power.
Check the local supply meets the AC input requirement given in the specification.
The Exoid is to only be used with power supplies and leads provided by Izon. Failure to use the
correct power supply may result in invalid operation.
Make sure the power supply is placed away from and to the rear of the instrument to avoid coming
into contact with any spills or fluid.
Exoid User Manual 9

3.4 General Operating Procedures
For indoor use only and to be used within the rated conditions specified.
Take care not to spill fluids on electrical parts during operation.
The Exoid must be installed into Earth Grounded Protected Outlets ONLY. To minimise the influence
of external noise from the environment, position equipment away from electrical switching gear and
interfering equipment.
3.5 Computer Setup
Devices connected to the Exoid should be compliant with a relevant safety standard such as IEC
60950-1 for IT equipment or IEC 61010-1 for laboratory equipment and should provide double or
reinforced insulation from hazardous voltage sources. Always use USB cables supplied by Izon to
connect the Exoid to the computer.
Minimum Computer Specifications
For the Exoid and ECS to work effectively, the minimum PC requirements must be in place. These are as
follows:
16 GB RAM
i7 processor
256 GB SSD
Dedicated graphics processor (GPU) with at least 1 GB graphics memory
Windows 10 Pro
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